IJMS, Vol. 21, Pages 3681: Exacerbated Imiquimod-Induced Psoriasis-Like Skin Inflammation in IRF5-Deficient Mice International Journal of Molecular Sciences doi: 10.3390/ijms21103681 Authors: Momoko Nakao Tomomitsu Miyagaki Makoto Sugaya Shinichi Sato Interferon regulatory factors (IRFs) play diverse roles in the regulation of the innate and adaptive immune responses in various diseases. In psoriasis, IRF2 is known to be involved in pathogenesis, while studies on other IRFs...
Sat May 23, 2020 03:00
IJMS, Vol. 21, Pages 3685: Neutrophils Modulate Fibroblast Function and Promote Healing and Scar Formation after Murine Myocardial Infarction International Journal of Molecular Sciences doi: 10.3390/ijms21103685 Authors: Curaj Schumacher Rusu Staudt Li Simsekyilmaz Jankowski Jankowski Dumitraşcu Hausenloy Schuh Liehn Aim: Recruitment of neutrophils to the heart following acute myocardial infarction (MI) initiates inflammation and contributes...
Sat May 23, 2020 03:00
IJMS, Vol. 21, Pages 3683: ER-Resident Transcription Factor Nrf1 Regulates Proteasome Expression and Beyond International Journal of Molecular Sciences doi: 10.3390/ijms21103683 Authors: Jun Hamazaki Shigeo Murata Protein folding is a substantively error prone process, especially when it occurs in the endoplasmic reticulum (ER). The highly exquisite machinery in the ER controls secretory protein folding, recognizes aberrant folding states, and retrotranslocates permanently misfolded...
Sat May 23, 2020 03:00
IJMS, Vol. 21, Pages 3679: Molecular Basis of Bone Aging International Journal of Molecular Sciences doi: 10.3390/ijms21103679 Authors: Addolorata Corrado Daniela Cici Cinzia Rotondo Nicola Maruotti Francesco Paolo Cantatore A decline in bone mass leading to an increased fracture risk is a common feature of age-related bone changes. The mechanisms underlying bone senescence are very complex and implicate systemic and local factors and are the result of the combination of...
Sat May 23, 2020 03:00
IJMS, Vol. 21, Pages 3684: Regulation of a PRMT5/NF-κB Axis by Phosphorylation of PRMT5 at Serine 15 in Colorectal Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21103684 Authors: Hartley Wang Jiang Wei Sun Prabhu Martin Safa Sun Liu Lu The overexpression of PRMT5 is highly correlated to poor clinical outcomes for colorectal cancer (CRC) patients. Importantly, our previous work demonstrated that PRMT5 overexpression could...
Sat May 23, 2020 03:00
IJMS, Vol. 21, Pages 3674: Synthesis, Properties, and Biodegradation of Sequential Poly(Ester Amide)s Containing γ-Aminobutyric Acid International Journal of Molecular Sciences doi: 10.3390/ijms21103674 Authors: Yuushou Nakayama Kazumasa Watanabe Ryo Tanaka Takeshi Shiono Norioki Kawasaki Naoko Yamano Atsuyoshi Nakayama Poly(ester amide)s are attracting attention because they potentially have excellent thermal and mechanical properties as well as biodegradability. In...
Sat May 23, 2020 03:00
IJMS, Vol. 21, Pages 3678: Neuroprotective and Anti-Inflammatory Effects of Low–Moderate Dose Ionizing Radiation in Models of Alzheimer’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21103678 Authors: Sujin Kim Yunkwon Nam Chanyang Kim Hyewon Lee Seojin Hong Hyeon Soo Kim Soo Jung Shin Yong Ho Park Han Ngoc Mai Sang-Muk Oh Kyoung Soo Kim Doo-Han Yoo Weon Kuu Chung Hyunju Chung Minho Moon Alzheimer’s disease (AD)...
Sat May 23, 2020 03:00
IJMS, Vol. 21, Pages 3675: Effect of Combining Low Temperature Plasma, Negative Pressure Wound Therapy, and Bone Marrow Mesenchymal Stem Cells on an Acute Skin Wound Healing Mouse Model International Journal of Molecular Sciences doi: 10.3390/ijms21103675 Authors: Hui Song Cui So Young Joo Yoon Soo Cho Ji Heon Park June-Bum Kim Cheong Hoon Seo Low-temperature plasma (LTP; 3 min/day), negative pressure wound therapy (NPWT; 4 h/day), and bone marrow mesenchymal stem cells...
