Abstract Introduction Oral glucocorticoids (GC) have been the mainstay of treatment for giant cell arteritis (GCA). We estimated the risk and dose–effect relationship of potential GC-related adverse events (AEs) in patients with GCA. Methods This retrospective, observational cohort study utilized data from the IBM Explorys Electronic Health Records database...
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Surface EMGs and activity of 73 single motor units (MUs) of the m. triceps brachii caput laterale (TBcl) and 25 units of the m. biceps brachii caput longum (BBcl) were recorded in five adults during unloading within the ramp phase of the isotorque ramp-and-hold movements in the elbow joint (“movement” task) and during maintaining of a certain position (“position control” task). Analysis of the surface EMGs showed that patterns of the MU responses to unloading in different motor tasks are dissimilar....
Psychophysiological sensing of pain is formed due to the activity of a number of neuronal mechanisms. Among the pain-related processes, nociception per se, peripheral sensitization, synaptic plasticity, central sensitization, forming of abnormal excitability, structural reorganization in the respective neuronal networks, modulation of recurrent suppression, and a few other phenomena/processes can be mentioned. Nociception includes the processes of transduction, transmission, spreading, and perception...
One of the hallmarks of Alzheimer’s disease (AD) is extracellular deposition of amyloid-β peptides, particularly in the hippocampus. Despite the antioxidant properties of taurine, its neuroprotective potential against amyloid-β accumulation in scopolamine-induced AD model remain unclear. In such a model, we aimed to assess the effects of taurine on passive avoidance memory impairment, accumulation of congophilic amyloid-β plaques, and neuronal density in the rat hippocampus. Rats, except the control...
The paradigm of brain ischemic preconditioning (BIP) rendering protection from succeeding chemical insults has not been established in vivo. Systemic administration of 3-nitropropionic acid (3-NP) damages cerebral basal ganglia by inducing a mitochondrial dysfunction: this serves as a translational model for Huntington’s disease. We tested the potential of BIP against the neurotoxic effects of 3-NP and investigated the role of glycogen synthase kinase 3-beta (GSK-3β) and heat shock protein-72 (HSP72)...
Surface EMG (sEMG) signals along with pattern recognition algorithms demonstrate a significant potential to identify and predict human motor activity. We propose a single-channel sEMG signalbased continuous locomotion identification method using a simple classifier. The performance of the proposed method was evaluated for three daily-life locomotion modes on a dataset of 15 subjects. A ranking-based feature selection method was applied to optimize the feature vector. The performance of the proposed...
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Related ArticlesA method to improve the accuracy between the presumed depth of excision and the actual depth of excision in women receiving LLETZ cervical treatment; a single-center, two-operator experience. Hippokratia. 2018 Jul-Sep;22(3):113-121 Authors: Papoutsis D, Kandanearachchi P, Antonakou A, Tzavara C, Sahu B Abstract BACKGROUND: We aimed to determine whether continuous auditing of the presumed depth of excision and comparing with the actual...
Related ArticlesPeripheral sympathetic block with therapeutic local anesthesia for the manage-ment of upper limb digital ischemia. Hippokratia. 2018 Jul-Sep;22(3):141-143 Authors: Mahli A, Coskun D, Cosarcan K Abstract BACKGROUND: Thromboangiitis obliterans (TAO) is a non-arteriosclerotic segmental inflammatory occlusive vasculitis typically in the upper and lower extremities affecting small- and medium-sized arteries and veins. We present the treatment...
Related ArticlesSurgical treatment of metastasis to the thyroid gland: a single center experience and literature review. Hippokratia. 2018 Jul-Sep;22(3):137-140 Authors: Zivaljevic V, Jovanovic M, Perunicic V, Paunovic I Abstract BACKGROUND: Metastasis to the thyroid gland or nonthyroid malignancy (NTM) is rarely an indication for thyroidectomy and constitute 1-3 % of all thyroid carcinomas. NTM has a poor prognosis, due to the advanced stage of the...
Related ArticlesAre expanded alleles of the FMR1 gene related to unexplained recurrent miscarriages? Hippokratia. 2018 Jul-Sep;22(3):132-136 Authors: Fragkos M, Bili H, Ntelios D, Tzimagiorgis G, Tarlatzis BC Abstract BACKGROUND: In women with recurrent miscarriages, up to 50 % of those cases remain unexplained. In this study, we evaluated the impact of Cytosine/Guanine/Guanine (CGG) trinucleotide expansions of the fragile-X mental retardation 1 (FMR1)...
