Cancers, Vol. 12, Pages 1339: Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications Cancers doi: 10.3390/cancers12051339 Authors: Wook Jin Src family kinases (SFKs) are non-receptor kinases that play a critical role in the pathogenesis of colorectal cancer (CRC). The expression and activity of SFKs are upregulated in patients with CRC. Activation of SFKs promotes CRC cell proliferation, metastases to other organs and chemoresistance, as well...
Sat May 23, 2020 03:00
Cancers, Vol. 12, Pages 1338: Anatomical Theories of the Pathophysiology of Cancer-Related Lymphoedema Cancers doi: 10.3390/cancers12051338 Authors: Hiroo Suami Lymphoedema is a well-known concern for cancer survivors. A crucial issue in lymphoedema is that we cannot predict who will be affected, and onset can occur many years after initial cancer treatment. The variability of time between cancer treatment and lymphoedema onset is an unexplained mystery. Retrospective cohort studies...
Sat May 23, 2020 03:00
Cancers, Vol. 12, Pages 1337: Targeting Mononuclear Phagocyte Receptors in Cancer Immunotherapy: New Perspectives of the Triggering Receptor Expressed on Myeloid Cells (TREM-1) Cancers doi: 10.3390/cancers12051337 Authors: Federica Raggi Maria Carla Bosco Inflammatory cells are major players in the onset of cancer. The degree of inflammation and type of inflammatory cells in the tumor microenvironment (TME) are responsible for tilting the balance between tumor progression and regression....
Sat May 23, 2020 03:00
Cancers, Vol. 12, Pages 1336: Therapeutic Approach to Low-Grade Serous Ovarian Carcinoma: State of Art and Perspectives of Clinical Research Cancers doi: 10.3390/cancers12051336 Authors: Angiolo Gadducci Stefania Cosio Low-grade serous ovarian carcinoma (LGSOC) is a distinct pathologic and clinical entity, characterized by less aggressive biological behavior, lower sensitivity to chemotherapy and longer survival compared with high-grade serous ovarian carcinoma. LGSOC often harbors...
Sat May 23, 2020 03:00
Cancers, Vol. 12, Pages 1340: Hakin-1, a New Specific Small-Molecule Inhibitor for the E3 Ubiquitin-Ligase Hakai, Inhibits Carcinoma Growth and Progression Cancers doi: 10.3390/cancers12051340 Authors: Olaia Martinez-Iglesias Alba Casas-Pais Raquel Castosa Andrea Díaz-Díaz Daniel Roca-Lema Ángel Concha Álvaro Cortés Federico Gago Angélica Figueroa The requirement of the E3 ubiquitin-ligase Hakai for the ubiquitination and subsequent degradation of E-cadherin has...
Sat May 23, 2020 03:00
Cancers, Vol. 12, Pages 1335: Can 18F-NaF PET/CT before Autologous Stem Cell Transplantation Predict Survival in Multiple Myeloma? Cancers doi: 10.3390/cancers12051335 Authors: Sachpekidis Kopp-Schneider Merz Jauch Raab Goldschmidt Dimitrakopoulou-Strauss There is an unmet need for positron emission tomography (PET) radiotracers that can image bone disease in multiple myeloma (MM) in a more sensitive and specific way than the widely used 18F-fluorodeoxyglucose...
Sat May 23, 2020 03:00
Cancers, Vol. 12, Pages 1334: Boron Neutron Capture Therapy and Photodynamic Therapy for High-Grade Meningiomas Cancers doi: 10.3390/cancers12051334 Authors: Yukiko Nakahara Hiroshi Ito Jun Masuoka Tatsuya Abe Meningiomas are the most common type of intracranial brain tumors in adults. The majority of meningiomas are benign with a low risk of recurrence after resection. However, meningiomas defined as grades II or III, according to the 2016 World Health Organization (WHO) classification,...
Sat May 23, 2020 03:00
Cancers, Vol. 12, Pages 1333: A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers Cancers doi: 10.3390/cancers12051333 Authors: Motais Charvátová Hrdinka Šimíček Jelínek Ševčíková Kořístek Hájek Bagó : Hematological malignancies comprise over a hundred different types of cancers and account for around 6.5% of all cancers. Despite the significant improvements in diagnosis and treatment, many of those cancers remain incurable. In...
