Syphilis, congenital: Infection of a fetus or newborn with syphilis. Syphilis in a fetus can cause deformity, particularly of the long bones, or death. Syphilis infection acquired at birth is also dangerous. See also TORCH infection.MedTerms (TM) is the Medical Dictionary of MedicineNet.com.We Bring Doctors' Knowledge To You
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Here's the most clicked-on item we featured from NEJM Group this week, in case you missed it the first time around: HIV and ID...
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Publication date: Available online 25 October 2019Source: NeuroImageAuthor(s): Mada Hashem, Qiong Zhang, Ying Wu, Thomas W. Johnson, Jeff F. DunnAbstractNon-invasive quantitative imaging of cerebral oxygen metabolism (CMRO2) in small animal models is crucial to understand the role of oxidative metabolism in healthy and diseased brains. In this study, we developed a multimodal method combining near-infrared spectroscopy (NIRS) and MRI to non-invasively study oxygen delivery and consumption in the...
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Publication date: Available online 25 October 2019Source: Brain StimulationAuthor(s): Fuminari Kaneko, Eriko Shibata, Megumi Okawada, Takashi NagamineAbstractBackgroundThe ability to manipulate the excitability of the network between the inferior parietal lobule (IPL) and primary motor cortex (M1) may have clinical value.ObjectiveTo investigate the possibility of inducing long-lasting changes in M1 excitability by applying quadripulse transcranial magnetic stimulation (QPS) to the IPL, and to ascertain...
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Contributors : Silvia Calabrese ; Alexis Sarazin ; Cusant Loïc ; Annette Niehl ; Alexander Erban ; Daphnée Brulé ; Ghislaine Recorbet ; Daniel Wipf ; Christophe Roux ; Joachim Kopka ; Thomas Boller ; Pierre-Emmanuel CourtySeries Type : Expression profiling by high throughput sequencingOrganism : Populus trichocarpa ; Rhizophagus irregularis ; Sorghum bicolorWe analyzed the impact of different phosphate levels on the regulation of plant and fungal transcriptomes.
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Contributor : Tao TanSeries Type : Expression profiling by high throughput sequencingOrganism : Macaca fascicularis ; Macaca mulattaThe induction of the primordial germ-like cells (PGCLCs) from primate pluripotent stem cells (PSCs)provides a powerful system to study the cellular and molecular mechanism underlying germline specification, which are difficult to study in vivo. However a comprehensive single cell RNA sequencing(scRNA-seq) analysis of the developmental trajectory of PGCLCs differentiation...
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Contributor : Jian LiuSeries Type : Expression profiling by arrayOrganism : Homo sapiensMTA1, SOX4, EZH2 and TGF-β are all potent inducers of epithelial-mesenchymal transition (EMT) in cancer; however, the signaling relationship among these molecules in EMT is poorly understood. Here, we investigated the function of MTA1 in cancer cells and demonstrated that MTA1 overexpression efficiently activates EMT. This activation resulted in a significant increase in the migratory and invasive properties...
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Contributors : Sara C Marques ; Linn Reinholdt ; Julie S Bødker ; Alexander Schmitz ; Jacob G Mikkelsen ; Hans E Johnsen ; Martin Bøgsted ; Karen DybkærSeries Type : Expression profiling by arrayOrganism : Homo sapiensAlthough diffuse large B-cell lymphoma (DLBCL) is a very heterogeneous disease, patients are as standard treated with a combination of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP). Since approximately 40% of patients die due to refractory disease...
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A randomized pilot study of nitrate supplementation with beetroot juice in acute respiratory failure
Publication date: Available online 25 October 2019Source: Nitric OxideAuthor(s): D. Clark Files, Timothy Heinrich, Katherine L. Shields, Nathan J. Love, Carly Brailer, Rita N. Bakhru, Lina Purcell, Lori Flores, Kevin Gibbs, Gary D. Miller, Peter E. Morris, Michael J. BerryAbstractNitrate rich beetroot juice (BRJ) can enhance nitric oxide signaling, leading to improved physical function in healthy and diseased populations, but its safety and biologic efficacy have not been evaluated in a critically...
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Conclusions: No obvious association of specific clinical features with individual ethnicity could be identified. We found a high rate of glaucoma in all ethnic groups. There was a delay in diagnosis and specific treatment of HCMV in most patients. PMID: 31642720 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
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Conclusion: More than 40% of our patients with intermediate uveitis had sarcoidosis, tuberculosis, multiple sclerosis, or TINU as the underlying etiology. Owing to their potential morbidity, these diseases need to be considered in Egyptian patients presenting with intermediate uveitis. PMID: 31642742 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
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The purpose of this systematic review was to evaluate implant survival in irradiated nasal, auricular, orbital sites and to compare them with non-irradiated respective sites. Four electronic databases and seven related journals were searched until December and March 2018, respectively. A total of 7892 articles were identified, 18 of which were included in this review; one non-randomized clinical trial, two prospective cohort, eight retrospective cohort and seven cross-sectional studies. Using the...
