Background. Mechanical stress-induced cardiac remodeling that results in heart failure is characterized by transcriptional reprogramming of gene expression. However, a systematic study of genomic changes involved in this process has not been performed to date. To investigate the genomic changes and underlying mechanism of cardiac remodeling, we collected and analyzed DNA microarray data for murine transverse aortic constriction (TAC) and human aortic stenosis (AS) from the Gene Expression Omnibus...
9h
In recent years, High-G MEMS accelerometers have been widely used in aviation, medicine, and other fields. So it is extremely important to improve the accuracy and performance of High-G MEMS accelerometers. For this purpose, we propose a fusion algorithm that combines EMD, wavelet thresholding, and temperature compensation to process measurement data from a High-G MEMS accelerometer. In the fusion algorithm, the original accelerometer signal is first decomposed by EMD to obtain the intrinsic mode...
9h
Footbridge lateral vibration remains an unsolved problem and is characterized by the following: (1) pedestrians are sensitive to bridge vibration, which causes the pedestrian’s excitation being dependent on the bridge vibration; (2) pedestrian lateral excitation is a stochastic process rather than a perfect periodic load. Therefore, footbridge lateral vibration is essentially a complex nonlinear stochastic vibration system. Thus far, an effective method of dealing with such nonlinear stochastic vibration...
9h
In order to explore the impact of traffic environmental microvibration on buildings, this paper studies indoor vibration isolation, a method applicable to existing buildings. The vibration isolation scheme is designed based on the residential buildings adjacent to metro lines in Shanghai. By using the dynamic theory, the effective range of vibration isolation stiffness is analyzed. The effectiveness of the indoor vibration isolation method is verified through theoretical calculations and comparison...
9h
The impact and collision behavior between the coal gangue and the hydraulic support widely exists in the top coal caving. However, due to the complex interactions between the large number of coal gangue particles in the mining surface and the limitations of the coal mining technology and other factors, it becomes a difficult problem to study the collision behavior and the contact response between the coal gangue and the hydraulic support or its main components under the actual caving conditions....
9h
Background. Over the past decades, knowledge and understanding have grown regarding the role that health information systems play in improving global health. Even so, using data to make evidence-informed decisions is still weak in most low- and middle-income countries. People do not always act on what they are told to do but act on sharing what is important and valued in an organization. Shared principles related to information systems are alluded to as a pre-existing culture of data collection or...
9h
Publication date: Available online 26 October 2019Source: Addictive BehaviorsAuthor(s): Nicholas C. Glodosky, Carrie CuttlerAbstractYoung adults in the U.S. report high levels of stress which are known to contribute to depression and anxiety. Regular cannabis users frequently cite coping with stress as their primary motivation for use. However, research indicates that coping motives are associated with potentially negative outcomes, including cannabis-related problems and negative affect. Therefore,...
16h
Publication date: Available online 25 October 2019Source: Addictive BehaviorsAuthor(s): Matt Vassar, Sam Jellison, Hannah Wendelbo, Cole WayantAbstractIntroductionTransparent, open scientific research practices aim to improve the validity and reproducibility of research findings. A key component of open science is the public sharing of data and metadata that constitute the basis for research findings.MethodsWe conducted a 6 year cross-sectional investigation of the rates and methods of data sharing...
16h
Abstract Objectives Partial loss of hippocampal striation (PLHS) is recently described in 3 T and 7 T MR imaging as a sensitive indicator of hippocampal sclerosis. Primary objective: We described the demographic characteristics of the population with seizure disorder having PLHS at 1.5 T MR imaging and tried to see the relation of PLHS to the classic signs of hippocampal sclerosis. Secondary objective: PLHS was also looked for in...
15h
Abstract Bats are the only flying placental mammals that constitute the second largest order of mammals and present all around the world except in Arctic, Antarctica and a few oceanic islands. Sixty percent of emerging infectious diseases originating from animals are zoonotic and more than two-thirds of them originate in wildlife. Bats were evolved as a super-mammal for harboring many of the newly identified deadly diseases without any signs and lesions. Their unique ability to...
6h
Abstract Non-structural protein 4 (nsP4) polymerase of chikungunya virus (CHIKV) has a crucial role in genome replication and hence could act as a promising target for novel therapeutics. Though, nsP4 is important in viral life cycle, but it is less explored as therapeutic target. The catalytic core of nsP4 Polymerase includes conserved GDD motif which is present not only across different CHIKV strains but also across other Alphaviruses. This emphasizes the uniqueness and importance...
6h
Abstract Purpose To develop a practical scoring system to assist clinicians in differentiating leptospirosis and hantavirus infections, whose epidemiological, clinical, and laboratory characteristics are literally like identical twins. Methods The study population consisted of 162 patients admitted to hospital with a confirmed diagnosis of leptospirosis (LG...
21h
AbstractSystemic inflammatory response and generation of oxidative stress are known to contribute to scorpion venom-induced tissue damage. TLR receptors might represent a link between oxidative stress and inflammation; we therefore investigated whether or not TLR4 is involved in venom-induced immunopathology. The obtained results showed that pharmacological targeting of TLR4 with the selective inhibitor TAK-242 (Resatorvid) prevents the inflammatory response induced by subcutaneous administration...
