Publication date: Available online 25 October 2019Source: Human PathologyAuthor(s): Sounak Gupta, Tatsuo Ito, Deepu Alex, Chad M. Vanderbilt, Jason C. Chang, Nasrin Islamdoust, Yanming Zhang, Khedoudja Nafa, John Healey, Marc Ladanyi, Meera R. HameedSummaryPrior cytogenetic profiling of osteosarcomas has suggested that amplifications at the 6p12–21 locus are relatively common alterations in these tumors. However, these studies have been limited by variable testing methodologies used as well as by...
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Publication date: Available online 25 October 2019Source: Human PathologyAuthor(s): Teklu Legesse, Andres Matoso, Jonathan I EpsteinSummaryNested variant of urothelial carcinoma is a rare variant of urothelial carcinoma morphologically characterized by infiltrative nests of cytologically bland urothelial cells. It is widely recognized that nested variant of urothelial carcinoma can closely mimic von Brunn nests. However, nested variant of urothelial carcinoma with tubule formation can also resemble...
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Publication date: Available online 24 October 2019Source: Human PathologyAuthor(s): Andrew L. FolpeSummaryHemangiopericytoma and fibrosarcoma represented at one time two of the most common diagnoses in soft tissue pathology. Both terms are now largely extinct. This article will review the clinicopathologic, immunohistochemical and molecular genetic advances that have led to these changes, and review the pathologic features of a select group of soft tissue tumors previously classified as hemangiopericytoma...
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Abstract Purpose To evaluate the effect of protective coatings on the surface roughness, contact angle, and Candida albicans (C. albicans) adhesion to polymethyl methacrylate (PMMA) denture base materials. Material and methods A total of 560 rectangular heat‐ and auto‐polymerized acrylic resin specimens were fabricated and divided into 5 groups (n = 14/group) according to coating agent. Uncoated specimens were used as control. Coating materials were: nano‐coat, Optiglaze, nano‐silica, or...
Fri Oct 25, 2019 22:38
Abstract Purpose : To report the rate of technical complications and prosthesis survival in a cohort of edentulous patients treated with implant‐supported fixed complete dental prostheses (IFCDPs) after a mean observation period of at least 1 year. Materials and Methods : The single‐visit examination included clinical and radiographic assessment, occlusal analysis, photographs and questionnaire assessing patient satisfaction in a cohort of 52 patients rehabilitated with 71 IFCDPs (supported...
Thu Oct 24, 2019 21:03
Related ArticlesAssociation between Depressive State and Lifestyle Factors among Residents in a Rural Area in Japan: A Cross-Sectional Study. Tohoku J Exp Med. 2019;249(2):101-111 Authors: Murayama Y, Inoue K, Yamazaki C, Kameo S, Nakazawa M, Koyama H Abstract For the prevention of suicides, the early detection of depression symptoms and the implementation of suicide prevention measures based on the local community's conditions are critical. In rural...
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Abstract Systemic inflammatory response and generation of oxidative stress are known to contribute to scorpion venom-induced tissue damage. TLR receptors might represent a link between oxidative stress and inflammation; we therefore investigated whether or not TLR4 is involved in venom-induced immunopathology. The obtained results showed that pharmacological targeting of TLR4 with the selective inhibitor TAK-242 (Resatorvid) prevents the inflammatory response induced by subcutaneous...
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Abstract Scaffold proteins such as radixin help to modulate the plasma membrane localization and transport activity of the multidrug resistance-associated protein 2 (MRP2/ABCC2) and P-glycoprotein (P-gp/ABCB1) efflux transporters in the liver. We examined changes in radixin expression and interaction with efflux transporters in adjuvant-induced arthritic (AA) rats, an animal model of rheumatoid arthritis, as well as in human liver cancer (HepG2) cells because inflammation affects...
Fri Oct 25, 2019 03:00
Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1017-3217Dexamethasone suppression tests are basic tools in diagnostics of hypercortisolemia. Low-dose tests play major role in screening and initial assessment. High-dose tests are aimed at more elaborate diagnostics, however their clinical value is questionable. Dexamethasone is a highly potent, synthetic steroid. It is metabolized by cytochrome P450 3A4 (CYP3A4), and so are various other xenobiotics. Due to wide spectrum of substances processed by CYP3A4,...
Fri Oct 25, 2019 02:00
Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1014-2510Thyroid hormone is well known for its profound effects on body temperature. This minireview summarizes the recent discoveries on the underlying mechanisms, including the role of the hormone’s central actions in the control of brown adipose tissue thermogenesis, its effect on browning of white adipose tissue, the possible involvement of thyroid hormone transporters, and the potential contribution of its downstream metabolites such as 3-iodothyronamine.[...]©...