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Publication date: Available online 25 October 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Tamir Dean Anver, Lida Mirzai, Peng Li, Kathlyn Powell, Peter D. WaiteAbstractPurposeUse cone-beam computed tomography (CBCT) analysis to assess the long term radiographic outcomes of early secondary alveolar bone grafting.Patients and MethodsThe most recent post-operative CBCT of 79 alveolar cleft patients that underwent of anterior iliac crest bone grafting (AICBG) by a single surgeon over...
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Publication date: Available online 25 October 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Warley Luciano Fonseca Tavares, Francielen Oliveira Fonseca, Lucas Moreira Maia, Vinícius de Carvalho Machado, Nelson Renato França Alves Silva, Gil Moreira Junior, Antônio Paulino Ribeiro SobrinhoAbstractWhen conventional endodontic treatment resources are depleted, endodontic surgery becomes an alternative treatment for apical periodontitis to remove unreachable infected areas and seal...
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Publication date: Available online 25 October 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Max Ward, Neil Majmundar, Antonios Mammis, Boris PaskhoverAbstractBackgroundTrigeminal neuralgia is a chronic and debilitating syndrome characterized by short paroxysms of lancinating facial pain. Patients may be medically managed; however, in cases of medically refractory trigeminal neuralgia surgical management is often required.ObjectiveTo present and describe the technique for endoscopic...
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Abstract Long noncoding RNAs (lncRNAs) have been shown to be aberrantly expressed in oral squamous cell carcinoma (OSCC), but the biological role and function of BRAF‐activated long noncoding RNA (BANCR) in OSCC remain poorly understood. In this study, we found that the expression of BANCR was up‐regulated in OSCC tissues and cell lines compared to the negative control. The decreased expression of BANCR in vitro markedly inhibited OSCC cell proliferation, migration, and invasion while the opposite...
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Crystal-cell interactions are a vital step toward kidney stone formation. However, its mechanisms remained unclear. Here, a protein-protein interaction (PPI) network analysis of a kidney stone revealed that the proteins were enriched in a posttranslational protein modification process in the endoplasmic reticulum (ER). The in vitro study showed that the markers of ER stress, including Bip and CHOP, were upregulated, PERK and ATF6 were activated, and XBP-1 mRNA was spliced. An ER stress-specific protein,...
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Long noncoding RNA (lncRNA) disorder has been found in many kinds of age-associated diseases. However, the role of lncRNA in the development of age-related hearing loss (AHL) is still largely unknown. This study sought to uncover AHL-associated lncRNAs and the function. RNA-sequencing was conducted to profile lncRNA expression in the cochlea of an early-onset AHL mouse model. RT-qPCR assay was used to validate the expression pattern of lncRNAs. ATP assay, JC-1 assay, mitochondrial probe staining,...
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Pharmaceutics, Vol. 11, Pages 553: Decellularized Lymph Node Scaffolding as a Carrier for Dendritic Cells to Induce Anti-Tumor Immunity Pharmaceutics doi: 10.3390/pharmaceutics11110553 Authors: Hung-Jun Lin Weu Wang Yi-You Huang Wei-Tsen Liao Ting-Yu Lin Shyr-Yi Lin Der-Zen Liu In recent decades, the decellularized extracellular matrix (ECM) has shown potential as a promising scaffold for tissue regeneration. In this study, an organic acid decellularized lymph node...
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Publication date: Available online 25 October 2019Source: Clinics in Plastic SurgeryAuthor(s): Natale Ferreira Gontijo-de-Amorim, Luiz Charles-de-Sá, Gino Rigotti
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Publication date: Available online 25 October 2019Source: Clinics in Plastic SurgeryAuthor(s): Lee L.Q. Pu
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Abstract Objective Anterior urethral anomalies (AUA) which present as anterior urethral valve, stenosis or atresia, are a rare cause for congenital urinary tract obstruction. We present our AUA prenatal diagnosis case series. Methods Fetuses presenting with prenatal findings suggestive for AUA according to post‐natal reported clinical and imaging signs (urinary tract dilatation, dilated bladder, enlarged edematous fetal penis, dilatation of the fetal urethra and diverticula) were followed...
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Évolution de la pollution atmosphérique urbaine dans 13 grandes villes françaises entre 2008 et 2015
Publication date: Available online 25 October 2019Source: Revue des Maladies RespiratoiresAuthor(s): F. Amrani, J. Prud’homme, C. Maesano, I. Annesi-MaesanoRésuméContexteLa pollution atmosphérique est un enjeu majeur de santé publique et constitue une préoccupation majeure en France et dans le monde. Preuve en est que la pollution de l’air est l’une des 1re préoccupations environnementales des français. Le but de cette étude fut d’établir un suivi des concentrations réelles de différents polluants...
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Publication date: 30 March 2020Source: Food Chemistry, Volume 309Author(s): Cuiling Liang, Zhiyuan Zhang, Huidan Zhang, Lifang Ye, Jianfeng He, Jiming Ou, Quanzhou WuAbstractIn this work, to improve the availability of the recognition sites of molecularly imprinted polymers (MIPs), ordered macroporous molecularly imprinted polymers (OMMIPs) were facilely prepared by grafting a quercetin-MIPs layer on the pore walls of the ordered macroporous thiol group functionalized silica. The pore structures...
