Publication date: Available online 26 October 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Adi Primov-Fever, Ory MadgarRecurrent laryngeal papillomatosis is a viral (human papillomavirus) disease that causes the growth of epithelial verrucous lesions. Patients with laryngeal papillomatosis undergo multiple surgeries due to the tendency of the lesions to reoccur and cause recurrent voice and breathing problems. The goal of the surgical treatment is to remove the...
11:20
Abstract Recently, neutrophil extracellular traps (NETs), three-dimensional structures formed of neutrophil enzymes such as neutrophil elastase (NE) and nuclear components (DNA), have been associated with progression in different types of cancer. However, data remain scarce in breast cancer. Thus, the aim of this study was to associate NETs with clinical stages of breast cancer. A prospective analysis was performed in 45 plasma samples of female patients with newly diagnosed breast...
03:00
Abstract Thirty-one cases of low-grade renal cell carcinoma (RCC) with clear cells and tubulopapillary/papillary architecture were analyzed retrospectively with immunohistochemical and genetic markers to gain more experience with the differential diagnosis of such cases. All samples coexpressed CK7 and CA9; the TFE3 or TFEB reactions were negative; the CD10 and the AMACR stainings were negative in 27 cases and 30 cases, respectively. The FISH assays for papillary RCC, available...
Sat Oct 26, 2019 03:00
Abstract Ewing sarcoma is a rare tumor developed in bone and soft tissues of children and teenagers. This entity is biologically led by a chromosomal translocation, typically including EWS and FLI1 genes. Little is known about Ewing sarcoma predisposition, although the role of environmental factors, ethnicity and certain polymorphisms on Ewing sarcoma susceptibility has been studied during the last few years. Its prevalence among cancer predisposition syndromes has also been thoroughly...
Sat Oct 26, 2019 03:00
Tue Oct 01, 2019 03:00
Tue Oct 01, 2019 03:00
Abstract The present study aimed to investigate the effects of the administration of boron on viability, apoptosis, and cell cycle of primary rat Sertoli cells (SCs) in vitro. SCs were aseptically isolated from 18–22-day-old male Sprague-Dawley (SD) rats. SCs were identified with immunofluorescence using anti-vimentin antibody. Further, to investigate the effects of boron on Sertoli cells, SCs of the boron treatment group were exposed to different concentrations (0.25, 0.5, 1,...
03:00
Abstract The purpose of this research is to investigate the absorption, distribution, excretion, and pharmacokinetics of selenite in rats after intragastric administration, and thus illustrate the efficiency of selenium (Se) supplementation. After a single gavage of sodium selenite, a concentration of Se in plasma and tissues was determined by inductively coupled plasma mass spectrometry (ICP-MS) at different time points. Through fitting the data with the metabolic kinetic model,...
Sat Oct 26, 2019 03:00
Background. Mechanical stress-induced cardiac remodeling that results in heart failure is characterized by transcriptional reprogramming of gene expression. However, a systematic study of genomic changes involved in this process has not been performed to date. To investigate the genomic changes and underlying mechanism of cardiac remodeling, we collected and analyzed DNA microarray data for murine transverse aortic constriction (TAC) and human aortic stenosis (AS) from the Gene Expression Omnibus...
03:05
Rheumatoid arthritis is a systemic, polygenic, and multifactorial syndrome characterized by erosive polyarthritis, damage to joint architecture, and presence of autoantibodies against several self-structures in the serum and synovial fluid. These autoantibodies (anticitrullinated protein/peptide antibodies (ACPAs), rheumatoid factors (RF), anticollagen type II antibodies, antiglucose-6 phosphate isomerase antibodies, anticarbamylated protein antibodies, and antiacetylated protein antibodies) have...
03:06
Information on subgroup assessments in systematic reviews (SR) of atrial fibrillation (AF) is limited. This review aims to describe subgroup analyses in AF SRs to inform the design of SRs and randomized trials...
Fri Oct 25, 2019 03:00
Abstract Objectives The aim of this crossover study was to compare clinical denture base deformation with different attachments used for mandibular implant overdentures. Materials and methods Twenty‐four patients with edentulous mandibular ridges received 2 implants in the former canine regions. Three months thereafter, each patient randomly given the following implant overdentures in a crossover design: 1) Bar implant overdentures (BOD), 2) Resilient telescopic implant overdentures (TOD)...
Sat Oct 26, 2019 15:53
Abstract Long noncoding RNAs (lncRNAs) have been shown to be aberrantly expressed in oral squamous cell carcinoma (OSCC), but the biological role and function of BRAF‐activated long noncoding RNA (BANCR) in OSCC remain poorly understood. In this study, we found that the expression of BANCR was up‐regulated in OSCC tissues and cell lines compared to the negative control. The decreased expression of BANCR in vitro markedly inhibited OSCC cell proliferation, migration, and invasion while the opposite...
