Abstract Duplication of 15q11.2‐q13.1 (dup15q syndrome) is one of the most common copy number variations associated with autism spectrum disorders (ASD) and intellectual disability (ID). As with many neurogenetic conditions, accurate behavioral assessment is challenging due to the level of impairment and heterogeneity across individuals. Large‐scale phenotyping studies are necessary to inform future clinical trials in this and similar ID syndromes. This study assessed developmental and behavioral...
12h
Abstract Kabuki syndrome (KS) is a disorder of epigenetic dysregulation due to heterozygous mutations in KMT2D or KDM6A, genes encoding a lysine‐specific methyltransferase or demethylase, respectively. The phenotype is highly variable, including congenital cardiac and renal anomalies, developmental delay, hypotonia, failure to thrive, short stature, and immune dysfunction. All affected individuals have characteristic facial features. As KS natural history has not been fully delineated, limited information...
12h
SummarySelf-learning healthcare systems are becoming a reality. As boundaries between research and healthcare delivery become increasingly blurred, there is an emerging opportunity to accelerate learning through the cyclical integration and analysis of patient phenotype, treatment and clinical outcome. Opportunities already exist to save money through the more efficient use of targeted and immune-based therapies Morgillo et al. [11], Zhao et al. [21], Keenan et al. [5], with a self-learning healthcare...
17h
Abstract Adult stem cells are rare, undifferentiated cells found in all tissues of the body. Although normally kept in a quiescent, nondividing state, these cells can proliferate and differentiate to replace naturally dying cells within their tissue and to repair its wounds in response to injury. Due to their proliferative nature and ability to regenerate tissue, adult stem cells have the potential to treat a variety of degenerative diseases as well as aging. In addition, since stem cells are often...
5h
A potato protein hydrolysate, APPH is a potential anti-obesity diet ingredient. Since, obesity leads to deterioration of liver function and associated liver diseases, in this study the effect of APPH on high f...
11h
Aim of this study was to evaluate the effectiveness of scalp, tongue, and Jin’s 3-needle acupuncture for the improvement of postapoplectic aphasia.
11h
The aim of this letter was to point out some methodological concerns about an article written by Shi et al. and published in the journal. There is an increasing trend in the isolation of Methicillin-susceptible S...
5h
Publication date: Available online 25 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): A. Ockerman, M. Vanhaverbeke, I. Miclotte, A. Belmans, T. Vanassche, C. Politis, R. Jacobs, P. VerhammeAbstractBleeding after dental extraction in patients treated with non-vitamin K oral anticoagulants (NOAC) may lead to unplanned reinterventions and interruption of anticoagulation, thereby exposing patients to a risk of thromboembolism. We have designed a study (EXTRACT-NOAC) to...
22h
Almost 70 per cent of patients with colorectal cancer in this population returned to work within 2 years after the start of the sick leave period. The models in this study can be used to guide patients with colorectal cancer early in their treatment about their likelihood of returning to work, and to identify and modify barriers that could facilitate this. Most return at two years Background The increase in prevalence of colorectal cancer among young patients coupled with an older retirement...
23h
The likelihood of a procedure receiving the most positive recommendation from the NICE Interventional Procedures Advisory Committee has decreased over time, while evidence requirements have increased. How NICE works Background This study explored the evidence base for recommendations by the National Institute of Health and Care Excellence (NICE) Interventional Procedures Advisory Committee, the only NICE committee not to consider cost. The four potential recommendations are: Standard Arrangements...
23h
Data of patients in Japan with hepatocellular carcinoma who had undergone a non‐anatomical or anatomical resection were extracted from a nationwide survey database. A microscopically positive margin was associated with poorer overall survival. The outcome of patients with a negative but 0‐mm margin was poor only in the non‐anatomical resection group, suggesting that anatomical resection with a negative 0‐mm margin is acceptable. Difference between anatomic and non‐anatomic resection Background...
23h
This study analysed the feasibility of laparoscopic living donor right hepatectomy. Propensity score matching was used for comparing preoperative and postoperative outcomes. The learning curve of laparoscopic living donor right hepatectomy was around 50 procedures. IVC, inferior vena cava; RPV, right portal vein; LPV, left portal vein; CBD, common bile duct; HA, hepatic artery; PV, portal vein; GB, gallbladder; RHD, right hepatic duct; CHD, common hepatic duct; RHV right hepatic vein. Better for...
