Abstract Human tissue plasminogen activator was the first recombinant therapy protein that successfully produced in Chinese hamster ovary cells in 1986 and approved for clinical use. Since then, more and more therapeutic proteins are being manufactured in mammalian cells, and the technologies for recombinant protein production in this expression system have developed rapidly, with the optimization of both upstream and downstream processes. One of the most promising strategies...
02:42
Abstract Currently, due to the special functions and potential application values, rare sugars become the hot topic in carbohydrate fields. l-Ribulose, an isomer of l-ribose, is an expensive rare ketopentose. As an important precursor for other rare sugars and l-nucleoside analogue synthesis, l-ribulose attracts more and more attention in recent days. Compared with complicated chemical synthesis, the bioconversion method becomes a good alternative approach...
Tue May 05, 2020 03:00
Abstract The latest WHO report estimates about 1.6 million global deaths annually from TB, which is further exacerbated by drug-resistant (DR) TB and comorbidities with diabetes and HIV. Exiguous dosing, incomplete treatment course, and the ability of the tuberculosis bacilli to tolerate and survive current first-line and second-line anti-TB drugs, in either their latent state or active state, has resulted in an increased prevalence of multidrug-resistant (MDR), extensively drug-resistant...
Tue May 05, 2020 03:00
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