The RNA-binding protein Musashi-2 (MSI2) has been implicated in the tumorigenesis and tumor progression of some human cancers. MSI2 has also been reported to suppress tumor epithelial-to-mesenchymal transition...
Sun May 24, 2020 03:00
Metformin in Pregnancy Study (MiPS): protocol for a systematic review with individual patient data meta-analysis. BMJ Open. 2020 May 21;10(5):e036981 Authors: Mousa A, Løvvik T, Hilkka I, Carlsen SM, Morin-Papunen L, Tertti K, Rönnemaa T, Syngelaki A, Nicolaides K, Shehata H, Burden C, Norman JE, Rowan J, Dodd JM, Hague W, Vanky E, Teede HJ Abstract INTRODUCTION: Gestational diabetes mellitus (GDM) is a common disorder of pregnancy and contributes to...
Sun May 24, 2020 15:21
Protocol for a randomised controlled trial of Subacromial spacer for Tears Affecting Rotator cuff Tendons: a Randomised, Efficient, Adaptive Clinical Trial in Surgery (START:REACTS). BMJ Open. 2020 May 21;10(5):e036829 Authors: Metcalfe A, Gemperle Mannion E, Parsons H, Brown J, Parsons N, Fox J, Kearney R, Lawrence T, Bush H, McGowan K, Khan I, Mason J, Hutchinson C, Gates S, Stallard N, Underwood M, Drew S Abstract INTRODUCTION: Shoulder pain due to...
Sun May 24, 2020 15:21
Early evaluation of the 'STOP SEPSIS!' WHO Global Maternal Sepsis Awareness Campaign implemented for healthcare providers in 46 low, middle and high-income countries. BMJ Open. 2020 May 21;10(5):e036338 Authors: Brizuela V, Bonet M, Trigo Romero CL, Abalos E, Baguiya A, Fawole B, Knight M, Lumbiganon P, Minkauskienė M, Nabhan A, Bique Osman N, Qureshi ZP, Souza JP, World Health Organization Global Maternal Sepsis Study Research Group Abstract OBJECTIVE:...
Sun May 24, 2020 15:21
Association of dietary vitamin K and risk of coronary heart disease in middle-age adults: the Hordaland Health Study Cohort. BMJ Open. 2020 May 21;10(5):e035953 Authors: Haugsgjerd TR, Egeland GM, Nygård OK, Vinknes KJ, Sulo G, Lysne V, Igland J, Tell GS Abstract OBJECTIVE: The role of vitamin K in the regulation of vascular calcification is established. However, the association of dietary vitamins K1 and K2 with risk of coronary heart disease (CHD)...
Sun May 24, 2020 15:21
Nurses' knowledge of peripherally inserted central catheter maintenance and its influencing factors in Hunan province, China: a cross-sectional survey. BMJ Open. 2020 May 21;10(5):e033804 Authors: Xu B, Zhang J, Hou J, Ma M, Gong Z, Tang S Abstract OBJECTIVES: The present study aimed to assess the level of knowledge on peripherally inserted central catheter (PICC) maintenance among nurses in China and to analyse the related factors influencing this variable....
Sun May 24, 2020 15:21
Association between organ damage and mortality in systemic lupus erythematosus: a systematic review and meta-analysis. BMJ Open. 2020 May 21;10(5):e031850 Authors: Murimi-Worstell IB, Lin DH, Nab H, Kan HJ, Onasanya O, Tierce JC, Wang X, Desta B, Alexander GC, Hammond ER Abstract OBJECTIVE: At least half of patients with systemic lupus erythematosus (SLE) develop organ damage as a consequence of autoimmune disease or long-term therapeutic steroid use....
Sun May 24, 2020 15:21
Related ArticlesCharacterising the evidence base for advanced clinical practice in the UK: a scoping review protocol. BMJ Open. 2020 May 20;10(5):e036192 Authors: Evans C, Poku B, Pearce R, Eldridge J, Hendrick P, Knaggs R, McLuskey J, Tomczak P, Thow R, Harris P, Conway J, Collier R Abstract INTRODUCTION: A global health workforce crisis, coupled with ageing populations, wars and the rise of non-communicable diseases is prompting all countries to consider...