23h
Abstract Objectives To compare residual shunt rate and complications associated with six different devices used for PFO closure. Background Transcutaneous PFO closure is an effective treatment for preventing recurrent stroke in patients with a history of cryptogenic stroke. The rate of residual shunt is one metric by which the technical success of PFO closure can be measured. Methods Patients who underwent PFO closure at a single center between February 2001 and July 2019 were retrospectively...
13h
Abstract Objectives To conduct a systematic review and meta‐analysis of studies examining the impact of periprocedural intravenous morphine on clinical outcomes in patients undergoing primary percutaneous coronary intervention (PCI) for ST‐elevation myocardial infarction (STEMI). Background Morphine analgesia may reduce the absorption of co‐prescribed P2Y12 antagonists attenuating platelet inhibition. The impact of periprocedural intravenous morphine on clinical outcomes in patients undergoing...
13h
Abstract Status epilepticus (SE) promotes neuronal proliferation and differentiation in the adult and developing rodent hippocampus. However, the effect of SE on other neurogenic brain regions such as the cerebellum has been less explored. To determine whether SE induced by pentylentetrazole (PTZ-SE) and lithium-pilocarpine (Li-Pilo-SE) increases cell proliferation and neurogenesis in the developing rat cerebellum. SE was induced in 14-day-old (P14) Wistar rat pups (both sexes)....
14h
Publication date: Available online 25 October 2019Source: Seminars in OrthodonticsAuthor(s): Lysle E. Johnston
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Metabolomic Profiling to Identify Molecular Biomarkers of Cellular Response to Methotrexate In Vitro
Variation in methotrexate (MTX) efficacy represents a significant barrier to early and effective disease control in the treatment of autoimmune arthritis. We hypothesize that the utilization of metabolomic techniques will allow for an improved understanding of the biochemical basis for the pharmacological activity of MTX, and can promote the identification and evaluation of novel molecular biomarkers of MTX response. In this work, erythroblastoid cells were exposed to MTX at the physiologic concentration...
21h
Abstract Bruton's tyrosine kinase (BTK) is a key regulator of B‐cell receptor and Fc receptor signaling, and a rational therapeutic target for autoimmune diseases. This first‐in‐human phase I, double‐blind, placebo‐controlled trial investigated the safety, tolerability, pharmacokinetics (PK), target occupancy, and effects on QT interval of evobrutinib, a highly selective, oral inhibitor of BTK, in healthy subjects. This dose escalation trial consisted of two parts. Part 1 included 48 subjects in...
21h
Abstract Genomic testing of adolescents is increasing yet engaging them in decision making is not routine. We assessed decisional conflict in adolescents and a parent making independent decisions about actual genomic testing results and factors that influenced their choices. We enrolled 163 dyads consisting of an adolescent (13‐17 years) not selected based on a specific clinical indication and one parent. After independently choosing categories of conditions to learn for the adolescent,...
22h
Publication date: Available online 25 October 2019Source: Clinical ImagingAuthor(s): W. James Tom, Xiangdong Xu, Noushin Vahdat, Fiona Cassidy, Lejla AganovicAbstractInflammatory pseudotumors imitate neoplasms on imaging but actually represent focal inflammation. We report a case of follicular pancreatitis, which is a recently recognized distinct form of mass-forming focal chronic pancreatitis pathologically characterized by lymphoid infiltration with abundant reactive germinal centers. In our patient,...
19h
Publication date: Available online 25 October 2019Source: Clinical ImmunologyAuthor(s): Katherine A. Murphy, Kartik Bhamidiphati, Samuel J.S. Rubin, Lucas Kipp, William H. Robinson, Tobias V. LanzAbstractInhibitory cell-surface receptors on lymphocytes, often called immune checkpoints, are powerful targets for cancer therapy. Despite their direct involvement in autoimmune pathology, they are currently not exploited therapeutically for autoimmune diseases. Understanding the receptors' expression patterns...