19h
The purpose of this systematic review was to evaluate implant survival in irradiated nasal, auricular, orbital sites and to compare them with non-irradiated respective sites. Four electronic databases and seven related journals were searched until December and March 2018, respectively. A total of 7892 articles were identified, 18 of which were included in this review; one non-randomized clinical trial, two prospective cohort, eight retrospective cohort and seven cross-sectional studies. Using the...
2h
Abstract We aim to characterize the kinetics of early and late microglial phenotypes after systemic inflammation in an animal model of severe sepsis and the effects of minocycline on these phenotypes. Rats were subjected to CLP, and some animals were treated with minocycline (10 ug/kg) by i.c.v. administration. Animals were killed 24 hours, 5, 10 and 30 days after sepsis induction, and serum and hippocampus were collected for subsequent analyses. Real‐time PCR was performed for M1 and M2 markers....
10h
Abstract Recent studies indicate circular RNAs are related to dysregulation of vascular endothelial cell function, yet the underlying mechanisms have remained elusive. Here, we characterized the functional role of circular RNA USP1 (circ‐USP1) in the regulation of the blood‐tumour barrier (BTB) permeability and the potential mechanisms. In the current study, the circ‐USP1 expressing level was up‐regulated in glioma cerebral microvascular endothelial cells (GECs) of the BTB model in vitro. Knockdown...
10h
ConclusionsKnowledge of these clinician perceptions can affect communication of findings with patients, as well as ongoing management, and thus, it is important to understand these fully to improve healthcare delivery to, and clinical management of, these patients. (Source: Journal of Clinical Immunology)
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(Source: Journal of Clinical Immunology)
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JCM, Vol. 8, Pages 1799: Is There Any Role for Super-Extended Limphadenectomy in Advanced Gastric Cancer? Results of an Observational Study from a Western High Volume Center Journal of Clinical Medicine doi: 10.3390/jcm8111799 Authors: Maria Bencivenga Giuseppe Verlato Valentina Mengardo Lorenzo Scorsone Michele Sacco Lorena Torroni Simone Giacopuzzi Giovanni de Manzoni Background: Although the Japan Clinical Oncology Group (JCOG) 9501 trial did not find that prophylactic...
2h
JCM, Vol. 8, Pages 1800: The Effect of the Intelligent Sepsis Management System on Outcomes among Patients with Sepsis and Septic Shock Diagnosed According to the Sepsis-3 Definition in the Emergency Department Journal of Clinical Medicine doi: 10.3390/jcm8111800 Authors: Juhyun Song Hanjin Cho Dae Won Park Sejoong Ahn Joo Yeong Kim Hyeri Seok Jonghak Park Sungwoo Moon We developed a novel computer program, the Intelligent Sepsis Management System, based on Sepsis-3...
2h
JCM, Vol. 8, Pages 1798: Immune-Inflammatory Responses in Atherosclerosis: The Role of Myeloid Cells
JCM, Vol. 8, Pages 1798: Immune-Inflammatory Responses in Atherosclerosis: The Role of Myeloid Cells Journal of Clinical Medicine doi: 10.3390/jcm8111798 Authors: Dimitry A. Chistiakov Dmitry A. Kashirskikh Victoriya A. Khotina Andrey V. Grechko Alexander N. Orekhov Inflammation plays a key role in the initiation and progression of atherosclerosis and can be caused by multiple agents, including increased concentration of circulating low-density lipoprotein (LDL) cholesterol....
5h
JCM, Vol. 8, Pages 1796: Is There Any Improvement of the Coagulation Imbalance in Sickle Cell Disease after Hematopoietic Stem Cell Transplantation? Journal of Clinical Medicine doi: 10.3390/jcm8111796 Authors: Laurence Rozen Denis F. Noubouossie Laurence Dedeken Phu Quoc Lê Alina Ferster Anne Demulder Several components of the clotting system are modified towards hypercoagulability in sickle cell disease (SCD). To date, hematopoietic stem cell transplantation (HSCT) is...
22h
JCM, Vol. 8, Pages 1797: Non-Invasive Assessment of Metabolic Adaptation in Paediatric Patients Suffering from Type 1 Diabetes Mellitus Journal of Clinical Medicine doi: 10.3390/jcm8111797 Authors: Phillip Trefz Sibylle C. Schmidt Pritam Sukul Jochen K. Schubert Wolfram Miekisch Dagmar-Christiane Fischer An analysis of exhaled volatile organic compounds (VOC) may deliver systemic information quicker than available invasive techniques. Metabolic aberrations in pediatric...
22h
JCM, Vol. 8, Pages 1795: Chronic Kidney Disease: The Silent Epidemy Journal of Clinical Medicine doi: 10.3390/jcm8111795 Authors: Antonio Bellasi Luca Di Lullo Biagio Di Iorio Numerous observations suggest that chronic kidney disease (CKD) is an epidemic condition [...]