Sat May 23, 2020 03:00
Cancers, Vol. 12, Pages 1332: Application of Next-Generation Sequencing for the Genomic Characterization of Patients with Smoldering Myeloma Cancers doi: 10.3390/cancers12051332 Authors: Martina Manzoni Valentina Marchica Paola Storti Bachisio Ziccheddu Gabriella Sammarelli Giannalisa Todaro Francesca Pelizzoni Simone Salerio Laura Notarfranchi Alessandra Pompa Luca Baldini Niccolò Bolli Antonino Neri Nicola Giuliani Marta Lionetti Genomic analysis...
Sat May 23, 2020 03:00
Cancers, Vol. 12, Pages 1330: From CENTRAL to SENTRAL (SErum aNgiogenesis cenTRAL): Circulating Predictive Biomarkers to Anti-VEGFR Therapy Cancers doi: 10.3390/cancers12051330 Authors: Riccardo Giampieri Pina Ziranu Bruno Daniele Antonio Zizzi Daris Ferrari Sara Lonardi Alberto Zaniboni Luigi Cavanna Gerardo Rosati Mariaelena Casagrande Nicoletta Pella Laura Demurtas Maria Giulia Zampino Pietro Sozzi Valeria Pusceddu Domenico Germano Eleonora...
Fri May 22, 2020 03:00
Cancers, Vol. 12, Pages 1331: Gold Nanoparticle Mediated Multi-Modal CT Imaging of Hsp70 Membrane-Positive Tumors Cancers doi: 10.3390/cancers12051331 Authors: Melanie A. Kimm Maxim Shevtsov Caroline Werner Wolfgang Sievert Wu Zhiyuan Oliver Schoppe Bjoern H. Menze Ernst J. Rummeny Roland Proksa Olga Bystrova Marina Martynova Gabriele Multhoff Stefan Stangl Imaging techniques such as computed tomographies (CT) play a major role in clinical imaging...
Fri May 22, 2020 03:00
Cancers, Vol. 12, Pages 1327: Patient-Derived Xenograft Models of Pancreatic Cancer: Overview and Comparison with Other Types of Models Cancers doi: 10.3390/cancers12051327 Authors: Patrick L. Garcia Aubrey L. Miller Karina J. Yoon Pancreatic cancer (PC) is anticipated to be second only to lung cancer as the leading cause of cancer-related deaths in the United States by 2030. Surgery remains the only potentially curative treatment for patients with pancreatic ductal adenocarcinoma...
Fri May 22, 2020 03:00
Cancers, Vol. 12, Pages 1329: TOM40 Inhibits Ovarian Cancer Cell Growth by Modulating Mitochondrial Function Including Intracellular ATP and ROS Levels Cancers doi: 10.3390/cancers12051329 Authors: Wookyeom Yang Ha-Yeon Shin Hanbyoul Cho Joon-Yong Chung Eun-ju Lee Jae-Hoon Kim Eun-Suk Kang TOM40 is a channel-forming subunit of translocase, which is essential for the movement of proteins into the mitochondria. We found that TOM40 was highly expressed in epithelial ovarian...
Fri May 22, 2020 03:00
Cancers, Vol. 12, Pages 1323: Metabolic Reprogramming in Metastatic Melanoma with Acquired Resistance to Targeted Therapies: Integrative Metabolomic and Proteomic Analysis Cancers doi: 10.3390/cancers12051323 Authors: Laura Soumoy Corentin Schepkens Mohammad Krayem Ahmad Najem Vanessa Tagliatti Ghanem E. Ghanem Sven Saussez Jean-Marie Colet Fabrice Journe Treatments of metastatic melanoma underwent an impressive development over the past few years, with the emergence...
Fri May 22, 2020 03:00
Cancers, Vol. 12, Pages 1326: Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis Cancers doi: 10.3390/cancers12051326 Authors: Karolina Kaźmierczak-Siedlecka Aleš Dvořák Marcin Folwarski Agnieszka Daca Katarzyna Przewłócka Wojciech Makarewicz The association between bacterial as well as viral gut microbiota imbalance and carcinogenesis has been intensively analysed in many studies; nevertheless, the role of fungal gut microbiota...
Fri May 22, 2020 03:00
Cancers, Vol. 12, Pages 1325: Tumor Cell Associated Hyaluronan-CD44 Signaling Promotes Pro-Tumor Inflammation in Breast Cancer Cancers doi: 10.3390/cancers12051325 Authors: Patrice M. Witschen Thomas S. Chaffee Nicholas J. Brady Danielle N. Huggins Todd P. Knutson Rebecca S. LaRue Sarah A. Munro Lyubov Tiegs James B. McCarthy Andrew C. Nelson Kathryn L. Schwertfeger Cancer has been conceptualized as a chronic wound with a predominance of tumor promoting...