Fri Oct 25, 2019 21:59
A 75-year-old non-atopic male had been suffering from a gastroenteritis-like illness for the last 24 hours characterized by diarrhea and malaise. He decided to take, for the first time, 4 mg of loperamide hydrochloride to assist with symptom relief. Within 30 minutes, he developed severe anaphylaxis with widespread urticaria, presyncope and acute worsening of diarrhea and vomiting. He was transported by ambulance to the hospital, where his initial blood pressure was 82/50. He was successfully resuscitated...
Sat Oct 26, 2019 03:00
Abstract Duplication of 15q11.2‐q13.1 (dup15q syndrome) is one of the most common copy number variations associated with autism spectrum disorders (ASD) and intellectual disability (ID). As with many neurogenetic conditions, accurate behavioral assessment is challenging due to the level of impairment and heterogeneity across individuals. Large‐scale phenotyping studies are necessary to inform future clinical trials in this and similar ID syndromes. This study assessed developmental and behavioral...
Sat Oct 26, 2019 12:33
Abstract Kabuki syndrome (KS) is a disorder of epigenetic dysregulation due to heterozygous mutations in KMT2D or KDM6A, genes encoding a lysine‐specific methyltransferase or demethylase, respectively. The phenotype is highly variable, including congenital cardiac and renal anomalies, developmental delay, hypotonia, failure to thrive, short stature, and immune dysfunction. All affected individuals have characteristic facial features. As KS natural history has not been fully delineated, limited information...
Sat Oct 26, 2019 12:29
Adaptation is often described in behavioral ecology as individuals maximizing their inclusive fitness. Under what conditions does this hold and how does this relate to the gene-centered perspective of adaptation? We unify and extend the literature on these questions to class-structured populations. We demonstrate that the maximization (in the best-response sense) of class-specific inclusive fitness obtains in uninvadable population states (meaning that all deviating mutant go extinct). This defines...
Sat Oct 26, 2019 03:00
Errors in gene transcription can be costly, and organisms have evolved to prevent their occurrence or mitigate their costs. The simplest interpretation of the drift barrier hypothesis suggests that species with larger population sizes would have lower transcriptional error rates. However, Escherichia coli seems to have a higher transcriptional error rate than species with lower effective population sizes, e.g. Saccharomyces cerevisiae. This could be explained if selection in E. coli were strong enough...
Sat Oct 26, 2019 03:00
The diversity and biology of unicellular relatives of animals has strongly informed our understanding of the transition from single-celled organisms to the multicellular Metazoa. Here we analyse the cellular structures and complex life cycles of the novel unicellular holozoans Pigoraptor and Syssomonas (Opisthokonta). Both lineages are characterized by complex life cycles with a variety of cell types, the formation of multicellular aggregations and syncytium-like structures, and an unusual diet for...
Sat Oct 26, 2019 03:00
When the ranges of closely-related lineages are large, and overlapping, we can often study introgression at many "replicated" contacts, with different locations and spatial scales. Here we analysed multiple contact zones of the M. edulis complex of marine mussel species, which represent a mosaic distribution of heterogeneously differentiated, semi-isolated genomes. Our aim was to contrast ongoing introgression at the heart of hybrid zones, with past introgression between similar parental populations,...
Sat Oct 26, 2019 03:00
The egalitarian allotment of gametes to each allele at a locus (Mendel's law of segregation) is a near-universal phenomenon characterizing inheritance in sexual populations. As exceptions to Mendel's law are known to occur, one can investigate why non-Mendelian segregation is not more common using modifier theory. Earlier work assuming sex-independent modifier effects in a random mating population with heterozygote advantage concluded that equal segregation is stable over long-term evolution. Subsequent...
Sat Oct 26, 2019 03:00
Ralstonia mannitolilytica is an emerging opportunistic pathogen that is associated with severe disease, including septic shock, meningitis, and renal transplant infections. Reports on this pathogen are limited, h...
Sat Oct 26, 2019 03:00
Pneumocephalus and pneumorachis, presence of air inside the skull and spinal canal, are mostly seen after neurosurgical procedures and neuraxial anesthesia. They have also been described after penetrating trau...
Fri Oct 25, 2019 03:00
Abstract Background Intracranial interdural cyst is a rare lesion. The exact pathophysiology of these cysts remains unknown. Clinical presentation We report an infant with interdural cyst of the tentorium cerebelli. Although the cyst mimicked an arachnoid cyst on pre- and postnatal magnetic resonance images, lateral suboccipital craniotomy revealed the cyst...
Sat Oct 26, 2019 03:00
Objective The use of microvascular free tissue transfer (MVFTT) for defects of the scalp and lateral temporal bone in patients with cochlear implants (CI) is uncommon. Herein, we report our experience with the utility, indications, and outcomes for MVFTT in patients with cochlear implants. Methods A retrospective review of patients at our institution from September 2016 to December 2017 identified subjects with coexistent cochlear implant and ipsilateral MVFTT of the lateral temporal bone...
