Fri Oct 25, 2019 17:34
Publication date: Available online 24 October 2019Source: Behavioural Brain ResearchAuthor(s): Ming-Yang Wang, Min Meng, Cui-cui Yang, Li Zhang, Ya-li Li, Lan Zhang, Lin LiAbstractChronic cerebral hypoperfusion is an important risk factor for vascular dementia (VaD) and other brain dysfunctions, for which there are currently no effective medications available. In the present study, we investigated the potential therapeutic effects of cornel iridoid glycoside (CIG) on VaD in rats modeled by permanent...
Fri Oct 25, 2019 18:13
Publication date: Available online 24 October 2019Source: American Journal of OtolaryngologyAuthor(s): Eugene H. Wong, Murray Smith, Richard Tjahjono, Danielle B. Stone, Niranjan Sritharan, Carsten E. Palme, Mark C. Smith, Faruque RiffatAbstractObjectiveCadaveric experiments and more recently clinical data have demonstrated that patients with vertical height discrepancy between their arytenoids experience poorer voice outcomes in patients with unilateral vocal cord palsy (UVP) after medialisation...
Fri Oct 25, 2019 18:10
Key points Wnt ligands belonging to both canonical and non‐canonical Wnt pathways regulate membrane potential signifying a very early event in the signal transduction. Wnts activate K+ currents by elevating intracellular Ca2+ and trigger Ca2+ release from intracellular stores. Control of potential by Wnt ligands has significant implications for gene transcription and opens up a novel avenue to interfere with this critical pathway. Abstract The Wnt signalling network determines gene...
Thu Oct 24, 2019 16:08
We report FDG PET/CT images of a 63-year-old woman referred for characterization of osteolytic lesions of the cervical spine. This patient with chronic renal failure had a history of follicular thyroid carcinoma with undifferentiated cells, treated by a total thyroidectomy, completed by radioactive iodine in 2017. Because of cancer history, a FDG PET/CT was performed and showed multiple moderately hypermetabolic osteolytic lesions of the spine from C3 to T1, with joint erosion on CT. A laminectomy...
Thu Oct 17, 2019 03:00
A 72-year-old man with a history of T1cN0M0 prostate adenocarcinoma and rising prostate-specific antigen underwent a fluciclovine PET/CT scan that showed high uptake in several para-aortic nodes, suspicious for prostate cancer. A right upper lobe single pulmonary nodule (SPN), demonstrated only mild uptake, which raised the suspicion for a lung primary. Subsequent FDG PET/CT showed high uptake in the SPN, revealing poorly differentiated adenocarcinoma at biopsy, but with no abnormal uptake in the...
Thu Oct 17, 2019 03:00
18F-FDG PET/CT for a 74-year-old man with elevated serum soluble interleukin 2 receptor showed multiple intense uptake in the liver, spleen, and bone. A surgical biopsy from 2 of liver tumors confirmed hepatosplenic αβ T-cell lymphoma. One and a half months after biopsy, FDG PET scan was performed again for staging before starting chemotherapy, and it showed the complete disappearance of all of the lesions. The excisional biopsy could be a possible trigger of his spontaneous regression. Received...
Thu Oct 17, 2019 03:00
Breast cancer is the most common cancer in women with rising incidence worldwide. 18F-FDG PET/CT imaging has already established itself as a pivotal modality for staging, restating and response assessment in patients with carcinoma breast. The complex biology of this cancer is increasingly being decoded and various molecular targets have been identified and exploited for guiding the treatment at various time points during the course of the disease. We here depict a series of various metabolic and...
Thu Oct 17, 2019 03:00
Metastatic involvement of the larynx is rare due to the absence of vessels within the cartilaginous tissue. The probability of metastatic spread increases with aging as a result of larynx ossification. The secondary involvement of larynx is more frequently associated with melanoma and renal cell carcinoma. Few observations have been reported also in prostate cancer patients, usually associated with advanced disease and diffuse metastatic bone involvement. We report a case of an 83-year-old man with...
Thu Oct 17, 2019 03:00
Extraocular muscles show physiologic radiotracer uptake on 18F-FDG PET/CT as is encountered in most routine scans. Certain pathologies can cause palsy of one or more of the extraocular muscles, leading to hypometabolism on 18F-FDG PET/CT. We present a case with a classical finding of unilateral hypometabolism of the lateral rectus muscle, disrupting the “V” sign formed due to physiologic uptake. The patient had presented with the complaint of diplopia and was being evaluated further to rule out the...
