Related ArticlesNeoadjuvant PD-1 immune checkpoint blockade reverses functional immunodominance among tumor-antigen specific T cells. Clin Cancer Res. 2019 Oct 23;: Authors: Friedman J, Moore EC, Zolkind P, Robbins Y, Clavijo PE, Sun L, Greene S, Morisada MV, Mydlarz WK, Schmitt N, Hodge JW, Schreiber H, Van Waes C, Uppaluri R, Allen C Abstract PURPOSE: Surgical resection of primary tumor with regional lymphadenectomy remains the treatment of choice...
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Related ArticlesUtility of Intraoperative Frozen Section in Large Thyroid Nodules. Otolaryngol Head Neck Surg. 2019 01;160(1):49-56 Authors: Bollig CA, Jorgensen JB, Zitsch RP, Dooley LM Abstract OBJECTIVE: To determine if the routine use of intraoperative frozen section (iFS) results in cost savings among patients with nodules >4 cm with nonmalignant cytology undergoing a thyroid lobectomy. STUDY DESIGN: Case series with chart review; cost...
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Related ArticlesPathologic Fibroblasts in Idiopathic Subglottic Stenosis Amplify Local Inflammatory Signals. Otolaryngol Head Neck Surg. 2019 01;160(1):107-115 Authors: Morrison RJ, Katsantonis NG, Motz KM, Hillel AT, Garrett CG, Netterville JL, Wootten CT, Majka SM, Blackwell TS, Drake WP, Gelbard A Abstract OBJECTIVE: To characterize the phenotype and function of fibroblasts derived from airway scar in idiopathic subglottic stenosis (iSGS) and to...
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Related ArticlesIntraductal Pneumatic Lithotripsy after Extended Transoral Duct Surgery in Submandibular Sialolithiasis. Otolaryngol Head Neck Surg. 2019 01;160(1):63-69 Authors: Koch M, Schapher M, Mantsopoulos K, Goncalves M, Iro H Abstract OBJECTIVE: Persistent, residual, or recurrent stones after transoral duct surgery are always associated with hilar to intraparenchymal and/or multiple sialolithiasis, causing difficulties in the treatment. This...
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Related ArticlesPrevalence and Risk of Vertebral Fractures in Primary Hyperparathyroidism: A Nested Case-Control Study. J Bone Miner Res. 2018 09;33(9):1657-1664 Authors: Ejlsmark-Svensson H, Bislev LS, Lajlev S, Harsløf T, Rolighed L, Sikjaer T, Rejnmark L Abstract Prevalence of vertebral fractures (VFx) in primary hyperparathyroidism (PHPT) remains uncertain. We aimed to estimate the prevalence of VFx, investigate potential risk factors associated...
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Related ArticlesA heart-stopping diagnosis. Eur Heart J. 2018 04 01;39(13):1113 Authors: Spapen J, Michiels V, Droogmans S PMID: 29409052 [PubMed - indexed for MEDLINE]
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Related ArticlesCorrection: POPX2 is a novel LATS phosphatase that regulates the Hippo pathway. Oncotarget. 2019 Oct 08;10(56):5890-5891 Authors: Rahmat MB, Zhang S, Koh CG Abstract [This corrects the article DOI: 10.18632/oncotarget.26689.].PMID: 31645909 [PubMed - in process]
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Related ArticlesCorrection: Epithelial-mesenchymal crosstalk induces radioresistance in HNSCC cells. Oncotarget. 2019 Oct 08;10(56):5889 Authors: Steinbichler TB, Abdelmoez A, Metzler VM, Dejaco D, Riechelmann H, Dudas J, Skvortsova II Abstract [This corrects the article DOI: 10.18632/oncotarget.23248.].PMID: 31645908 [PubMed - in process]
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Related ArticlesCorrection: Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors. Oncotarget. 2019 Oct 08;10(56):5888 Authors: Xu M, Zhu C, Zhao X, Chen C, Zhang H, Yuan H, Deng R, Dou J, Wang Y, Huang J, Chen Q, Jiang B, Yu J Abstract [This corrects the article DOI: 10.18632/oncotarget.2825.].PMID: 31645907 [PubMed - in process]
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Related ArticlesTwo novel ligand-independent variants of the VEGFR-1 receptor are expressed in human testis and spermatozoa, one of them with the ability to activate SRC proto-oncogene tyrosine kinases. Oncotarget. 2019 Oct 08;10(56):5871-5887 Authors: Alvarez-Palomo B, Barrot-Feixat C, Sarret H, Requena J, Pau M, Vidal-Taboada JM, Oliva R, Ballesca JL, Edel MJ, Mezquita-Pla J Abstract The vascular endothelial growth factor receptor 1 (VEGFR-1) family...