Fri May 22, 2020 03:00
Cancers, Vol. 12, Pages 1322: Hypoxia PET Imaging with [18F]-HX4—A Promising Next-Generation Tracer Cancers doi: 10.3390/cancers12051322 Authors: Sebastian Sanduleanu Alexander M.A. van der Wiel Relinde I.Y. Lieverse Damiënne Marcus Abdalla Ibrahim Sergey Primakov Guangyao Wu Jan Theys Ala Yaromina Ludwig J. Dubois Philippe Lambin Hypoxia—a common feature of the majority of solid tumors—is a negative prognostic factor, as it is associated...
Fri May 22, 2020 03:00
Cancers, Vol. 12, Pages 1324: An Integrated Genomic Strategy to Identify CHRNB4 as a Diagnostic/Prognostic Biomarker for Targeted Therapy in Head and Neck Cancer Cancers doi: 10.3390/cancers12051324 Authors: Yi-Hsuan Chuang Chia-Hwa Lee Chun-Yu Lin Chia-Lin Liu Sing-Han Huang Jung-Yu Lee Yi-Yuan Chiu Jih-Chin Lee Jinn-Moon Yang Although many studies have shown the association between smoking and the increased incidence and adverse prognosis of head and neck squamous...
Fri May 22, 2020 03:00
Cancers, Vol. 12, Pages 1328: Ibrutinib Resistance Mechanisms and Treatment Strategies for B-Cell lymphomas Cancers doi: 10.3390/cancers12051328 Authors: Bhawana George Sayan Mullick Chowdhury Amber Hart Anuvrat Sircar Satish Kumar Singh Uttam Kumar Nath Mukesh Mamgain Naveen Kumar Singhal Lalit Sehgal Neeraj Jain Chronic activation of B-cell receptor (BCR) signaling via Bruton tyrosine kinase (BTK) is largely considered to be one of the primary mechanisms...
Fri May 22, 2020 03:00
Cancers, Vol. 12, Pages 1319: WRN-Mutated Colorectal Cancer Is Characterized by a Distinct Genetic Phenotype Cancers doi: 10.3390/cancers12051319 Authors: Kai Zimmer Alberto Puccini Joanne Xiu Yasmine Baca Gilbert Spizzo Heinz-Josef Lenz Francesca Battaglin Richard M. Goldberg Axel Grothey Anthony F. Shields Mohamed E. Salem John L. Marshall W. Michael Korn Dominik Wolf Florian Kocher Andreas Seeber Werner syndrome gene (WRN) contributes to...
Fri May 22, 2020 03:00
Cancers, Vol. 12, Pages 1320: Erratum: Boland, P.M., et al. Immunotherapy for Colorectal Cancer, Cancers 2017, 9, 50 Cancers doi: 10.3390/cancers12051320 Authors: Patrick M. Boland Wen Wee Ma The authors wish to make the following corrections to this paper [...]
Fri May 22, 2020 03:00
Cancers, Vol. 12, Pages 1318: Application of In Vivo Imaging Techniques for Monitoring Natural Killer Cell Migration and Tumor Infiltration Cancers doi: 10.3390/cancers12051318 Authors: Prakash Gangadaran Ramya Lakshmi Rajendran Byeong-Cheol Ahn In recent years, the use of natural killer (NK) cell-based immunotherapy has shown promise against various cancer types. To some extent therapeutic potential of NK cell-based immunotherapy depends on migration of NK cells towards tumors...
Fri May 22, 2020 03:00
Cancers, Vol. 12, Pages 1321: Insights into the Molecular Mechanisms Behind Intralesional Immunotherapies for Advanced Melanoma Cancers doi: 10.3390/cancers12051321 Authors: Dejan Vidovic Carman Giacomantonio The incidence of cutaneous melanoma, a highly malignant skin cancer, is increasing yearly. While surgical removal of the tumor is the mainstay of treatment for patients with locally confined disease, those with metastases face uncertainty when it comes to their treatment. As...