Thu Oct 17, 2019 03:00
A 65-year-old man underwent FDG PET/CT for evaluation of vertebral lesions, radiologically suspected to be metastases. The scan showed hypermetabolism in D8 to D9 vertebrae, retroperitoneal lymph nodes, and both the lobes of prostate. Transrectal ultrasound-guided biopsy of prostate was performed with suspicion of prostate malignancy. The biopsy revealed caseating granulomatous lesions in prostate suggestive of tuberculosis. Post antitubercular treatment patient showed excellent clinical response....
Thu Oct 17, 2019 03:00
Brown tumors are rare skeletal anomalies occurring in patients with hyperparathyroidism and exposing patients to pathological fractures. We report the case of a 26-year-old woman with severe primary hyperparathyroidism (calcemia, 2.9 mmol/L; parathyroid hormone, 59 pmol/L) who underwent 18F-fluorocholine (FCH) PET/CT before parathyroidectomy. FCH PET localized the hyperfunctioning parathyroid gland and showed multiple foci in correspondence with bone lytic lesions on CT. Those lesions were not visible...
Thu Oct 17, 2019 03:00
Nature Chemistry, Published online: 25 October 2019; doi:10.1038/s41557-019-0355-1Understanding the effects of adding a simple salt to an aqueous solution of a protein is far from simple — and Bruce C. Gibb explains why.
Fri Oct 25, 2019 03:00
Nature Chemistry, Published online: 25 October 2019; doi:10.1038/s41557-019-0344-4Tuning the selectivity for [2+2] photocycloadditions remains challenging. Now, triplet–triplet energy transfer from CdSe quantum dots enables the homo- and heterocouplings of 4-vinylbenzoic acid derivatives via [2+2] photocycloaddition. Preorganization of substrates on the quantum dots reverses intrinsic stereoelectronic preferences to yield cyclobutane products with unprecedented diastereo- and regioselectivity.
Fri Oct 25, 2019 03:00
Nature Chemistry, Published online: 25 October 2019; doi:10.1038/s41557-019-0363-1Although transporting a starship crewmember onto the surface of an alien planet is clearly science fiction, quantum state teleportation is not, and has been observed in various systems over the last few decades. Now, electron-spin teleportation has been observed in a carefully designed molecular system, paving the way for such behaviour to be tailored through molecular engineering.
Fri Oct 25, 2019 03:00
Nature Chemistry, Published online: 25 October 2019; doi:10.1038/s41557-019-0359-xThe in situ, nanoscale positioning of a single molecule below the diffraction limit remains a challenge for chemists. Now, two approaches show how this can be accomplished through a combination of super-resolution microscopy and photo-inducible crosslinking chemistry.
Fri Oct 25, 2019 03:00
Publication date: Available online 24 October 2019Source: Computer Speech & LanguageAuthor(s): Bing Ma, Qi Qi, Jianxin Liao, Haifeng Sun, Jingyu WangAbstractWord embedding is a basic task in natural language processing area. Unlike English, Chinese subword units, such as characters, radicals, and components, contain rich semantic information which can be used to enhance word embeddings. However, existing methods neglect the semantic contribution of corresponding subword units to the word. In...
Fri Oct 25, 2019 17:57
Abstract Foraging in burned areas has been suggested to represent the earliest stage in the use and control of fire by early hominins. Recently burned areas offer immediate foraging benefits including increased search efficiency for high‐ranked food items and decreased hunting opportunities for ambush predators. As such, they provide a triple‐bonus (reduced risk from ambush, ease of terrestrial travel and higher foraging returns) for some primates. However, previous studies have not yet accounted...
Fri Oct 25, 2019 17:08
Publication date: Available online 24 October 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): David Z. Allen, Noah Worobetz, Jordan Lukens, Cameron Sheehan, Amanda Onwuka, Ryan M. Dopirak, Tendy Chiang, Charles ElmaraghyAbstractIntroductionAdenotonsillectomy (AT) is the most common surgical procedure for the treatment of sleep related breathing issues in children. While overnight observation in the hospital setting is utilized frequently in children after a AT, ICU setting...