Sat May 23, 2020 15:21
Related ArticlesPrevalence of hyperuricaemia in an Eastern Chinese population: a cross-sectional study. BMJ Open. 2020 May 20;10(5):e035614 Authors: Han B, Wang N, Chen Y, Li Q, Zhu C, Chen Y, Lu Y Abstract OBJECTIVES: In the past decade, China has been characterised by large-scale urbanisation as well as rapid economic growth. The aim of this study was to further investigate the prevalence of hyperuricaemia (HUA) in an Eastern Chinese population. ...
Sat May 23, 2020 15:21
Related ArticlesCompliance with national guidelines for antibiotic prophylaxis in hip fracture patients: a quality assessment study of 13 329 patients in the Norwegian Hip Fracture Register. BMJ Open. 2020 May 20;10(5):e035598 Authors: Lian T, Dybvik E, Gjertsen JE, Dale H, Westberg M, Nordsletten L, Figved W Abstract OBJECTIVE: We assessed compliance with new guidelines for prophylactic antibiotics in hip fracture surgery in Norway introduced in 2013....
Sat May 23, 2020 15:21
Related ArticlesUnderstanding the patient experience of early unplanned hospital readmission following acute care discharge: a qualitative descriptive study. BMJ Open. 2020 May 20;10(5):e034728 Authors: Considine J, Berry D, Sprogis SK, Newnham E, Fox K, Darzins P, Rawson H, Street M Abstract OBJECTIVES: To understand from a patient and carer perspective: (1) what features of the discharge process could be improved to avoid early unplanned hospital readmission...
Sat May 23, 2020 15:21
Related ArticlesAccidental poisoning, intentional self-harm and event of undetermined intent mortality over 20 years in Iceland: a population-based cohort study. BMJ Open. 2020 May 20;10(5):e034590 Authors: Gunnarsdottir OS, Rafnsson V Abstract OBJECTIVES: The aim was to study mortality due to suicide, accidental poisoning, event of undetermined intent and drug-related deaths through 20 years in Iceland. DESIGN: A population-based register study....
Sat May 23, 2020 15:21
Dabigatran initiation in patients with non-valvular AF and first acute ischaemic stroke: a retrospective observational study from the SITS registry. BMJ Open. 2020 May 19;10(5):e037234 Authors: Escudero-Martinez I, Mazya M, Teutsch C, Lesko N, Gdovinova Z, Barbarini L, Fryze W, Karlinski M, Kobayashi A, Krastev G, Paiva Nunes A, Pasztoova K, Peeters A, Sobolewski P, Vilionskis A, Toni D, Ahmed N, SITS Investigators Abstract BACKGROUND AND OBJECTIVE:...
Fri May 22, 2020 15:19
Quality of informed consent documents among US. hospitals: a cross-sectional study. BMJ Open. 2020 May 19;10(5):e033299 Authors: Spatz ES, Bao H, Herrin J, Desai V, Ramanan S, Lines L, Dendy R, Bernheim SM, Krumholz HM, Lin Z, Suter LG Abstract OBJECTIVE: To determine whether informed consent for surgical procedures performed in US hospitals meet a minimum standard of quality, we developed and tested a quality measure of informed consent documents. ...
Fri May 22, 2020 15:19
An instrument for assessing the quality of informed consent documents for elective procedures: development and testing. BMJ Open. 2020 May 19;10(5):e033297 Authors: Spatz ES, Suter LG, George E, Perez M, Curry L, Desai V, Bao H, Geary LL, Herrin J, Lin Z, Bernheim SM, Krumholz HM Abstract OBJECTIVE: To develop a nationally applicable tool for assessing the quality of informed consent documents for elective procedures. DESIGN: Mixed qualitative-quantitative...