Fri Oct 25, 2019 20:19
Primary laryngectomy versus salvage laryngectomy: A comparison of outcomes in the chemoradiation era
Objective To compare primary total laryngectomy (TL) versus salvage TL and analyze the functional outcomes, complications, recurrence rates, and survival. Study Design Case series with chart review. Setting Tertiary care center. Subjects and Methods Fifteen‐year retrospective analysis of 208 patients with laryngeal squamous cell carcinoma treated by TL was completed. Outcome measures included survival, swallowing rehabilitation, speech rehabilitation, complications, and assessment...
Fri Oct 25, 2019 20:11
Objective Competing risk analysis is a powerful assessment for cancer risk factors and covariates. This method can better elucidate insurance status and other social determinants of health covariates in oral cavity cancer treatment, survival, and disparities. Study Design Retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) database. Methods Data regarding patient characteristics, clinical stage at diagnosis, treatment, and survival data for 20,271...
Fri Oct 25, 2019 20:09
Objectives/Hypothesis The incidence of cognitive impairment (CI) in the elderly general population is 10% to 20%. The incidence of CI in the elderly laryngology treatment–seeking population is unknown, and CI may impact decision making for elective medical/surgical treatment and negatively impact the outcome of voice/swallowing therapy. We sought to determine the prevalence of CI in elderly patients who are seeking laryngology care and to evaluate the feasibility of administering a cognitive screening...
Fri Oct 25, 2019 20:03
Fri Oct 25, 2019 20:03
Sinus, cold, and allergy remedies comprise the most widely used sector of the over‐the‐counter (OTC) drug market. Direct‐to‐consumer advertising (DTCA) of pharmaceutical products has increased over the past 30 years, including the promotion of OTC drugs. The influence of DTCA on OTC sinonasal remedies comprises several positive and negative effects. Favorable aspects of this influence include empowerment and promotion of autonomy among patients, avoidance of low‐value clinical encounters, self‐directed...
Fri Oct 25, 2019 20:00
The purpose of this systematic review was to evaluate implant survival in irradiated nasal, auricular, orbital sites and to compare them with non-irradiated respective sites. Four electronic databases and seven related journals were searched until December and March 2018, respectively. A total of 7892 articles were identified, 18 of which were included in this review; one non-randomized clinical trial, two prospective cohort, eight retrospective cohort and seven cross-sectional studies. Using the...
Sat Oct 26, 2019 03:00
Polo-like kinase 3 (PLK3) has been documented as a tumor suppressor in several types of malignancies. However, the role of PLK3 in colorectal cancer (CRC) progression and glucose metabolism remains to be known.
Sat Oct 26, 2019 03:00
Abstract Transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) is widely used to study the reactivity and connectivity of brain regions for clinical or research purposes. The electromagnetic pulse of the TMS device generates at the instant of administration an artifact of large amplitude and a duration up to tens of milliseconds that overlaps with brain activity. Methods for TMS artifact correction have been developed to remove the artifact and recover...
Sat Oct 26, 2019 03:00
Carbon fluxes in the cryosphere are hardly assessed yet but are crucial regarding climate change. Here we show a novel prototype device that captures the phototrophic potential in supraglacial environments based on laser-induced fluorescence emission (L.I.F.E.) technology offering high spectral and spatial resolution data under in situ conditions.
Sat Oct 26, 2019 22:29
Conducting in vitro experiments to reflect in vivo conditions as adequately as possible is not an easy task. The use of primary cell cultures is an important step toward understanding cell biology in a whole organism. The provided protocol outlines how to successfully grow and culture embryonic mouse cerebellar neurons.
Sat Oct 26, 2019 21:29
Here we present a training and testing system where a trainee can complete manual vascular reconstruction in vitro individually using a magnetic anchoring technique. The system can also be used to test the quality of reconstruction.
Sat Oct 26, 2019 20:31
Here, we present a protocol to establish a replicable conductive hearing loss induction via surgical tympanic membrane puncture and verification by otoscope visualization and behavioral assessment by clap startle.
Sat Oct 26, 2019 19:30
Publication date: Available online 25 October 2019Source: Journal of Human EvolutionAuthor(s): Guido Bataille, Armando Falcucci, Yvonne Tafelmaier, Nicholas J. Conard
Sat Oct 26, 2019 22:05
Publication date: Available online 25 October 2019Source: Behavioural Brain ResearchAuthor(s): Sakineh Alizadeh Golsorkhdan, Mahdi Eskandarian Boroujeni, Abbas Aliaghaei, Mohammad Amin Abdollahifar, Afshar Ramezanpour, Reza Nejatbakhsh, Iraj Jafari Anarkooli, Elahe Barfi, Mohammad Javad FridoniAbstractMethamphetamine (METH) is a strong psychostimulant drug which can essentially affect different brain regions. Hippocampus as one of main components of limbic system plays key roles in processing of...
Sat Oct 26, 2019 21:52
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου