Amino acid substitution models play an important role in inferring phylogenies from proteins. Although different amino acid substitution models have been proposed, only a few were estimated from mitochondrial ...
Tue May 19, 2020 03:00
Related ArticlesGlobal quantification of pulmonary artery atherosclerosis using 18F-sodium fluoride PET/CT in at-risk subjects. Am J Nucl Med Mol Imaging. 2020;10(2):119-126 Authors: Zhang V, Borja AJ, Rojulpote C, Padmanabhan S, Patil S, Gonuguntla K, Revheim ME, Werner TJ, Høilund-Carlsen PF, Alavi A Abstract The goal of this study was to assess pulmonary artery calcification in healthy controls and subjects with suspicion of stable angina pectoris...
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Related ArticlesAccuracy of 68Ga-PSMA-11 PET/CT and multiparametric MRI for the detection of local tumor and lymph node metastases in early biochemical recurrence of prostate cancer. Am J Nucl Med Mol Imaging. 2020;10(2):106-118 Authors: Radzina M, Tirane M, Roznere L, Zemniece L, Dronka L, Kalnina M, Mamis E, Biederer J, Lietuvietis V, Freimanis A, Vjaters E Abstract Anatomical and functional imaging plays a decisive role for detection and staging,...
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Related ArticlesDevelopment of zirconium-89 PET for in vivo imaging of alpha-klotho. Am J Nucl Med Mol Imaging. 2020;10(2):95-105 Authors: Lau WL, Liang C, Liu H, Singh K, Mukherjee J Abstract Alpha-klotho is a single-pass membrane protein primarily expressed by the kidneys. Klotho deficiency in chronic kidney disease contributes to an accelerated aging phenotype. We report here development of [89Zr]DFO-anti-klotho positron emission tomography (PET)...
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Related ArticlesPET/CT in pediatric oncology. Am J Nucl Med Mol Imaging. 2020;10(2):83-94 Authors: Masselli G, De Angelis C, Sollaku S, Casciani E, Gualdi G Abstract The use of PET/CT in adult oncology has been consolidated by several and authoritative multicentric studies, metanalyses and systematic reviews. International guidelines help everyday nuclear medicine specialists, oncologists and radiologists in choosing the most suitable diagnostic path...
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Related ArticlesNo tight junctions in tight junction protein-1 expressing HeLa and fibroblast cells. Int J Physiol Pathophysiol Pharmacol. 2020;12(2):70-78 Authors: Shi Y, Li R, Yang J, Li X Abstract Tight junctions are important structures that form the barrier of cells and tissues, and they play key roles in maintaining homeostasis of our body. The backbone of the tight junction proteins are claudins, which composed more than twenty members. The tight...
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Related ArticlesAlcohol and multiple sclerosis: an immune system-based review. Int J Physiol Pathophysiol Pharmacol. 2020;12(2):58-69 Authors: Fahim M, Rafiee Zadeh A, Shoureshi P, Ghadimi K, Cheshmavar M, Sheikhinia N, Afzali M Abstract Multiple sclerosis is a chronic inflammatory disease of the central nervous system (CNS). Although the exact etiology of multiple sclerosis is unknown, researchers suggest that genetic, environmental, and microbial factors...
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Related ArticlesRisk factors for excessive tidal volumes delivered during intraoperative mechanical ventilation, a retrospective study. Int J Physiol Pathophysiol Pharmacol. 2020;12(2):51-57 Authors: Kowa CY, Jin Z, Longbottom R, Cullinger B, Walker P Abstract BACKGROUND: Lung Protective Ventilation (LPV) refers to a combination of measures aimed at reducing ventilator-associated lung injury. This includes: delivering tidal volumes of 6-8 ml/kg of ideal...
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Glioblastoma is the most common primary malignant brain tumor in adults. Despite aggressive treatment, outcomes remain poor with few long-term survivors. Therefore, considerable effort is being made to identify novel therapies for this malignancy. Targeting tumor metabolism represents a promising therapeutic strategy and activation of fatty acid oxidation (FAO) has been identified as a central metabolic node contributing towards gliomagenesis. Perhexiline is a compound with a long clinical track-record...