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Related ArticlesClinicopathological correlation of immune response in human cancers. Oncotarget. 2019 Oct 08;10(56):5859-5870 Authors: Liu Y Abstract Background: The clinicopathologic association of tumor immune response is largely unknown. We systematically investigated this matter in human cancers. Results: Different cancer types exhibited distinct immune gene profiling. Four cancer types exhibited a significant and positive correlation of...
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Related ArticlesGCN5 HAT inhibition reduces human Burkitt lymphoma cell survival through reduction of MYC target gene expression and impeding BCR signaling pathways. Oncotarget. 2019 Oct 08;10(56):5847-5858 Authors: Farria AT, Mustachio LM, Akdemir ZHC, Dent SYR Abstract GCN5, the catalytic subunit in the acetyltransferase modules of SAGA and ATAC, functions as a coactivator of gene transcription. The SAGA complex is recruited to chromatin by transcription...
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Related ArticlesEngineered human platelet-derived microparticles as natural vectors for targeted drug delivery. Oncotarget. 2019 Oct 08;10(56):5835-5846 Authors: Kailashiya J, Gupta V, Dash D Abstract Drug targeting has opened a new paradigm in therapeutics with development of delivery vectors like liposomes and polymeric nanoparticles. Although their clinical application is crippled by limited biological adaptability. Off-target toxicity and biocompatibility...
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Related ArticlesMutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity. Oncotarget. 2019 Oct 08;10(56):5824-5834 Authors: Woodford MR, Hughes M, Sager RA, Backe SJ, Baker-Williams AJ, Bratslavsky MS, Jacob JM, Shapiro O, Wong M, Bratslavsky G, Bourboulia D, Mollapour M Abstract The molecular chaperone Heat shock protein 90 (Hsp90) is essential for the folding, stability, and activity...
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Related ArticlesFewer actionable mutations but higher tumor mutational burden characterizes NSCLC in black patients at an urban academic medical center. Oncotarget. 2019 Oct 08;10(56):5817-5823 Authors: Choudhury NJ, Eghtesad M, Kadri S, Cursio J, Ritterhouse L, Segal J, Husain A, Patel JD Abstract Background: Black patients have been historically underrepresented in studies investigating molecular patterns in non-small cell lung cancer (NSCLC). We aimed...
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Related ArticlesMechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast. Oncotarget. 2019 Oct 08;10(56):5780-5816 Authors: Medkour Y, Mohammad K, Arlia-Ciommo A, Svistkova V, Dakik P, Mitrofanova D, Rodriguez MEL, Junio JAB, Taifour T, Escudero P, Goltsios FF, Soodbakhsh S, Maalaoui H, Simard É, Titorenko VI Abstract We have recently found that PE21, an extract from the white willow Salix alba,...
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Related ArticlesNew prognostic markers revealed by RNA-Seq transcriptome analysis after MYC silencing in a metastatic gastric cancer cell line. Oncotarget. 2019 Oct 08;10(56):5768-5779 Authors: Lopes LO, Maués JH, Ferreira-Fernandes H, Yoshioka FK, Júnior SCS, Santos AR, Ribeiro HF, Rey JA, Soares PC, Burbano RR, Pinto GR Abstract MYC overexpression is considered a driver event in gastric cancer (GC), and is frequently correlated with poor prognosis...
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Related ArticlesPTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors. Oncotarget. 2019 Oct 08;10(56):5755-5767 Authors: Smith AM, Zhang CRC, Cristino AS, Grady JP, Fink JL, Moore AS Abstract Kinases such as MEK are attractive targets for novel therapy in cancer, including acute myeloid leukaemia (AML). Acquired and inherent resistance to kinase inhibitors, however, is becoming an increasingly important challenge for the clinical success...