Fri Oct 25, 2019 02:00
An early ancestor of the Neandertals previously thought to be deaf because of the presence of bony growth in both ears has been found to have normal hearing in a new study (J Hum Evol. 2019 Oct;135:102663). An international team of researchers analyzed high-resolution CT scans to create virtual 3D models of the ear structures of Cranium 4, one of the most complete crania of a human ancestor with bony growths in both ears that led researchers to speculate hearing loss from northern Spain. Data from...
Fri Oct 25, 2019 18:38
An early ancestor of the Neandertals previously thought to be deaf because of the presence of bony growth in both ears has been found to have normal hearing in a new study (J Hum Evol. 2019 Oct;135:102663). An international team of researchers analyzed high-resolution CT scans to create virtual 3D models of the ear structures of Cranium 4, one of the most complete crania of a human ancestor with bony growths in both ears that led researchers to speculate hearing loss from northern Spain. Data from...
Fri Oct 25, 2019 18:38
Related ArticlesReduced histologic neo in-stent restenosis after use of a paclitaxel-coated cutting balloon in porcine coronary arteries. Histol Histopathol. 2019 Oct 24;:18177 Authors: Traxler D, Hemetsberger R, Spannbauer A, Zlabinger K, Gugerell A, Lukovic D, Mandic L, Pavo N, Winkler J, Gyöngyösi M Abstract The incidence of in-stent restenosis (ISR) has declined dramatically, but once it develops, no current treatment option, such as drug-eluting...
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2411 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/10/25PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Investigation of answer changes on the USMLE® Step 2 Clinical Knowledge examination. BMC Med Educ. 2019 Oct 23;19(1):389 Authors: Ouyang W, Harik P, Clauser BE, Paniagua MA Abstract BACKGROUND: Examinees often believe that changing answers will lower their scores; however, empirical studies suggest that allowing examinees to change responses may improve their performance in classroom assessments. To date, no studies have been able to examine answer changes...
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The Effects of Obstructive Sleep Apnea on Risk factors for Cardiovascular diseases. Ear Nose Throat J. 2019 Oct 24;:145561319882548 Authors: Jung JH, Park JW, Kim DH, Kim ST Abstract INTRODUCTION: Obstructive sleep apnea (OSA) is known to cause variety of cardiovascular diseases. OBJECTIVE: The aim of this study was to examine the correlation between polysomnography (PSG) and risks factor for coronary heart disease in patients suspected to have...
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Intraoperative Surgical Complications in Transoral Laser CO2 Microsurgery of the Larynx: An Observational, Prospective, Single-Center Study. Ear Nose Throat J. 2019 Oct 24;:145561319882786 Authors: Chiesa-Estomba CM, Sistiaga-Suarez JA, González-García JA, Larruscain E, Altuna-Mariezcurrena X Abstract INTRODUCTION: Despite good outcomes of CO2 laser of the larynx, a lack of prospective data related to intraoperative complications in the indexed literature...
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Benign Dermal Cylindroma in the External Auditory Canal-A Case Report. Ear Nose Throat J. 2019 Oct 24;:145561319885237 Authors: Ross T, Virk JS, Karim S, Awad Z PMID: 31646891 [PubMed - as supplied by publisher]
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Mandibular dental changes following serial and late extraction of mandibular second premolars. Angle Orthod. 2019 Oct 24;: Authors: Mintenko R, Kennedy DB, Aleksejuniene J, Hannam AG, Yen EH Abstract OBJECTIVES: To determine changes in occlusal curves and dental tipping occurring from mandibular second premolar serial extraction, early extraction of deciduous mandibular second molars with missing second premolars, and late second premolar extraction...
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Necrotizing skin and soft tissue infections (NSTIs) require both prompt medical and surgical treatment. The coordination of multiple urgent interventions by care bundles has improved outcome in other settings....
Thu Oct 24, 2019 03:00
Modulation of I-wave generating pathways by TBS: a model of plasticity induction. J Physiol. 2019 Oct 24;: Authors: Volz L, Hamada M, Michely J, Pool EM, Nettekoven C, Rothwell JC, Grefkes-Hermann C Abstract KEY POINTS: •Mechanisms underlying plasticity induction by repetitive transcranial magnetic stimulation protocols such as intermittent theta-burst stimulation (iTBS) remain poorly understood. •Individual response to iTBS is associated with recruitment...
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Agency and responsibility over virtual movements controlled through different paradigms of brain-computer interface. J Physiol. 2019 Oct 24;: Authors: Nierula B, Spanlang B, Martini M, Borrell M, Nikulin VV, Sanchez-Vives MV Abstract Agency is the attribution of an action to the self and is a prerequisite for experiencing responsibility over its consequences. Here we investigated agency and responsibility by studying the control of movements of an embodied...