Fri Oct 25, 2019 17:47
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01485C, PaperJesus Maldonado, M.-Carmen Estevez, Adrián Fernández Gavela, Juan Jose Gonzalez-Lopez, Ana Belén Gonzalez-Guerrero, Laura Maria LechugaNosocomial infections are a major concern at worldwide level. Early and accurate identification of nosocomial pathogens is crucial to provide a timely and adequate treatment. A prompt response also prevents...The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Oct 25, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01699F, PaperHuiyuan Guo, Qishen Huang, Weinan Leng, Ying Zhan, Bahareh Behkam, Marjorie Willner, Haoran Wei, Linsey Marr, Peter Vikesland4-mercaptopyridine (4-Mpy) is a pH reporter molecule commonly used to functionalize nanoprobes for surface-enhanced Raman spectroscopy (SERS) based pH measurements. However, nanoprobes functionalized by 4-Mpy alone have low pH sensitivity...The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Oct 25, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01258C, Critical ReviewAlienke van Pijkeren, Rainer Bischoff, Marcel KwiatkowskiBiological organisms represent highly dynamic systems, which are continually exposed to environmental factors and always strive to restore steady-state homeostasis. Posttranslational modifications are key regulators with which biological systems respond...The content of this RSS Feed (c) The Royal Society of Chemistry
Fri Oct 25, 2019 02:00
Publication date: Available online 25 October 2019Source: Radiotherapy and OncologyAuthor(s): Nicolas Audag, Geneviève Van Ooteghem, Giuseppe Liistro, Armand Salini, Xavier Geets, Gregory ReychlerAbstractWe developed a training protocol based on Intrapulmonary Percussive Ventilation in order to prolong breath-hold while nearly suppressing the thorax motion. This protocol allowed ten subjects to achieve a 20-minutes-breath-hold, while reducing the residual surface motion to 1 mm around its mean position...
Fri Oct 25, 2019 17:25
Publication date: Available online 24 October 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Vincent Cox, Vera Schepers, Marjolijn Ketelaar, Caroline van Heugten, Anne Visser-MeilyAbstractObjectiveTo investigate participation restrictions and satisfaction with participation in partners of patients with stroke.DesignCross-sectional study.SettingFive rehabilitation centers and three hospitals in [country censored for review process].ParticipantsA consecutive sample of 54 partners...
Fri Oct 25, 2019 17:14
Publication date: Available online 24 October 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Connie L. Fiems, Stephanie A. Combs-Miller, Nathan Buchanan, Erin Knowles, Elizabeth Larson, Rachel Snow, Elizabeth S. MooreObjectiveTo determine whether a sway-based mobile application (SWAY) predicts falls and to evaluate its discriminatory sensitivity and specificity relative to other clinical measures in identifying fallers in individuals with Parkinson disease (PD).DesignObservational...
Fri Oct 25, 2019 17:14
Publication date: Available online 24 October 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Jake M. Tablerion, Tyler A. Wood, Katherine L. Hsieh, Alka Bishnoi, Ruopeng Sun, Manuel Hernandez, Ruopeng An, Jacob J. SosnoffAbstractObjectivesTo systematically review and quantitatively synthesize the existing evidence of motor learning in persons with Multiple Sclerosis (PwMS).Data sourcesPubMed, CINAHL, and Web of Science were searched using the terms: multiple sclerosis, task...
Fri Oct 25, 2019 17:14
Publication date: Available online 24 October 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): E. Morghen Sikes, Katie L. Cederberg, Brian M. Sandroff, Alfred Bartolucci, Robert W. MotlAbstractObjectiveTo provide a meta-analysis of papers that have included the timed 25-foot walk (T25FW) in persons with multiple sclerosis (MS), and quantify differences in T25FW scores between those with MS and healthy controls without MS (HC), and between categories of disability status and...
Fri Oct 25, 2019 17:14
Purpose of review Finding suitable biomarkers to phenotype asthma, identify individuals at risk of worsening and guide treatment is highly prioritized in asthma research. We aimed to provide an analysis of currently used and upcoming biomarkers, focusing on developments published in the past 2 years. Recent findings Type 2 inflammation is the most studied asthma mechanism with the most biomarkers in the pipeline. Blood eosinophils and fractional exhaled nitric oxide (FeNO) are those most...
Thu Oct 24, 2019 03:00
The authors report a rare case of intraosseous hemangioma of the mandible in a 14-year-old male. Surgical intervention with embolization is as important as histological and radiological examination to reduce the bleeding complication. Magnetic resonance angiography is paramount of importance in these lesions to detect the supplier arteries. Address correspondence and reprint requests to Mustafa Yalcin, DDS, PhD, Department of the Oral and Maxillofacial Surgery, Faculty of Dentistry, Gaziantep University,...
