This paper presents the numerical analysis of settlement to profile the vulnerable zone or influence zone due to tunneling activities in cohesionless deposits for free field or Greenfield conditions. The analysis considers the factors like saturated density (γsat), unsaturated density (γunsat), angle of shearing resistance (φ), deformation modulus (ES), volume loss (VL), and the support pressure of the shield head at the tunnel face. The obtained results using a finite element program (FEM) PLAXIS...
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In the geological survey, the recognition and classification of rock lithology are an important content. The recognition method based on rock thin section leads to long recognition period and high recognition cost, and the recognition accuracy cannot be guaranteed. Moreover, the above method cannot provide an effective solution in the field. As a communication device with multiple sensors, smartphones are carried by most geological survey workers. In this paper, a smartphone application based on...
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Vascular oxidative stress and inflammation play a major role in vascular diseases. This study was aimed at determining the protective roles of fibronectin type III domain-containing 5 (FNDC5) in angiotensin II- (Ang II-) induced vascular oxidative stress and inflammation and underlying mechanisms. Wild-type (WT) and FNDC5-/- mice, primary mouse vascular smooth muscle cells (VSMCs), and the rat aortic smooth muscle cell line (A7R5) were used in the present study. Subcutaneous infusion of Ang II caused...
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We report a 44-year-old male, who was diagnosed with hypogonadotropic hypogonadism after complaining of erectile dysfunction, depression, and fatigue. He was started on testosterone replacement therapy. He persistently complained of fatigue despite increasing the dose of testosterone over two years and having therapeutic testosterone levels. He was found to have homozygous C677T methylenetetrahydrofolate reductase (MTHFR) gene mutation. After treatment with folate and B12, his symptoms resolve completely....
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Diabetes mellitus (DM) and tuberculosis (TB) are major public health and economic burdens. DM increases Mycobacterium tuberculosis (M.tb) infection rates and treatment durations. This study evaluated the relationship between five classes of oral DM medications and TB infection risk in DM patients. We used longitudinal records from the Taiwan Longitudinal Health Insurance Research Database. DM patients were identified using the International Classification of Diseases, Ninth Revision, Clinical Modification...
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Photochemical tissue bonding (PTB), based on photosensitizer rose bengal (RB) and green light, has been regarded as an effective alternative to surgical suture and has been reported to provide benefits for Achilles tendon repair. Limited to the poor penetration of green light, secondary damage still exists while applying PTB for closed Achilles tendon rupture. This study is aimed at exploring the effects of noninvasive photochemical sealing on Achilles tendon rupture by the combination of PTB and...
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Testicular dysfunction due to hyperglycemia is the main cause of infertility in diabetic men. Over the years, in order to solve this growing problem, a lot of research has been done and a variety of treatments have been created, but so far, there is no safe, effective, and practical method to prevent male infertility caused by diabetes. In this review, we emphasize the male infertility mechanism caused by diabetes from the effects of oxidative stress and autophagy on the function of testes via the...
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In this work, CeMgAl-LDHs protective thin films were developed directly on the anodized aluminum surface, and on the “hot water-sealed” anodized aluminum specimens. The synthesized coatings were investigated by SEM-EDS and XRD and through long-term electrochemical impedance spectroscopy (EIS) spectra. The growth of CeMgAl-LDHs into/onto the micropores/defects of anodized film was found to significantly improve the LDH barrier properties with delaying coating degradation compared to LDHs developed...
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Zinc finger protein X-linked (Zfx) was regarded to be a sex determination factor and plays a critical role in spermatogenesis. RNAi is an effective method of silencing Zfx mRNA expression. However, there has been little research on the use of RNAi technology to control the sex of the offspring of red deer (Cervus elaphus). The objective of this study was first to explore an efficient method to alter the red deer offspring sex-ratio by silencing the gene Zfx during spermatogenesis. Three recombinant...
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In recent years, the efficacy of electroacupuncture (EA) pretreatment generating ischemic tolerance mimicking ischemic pretreatment (IP) has been continuously confirmed, which was first found in the brain and then in the heart. Furthermore, researchers have observed the intensive cardioprotection impact of EA pretreatment on patients undergoing percutaneous coronary intervention (PCI) and heart valve replacement, indicating that EA pretreatment tends to be a valuable and advantageous avenue for preventing...