19h
In this study, we investigated the frequency and types of stuttering-like (SLD) and other (OD) disfluencies in 59 typically developing bilingual Yiddish-Dutch (YD) speaking children. Participants were divided in two age categories: 6.01-7.07 and 9.00-10.04-year-olds. All children (1) were successive, bilingual YD speaking, (2) had Yiddish as their dominant language and (3) were sufficiently intelligible in both languages. A conversation sample of at least 300 syllables was collected in each of the...
8h
Publication date: Available online 25 October 2019Source: Clinical TherapeuticsAuthor(s): Bereket Molla Tigabu, Majid Davari, Abbas Kebriaeezadeh, Mojtaba Mojtahedzadeh, Kourosh Sadeghi, Farhad Najmeddin, Zahra Jahangard-RafsanjaniAbstractPurposeAlbumin-based fluid therapy in septic shock is a matter of debate and criticism. The aim of this study was to assess the cost-effectiveness of albumin therapy in patients with septic shock.MethodsA retrospective cohort study was conducted in Imam Khomeini,...
16h
Gestational diabetes mellitus (GDM) leads to poor pregnancy outcomes. Strategies that improve trophoblast cell function are important methods for GDM treatment. This study aimed to investigate the expression a...
10h
Diagnostics, Vol. 9, Pages 165: Breast Cancer Diagnosis Using an Efficient CAD System Based on Multiple Classifiers Diagnostics doi: 10.3390/diagnostics9040165 Authors: Ragab Sharkas Attallah Breast cancer is one of the major health issues across the world. In this study, a new computer-aided detection (CAD) system is introduced. First, the mammogram images were enhanced to increase the contrast. Second, the pectoral muscle was eliminated and the breast was suppressed from the...
22h
Background. Mechanical stress-induced cardiac remodeling that results in heart failure is characterized by transcriptional reprogramming of gene expression. However, a systematic study of genomic changes involved in this process has not been performed to date. To investigate the genomic changes and underlying mechanism of cardiac remodeling, we collected and analyzed DNA microarray data for murine transverse aortic constriction (TAC) and human aortic stenosis (AS) from the Gene Expression Omnibus...
8h
The flu shot cannot give a person the flu because it does not contain active viruses. In this article, learn about how the vaccine works and why a person may feel sick after a flu shot.
5h
K-singular value decomposition (K-SVD) is a frequently used dictionary learning (DL) algorithm that iteratively works between sparse coding and dictionary updating. The sparse coding process generates sparse c...
12h
Abstract Adaptation of automatic postural responses (APR) to balance perturbations might be thought to be impaired by muscle fatigue, given the associated proprioceptive and effector deficits. In this investigation, we aimed to evaluate the effect of muscular fatigue on APR adaptation over repetitive balance perturbations through support base backward translations. APR adaptation was evaluated in three epochs: (a) pre‐fatigue; (b) post‐fatigue, immediately following fatigue of the plantiflexor muscles...
21h
This paper by Haine et al.1 presents further data to attempt to guide optimal revascularisation strategies in patients with symptomatic lower limb peripheral artery disease (PAD).1 The authors have compared two differing stent platforms (interwoven nitinol stents and drug eluting stents) in the management of femoropopliteal lesions and conclude that they show comparable efficiency with regard to the primary outcome measure of clinically derived target lesion revascularisation. While each stent platform...
13h
Many acupuncture therapies were used to treat spinal cord injury (SCI) and its complications. The difference in efficacy among these therapies has not been assessed. To compare the efficacy of different acupuncture therapies for SCI, we searched databases (PubMed, Embase, Cochrane Library, CNKI, and WanFang) for relevant RCTs in both English and Chinese before June 2019 that reported the association between acupuncture therapies and SCI. The RCTs were categorized according to the location of the...
8h
Foshou San is a typical gynaecological formula with wild usage in traditional Chinese medicine. Jiawei Foshou San (JFS) is a novel ingredient prescription from Foshou San with antiendometriosis effect in unclear mechanisms. To uncover the potential application and proapoptotic mechanisms of JFS, JFS ingredient-drug target-disease networks, GO enrichment, and pathway analysis were established for potential application prediction. Molecular docking and validation in vivo were investigated by the proapoptotic...
8h
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