Fri May 22, 2020 03:00
Fri May 22, 2020 03:00
Fri May 22, 2020 03:00
Fri May 22, 2020 03:00
Orbital involvement with histologic necrosis is a rare manifestation of systemic sarcoidosis. The authors present a case of necrotizing dacryoadenitis in addition to non-necrotizing granulomas in a hypertrophic scar that is consistent with a diagnosis of sarcoidosis. A 60-year-old female presented with 2 months of painless right upper eyelid fullness and ptosis. CT imaging demonstrated right greater than left lacrimal gland enlargement. A biopsy demonstrated necrotizing granulomatous inflammation...
Tue May 19, 2020 03:00
No abstract available
Tue May 19, 2020 03:00
Purpose: This study seeks to test a novel technique of custom-printed midface contour models with orbital floor “stamps” to guide reconstruction of orbital floor blowout fractures, with or without concomitant zygomaticomaxillary complex injury. Methods: A series of 4 consecutive patients with orbital floor blowout fractures (including 3 with zygomatic maxillary complex fractures) were retrospectively examined for outcomes associated with orbital floor reconstruction using 3-dimensional–printed...
Tue May 19, 2020 03:00
Many postoperative complications are known to occur as a result of orbital floor fracture repair, but loss of lacrimal gland function has not been reported. The authors present a patient who lost reflex tearing after undergoing orbital floor fracture repair by an outside surgeon. CT scan showed placement of the posterolateral edge of the implant through the inferior orbital fissure, which presumably transected the parasympathetic fibers innervating the lacrimal gland. Accepted for publication...
Tue May 19, 2020 03:00
A 63 year-old man presented with 3 weeks of worsening, painless left-sided proptosis, ptosis, and diplopia. Examination of the affected eye revealed normal visual acuity, normal intraocular pressure in the presence of a shallow anterior chamber, grade 1 relative afferent pupillary defect, restricted motility in all directions of gaze, and 6 mm of proptosis. Ultrasound biomicroscopy revealed uveal effusions with anterior rotation of the ciliary body causing appositional angle closure. B-scan ultrasonography...
Tue May 19, 2020 03:00
The coronavirus disease 2019 (COVID-19) pandemic has necessitated rapid response plans to minimize risks of infection in the workforce while ensuring maintenance of essential functions of radiology departments. Plan adoption is, however, challenged by the need to coordinate with institutional efforts, a rapidly expanding number of patients, and the diversity of clinical and administrative functions in the department. Here, we describe the implementation of a response plan in an academic radiology...
Tue May 19, 2020 03:00
Abstract Purpose of Review In spite of recent advances in treatment, many people with multiple sclerosis (MS) require ongoing care and support. Informal caregivers can experience burden as a result of their role, with possible implications for quality of life (QOL). We review recent research examining MS caregiver experience to (1) understand current risk factors for caregiver burden and (2) identify possible strategies for increasing...
Fri May 22, 2020 03:00
Abstract Purpose of Review Molecular testing has become essential for the optimal workup of central nervous system (CNS) tumors. There is a vast array of testing from which to choose, and it can sometimes be challenging to appropriately incorporate findings into an integrated report. This article reviews various molecular tests and provides a concise overview of the most important molecular findings in the most commonly encountered...
Fri May 22, 2020 03:00
Abstract Purpose of Review Glioblastoma (GBM) is the most common malignant primary brain tumor, and the available treatment options are limited. This article reviews the recent preclinical and clinical investigations that seek to expand the repertoire of effective medical and radiotherapy options for GBM. Recent Findings Recent phase...
Fri May 22, 2020 03:00
Abstract Purpose of Review Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that mainly affects young adults and that is one of the leading causes of disability in this age group, with cognitive impairment occurring early in the course of the disease. This article summarizes the current knowledge about cognitive dysfunction in the early phase of MS, including biomarkers, MRI correlates, and its...
Fri May 22, 2020 03:00
Abstract Purpose of Review Low-grade gliomas (LGG) are a group of primary brain tumors that arise from supporting glial cells. They are characterized by a mutation in the isocitrate dehydrogenase (IDH) enzyme and include astrocytomas and oligodendrogliomas. They usually affect young adults, and their main treatment consists of surgical resection, followed by radiation and chemotherapy in selected patients. This article reviews...
Fri May 22, 2020 03:00
Abstract Purpose of Review Idiopathic intracranial hypertension (IIH) is a disorder characterized by long-standing elevated intracranial pressure (ICP). As the name applies, no uniform cause has been identified. IIH is typically characterized by headaches, pulsatile tinnitus, and visual deterioration. Recent Findings Anomalies in cerebrospinal...
Fri May 22, 2020 03:00
Abstract Although prior studies have reported that patients with anaplastic thyroid carcinoma (ATC) with a focal anaplastic component may have a prolonged survival compared to other ATC patients, the outcome data are limited. We evaluated a cohort of ATC resected between 2003 and 2018. Tumor slides were reviewed to confirm the diagnosis and to identify cases with a minor ATC component (defined as comprising < 10% of the tumor). We evaluated the clinical outcome of these patients...
Fri May 22, 2020 03:00
Fri May 22, 2020 03:00
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Metastatic cancer that involves the structures of the heart is a rare complication and most commonly diagnosed during postmortem examination. Classically, the development of secondary tumors involves invasion of the pericardium or the myocardium and may disrupt the cardiac conduction system, causing new arrhythmias and heart failure. In this article, we present the case of a 58-year-old female with...
Thu May 21, 2020 11:44
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Immunoglobulin A vasculitis (IgAV), formerly known as Henoch-Schönlein purpura, is an immune-mediated small vessel vasculitis characterized by palpable purpura, arthralgia, abdominal pain, and renal disease. It is primarily a childhood disease and usually resolves spontaneously with supportive therapy. Treatment of IgAV in adults is controversial with no clearly established guidelines. We report a...