Sat May 23, 2020 03:00
IJMS, Vol. 21, Pages 3673: Interplay between Type 2 Transglutaminase (TG2), Gliadin Peptide 31-43 and Anti-TG2 Antibodies in Celiac Disease International Journal of Molecular Sciences doi: 10.3390/ijms21103673 Authors: Martucciello Sposito Esposito Paolella Caputo Celiac disease (CD) is a common intestinal inflammatory disease involving both a genetic background and environmental triggers. The ingestion of gluten, a proteic component of several cereals, represents the...
Sat May 23, 2020 03:00
IJMS, Vol. 21, Pages 3676: Unravelling the Role of Glycogen Synthase Kinase-3 in Alzheimer’s Disease-Related Epileptic Seizures International Journal of Molecular Sciences doi: 10.3390/ijms21103676 Authors: Lin Jones Kwan Alzheimer’s disease (AD) is the most common form of dementia. An increasing body of evidence describes an elevated incidence of epilepsy in patients with AD, and many transgenic animal models of AD also exhibit seizures and susceptibility to epilepsy....
Sat May 23, 2020 03:00
IJMS, Vol. 21, Pages 3677: Silicon Regulates Source to Sink Metabolic Homeostasis and Promotes Growth of Rice Plants Under Sulfur Deficiency International Journal of Molecular Sciences doi: 10.3390/ijms21103677 Authors: Réthoré Ali Yvin Hosseini Being an essential macroelement, sulfur (S) is pivotal for plant growth and development, and acute deficiency in this element leads to yield penalty. Since the last decade, strong evidence has reported the regulatory function of...
Sat May 23, 2020 03:00
IJMS, Vol. 21, Pages 3672: Sonic Hedgehog and Triiodothyronine Pathway Interact in Mouse Embryonic Neural Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms21103672 Authors: Ostasov Tuma Pitule Moravec Houdek Vozeh Kralickova Cendelin Babuska Neural stem cells are fundamental to development of the central nervous system (CNS)—as well as its plasticity and regeneration—and represent a potential tool for neuro transplantation...
Sat May 23, 2020 03:00
IJMS, Vol. 21, Pages 3670: Vitamin D in Triple-Negative and BRCA1-Deficient Breast Cancer—Implications for Pathogenesis and Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21103670 Authors: Janusz Blasiak Elzbieta Pawlowska Jan Chojnacki Joanna Szczepanska Michal Fila Cezary Chojnacki Several studies show that triple-negative breast cancer (TNBC) patients have the lowest vitamin D concentration among all breast cancer types, suggesting that this vitamin...
Sat May 23, 2020 03:00
IJMS, Vol. 21, Pages 3671: Activity to Breast Cancer Cell Lines of Different Malignancy and Predicted Interaction with Protein Kinase C Isoforms of Royleanones International Journal of Molecular Sciences doi: 10.3390/ijms21103671 Authors: Vera M. S. Isca Milan Sencanski Nenad Filipovic Daniel J. V. A. Dos Santos Ana Čipak Gašparović Lucília Saraíva Carlos A. M. Afonso Patrícia Rijo Alfonso T. García-Sosa Plants have been used for centuries to treat several illnesses....
Sat May 23, 2020 03:00
IJMS, Vol. 21, Pages 3669: Vitamin B6 and Diabetes: Relationship and Molecular Mechanisms International Journal of Molecular Sciences doi: 10.3390/ijms21103669 Authors: Elisa Mascolo Fiammetta Vernì Vitamin B6 is a cofactor for approximately 150 reactions that regulate the metabolism of glucose, lipids, amino acids, DNA, and neurotransmitters. In addition, it plays the role of antioxidant by counteracting the formation of reactive oxygen species (ROS) and advanced glycation end-products...
Sat May 23, 2020 03:00
IJMS, Vol. 21, Pages 3668: Development of Biodegradable Whey-Based Laminate Functionalised by Chitosan–Natural Extract Formulations International Journal of Molecular Sciences doi: 10.3390/ijms21103668 Authors: Sanja Potrč Lidija Fras Zemljič Meta Sterniša Sonja Smole Možina Olivija Plohl In this research, antimicrobial polysaccharide chitosan and natural extracts were used as surface coating of a plastic laminate with an integrated whey layer on the inside. The aim was to...