Fri May 22, 2020 15:19
Vaginal probiotic adherence and acceptability in Rwandan women with high sexual risk participating in a pilot randomised controlled trial: a mixed-methods approach. BMJ Open. 2020 May 19;10(5):e031819 Authors: Verwijs MC, Agaba S, Umulisa MM, Uwineza M, Nivoliez A, Lievens E, van de Wijgert JHHM Abstract OBJECTIVES: To evaluate adherence and acceptability of intermittent vaginal probiotic or antibiotic use to prevent bacterial vaginosis (BV) recurrence....
Fri May 22, 2020 15:19
Pediatric pulmonology year in review 2019: Sleep Medicine. Pediatr Pulmonol. 2020 May 23;: Authors: Afolabi-Brown O, Tapia IE Abstract Pediatric Pulmonology publishes original research, review articles as well as case reports on a wide variety of pediatric respiratory disorders. In this article, we summarize the past year's publications in sleep medicine and we review selected literature from other journals within this field. Articles highlighted are...
Sun May 24, 2020 15:20
Pacing therapies for sleep apnea and cardiovascular outcomes: A systematic review. J Interv Card Electrophysiol. 2020 May 22;: Authors: Murtaza G, Turagam MK, Akella K, Madoukh B, Sharma SP, Gopinathannair R, Lakkireddy D Abstract PURPOSE: Phrenic and hypoglossal nerve pacing therapies have shown benefit in sleep apnea. We sought to analyze the role of pacing therapies in sleep apnea and their impact on heart failure. METHODS: A comprehensive...
Sun May 24, 2020 15:20
Outcomes and safety of adenoidectomy in infants up to 12 months of age compared to older children. Eur Arch Otorhinolaryngol. 2020 May 22;: Authors: Stahl A, Dagan O, Nageris B, Ebner Y Abstract PURPOSE: To evaluate the safety and outcomes of adenoidectomy for the treatment of sleep disordered breathing (SDB) in infants up to 12 months of age as compared to children ages 13-72 months METHODS: A retrospective analysis was performed by reviewing the medical...
Sun May 24, 2020 15:20
High-flow nasal cannula ventilation therapy for obstructive sleep apnea in ischemic stroke patients requiring nasogastric tube feeding: a preliminary study. Sci Rep. 2020 May 22;10(1):8524 Authors: Ho CH, Chen CL, Yu CC, Yang YH, Chen CY Abstract Obstructive sleep apnea (OSA) is associated with increasing risk of recurrent stroke and mortality. Nasogastric tubes used by dysphagic stroke patients may interfere with nasal continuous positive airway pressure...
Sun May 24, 2020 15:20
Intervention Design and Trial Protocol: Mindfulness-based Exposure for PAP-associated Claustrophobia. West J Nurs Res. 2020 May 22;:193945920924608 Authors: Gawrysiak MJ, Baime M, King TS, Watach AJ, McPhillips MV, Kolanowski A, Schutte-Rodin S, Sawyer AM Abstract Positive airway pressure (PAP) associated claustrophobia is common among obstructive sleep apnea patients and plays a prominent role in low adherence and treatment failure. As there are no...
Sun May 24, 2020 15:20
Related ArticlesAssociations of Sedentary Behaviour, Physical Activity, Cardiorespiratory Fitness and Body Composition with Risk of Sleep-Related Breathing Disorders in Children with Overweight/Obesity: A Cross-Sectional Study. J Clin Med. 2020 May 20;9(5): Authors: Torres-Lopez LV, Cadenas-Sanchez C, Migueles JH, Adelantado-Renau M, Plaza-Florido A, Solis-Urra P, Molina-Garcia P, Ortega FB Abstract The aim of this study was to examine the associations...
Sun May 24, 2020 15:20
Related ArticlesAge and Upper Airway Obstruction: A Challenge to the Clinical Approach in Pediatric Patients. Int J Environ Res Public Health. 2020 May 18;17(10): Authors: Luana N, Marco Z, Francesca B, Giorgio P, Giulia R, Silvia S, Daniela S, Angelo P, Massimo A Abstract Upper airway abnormalities increase the risk of pediatric morbidity in infants. A multidisciplinary approach to obstructive sleep apnea syndrome (OSAS) poses challenges to clinical...