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Related ArticlesTumor necrosis factor related apoptosis inducing ligand (TRAIL) regulates deubiquitinase USP5 in tumor cells. Oncotarget. 2019 Oct 08;10(56):5745-5754 Authors: Potu H, Kandarpa M, Peterson LF, Donato NJ, Talpaz M Abstract The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) pathway has emerged as a cancer therapeutic target. However, clinical trials have proven that most human cancers are resistant to TRAIL. We show that...
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Related ArticlesA side-by-side evaluation of [18F]FDOPA enantiomers for non-invasive detection of neuroendocrine tumors by positron emission tomography. Oncotarget. 2019 Oct 08;10(56):5731-5744 Authors: Narayan A, Yan Y, Lisok A, Brummet M, Pomper MG, Lesniak WG, Dannals RF, Merino VF, Azad BB Abstract Neuroendocrine tumors (NETs) are an extremely heterogenous group of malignancies with variable clinical behavior. Molecular imaging of patients with NETs...
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Related ArticlesCorrection: mTOR inhibition affects Yap1-β-catenin-induced hepatoblastoma growth and development. Oncotarget. 2019 Sep 24;10(54):5670 Authors: Molina L, Yang H, Michael AOA, Oertel M, Bell A, Singh S, Chen X, Tao J, Monga SP Abstract [This corrects the article DOI: 10.18632/oncotarget.26668.].PMID: 31645895 [PubMed - in process]
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Gene Expression Analysis to Investigate Biological Networks Underlying Nasal Inflammatory Dysfunctions Induced by Diesel Exhaust Particles Using an In Vivo System. Ann Otol Rhinol Laryngol. 2019 Oct 24;:3489419883289 Authors: Kim HS, Kim BG, Park S, Kim N, Jang AS, Seo YR, Park MK Abstract OBJECTIVES: Diesel exhaust particles (DEP)s are notorious ambient pollutants composed of a complex mixture of a carbon core and diverse chemical irritants. Several...
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Real-life experience on effectiveness and safety of dupilumab in adult patients with moderate-to-severe atopic dermatitis. J Dermatolog Treat. 2019 Oct 24;:1-20 Authors: Fargnoli MC, Esposito M, Ferrucci S, Girolomoni G, Offidani A, Patrizi A, Peris K, Costanzo A, Malara G, Pellacani G, Romanelli M, Amerio P, Cristaudo A, Flori ML, Motolese A, Betto P, Patruno C, Pigatto P, Sirna R, Stinco G, Zalaudek I, Bianchi L, Boccaletti V, Cannavò SP, Cusano F, Lembo S, Mozzillo...
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Bleeding after dental extraction in patients treated with non-vitamin K oral anticoagulants (NOAC) may lead to unplanned reinterventions and interruption of anticoagulation, thereby exposing patients to a risk of thromboembolism. We have designed a study (EXTRACT-NOAC) to investigate whether tranexamic acid (TXA) mouthwash decreases bleeding after extraction in such patients. The study is a randomised, double-blind, placebo-controlled trial. We plan to randomise 236 patients listed for dental extraction...
Fri Oct 25, 2019 03:00
Food control is defined as a mandatory regulatory activity of enforcement aimed at ensuring that all foods during production, handling, storage, processing, and distribution are safe, wholesome, and fit for hu...
Fri Oct 25, 2019 03:00
In the original publication of this article, [1] the affiliation for Katia Scotlandi needs to be revised, because the author prefers using its Italian name: Experimental Oncology Lab, Experimental Oncology Lab...
Fri Oct 25, 2019 03:00
Abstract Streptococcus agalactiae is a major pathogen causing streptococcosis. To prevent and control this bacterial disease, antagonistic bacteria have become a new research hotspot. This study evaluated the probiotic potential of Bacillus velezensis LF01 strain, which is antagonistic to S. agalactiae. The active compounds produced by LF01 showed antimicrobial activity against a broad spectrum of fish pathogens, including S. agalactiae, Streptococcus iniae, Aeromonas hydrophila,...
Fri Oct 25, 2019 03:00
Abstract Objective Patients with non-communicating hydrocephalus due to aqueductal stenosis are often successfully treated with endoscopic third ventriculocisternostomy (ETV). In hydrocephalus, due to other locations of obstruction of the major CSF pathways, endoscopic treatment may also be a good option. We investigated our cohort of patients treated by ETV with patent ventricular outflow but pressure gradient signs at the third ventricle...