Tue May 19, 2020 15:46
The frequent activation of HER3 signaling as a resistance mechanism to EGFR-targeted therapy has motivated the development of combination therapies that block more than one receptor tyrosine kinase. Here, we have developed a novel tetravalent, bispecific single-chain diabody-Fc fusion protein targeting EGFR and HER3 (also known als ErbB3) that integrates the antigen-binding sites of a humanized version of Cetuximab as well as a recently developed anti-HER3 antibody, IgG 3-43. This bispecific antibody...
Tue May 19, 2020 15:46
The camptothecin derivatives topoisomerase I (TOP1) inhibitors, irinotecan and topotecan are US-FDA approved for the treatment of colorectal, ovarian, lung and breast cancers. Because of the chemical instability of camptothecins, short plasma half-life, drug efflux by the multidrug-resistance ABC transporters and the severe diarrhea produced by irinotecan, indenoisoquinoline TOP1 inhibitors (LMP400, LMP776 and LMP744), which overcome these limitations, have been developed and are in clinical development....
Tue May 19, 2020 15:46
Cetuximab, a monoclonal antibody targeting EGFR, is a standard of care for the treatment for locally advanced or metastatic head and neck squamous cell carcinoma (HNSCC). However, despite overexpression of EGFR in over 90% of HNSCC lesions, most HNSCC patients fail to respond to cetuximab treatment. In addition, there are no available biomarkers to predict sensitivity or resistance to cetuximab in the clinic. Here, we sought to advance precision medicine approaches for HNSCC by identifying PI3K-mTOR...
Tue May 19, 2020 15:46
Frequent GNAQ and GNA11 mutations in uveal melanoma (UM) hyperactivate the MEK-ERK signaling pathway, leading to aberrant regulation of cyclin dependent kinases (CDK) and cell cycle progression. MEK inhibitors (MEKi) alone show poor efficacy in UM, raising the question of whether downstream targets can be vertically inhibited to provide long-term benefit. CDK4/6 selective inhibitors are FDA-approved in ER-positive breast cancer patients in combination with ER antagonists/aromatase inhibitors. We...
Tue May 19, 2020 15:46
Although gemcitabine is the cornerstone of care for pancreatic ductal adenocarcinoma (PDA), patients lack durable responses and relapse is inevitable. While the underlying mechanisms leading to gemcitabine resistance are likely to be multifactorial, there is a strong association between activating gemcitabine metabolism pathways and clinical outcome. This study evaluated CK1 as a potential therapeutic target for PDA and bladder cancer, in which CK1 is frequently overexpressed. We assessed the anti-tumor...
Tue May 19, 2020 15:46
The next generation anti-androgen drugs, XTANDI® (Enzalutamide), ZYTIGA® (Abiraterone acetate), ERLEADA™ (Apalutamide) and NUBEQA (Darolutamide) extend survival times and improve quality of life in advanced prostate cancer patients. Despite these advances, resistance occurs frequently and there is currently no definitive cure for Castration-Resistant Prostate Cancer (CRPC). Our previous studies identified that similar mechanisms of resistance to enzalutamide or abiraterone occur following treatment...
Tue May 19, 2020 15:46
Bacterial infections are frequent triggers for diabetic ketoacidosis. In this context, delayed antibiotic treatment is associated with increased morbidity and mortality. Unnecessary administration of antimicro...
Tue May 19, 2020 03:00
Abstract Purpose Results from studies on the relationship between restless legs syndrome (RLS) and coronary artery disease (CAD) are conflicting. Some studies associate RLS with CAD by heart rate variability, blood pressure variability, and other autonomic, neuronal reasons, while other studies do not support these observations. The aim of this study was to investigate the prevalence of RLS in patients undergoing coronary angiography...
Tue May 19, 2020 03:00
Abstract Coping styles describe behavioral differences during stressful or challenging situations. Coping styles are stable over time but little is known about early life manifestation and development of these behavioral differences. We aimed to investigate if differences in the way marmosets produce vocalizations at an early age are related to their coping style in the future. We studied 14 common marmosets (Callithrix jacchus) from three social groups housed at the marmoset...
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Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00383
Tue May 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13462
Tue May 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05104
Tue May 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03993
Tue May 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02430
Tue May 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13029
Tue May 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02390
Tue May 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03859
Tue May 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13907
Tue May 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05403
Tue May 19, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13737
Tue May 19, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00957
Tue May 19, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05812
Tue May 19, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05208
Tue May 19, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00124
Tue May 19, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00710
Tue May 19, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00711
Tue May 19, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01323
Tue May 19, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00976
Tue May 19, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00995
Tue May 19, 2020 07:00
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