Sun May 24, 2020 15:20
Related ArticlesBetter Objective Sleep Was Associated with Better Subjective Sleep and Physical Activity; Results from an Exploratory Study under Naturalistic Conditions among Persons with Multiple Sclerosis. Int J Environ Res Public Health. 2020 May 18;17(10): Authors: Sadeghi Bahmani D, Gonzenbach R, Motl RW, Bansi J, Rothen O, Niedermoser D, Gerber M, Brand S Abstract Persons with multiple sclerosis (PwMS) often complain about sleep problems. There...
Sun May 24, 2020 15:20
Related ArticlesEffectiveness of respiratory muscle training for patients with obstructive sleep apnea: A protocol of systematic review and meta-analysis. Medicine (Baltimore). 2020 May;99(20):e20309 Authors: Xue SM, Jia J, Fan P, He SW Abstract BACKGROUND: This study will evaluate the effectiveness and safety of respiratory muscle training (RMT) for patients with obstructive sleep apnea (OSA). METHODS: Randomized controlled trials will be retrieved...
Sun May 24, 2020 15:20
Related ArticlesMedication of comorbidities in females with sleep-disordered breathing during long-term CPAP therapy. Respir Med. 2020 May 12;169:106014 Authors: Aro M, Saaresranta T, Vahlberg T, Anttalainen U Abstract BACKGROUND: Treating sleep disordered breathing (SDB) with nasal continuous positive airway pressure (CPAP) may reduce mortality, but the studies on the effect on medication use are few. Women tend to have more mild sleep apnoea and partial...
Sat May 23, 2020 14:23
Related ArticlesPredictors of changes in subjective daytime sleepiness in response to CPAP therapy withdrawal in OSA: A post-hoc analysis. J Sleep Res. 2020 May 22;:e13078 Authors: Roeder M, Sievi NA, Kohler M, Schwarz EI Abstract Subjective sleepiness is the hallmark symptom of untreated obstructive sleep apnea (OSA) and leads to an increased risk of motor vehicle accidents and impaired quality of life. Continuous positive airway pressure (CPAP) is...
Sat May 23, 2020 14:23
Related ArticlesInterhemispheric sleep depth coherence predicts driving safety in sleep apnea. J Sleep Res. 2020 May 22;:e13092 Authors: Azarbarzin A, Younes M, Sands SA, Wellman A, Redline S, Czeisler CA, Gottlieb DJ Abstract Obstructive sleep apnea is associated with increased risk of car crashes; however, conventional measures of sleep apnea severity do not clearly identify those individuals who are at greatest risk. Here we tested whether, among...
Sat May 23, 2020 14:23
Related ArticlesDistinguishing Obstructive Versus Central Apneas in Infrared Video of Sleep Using Deep Learning: Validation Study. J Med Internet Res. 2020 May 22;22(5):e17252 Authors: Akbarian S, Montazeri Ghahjaverestan N, Yadollahi A, Taati B Abstract BACKGROUND: Sleep apnea is a respiratory disorder characterized by an intermittent reduction (hypopnea) or cessation (apnea) of breathing during sleep. Depending on the presence of a breathing effort,...
Sat May 23, 2020 14:23
Related ArticlesMuscle type of palatopharyngeal muscle in children with severe obstructive sleep apnea. J Clin Sleep Med. 2020 May 22;: Authors: Chen H, Huang X, Ye Y, Luo Y, Huang Y, Li X Abstract STUDY OBJECTIVES: To investigate the fiber type distribution in palatopharyngeal muscle via adenosine triphosphatase (ATPase) and Quantitative Real-time Polymerase Chain Reaction (qRT-PCR) in children with severe obstructive sleep apnea (OSA). METHODS:...