Thu May 21, 2020 11:44
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Background. Fulminant hepatitis is acute hepatic injury with severe decline in hepatic function manifested by encephalopathy, hypercoagulable state, jaundice, renal failure, hypoglycemia, or a constellation of these symptoms in patients without preexisting liver disease. Etiologies include viral infections, hepatotoxic drugs, autoimmune diseases, vaso-occlusive diseases, sepsis, and malignant infiltration....
Thu May 21, 2020 11:42
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Prosthetic valve thrombosis is a rare and severe complication of the mechanical prosthetic valve. Management can be challenging due to varying clinical presentation, overlapping features of differential diagnosis, and lack of randomized controlled trials on the therapeutic options. In this article, we report the case of a patient with a mechanical prosthetic mitral valve presented with symptoms of...
Thu May 21, 2020 11:41
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Calciphylaxis is a rare and severe complication characterized by calcification of arterioles and capillaries in the dermis and subcutaneous adipose tissue that leads to ischemia, necrosis, and painful skin lesions in patients with end-stage renal disease (ESRD). It is also known as calcific uremic arteriolopathy. Calciphylaxis occurs most commonly with the ESRD with skin ulceration as a predominant...
Thu May 21, 2020 11:39
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Acute pancreatitis is caused by alcohol, gall stone disease, drugs, trauma, infections, and metabolic causes such as hypercalcemia and hyperlipidemia. Hypercalcemia-induced acute pancreatitis has been well documented but only rarely occurs due to over-the-counter calcium carbonate. In this article, we present a case of over-the-counter calcium carbonate–induced acute pancreatitis.
Thu May 21, 2020 11:37
Journal of International Medical Research, Volume 48, Issue 5, May 2020. There are several situations such as medical emergencies and incidents involving mass casualties where drugs and antidotes have to be administered immediately along with other first aid at the site of the event. Self-administration by the affected person or by a companion is required as a life-saving measure. Autoinjector devices (AIDs) are useful for the rapid administration of drugs and antidotes and they can also be used...
Thu May 21, 2020 13:16
Journal of International Medical Research, Volume 48, Issue 5, May 2020. Bilateral Tessier no. 7 clefts are rarely reported in the literature. Here, we describe the presence of accessory maxilla with supernumerary teeth in a patient who exhibited bilateral Tessier no. 7 clefts; the diagnosis was established based on the patient’s history, clinical presentation, and computed tomography images. A review of the available literature revealed 24 patients with Tessier no. 7 clefts from 2000 to 2020, including...
Thu May 21, 2020 13:12
Journal of International Medical Research, Volume 48, Issue 5, May 2020. Bronchogenic cysts are primitive, foregut-derived developmental anomalies with bronchial-type, pseudostratified cylindrical epithelium. They are usually discovered in the thorax. The occurrence of such cysts in the retroperitoneum is extremely rare. Imaging techniques are generally effective in the detection of retroperitoneal bronchogenic cyst. Here, we report two cases (a 27-year-old man and a 33-year-old man) who had no clinical...
Thu May 21, 2020 13:10
Journal of International Medical Research, Volume 48, Issue 5, May 2020. ObjectiveBleomycin is an important chemotherapeutic drug that activates premature senescence to decrease the tumorigenic process. We aimed to investigate the role of phosphatase and tensin homolog deleted on chromosome ten (PTEN) in bleomycin-induced premature senescence in lung cancer cells.MethodsHuman lung cancer A549 cells were incubated in the presence of different concentrations of bleomycin for 5 days. A lentivirus vector...
Thu May 21, 2020 13:08
Journal of International Medical Research, Volume 48, Issue 5, May 2020. ObjectiveUrinary retention caused by bladder clots can be frustrating because such blood clots are difficult to remove. We established a novel technique in which hydrogen peroxide is applied to evacuate bladder clots.MethodsIn this single-center retrospective study, we evaluated 31 patients with retention of blood clots in the bladder who underwent emergency evacuation using hydrogen peroxide.ResultsThe patients comprised 17...
Thu May 21, 2020 13:00
Journal of International Medical Research, Volume 48, Issue 5, May 2020. ObjectiveSome patients have been found to develop intraoperative amaurosis under sub-Tenon’s anesthesia. We explored whether these patients have poor surgical outcomes during mid- to long-term postoperative follow-up.MethodsIn this case series, 74 of 85 patients with macular diseases who underwent phacoemulsification combined with vitrectomy under sub-Tenon’s anesthesia developed intraoperative amaurosis. The surgical outcomes...
Thu May 21, 2020 12:53
Journal of International Medical Research, Volume 48, Issue 5, May 2020. ObjectiveTo investigate the features of neuropeptide Y (NPY), α-melanocyte stimulating hormone (α-MSH), and agouti-related protein (AgRP) in type 2 diabetes mellitus (T2DM) patients with hypertension.MethodsPatients with T2DM (n = 384) and healthy volunteers (n = 80) were enrolled into this study. Serum NPY, α-MSH, and AgRP levels were detected using ELISA.ResultsSignificantly higher NPY and lower α-MSH and AgRP levels were...
Thu May 21, 2020 12:45
Journal of International Medical Research, Volume 48, Issue 5, May 2020. Acrometastasis is an exceedingly rare condition and is often misdiagnosed or overlooked. We herein describe a 50-year-old patient who developed acrometastasis in the big toe from nasopharyngeal carcinoma. The treatment consisted of amputation through the proximal phalanx, and the patient recovered well. To our knowledge, only one case of acrometastasis from this origin has been reported in the literature to date. Acrometastasis...
Thu May 21, 2020 12:40
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