Thu Oct 24, 2019 03:00
Craniosynostosis is a congenital cranial malformation involving premature fusion of cranial sutures. Indications for surgical repair of craniosynostosis include elevation of intracranial pressure, which can result in impaired vision and mental disability, as well as correction of abnormal skull shape. Resorbable plating systems have become the preferred technique for bony fixation in the repair of craniosynostosis. Multiple studies demonstrate the safety and low complication rate of resorbable plating...
Thu Oct 24, 2019 03:00
Background: The impact of metopic craniosynostosis on intracranial volume (ICV) and ICV growth is unclear. In addition, the relationship between head circumference (HC) and ICV in these patients is not previously described. Methods: A retrospective review of 72 patients with metopic craniosynostosis was performed. The ICVs were calculated from manually segmented preoperative computed tomography scans. Magnetic resonance imaging data for 270 healthy children were available. The ICVs were calculated...
Thu Oct 24, 2019 03:00
In nasal reconstruction, it is necessary to replace all anatomic layers in order to reinstate correct aesthetics. The most apt donor site to use in order to cover the nose has been recognized as forehead skin. Traditionally 2 phases are required to reconstruct the forehead flap; however, an intermediate third phase was described by Millard which is between transfer of the flap and division of the pedicle. These methods will be compared in this study with regard to both complication rates and aesthetic...
Thu Oct 24, 2019 03:00
Nasal bone stabilization, in the setting of comminuted nasal fracture or surgical osteotomy, represents a challenging surgical experience. Postoperative shifting of osseous fragments may result in compromised outcomes in an otherwise well-performed procedure. Although prior studies have reported nasal bone fixation with implementation of wires, plates, or halos, these techniques are often difficult to employ routinely. Herein, the authors describe a novel and facile technique for the maintenance...
Thu Oct 24, 2019 03:00
Objective: Complex secondary deformities of cleft lip include nasal and labial deformities, alveolar cleft, oronasal fistula, and so on. In this report, the authors present a method to simultaneously repair the above complex deformities with autogenous costal cartilage and rib grafts. Methods: The surgical procedure of simultaneous correction includes filling the alveolar cleft with autologous rib;repairing the oronasal fistula with a local mucosal flap;correcting the nasal deformity with...
Thu Oct 24, 2019 03:00
Purpose: The aim of this study was to evaluate the efficacy, feasibility, and safety of the endoscopic optic canal and orbital apex decompression for patients with traumatic orbital apex syndrome. Design: Retrospective, noncomparative case series. Method: Thirty-one patients (31 eyes) with traumatic orbital apex syndrome underwent endoscopic transethmosphenoid optic canal and orbital apex decompression at the Eye Hospital of Wenzhou Medical University from May 1st, 2012 to May 1st, 2018....
Thu Oct 24, 2019 03:00
Cutaneous lymphangioma circumscriptum (CLC) is an uncommon congenital lymphatic malformation. Its dermoscopic features have been reported, however, if blood has infiltrated the lacunas, a pink hue overwhelms the lacunar structures, rendering dermoscopic features indistinguishable. In addition, dermoscopy cannot assess the subcutaneous extent of the lesion before surgery. The high-frequency array transducer Sonography with a high-frequency transducer is excellent in its resolution to evaluate skin...
Thu Oct 24, 2019 03:00
Publication date: Available online 24 October 2019Source: Archives of Oral BiologyAuthor(s): L. Nibali, S.A. Almofareh, J. Bayliss-Chapman, Y. Zhou, A.R. Vieira, K. DivarisAbstractObjectiveThe aim of this study was to quantify the heritability of periodontitis via a systematic appraisal of the existing evidence derived from animal studies.DesignA search was conducted through the electronic databases MEDLINE, Embase, LILACS, Cochrane Library, Open Grey, Google Scholar and ResearchGate, complemented...
Fri Oct 25, 2019 16:56
Publication date: Available online 24 October 2019Source: Archives of Oral BiologyAuthor(s): Jorge MartinsAbstractObjectiveTo assess the influence of cone-beam computed tomographic (CBCT) voxel size and population demographic aspects (age, gender and geographic region) on the prevalence of the second mesiobuccal root canal (MB2) in maxillary first and second molars.DesignPrevalence studies using CBCT technology on MB2 canal were searched between May and September 2019. The protocol was registered...
Fri Oct 25, 2019 16:56
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