Fri May 22, 2020 03:00
Cells, Vol. 9, Pages 1308: Molecular Chaperones and Proteolytic Machineries Regulate Protein Homeostasis In Aging Cells Cells doi: 10.3390/cells9051308 Authors: Margulis Tsimokha Zubova Guzhova Throughout their life cycles, cells are subject to a variety of stresses that lead to a compromise between cell death and survival. Survival is partially provided by the cell proteostasis network, which consists of molecular chaperones, a ubiquitin-proteasome system of degradation...
Sun May 24, 2020 03:00
Cells, Vol. 9, Pages 1305: γδ T Cells: The Ideal Tool for Cancer Immunotherapy Cells doi: 10.3390/cells9051305 Authors: Mahboubeh Yazdanifar Giulia Barbarito Alice Bertaina Irma Airoldi γδ T cells have recently gained considerable attention as an attractive tool for cancer adoptive immunotherapy due to their potent anti-tumor activity and unique role in immunosurveillance. The remarkable success of engineered T cells for the treatment of hematological malignancies...
Sun May 24, 2020 03:00
Cells, Vol. 9, Pages 1306: Lamin A/C Mechanotransduction in Laminopathies Cells doi: 10.3390/cells9051306 Authors: Francesca Donnaloja Federica Carnevali Emanuela Jacchetti Manuela Teresa Raimondi Mechanotransduction translates forces into biological responses and regulates cell functionalities. It is implicated in several diseases, including laminopathies which are pathologies associated with mutations in lamins and lamin-associated proteins. These pathologies affect muscle,...
Sun May 24, 2020 03:00
Cells, Vol. 9, Pages 1307: Joint Reconstituted Signaling of the IL-6 Receptor via Extracellular Vesicles Cells doi: 10.3390/cells9051307 Authors: Philipp Arnold Wiebke Lückstädt Wenjia Li Inga Boll Juliane Lokau Christoph Garbers Ralph Lucius Stefan Rose-John Christoph Becker-Pauly Interleukin-6 (IL-6) signaling is a crucial regulatory event important for many biological functions, such as inflammation and tissue regeneration. Accordingly, several pathological...
Sun May 24, 2020 03:00
Cells, Vol. 9, Pages 1304: Epigenetic Features of Human Perinatal Stem Cells Redefine Their Stemness Potential Cells doi: 10.3390/cells9051304 Authors: Giulia Gaggi Andrea Di Credico Pascal Izzicupo Ivana Antonucci Clara Crescioli Viviana Di Giacomo Annalisa Di Ruscio Giovanni Amabile Francesco Alviano Angela Di Baldassarre Barbara Ghinassi Human perinatal stem cells (SCs) can be isolated from fetal annexes without ethical or safety limitations. They are...
Sun May 24, 2020 03:00
Cells, Vol. 9, Pages 1303: Lung Tumor Cell-Derived Exosomes Promote M2 Macrophage Polarization Cells doi: 10.3390/cells9051303 Authors: Alexandra Pritchard Sultan Tousif Yong Wang Kenneth Hough Saad Khan John Strenkowski Balu K. Chacko Victor M. Darley-Usmar Jessy S. Deshane Cellular cross-talk within the tumor microenvironment (TME) by exosomes is known to promote tumor progression. Tumor promoting macrophages with an M2 phenotype are suppressors of anti-tumor...
Sun May 24, 2020 03:00
Cells, Vol. 9, Pages 1302: Protein Phase Separation during Stress Adaptation and Cellular Memory Cells doi: 10.3390/cells9051302 Authors: Yasmin Lau Henry Patrick Oamen Fabrice Caudron Cells need to organise and regulate their biochemical processes both in space and time in order to adapt to their surrounding environment. Spatial organisation of cellular components is facilitated by a complex network of membrane bound organelles. Both the membrane composition and the intra-organellar...
Sat May 23, 2020 03:00
Cells, Vol. 9, Pages 1300: The Enigma of Centriole Loss in the 1182-4 Cell Line Cells doi: 10.3390/cells9051300 Authors: Alain Debec Benjamin Loppin Chunfeng Zheng Xiuwen Liu Timothy L. Megraw The Drosophila melanogaster cell line 1182-4, which constitutively lacks centrioles, was established many years ago from haploid embryos laid by females homozygous for the maternal haploid (mh) mutation. This was the first clear example of animal cells regularly dividing in the absence...