Related ArticlesReal-life cost of managing chronic HCV infection in Greece prior to Direct-Acting Antivirals (DAAs): an undeniable truth of spending more for less. Hippokratia. 2018 Jul-Sep;22(3):127-131 Authors: Souliotis K, Siakavellas S, Golna C, Manesis E, Papatheodoridis G, Hatzakis A Abstract PURPOSE: Chronic hepatitis C virus (HCV) infection is a major public health challenge across the world. Before the introduction of Direct-Acting Antivirals...
Related ArticlesEffect of pregnancy on recurrence of symptomatic uterine myomas in women who underwent myomectomy. Hippokratia. 2018 Jul-Sep;22(3):122-126 Authors: Aksoy RT, Tokmak A, Guzel AI, Yildirim G, Kokanali MK, Doganay M Abstract BACKGROUND: There is no consensus in the literature regarding risk factors associated with recurrence of uterine leiomyomas. In this study, we evaluated the factors that affect the recurrence of uterine leiomyomas in...
Related ArticlesC6 cell line: the gold standard in glioma research. Hippokratia. 2018 Jul-Sep;22(3):105-112 Authors: Giakoumettis D, Kritis A, Foroglou N Abstract BACKGROUND: Glioblastoma multiforme is the most aggressive brain tumor with poor prognosis and an average survival of 1-2 years. Animal models that simulate the features of human glioma are the key to newer agents or therapeutic strategies. In order to establish such models, the C6 glioma cell...
Related ArticlesMatrix metalloproteinases and tissue inhibitors of metalloproteinases in chronic kidney disease and acute kidney injury: a systematic review of the literature. Hippokratia. 2018 Jul-Sep;22(3):99-104 Authors: Sampieri CL, Orozco-Ortega RA Abstract INTRODUCTION: Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases involved in remodeling the extracellular matrix. Tissue inhibitors of metalloproteinases (TIMPs) are...
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Abstract Background Well-differentiated thyroid carcinoma is defined as locally advanced in the presence of an extra thyroid extension, e.g., when the surrounding structures such as the trachea, larynx, esophagus and main blood vessels are invaded by cancer. The 8th edition AJCC Cancer Staging Manual states that this is the main characteristic to evaluate for the staging and consequently for the prognosis in patients over 55 years...
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Abstract Background The sleeve gastrectomy (SG) has gained popularity which has resulted in a rising number of patients with T2DM to undergo this procedure. This systematic review and meta-analysis aimed to compare the long-term effects of SG on T2DM remission with remission seen after Roux-en-Y gastric bypass (RYGB) or gastric banding (GB). Methods A literature...
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Abstract Background and Aims Taurine-upregulated gene 1 (TUG1) is reported to be upregulated and contributes to the progression of Pancreatic cancer (PC) by serving as an oncogene. Our aims were to explore the precise mechanism of TUG1 involved in PC pathogenesis. Methods TUG1 and miR-299-3p expression profiles were measured by qRT-PCR. The direct interaction between...
Abstract Background Patients with inflammatory bowel disease are currently managed with the assumption that trial data are applicable to all ethnic groups. Previous studies demonstrate differences in disease severity and phenotype of Asian patients with Crohn’s disease (CD), including Bangladeshi Asians within the UK. No study has evaluated the impact of ethnicity on response to anti-TNFs. ...
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Abstract The present study aimed to investigate the effects of the administration of boron on viability, apoptosis, and cell cycle of primary rat Sertoli cells (SCs) in vitro. SCs were aseptically isolated from 18–22-day-old male Sprague-Dawley (SD) rats. SCs were identified with immunofluorescence using anti-vimentin antibody. Further, to investigate the effects of boron on Sertoli cells, SCs of the boron treatment group were exposed to different concentrations (0.25, 0.5, 1,...
Abstract The purpose of this research is to investigate the absorption, distribution, excretion, and pharmacokinetics of selenite in rats after intragastric administration, and thus illustrate the efficiency of selenium (Se) supplementation. After a single gavage of sodium selenite, a concentration of Se in plasma and tissues was determined by inductively coupled plasma mass spectrometry (ICP-MS) at different time points. Through fitting the data with the metabolic kinetic model,...
