Τετάρτη 13 Μαΐου 2020

Evidence for improved survival with bevacizumab treatment in recurrent high-grade gliomas: a retrospective study with (“pseudo-randomized”) treatment allocation by the health insurance provider
Abstract Introduction Despite a large number of trials, the role of bevacizumab (BEV) in the treatment of recurrent high-grade gliomas is still controversial. Evidence regarding an effect on overall survival in this context is ultimately inconclusive. At the Department of Radiation Oncology at Erlangen, Germany we treated a large cohort of patients with recurrent gliomas where bevacizumab use was determined exclusively by the health...
Neuro-Oncology
40m
Repeated gamma knife radiosurgery enables longer tumor control in cases of highly-recurrent intracranial ependymoma
Abstract Purpose Stereotactic radiosurgery (SRS) is a potential re-irradiation treatment for recurrent intracranial ependymoma after prior radiation therapy. The purpose of this study was to examine the efficacy and safety of repeated SRS in the treatment of recurrent intracranial ependymomas. Methods This is a retrospective study of consecutive patients...
Neuro-Oncology
19h
Transferrin receptor 1 targeted optical imaging for identifying glioma margin in mouse models
Abstract Objective Optical molecular imaging technology that indiscriminately detects intracranial glioblastoma (GBM) can help neurosurgeons effectively remove tumor masses. Transferrin receptor 1 (TfR 1) is a diagnostic and therapeutic target in GBM. A TfR 1-targeted peptide, CRTIGPSVC (CRT), was shown to cross the blood brain barrier (BBB) and accumulate at high levels in GBM tissues. In this study, we synthesized a TfR 1-targeted...
Neuro-Oncology
22h
Use of FDG-PET/CT for systemic assessment of suspected primary central nervous system lymphoma: a LOC study
Abstract Introduction Primary Central Nervous System Lymphoma (PCNSL) is a rare disease with different therapeutic implications than systemic lymphoma. In this study, we evaluated whole-body 18FDG-PET/CT for pre-chemotherapy imaging of suspected PCNSL. Methods One hundred and thirty consecutive immunocompetent patients were retrospectively included....
Neuro-Oncology
22h

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