Fri May 22, 2020 03:00
IJMS, Vol. 21, Pages 3661: Synthetic Strategies and Computational Inhibition Activity Study for Triazinyl-Substituted Benzenesulfonamide Conjugates with Polar and Hydrophobic Amino Acids as Inhibitors of Carbonic Anhydrases International Journal of Molecular Sciences doi: 10.3390/ijms21103661 Authors: Mária Bodnár Mikulová Dáša Kružlicová Daniel Pecher Claudiu T. Supuran Peter Mikuš Various sulfonamide derivatives are intensively studied as anticancer agents owing to their...
Fri May 22, 2020 03:00
IJMS, Vol. 21, Pages 3664: Harmful Iron-Calcium Relationship in Pantothenate kinase Associated Neurodegeneration International Journal of Molecular Sciences doi: 10.3390/ijms21103664 Authors: Paolo Santambrogio Maddalena Ripamonti Chiara Paolizzi Celeste Panteghini Miryam Carecchio Luisa Chiapparini Marzia Raimondi Alicia Rubio Ivano Di Meo Anna Cozzi Stefano Taverna Giuseppe De Palma Valeria Tiranti Sonia Levi Pantothenate Kinase-associated Neurodegeneration...
Fri May 22, 2020 03:00
IJMS, Vol. 21, Pages 3666: A Guide to the Short, Long and Circular RNAs in Hypertension and Cardiovascular Disease International Journal of Molecular Sciences doi: 10.3390/ijms21103666 Authors: Priscilla R. Prestes Michelle C. Maier Bradley A. Woods Fadi J. Charchar Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in adults in developed countries. CVD encompasses many diseased states, including hypertension, coronary artery disease and atherosclerosis....
Fri May 22, 2020 03:00
IJMS, Vol. 21, Pages 3667: Cyclophilin A Promotes Inflammation in Acute Kidney Injury but Not in Renal Fibrosis International Journal of Molecular Sciences doi: 10.3390/ijms21103667 Authors: Khai Gene Leong Elyce Ozols John Kanellis David J. Nikolic-Paterson Frank Y. Ma Cyclophilin A (CypA) is a highly abundant protein in the cytoplasm of most mammalian cells. Beyond its homeostatic role in protein folding, CypA is a Damage-Associated Molecular Pattern which can promote inflammation...
Fri May 22, 2020 03:00
IJMS, Vol. 21, Pages 3663: Delayed NK Cell Reconstitution and Reduced NK Activity Increased the Risks of CMV Disease in Allogeneic-Hematopoietic Stem Cell Transplantation International Journal of Molecular Sciences doi: 10.3390/ijms21103663 Authors: Ki Hyun Park Ji Hyeong Ryu Hyunjoo Bae Sojeong Yun Joo Hee Jang Kyungja Han Byung Sik Cho Hee-Je Kim Hyeyoung Lee Eun-Jee Oh Cytomegalovirus (CMV) infection has a significant impact in patients after allogeneic...
Fri May 22, 2020 03:00
IJMS, Vol. 21, Pages 3662: Seminal Plasma Induces Overexpression of Genes Associated with Embryo Development and Implantation in Day-6 Porcine Blastocysts International Journal of Molecular Sciences doi: 10.3390/ijms21103662 Authors: Cristina A. Martinez Josep M. Cambra Maria A. Gil Inmaculada Parrilla Manuel Alvarez-Rodriguez Heriberto Rodriguez-Martinez Cristina Cuello Emilio A. Martinez The infusion of boar seminal plasma (SP) before artificial insemination (AI)...
Fri May 22, 2020 03:00
IJMS, Vol. 21, Pages 3659: Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes International Journal of Molecular Sciences doi: 10.3390/ijms21103659 Authors: Tanira Matutino Bastos Milena Botelho Pereira Soares Caio Haddad Franco Laura Alcântara Lorenzo Antonini Manuela Sabatino Nicola Mautone Lucio Holanda Freitas-Junior Carolina Borsoi Moraes Rino Ragno Dante Rotili Sergio Schenkman Antonello Mai Nilmar...
Fri May 22, 2020 03:00
IJMS, Vol. 21, Pages 3665: Immunoregulatory Property of C-Type Lectin-Like Receptors in Fibrosing Interstitial Lung Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21103665 Authors: Wiwin Is Effendi Tatsuya Nagano Helmia Hasan Resti Yudhawati The innate immune system identifies exogenous threats or endogenous stress through germline-encoded receptors called pattern recognition receptors (PRRs) that initiate consecutive downstream signaling pathways to control...