Fri Oct 25, 2019 03:00
Abstract Introduction Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting 5–10% of women of reproductive age. It is characterized by chronic anovulation leading to menstrual disorders, and increased infertility. The syndrome can also manifest as hirsutism and acne. Aim of the study The aim of the study was to compare, over a...
Fri Oct 25, 2019 03:00
Abstract Purpose Radiofrequency (RF) treatment has played an increasing role in the management of benign thyroid nodules in recent years. The aim of this retrospective study was to evaluate the efficacy of RF treatment on volume reduction in functioning and non-functioning thyroid nodules. Patients and methods We reviewed the medical records of patients who...
Fri Oct 25, 2019 03:00
Immune checkpoint inhibitor therapy has changed the standard drug therapy for relapsed or advanced non-small cell lung cancer; its efficacy is well-recognized by pulmonary physicians, oncologists, and thoracic...
Thu Oct 24, 2019 03:00
Thank you for asking us to comment on the letter received from the reader. The photograph in our article is of the same patient at 6 months post-treatment1. The photograph was taken in the same room with a similar environment; unfortunately the patient wore the same shirt. We have enclosed a more recent photograph taken at 6 years post-treatment with a similar profile (Fig. 1).
Fri Oct 25, 2019 03:00
Acinic cell adenocarcinoma (ACA) is a malignant epithelial neoplasm of the salivary glands. The patient reported herein presented with an unusual case of a metastatic ACA originating from the right parapharyngeal region, which eventually metastasized to the ipsilateral cavernous sinus and the contralateral mandibular ramus. The trigeminal nerve may have served as a channel for the spread of the cancer from the right parapharyngeal region to the cavernous sinus, and subsequently to the left mandibular...
Fri Oct 25, 2019 03:00
The objective of this study was to compare the effect of intraosseous dexamethasone injection and submucosal dexamethasone injection on postoperative sequelae after mandibular third molar surgery. This was a randomized, triple-blind, split-mouth clinical trial. Fifty-four mandibular third molars (27 patients) were subdivided according to the side (right and left); intraosseous injection of dexamethasone (4mg) was randomly assigned to one side and submucosal injection to the other. All surgeries were...
Fri Oct 25, 2019 03:00
Chordoma is a rare primary malignant bone tumor with an incidence of 1 every million individuals per year [1], and skull base chordomas (SBC) represent thirty percent of the cases [2]. SBC has poor prognosis and a 10-year survival rate of 58.7% [3]. The poor outcome is primarily due to a high rate of local recurrence [4], which was reported to be as high as 68% [5], with most recurrences occurring within 5 years after the initial surgery [6]. Local recurrence of SBC is the marker of treatment failure,...
Fri Oct 25, 2019 03:00
We developed a training protocol based on Intrapulmonary Percussive Ventilation in order to prolong breath-hold while nearly suppressing the thorax motion. This protocol allowed ten subjects to achieve a 20-minutes-breath-hold, while reducing the residual surface motion to 1 mm around its mean position for more than 95% of the breath-hold duration.
Fri Oct 25, 2019 03:00
Publication date: Available online 24 October 2019Source: Gait & PostureAuthor(s): Jade M. Tan, Kane J. Middleton, Harvi F. Hart, Hylton B. Menz, Kay M. Crossley, Shannon E. Munteanu, Natalie J. CollinsAbstractBackgroundFoot orthoses are a recommended treatment for patellofemoral (PF) pain and a number of lower limb osteoarthritis (OA) conditions. However, their mechanism of effect is poorly understood.Research questionTo compare the immediate effects of foot orthoses and flat inserts on lower...
Fri Oct 25, 2019 23:33
Publication date: Available online 24 October 2019Source: Gait & PostureAuthor(s): Namika Miura, Koutatsu Nagai, Keiichi Tagomori, Hisashi Ikutomo, Kenichi Okamura, Takato Okuno, Norikazu Nakagawa, Kensaku MasuharaAbstractBackgroundPatients with hip osteoarthritis (OA) experience abnormal movement patterns and reduced loading of the affected leg. The plantar contacts the ground and receives force from the ground. Plantar pressure distribution may differ in patients with hip OA compared to healthy...
Fri Oct 25, 2019 23:33
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