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The moisture and the temperature variation of shallow loess during the freeze-thaw process have tremendous influences on the freeze-thaw disease and agricultural development. The present paper, based on the field test of the temperature and water content of the shallow loess in the seasonal frozen region, probes into the variation of the temperature and moisture fields of shallow loess in the freeze-thaw period. Field test shows that the daily variation of surface temperature reaches the maximum...
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In order to reduce the failure accidents of conventional packers, a kind of sealing structure of retrievable packers is designed, which can provide reference for optimizing the sealing performance and pressure capacity of packers. And theoretical calculation and experimental research on their sealing performance and pressure capacity are carried out through the finite element analysis on the contact with large deformation based on Abaqus and experimental study. The results show that the upper packer...
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This paper presents an experimental investigation of stayed cable vibrations in dry-wind and rain-wind coupling hazards. To mitigate large vibrations of the cable, the use of spiral wires wrapped around the cable is proposed. By testing two cable models in a wind tunnel in dry and rain conditions for different yaw angles and wind speeds, the effectiveness of using the spiral wires to mitigate large vibrations is clarified. Finally, the paper provides a further understanding of the complex mechanism...
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Drug discovery is a costly process which usually takes more than 10 years and billions of dollars for one successful drug to enter the market. Despite all the safety tests, drugs may still cause adverse reactions and be restricted in use or even withdrawn from the market. Drug-induced liver injury (DILI) is one of the major adverse drug reactions, and computational models may be used to predict and reduce it. To assess the computational prediction performance of DILI, we curated DILI endpoints from...
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Age-related cataract (ARC) is the major cause of blindness worldwide. The most significant factors are the maximal exposure of the eye lens to environmental stressors, including oxidative and glycative load. The administration of antioxidant and antiglycative supplements may reduce the risk of cataract progression. In this study, the effects of lutein (LU) and water chestnut (Trapa bispinosa Roxb.) extract (TBE) on cataracts and the expression of antioxidant-related genes were assessed in Shumiya...
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Background. Recently, a large-scale novel coronavirus pneumonia (NCP) outbreak swept China. As of Feb. 9, 2020, a total of 40,260 patients have been diagnosed with NCP, and 23,589 patients were suspected to have infected by the 2019 novel coronavirus (COVID-19), which puts forward a great challenge for public health and clinical treatment in China. Until now, we are in the high-incidence season of NCP. Thus, the analysis of the transmissibility change of NCP and its potential factors may provide...
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Acrylamide (AA) is a carcinogenic substance found in food, cigarette smoke and in an environment exposed to acrylamide. This study aims to analyze AA levels in dried blood spot (DBS) samples of lung cancer patients with smoking record, without smoking record, and also in the negative blank. Analysis of AA levels was determined by liquid chromatography tandem mass spectrometry (LC-MS/MS) and DBS extraction using protein precipitation techniques. Mass detection was done using positive electron spray...
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With the development of the transportation, the bridge approach settlement (BAS) received great attention which can result in structure deterioration of the bridge and road, costly maintenance, and hazardous driving conditions. Therefore, accurate prediction of BAS is important. In this paper, a methodology using the iterative procedure is presented to predict the long-term BAS. In this method, the dynamic deviator stress is obtained by a 3D finite element road model and the settlement is calculated...
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Existing research studies on torque ripple suppression mostly ignore the electrical loss of PMSM. However, the electrical loss will not only decrease the operating efficiency but also adversely influence the suppression of torque ripple. This paper attempts to construct a unified framework to suppress torque ripple with consideration of electrical loss. Firstly, a dynamic mathematical model of PMSM under current vector orientation is established with a combination of electrical loss. The constraints...
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This paper constructs a discrete-space train movement model to evaluate the impact of a temporary speed restriction (TSR) for a high-speed railway train. The established model can demonstrate train movement under different TSR conditions. The proposed model can reveal whether a train is affected by the block section influenced by the TSR within a time duration. Moreover, the model can output detailed train trajectories and the minimal train running time between two adjacent stations to analyse the...