23h
Ticagrelor is an antiplatelet agent used for treatment of coronary artery disease [1] and it reversibly inhibits platelet function via P2Y12 receptor [2]. There is limited literature on intravenous thrombolysis for ischemic stroke in patients taking ticagrelor. Two cases of symptomatic intracranial hemorrhage and one case of retropharyngeal hematoma have been reported [2,3]. It is likely that more patients taking ticagrelor will present with acute ischemic stroke who may otherwise be eligible for...
12h
Abstract Background In recent literature, different approaches have been proposed to improve the long‐lasting treatment of age‐related alterations on the human face with decreased invasiveness and side effects such as scar tissue. Voltaic arc dermabrasion is a minimally painful procedure that does not create discomfort to the patient and requires no anaesthesia. Aims The aim of this investigation was to evaluate the voltaic arc technique for the treatment of skin wrinkles in the periauricular...
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AIM To investigate the association between genetic polymorphisms in ATG16L1 and IRGM genes with Crohn's disease (CD) in Malaysian patients. METHODS A total of 335 subjects were recruited, including 85 CD patients and 250 unrelated healthy controls, and informed consent was obtained. Genomic DNA was extracted via a conventional phenol‐chloroform extraction method. Genotyping of six SNPs in ATG16L1 and IRGM genes was conducted via TaqMan SNP genotyping assays. The association of the SNPs with...
18h
Publication date: Available online 25 October 2019Source: Journal of Human EvolutionAuthor(s): Guido Bataille, Armando Falcucci, Yvonne Tafelmaier, Nicholas J. Conard
14h
Background Accurate preoperative assessment of the pathological grade of hepatocellular carcinoma (HCC) could greatly benefit prognostic predictions. Purpose To assess and compare the diagnostic accuracy of the apparent diffusion coefficient (ADC) and tissue diffusivity (D) for the noninvasive pathological grading of HCC. Study Type Meta‐analysis. Data Sources PubMed/Medline, EMBASE, the Web of Science, and the Cochrane Library were searched to find related original articles published...
13h
Background Quantitative diffusion MRI is a promising technique for evaluating peripheral nerve integrity but low signal‐to‐noise ratio (SNR) can impede measurement accuracy. Purpose To evaluate principal component analysis (PCA) and generalized spherical deconvolution (genSD) denoising techniques to improve within‐subject reproducibility and peripheral nerve conspicuity. Study Type Prospective. Subjects Seven healthy volunteers and three peripheral neuropathy patients. Field...
13h
Background Glioblastoma (GBM) is the most aggressive primary brain tumor, characterized by a heterogeneous and abnormal vascularity. Subtypes of vascular habitats within the tumor and edema can be distinguished: high angiogenic tumor (HAT), low angiogenic tumor (LAT), infiltrated peripheral edema (IPE), and vasogenic peripheral edema (VPE). Purpose To validate the association between hemodynamic markers from vascular habitats and overall survival (OS) in glioblastoma patients, considering...
13h
Background In mitral valve dysfunction, noninvasive measurement of transmitral blood flow is an important clinical examination. Flow imaging of the mitral valve, however, is challenging, since it moves in and out of the image plane during the cardiac cycle. Purpose To more accurately measure mitral flow, a slice‐following MRI phase contrast sequence is proposed. This study aimed to implement such a sequence, validate its slice‐following functionality in a phantom and healthy subjects, and...
13h
The use of integrated robotic technology to quantify the spectrum of motor symptoms of Parkinson’s Disease (PD) has the potential to facilitate objective assessment that is independent of clinical ratings. The...
17h
Trans-spinal direct current stimulation (tsDCS) is a non-invasive technique with promising neuromodulatory effects on spinal cord (SC) circuitry. Computational studies are essential to guide effective tsDCS pr...
17h
Leptin (LEP) may contribute to the pathogenesis of multiple sclerosis (MS) by its immunomodulatory, proinflammatory and prooxidant effects. Therefore, plasma LEP levels and mRNA expression of five genes related to the LEP signaling pathway (LEP, LEP receptor (LEPR), peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1A), superoxide dismutase 2, tumor necrosis factor-alpha) were investigated in relapsing-remitting MS. In patients (N = 64), compared to healthy subjects (N = 62),...
4h
The FDA-approved small-molecule drug dasatinib is currently used as a treatment for chronic myeloid leukemia (CML). However, the effects of dasatinib on microglial and/or astrocytic neuroinflammatory responses...
10h
Prostatodynia is the main symptom of chronic prostatitis and the main reason that patients go to the hospital for treatment. Although a variety of factors, including inflammatory immune response, nervous syste...
10h
Publication date: Available online 25 October 2019Source: Journal of Neuroscience MethodsAuthor(s): Barilin Dkhar, Abhijeet Bhatia, Pranjal Pratim Saikia, Haphidasara PyngropeABSTRACTObjectivesResearch using rat as an in-vivo model has played an important role in otological research. The rat ear anatomy has been described; however, detailed surgical procedures to access the temporal bone are limited. The authors present a technique to approach the inner ear of rat that was standardized by cadaveric...
19h
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