Sat May 23, 2020 03:00
Cells, Vol. 9, Pages 1301: Dynamic Characterization of Structural, Molecular, and Electrophysiological Phenotypes of Human-Induced Pluripotent Stem Cell-Derived Cerebral Organoids, and Comparison with Fetal and Adult Gene Profiles Cells doi: 10.3390/cells9051301 Authors: Sarah Logan Thiago Arzua Yasheng Yan Congshan Jiang Xiaojie Liu Lai-Kang Yu Qing-Song Liu Xiaowen Bai Background: The development of 3D cerebral organoid technology using human-induced pluripotent...
Sat May 23, 2020 03:00
Cells, Vol. 9, Pages 1298: Axonal Transport as an In Vivo Biomarker for Retinal Neuropathy Cells doi: 10.3390/cells9051298 Authors: Lucia G. Le Roux Xudong Qiu Megan C. Jacobsen Mark D. Pagel Seth T. Gammon David Piwnica-Worms Dawid Schellingerhout We illuminate a possible explanatory pathophysiologic mechanism for retinal cellular neuropathy by means of a novel diagnostic method using ophthalmoscopic imaging and a molecular imaging agent targeted to fast axonal transport....
Fri May 22, 2020 03:00
Cells, Vol. 9, Pages 1299: The Role of Tumor-Associated Macrophages in the Progression and Chemoresistance of Ovarian Cancer Cells doi: 10.3390/cells9051299 Authors: Marek Nowak Magdalena Klink Tumor-associated macrophages (TAMs) constitute the main population of immune cells present in the ovarian tumor microenvironment. These cells are characterized by high plasticity and can be easily polarized by colony-stimulating factor-1, which is released by tumor cells, into an immunosuppressive...
Fri May 22, 2020 03:00
Cells, Vol. 9, Pages 1297: Mechanisms Regulating Muscle Regeneration: Insights into the Interrelated and Time-Dependent Phases of Tissue Healing Cells doi: 10.3390/cells9051297 Authors: Laura Forcina Marianna Cosentino Antonio Musarò Despite a massive body of knowledge which has been produced related to the mechanisms guiding muscle regeneration, great interest still moves the scientific community toward the study of different aspects of skeletal muscle homeostasis, plasticity,...
Fri May 22, 2020 03:00
Cells, Vol. 9, Pages 1296: Deficiency of GABARAP but not its Paralogs Causes Enhanced EGF-induced EGFR Degradation Cells doi: 10.3390/cells9051296 Authors: Jochen Dobner Indra M. Simons Kerstin Rufinatscha Sebastian Hänsch Melanie Schwarten Oliver H. Weiergräber Iman Abdollahzadeh Thomas Gensch Johannes G. Bode Silke Hoffmann Dieter Willbold The γ-aminobutyric acid type A receptor-associated protein (GABARAP) and its close paralogs GABARAPL1 and...
Fri May 22, 2020 03:00
Cells, Vol. 9, Pages 1293: Blood and Cancer: Cancer Stem Cells as Origin of Hematopoietic Cells in Solid Tumor Microenvironments Cells doi: 10.3390/cells9051293 Authors: Ghmkin Hassan Masaharu Seno The concepts of hematopoiesis and the generation of blood and immune cells from hematopoietic stem cells are some steady concepts in the field of hematology. However, the knowledge of hematopoietic cells arising from solid tumor cancer stem cells is novel. In the solid tumor microenvironment,...
Fri May 22, 2020 03:00
Cells, Vol. 9, Pages 1295: Dual Independent Roles of the p24 Complex in Selectivity of Secretory Cargo Export from the Endoplasmic Reticulum Cells doi: 10.3390/cells9051295 Authors: Sergio Lopez Ana Maria Perez-Linero Javier Manzano-Lopez Susana Sabido-Bozo Alejandro Cortes-Gomez Sofia Rodriguez-Gallardo Auxiliadora Aguilera-Romero Veit Goder Manuel Muñiz The cellular mechanisms that ensure the selectivity and fidelity of secretory cargo protein transport from...
Fri May 22, 2020 03:00
Cells, Vol. 9, Pages 1294: On the Host Side of the Hepatitis E Virus Life Cycle Cells doi: 10.3390/cells9051294 Authors: Noémie Oechslin Darius Moradpour Jérôme Gouttenoire Hepatitis E virus (HEV) infection is one of the most common causes of acute hepatitis in the world. HEV is an enterically transmitted positive-strand RNA virus found as a non-enveloped particle in bile as well as stool and as a quasi-enveloped particle in blood. Current understanding of the molecular mechanisms...
Fri May 22, 2020 03:00
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