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Publication date: Available online 25 October 2019Source: Food ChemistryAuthor(s): Xuejin Mao, Yiqun Wan, Zhanming Li, Lin Chen, Hueylee Lew, Hongshun YangAbstractA simple, sensitive and environmentally-friendly method for determining organophosphorus and pyrethroid pesticides in vegetables was developed to better evaluate the risk of consuming them. The pesticides in vegetables were extracted, purified and concentrated by using the QuEChERS (quick, easy, cheap, effective, rugged and safe method)...
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Publication date: Available online 25 October 2019Source: Food ChemistryAuthor(s): Weiwei He, Yuxi Wang, Hao Luo, Dajing Li, Chunquan Liu, Jiangfeng Song, Zhongyuan Zhang, Chunju Liu, Liying NiuAbstractGerminated edible seeds and sprouts are becoming increasingly common in the human diet because they are rich in bioactive compounds and antioxidants and are highly nutritious. In this study, the effects of NaCl stress and supplemental CaCl2 on carotenoid accumulation, antioxidant capacity and expression...
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Publication date: Available online 25 October 2019Source: Food ChemistryAuthor(s): Seyed Saeid Hosseini, Faramarz Khodaiyan, Seyed Mohammad E. Mousavi, Seyedeh Zahra Azimi, Mohammad GharaghaniAbstractFor the first time, polyaldehyde kefiran was applied to immobilize the pectinase on the glass bead and the finding was compared with free enzyme. Polyaldehyde kefiran, produced by periodate oxidation of kefiran, showed an aldehyde content of 23.6 ± 0.9% that was confirmed by FTIR. The results showed...
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Publication date: Available online 25 October 2019Source: Food ChemistryAuthor(s): C. Loganathan, E. Narayanamoorthi, S. Abraham JohnAbstractDevelopment of a novel colorimetric and turn-on fluorescent sensor for potassium metabisulphite (KMS) using graphene oxide stabilized gold nanoparticles (GO-AuNPs) was described. The red color GO-AuNPs was changed to violet while adding 250 × 10-5 M KMS whereas the absorbance band at 523 nm was decreased. The observed changes were ascribed to the leaching of...
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Publication date: Available online 25 October 2019Source: Food ChemistryAuthor(s): Mohammad Zahirul Islam, Buem-Jun Park, Ho-Min Kang, Young-Tack LeeAbstractThe study was conducted to confirm the effects of selenium biofortification on the bioactive compounds and antioxidant activity of wheat microgreen extract. The microgreens were cultivated in the DFT hydroponic system with different concentrations of Se (0 [control], 0.125, 0.25, 0.50, and 1.00 mg/L from sodium selenite) in a growth chamber by...
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Publication date: Available online 25 October 2019Source: Food ChemistryAuthor(s): Jun Chen, Xiaoqin Niu, Taotao Dai, Hui Hua, Sijie Feng, Chengmei Liu, David Julian McClements, Ruihong LiangAbstractThere is interest in extending the functionality of natural polymers using simple chemical derivatization methods. In this study, the ability of pectin to react with various amino acids (40 oC) in aqueous solution without a catalyst was investigated, including glutamic acid, glycine, cysteine, lysine,...
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Publication date: Available online 25 October 2019Source: Food ChemistryAuthor(s): Yusen Wu, Wenwen Zhang, Shiren Song, Wenping Xu, Caixi Zhang, Chao Ma, Lei Wang, Shiping WangAbstractThis study investigated the evolution of both free and bound volatile compounds in ‘Shine Muscat’ grape from post-fruit set to post-maturity and limiting factors of the lipoxygenase (LOX) pathway. C6 compounds and terpenes were the main free and bound volatile compounds, respectively. At pre-softening, volatile compounds...
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Publication date: Available online 25 October 2019Source: Food ChemistryAuthor(s): Bruna Cavecci-Mendonça, José Cavalcante de Souza Vieira, Paula Monteiro de Lima, Aline Lima Leite, Marília Afonso Rabelo Buzalaf, Luiz Fabrício Zara, Pedro de Magalhães PadilhaAbstractThe high concentrations of mercury found in Amazon have been intensively studied by the scientific community in the last decades. These mercurial species bind preferentially to proteins. Therefore, this work proposal sought to obtain...
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Publication date: Available online 25 October 2019Source: Food ChemistryAuthor(s): Mayumi Silva, Bogdan Zisu, Jayani ChandrapalaAbstractEmulsions were designed under low frequency ultrasound (20 kHz) at energy densities of 11.7 – 117.0 J/mL using grape seed oil and milk protein solutions containing different casein to whey protein ratios of 80:20, 60:40, 50:50 and 40:60. An increase in energy densities produced emulsions with a smaller droplet size and narrow size distribution at all milk protein...
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