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Abstract Climate change is causing wide-ranging effects on ecosystem services critical to coastal communities and livelihoods, creating an urgent need to adapt. Most studies of climate change adaptation consist of narrative descriptions of individual cases or global synthesis, making it difficult to formulate and test locally rooted but generalizable hypotheses about adaptation processes. In contrast, researchers in this study analyzed key points in climate change adaptation derived...
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The aim of this letter was to point out some methodological concerns about an article written by Shi et al. and published in the journal. There is an increasing trend in the isolation of Methicillin-susceptible S...
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Thank you very much for your interest and inquiry regarding our study (Yeom JS, Buchowski JM, Park KW, et al. Lateral fluoroscopic guide to prevent occipitocervical and atlantoaxial joint violation during C1 lateral mass screw placement. Spine J. 2009;9(7):574-9.). As described in our study, we concur that the shape of the C1 lateral mass is somewhat triangular so that when evaluated on coronal reconstruction images the C1 lateral masses look like a bowtie (Fig. A). Regarding your concern that only...
We wholeheartedly agree with Klyne and Hodges [1] who emphasized in response to our Perspective [2] that the association between systemic inflammation and musculoskeletal pain is complex. In our Perspective, we called for a prudent interpretation of the literature because multiple confounders influence the association between low-grade systemic inflammation and musculoskeletal pain. A recent systematic review reiterated our viewpoint (“The potential role of confounding factors on the association...
We read with interest the article by Schipholt et al. 2018 [1] which provides a timely perspective on controlling factors that influence the association between systemic inflammation and musculoskeletal pain. Although we agree with their point, it may not be as simple as it appears.
We read with great interest the article by Yeom et al. [1]. The authors introduced the concept of the anterior arch target point to help prevent occipitocervical (C0–C1) and atlantoaxial joint violations during C1 lateral mass screw insertion. They defined joint violation as the contact of the screw with the inner margin of the subchondral bone using 2D and 3D computed tomography (CT) images. In the provided Figure (panel A), only the sagittal reconstruction view was provided. The height of the lateral...
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Many acupuncture therapies were used to treat spinal cord injury (SCI) and its complications. The difference in efficacy among these therapies has not been assessed. To compare the efficacy of different acupuncture therapies for SCI, we searched databases (PubMed, Embase, Cochrane Library, CNKI, and WanFang) for relevant RCTs in both English and Chinese before June 2019 that reported the association between acupuncture therapies and SCI. The RCTs were categorized according to the location of the...
Foshou San is a typical gynaecological formula with wild usage in traditional Chinese medicine. Jiawei Foshou San (JFS) is a novel ingredient prescription from Foshou San with antiendometriosis effect in unclear mechanisms. To uncover the potential application and proapoptotic mechanisms of JFS, JFS ingredient-drug target-disease networks, GO enrichment, and pathway analysis were established for potential application prediction. Molecular docking and validation in vivo were investigated by the proapoptotic...
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Background. Mechanical stress-induced cardiac remodeling that results in heart failure is characterized by transcriptional reprogramming of gene expression. However, a systematic study of genomic changes involved in this process has not been performed to date. To investigate the genomic changes and underlying mechanism of cardiac remodeling, we collected and analyzed DNA microarray data for murine transverse aortic constriction (TAC) and human aortic stenosis (AS) from the Gene Expression Omnibus...
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The present study aimed to first describe the long‐term effects of cancer diagnosis and treatment on the work status of cancer survivors, and to then identify those characteristics that influenced the decision to stop working in rural China Abstract Background The present study aimed to first describe the work‐related outcomes of cancer survivors and to then identify those characteristics that influenced the decision to stop working in rural China. Methods We assessed 752 cancer survivors...
To explore different fusion genes in a single assay and to detect gene partners engaged in ALK (anaplastic lymphoma kinase) or ROS1 fusion, we evaluated two commercially available targeted RNA‐sequencing assays in a set of 37 tumor samples. The results of this study showed high concordance between targeted RNA‐sequencing and standard fluorescence in situ hybridization/immunohistochemistry (FISH/IHC) methods and illustrate the benefits of molecular technique to address the issue of FISH/IHC discordant...
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