Fri May 22, 2020 03:00
IJMS, Vol. 21, Pages 3660: Genome-Wide Dissection of the CRF Gene Family in Brassica napus Indicates that BnaCRF8s Specifically Regulate Root Architecture and Phosphate Homeostasis against Phosphate Fluctuation in Plants International Journal of Molecular Sciences doi: 10.3390/ijms21103660 Authors: Wang Zhang Shi Xu Ding Phosphorus (P) is an essential macronutrient required for plant growth and development. The involvement of cytokinin response factors (CRFs) in phosphate...
Fri May 22, 2020 03:00
IJMS, Vol. 21, Pages 3658: Targeted Delivery of Iron Oxide Nanoparticle-Loaded Human Embryonic Stem Cell-Derived Spherical Neural Masses for Treating Intracerebral Hemorrhage International Journal of Molecular Sciences doi: 10.3390/ijms21103658 Authors: Min Kyoung Kang Tae Jung Kim Young-Ju Kim Lamie Kang Jonghoon Kim Nohyun Lee Taeghwan Hyeon Mi-sun Lim Hee Jung Mo Jung Hwan Shin Sang-Bae Ko Byung-Woo Yoon This study evaluated the potential of iron oxide...
Fri May 22, 2020 03:00
IJMS, Vol. 21, Pages 3657: 3-Hydroxytyrosol Promotes Angiogenesis In Vitro by Stimulating Endothelial Cell Migration International Journal of Molecular Sciences doi: 10.3390/ijms21103657 Authors: Mario Abate Simona Pisanti Mariella Caputo Marianna Citro Carmine Vecchione Rosanna Martinelli Cardiovascular diseases, followed by strokes, represent the leading cause of mortality worldwide. Despite its success in preventing cardiovascular diseases, the therapeutic potential...
Fri May 22, 2020 03:00
IJMS, Vol. 21, Pages 3656: Microbial Transglutaminase as a Tool to Improve the Features of Hydrocolloid-Based Bioplastics International Journal of Molecular Sciences doi: 10.3390/ijms21103656 Authors: C. Valeria L. Giosafatto Antonio Fusco Asmaa Al-Asmar Loredana Mariniello Several proteins from animal and plant origin act as microbial transglutaminase substrate, a crosslinking enzyme capable of introducing isopeptide bonds into proteins between the aminoacids glutamines and...
Fri May 22, 2020 03:00
IJMS, Vol. 21, Pages 3655: Sushi Repeat Containing Protein X-linked 2 Is a Downstream Signal of LEM Domain Containing 1 and Acts as a Tumor-Promoting Factor in Oral Squamous Cell Carcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21103655 Authors: Tomonori Sasahira Miyako Kurihara-Shimomura Yukiko Nishiguchi Hiroyuki Shimomura Tadaaki Kirita Because oral squamous cell carcinomas (OSCCs) have a high potential for locoregional invasion and nodal metastasis,...
Fri May 22, 2020 03:00
JCDD, Vol. 7, Pages 19: Transforming Growth Factor Beta3 is Required for Cardiovascular Development Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd7020019 Authors: Mrinmay Chakrabarti Nadia Al-Sammarraie Mengistu G. Gebere Aniket Bhattacharya Sunita Chopra John Johnson Edsel A. Peña John F. Eberth Robert E. Poelmann Adriana C. Gittenberger-de Groot Mohamad Azhar Transforming growth factor beta3 (TGFB3) gene mutations in patients of arrhythmogenic...
Sun May 24, 2020 03:00
JCM, Vol. 9, Pages 1596: Impact of the Gut Microbiota on Atorvastatin Mediated Effects on Blood Lipids Journal of Clinical Medicine doi: 10.3390/jcm9051596 Authors: Friederike Zimmermann Johann Roessler David Schmidt Andrzej Jasina Paul Schumann Martina Gast Wolfgang Poller David Leistner Hector Giral Nicolle Kränkel Adelheid Kratzer Sven Schuchardt Markus M. Heimesaat Ulf Landmesser Arash Haghikia Background and Aims: The mechanisms of interindividual...
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JCM, Vol. 9, Pages 1594: Anti-angiogenesis and Immunotherapy: Novel Paradigms to Envision Tailored Approaches in Renal Cell-Carcinoma Journal of Clinical Medicine doi: 10.3390/jcm9051594 Authors: Antonella Argentiero Antonio Giovanni Solimando Markus Krebs Patrizia Leone Nicola Susca Oronzo Brunetti Vito Racanelli Angelo Vacca Nicola Silvestris Although decision making strategy based on clinico-histopathological criteria is well established, renal cell carcinoma...