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Publication date: 15 September 2020Source: International Journal of Biological Macromolecules, Volume 159Author(s): Basavraj Khanppnavar, Anupam Roy, Kausik Chandra, Vladimir N. Uversky, Nakul Chandra Maiti, Saumen Datta
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Publication date: 1 September 2020Source: International Journal of Biological Macromolecules, Volume 158Author(s): Qian Wang, Li Zhang, Wu Ding
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Publication date: Available online 19 May 2020Source: International Journal of Biological MacromoleculesAuthor(s): Revathy Nair, Anirban Roy Choudhury
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Publication date: Available online 19 May 2020Source: International Journal of Biological MacromoleculesAuthor(s): Marjan Soleimanpour, Ali Mohammad Tamaddon, Mahdi Kadivar, Samira Sadat Abolmaali, Hajar Shekarchizadeh
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Abstract The continuous increase of the human population worldwide has led to an increase of pharmaceuticals’ consumption, such as diclofenac (DCF), a widely used non-steroidal anti-inflammatory drug (NSAID), that is not removed by wastewater treatment processes. Although there is some research regarding the effects of DCF on animals and aquatic invertebrates, information concerning its influence on plants’ metabolism is still scarce. Through an integrated approach, using combined...
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Cancers, Vol. 12, Pages 1288: Thioholgamide A, a New Anti-Proliferative Anti-Tumor Agent, Modulates Macrophage Polarization and Metabolism Cancers doi: 10.3390/cancers12051288 Authors: Charlotte Dahlem Wei Xiong Siow Maria Lopatniuk William K. F. Tse Sonja M. Kessler Susanne H. Kirsch Jessica Hoppstädter Angelika M. Vollmar Rolf Müller Andriy Luzhetskyy Karin Bartel Alexandra K. Kiemer Natural products represent powerful tools searching...
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Abstract Given the sordid history of injustices linking genetics to race and ethnicity, considerations of justice are central to ensuring the responsible development of precision medicine programmes around the world. While considerations of justice may be in tension with other areas of concern, such as scientific value or privacy, there are also tensions between different aspects of justice. This paper focuses on three particular aspects of justice relevant to this precision medicine: social justice,...
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Publication date: Available online 19 May 2020Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Wayne Pearce
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Publication date: Available online 19 May 2020Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Joshua H. Atkins, Christopher H. Rassekh
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Publication date: Available online 19 May 2020Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): John W. Lally, Alexandra Ortiz, Jon Robitschek, Michael Demarcantonio
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Publication date: Available online 18 May 2020Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Vijay A. Patel, Khaled A. Sedeek, Meghan N. Wilson
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Publication date: Available online 18 May 2020Source: Microbiological ResearchAuthor(s): Muhammad Kashif Hanif, Kauser Abdullah Malik, Sohail Hameed, Muhammad Jawad Saddique, Ayesha, Kaneez Fatima, Tahir Naqqash, Afshan Majeed, Muhammad Javed Iqbal, Asma Imran
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Coronavirus disease-19 is a respiratory viral disease that commonly presents with mild symptoms. However, it can cause serious complications such as acute respiratory disease, especially in patients with comorbidities. As it is a new disease, the full picture of the disease and its complications are not yet fully understood. Moreover, the patients at risk of complications are not well identified; and the data about the risk in patients with hematological malignancies is limited. Here, we report a...
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The distal ulna has always been considered to be expendable and its removal has been advocated for a variety of post-traumatic degenerative and oncological conditions but recent studies showed that the distal radioulnar joint allows supination and protonation of the forearm and is important to one’s grip strength and lifting ability. Several prosthesis models have already been made to replace the mechanical functionality of the distal radioulnar joint. We present two cases of females aged 22 and...
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By: Jill Huettich With more and more employees working from home, productivity is an even greater concern for businesses. After all, how do you keep employees on track when you can’t monitor them on a day-to-day basis? It’s an important question. Fortunately, we have good news. While your fears of reduced productivity are reasonable, employees who work from home typically put in more hours than their counterparts at the office. For instance, according to one...
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A cross party group of MPs has said that Public Health England’s failure to publish the evidence behind its decision to discontinue community testing at the start of the covid-19 outbreak is...
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What’s new in this guidance?If clinical suspicion of pulmonary embolism is low, consider using the pulmonary embolism rule-out criteria (PERC) to help determine whether any further investigations for...
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