Sat May 23, 2020 14:23
Related ArticlesDoes obstructive sleep apnea lead to increased risk of COVID-19 infection and severity? J Clin Sleep Med. 2020 May 22;: Authors: Tufik S, Gozal D, Ishikura IA, Pires GN, Andersen ML PMID: 32441246 [PubMed - as supplied by publisher]
Sat May 23, 2020 14:23
Related ArticlesDiscriminating the severity of pharyngeal collapsibility (Pcrit) using anthropometric and polysomnographic indices. J Clin Sleep Med. 2020 May 22;: Authors: Genta PR, Schorr F, Edwards BA, Wellman A, Filho GL Abstract STUDY OBJECTIVES: While obstructive sleep apnea (OSA) results from the combination of different pathophysiological mechanisms, the degree of anatomical compromise remains the main factor responsible. The passive pharyngeal...
Sat May 23, 2020 14:23
Related ArticlesAdjudication of cardiovascular events in patients with chronic obstructive pulmonary disease: SUMMIT trial. Clin Trials. 2020 May 22;:1740774520920897 Authors: Wise RA, Anderson JA, Amarenco P, Cowans NJ, Crim C, Denvir MA, Gomez CR, Jones MP, Morris A, Niewoehner D, Yates JC Abstract BACKGROUND: Adjudicated cause-specific mortality has been used in major trials of chronic obstructive pulmonary disease. However, there is less experience...
Sat May 23, 2020 14:23
Related ArticlesObstructive sleep apnea syndrome and risk of renal impairment: a systematic review and meta-analysis with trial sequential analysis. Sleep Breath. 2020 May 21;: Authors: Liu T, Zhan Y, Wang Y, Li Q, Mao H Abstract BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is associated with a variety of systemic diseases. Among patients with chronic kidney diseases (CKD), the prevalence of OSAS is high. OSAS can induce progression of CKD. However,...
Sat May 23, 2020 14:23
Related ArticlesThe Clinical Role of Angiopoietin-Like Protein 3 in Evaluating Coronary Artery Disease in Patients with Obstructive Sleep Apnea. Cardiovasc Drugs Ther. 2020 May 21;: Authors: Li J, Yang Y, Jiao X, Yu H, Du Y, Zhang M, Hu C, Wei Y, Qin Y Abstract PURPOSE: Hyperlipidemia is the most important early atherosclerosis and coronary artery disease (CAD) indicator. Angiopoietin-like proteins (ANGPTLs) 3, 4, and 8 are lipid dysfunction markers...
Sat May 23, 2020 14:23
Related ArticlesCognitive behavioural therapy for insomnia reduces sleep apnoea severity: a randomised controlled trial. ERJ Open Res. 2020 Apr;6(2): Authors: Sweetman A, Lack L, McEvoy RD, Antic NA, Smith S, Chai-Coetzer CL, Douglas J, O'Grady A, Dunn N, Robinson J, Paul D, Eckert D, Catcheside PG Abstract Insomnia and obstructive sleep apnoea (OSA) frequently co-occur and may be causally related through sleep fragmentation and/or hyperarousal mechanisms....
Sat May 23, 2020 14:23
Related ArticlesThe Relationship of Serum 25-Hydroxyvitamin-D Level with Severity of Obstructive Sleep Apnea in Patients with Type 2 Diabetes Mellitus. Diabetes Metab Syndr Obes. 2020;13:1391-1398 Authors: Ma D, Zheng X, Dong L, Zheng C, Chen Y, Chen Z, Lin M, Li X, Li Z, Liu C Abstract Objective: To explore the association of serum vitamin-D levels with the severity of obstructive sleep apnea (OSA) in patients with type 2 diabetes mellitus (T2DM). ...
Sat May 23, 2020 14:23
Related ArticlesObesity as a risk factor for poor outcome in COVID-19-induced lung injury: the potential role of undiagnosed obstructive sleep apnoea. Br J Anaesth. 2020 May 01;: Authors: Memtsoudis SG, Ivascu NS, Pryor KO, Goldstein PA PMID: 32439072 [PubMed - as supplied by publisher]
Sat May 23, 2020 14:23
Biomarkers of Cardiovascular Risk in Obstructive Sleep Apnea - Innovation or Illusion? Trends Cardiovasc Med. 2020 May 10;: Authors: Maeder MT PMID: 32437867 [PubMed - as supplied by publisher]
Fri May 22, 2020 13:12
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