Sun May 24, 2020 03:00
JCM, Vol. 9, Pages 1593: Automated Classification of Colorectal Neoplasms in White-Light Colonoscopy Images via Deep Learning Journal of Clinical Medicine doi: 10.3390/jcm9051593 Authors: Young Joo Yang Bum-Joo Cho Myung-Je Lee Ju Han Kim Hyun Lim Chang Seok Bang Hae Min Jeong Ji Taek Hong Gwang Ho Baik Background: Classification of colorectal neoplasms during colonoscopic examination is important to avoid unnecessary endoscopic biopsy or resection. This study...
Sun May 24, 2020 03:00
JCM, Vol. 9, Pages 1595: Monitoring of Delayed Cerebral Ischemia in Patients with Subarachnoid Hemorrhage via Near-Infrared Spectroscopy Journal of Clinical Medicine doi: 10.3390/jcm9051595 Authors: Jeong Jin Park Chulho Kim Jin Pyeong Jeon We investigated the role of near infrared spectroscopy (NIRS) in identifying delayed cerebral ischemia (DCI) in patients with subarachnoid hemorrhage (SAH). We measured the cerebral regional oxygen saturation (rSO2) continuously for 14 days....
Sun May 24, 2020 03:00
JCM, Vol. 9, Pages 1591: Liver Transplant Patients with High Preoperative Serum Bilirubin Levels Are at Increased Risk of Postoperative Delirium: A Retrospective Study Journal of Clinical Medicine doi: 10.3390/jcm9051591 Authors: Kyu Hee Park Hyo Jung Son Yoon Ji Choi Gene Hyun Park Yoon Sook Lee Ju Yeon Park Hyun-Su Ri Jae Ryong Shim Postoperative delirium is a common complication after liver transplantation (LT). A high model for end-stage liver disease (MELD)...
Sun May 24, 2020 03:00
JCM, Vol. 9, Pages 1590: Prevalence of Elbow Joint Arthritis and Enthesitis in Rheumatoid Arthritis Journal of Clinical Medicine doi: 10.3390/jcm9051590 Authors: Valentin Sebastian Schäfer Florian Recker Diana Vossen Isabelle Geffken Eva Matuschek Wolfgang Hartung Objectives: The prevalence of elbow joint arthritis in rheumatoid arthritis (RA) assessed by ultrasound has not yet been investigated. Methods: We investigated 102 patients with RA and 50 patients without rheumatological...
Sun May 24, 2020 03:00
JCM, Vol. 9, Pages 1592: Pentaglobin® Efficacy in Reducing the Incidence of Sepsis and Transplant-Related Mortality in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation: A Retrospective Study Journal of Clinical Medicine doi: 10.3390/jcm9051592 Authors: Carlone Giorgia Torelli Lucio Maestro Alessandra Zanon Davide Barbi Egidio Maximova Natalia The 12-month mortality rate in patients undergoing hematopoietic stem cell transplantation (HSCT) remains high,...
Sun May 24, 2020 03:00
JCM, Vol. 9, Pages 1589: Major Lipids, Apolipoproteins, and Alterations of Gut Microbiota Journal of Clinical Medicine doi: 10.3390/jcm9051589 Authors: Kyung Eun Yun Jimin Kim Mi-hyun Kim Eunkyo Park Hyung-Lae Kim Yoosoo Chang Seungho Ryu Han-Na Kim The gut microbiota has been linked to blood lipids. However, the relationship between the gut microbiome and other lipid markers like apolipoproteins A1 (apoA1) and B (apoB) as well as classical lipid markers in Asians...
Sat May 23, 2020 03:00
JCM, Vol. 9, Pages 1588: Role of Menopausal Transition and Physical Activity in Loss of Lean and Muscle Mass: A Follow-Up Study in Middle-Aged Finnish Women Journal of Clinical Medicine doi: 10.3390/jcm9051588 Authors: Hanna-Kaarina Juppi Sarianna Sipilä Neil J. Cronin Sira Karvinen Jari E. Karppinen Tuija H. Tammelin Pauliina Aukee Vuokko Kovanen Urho M. Kujala Eija K. Laakkonen In midlife, women experience hormonal changes due to menopausal transition. A...
Sat May 23, 2020 03:00
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