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Related ArticlesLiver sympathetic nerve activity and steatosis. J Physiol. 2019 Oct 23;: Authors: Edinburgh RM, Frampton J PMID: 31646632 [PubMed - as supplied by publisher]
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Related ArticlesRelationship between the nutritional state of elderly people in need of support or nursing care and jaw-opening force and tongue pressure. J Phys Ther Sci. 2019 Oct;31(10):747-750 Authors: Hoyano K, Tsujihashi E, Nishio K, Tsuji T Abstract [Purpose] We hypothesized that an association exists between the nutritional state of elderly people and the deterioration in the swallowing function associated with sarcopenia, which is reflected by...
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Related ArticlesComment on "Sarcopenia is an Independent Risk Factor for Dysphagia in Community-Dwelling Older Adults". Dysphagia. 2019 10;34(5):718-719 Authors: Wakabayashi H PMID: 30701311 [PubMed - indexed for MEDLINE]
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Comparison of ultra-early hematoma growth and common non-contrast computed tomography features in predicting hematoma enlargement in patients with spontaneous intracerebral hemorrhage. World Neurosurg. 2019 Oct 21;: Authors: Xiang Y, Zhang T, Li Y, Liu J, Xu H, He W, Chen Q, Yang Y Abstract OBJECTIVE: Ultra-early hematoma growth(uHG), the black hole sign, and the blend sign are common predictors of hematoma enlargement(HE). This study aimed to develop...
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Susceptibility of Cervical Spinal Stenosis to Hypoxic Ischemic Cord Injury. World Neurosurg. 2019 Oct 21;: Authors: Shah LM, Bisson EF Abstract BACKGROUND: The adult spinal cord is typically resistant to hypoxic ischemic injury (HII) because of collateral blood supply; however, congenital or acquired stenosis may result in baseline maximal vasodilatation, such as superimposed hemodynamic stresses, that cannot be accommodated, leaving the spinal cord...
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Related ArticlesEffects of synthetic (JWH-018) cannabinoids treatment on spermatogenesis and sperm function. Drug Chem Toxicol. 2019 Oct 23;:1-8 Authors: Mutluay D, Güngör Ş, Tenekeci GY, Köksoy S, Çoban CS Abstract JWH-018 is a synthetic cannabinoid which has been increasingly used by adolescents and adults, and is known to cause severe multi-organ failure. However, little is known about the complications and toxicological effects of JWH-018 on reproduction...
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Related ArticlesChemical composition, antioxidant activities, in an allergic asthma model, of Olea europaea L. leaf extracts from Collo (Skikda, Algeria). Drug Chem Toxicol. 2019 Oct 23;:1-12 Authors: Rouibah Z, Ben Mensour A, Rekik O, Boumendjel M, Taibi F, Bouaziz M, El Feki A, Messarah M, Boumendjel A Abstract This study is an attempt to characterize the chemical composition and antioxidant activity of olive leaves variety (namely Bouricha variety)...
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Related ArticlesAntioxidant and cytoprotective properties of loganic acid isolated from seeds of Strychnos potatorum L. against heavy metal induced toxicity in PBMC model. Drug Chem Toxicol. 2019 Oct 23;:1-11 Authors: Abirami A, Sinsinwar S, Rajalakshmi P, Brindha P, Rajesh YBRD, Vadivel V Abstract Present work carried out with the objectives to isolate active component of S. potatorum and also to evaluate its free radical scavenging activity and preventing...
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Related Articlesdl-Malic acid as a component of α-hydroxy acids: effect on 2,4-dinitrochlorobenzene-induced inflammation in atopic dermatitis-like skin lesions in vitro and in vivo. Immunopharmacol Immunotoxicol. 2019 Oct 24;:1-8 Authors: Lee B, Heo J, Hong S, Kim EY, Sohn YJ, Jung HS Abstract Background: dl-Malic acid (dl-M) is used widely in cosmetic formulations as a pH-adjuster or as a preservative. dl-M is used as an exfoliator in the form of α-hydroxy...
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DRG microstimulation evokes postural responses in awake, standing felines. J Neural Eng. 2019 Oct 24;: Authors: King KW, Cusack WF, Nanivadekar AC, Ayers CA, Urbin MA, Gaunt RA, Fisher LE, Weber D Abstract We have demonstrated previously that microstimulation in the dorsal root ganglia (DRG) can selectively evoke activity in primary afferent neurons in anesthetized cats. This study describes the results of experiments focused on characterizing the postural...
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23 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2019/10/25PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Related ArticlesKnee arthroscopy without the use of the tourniquet could enhance the use of the Y sign for determining optimal placement of the anteromedial portal. Surg Radiol Anat. 2019 Oct 23;: Authors: Dimnjaković D, Bojanić I PMID: 31646351 [PubMed - as supplied by publisher]
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It is generally assumed that when singing across the region where registration events for untrained voices occur (the passaggio), singers modify the voice production system in order to avoid changes of voice quality. In this context, it has been postulated that nasalance could be used to stabilize vocal function throughout the passaggio. However, whether nasalance is frequently used by professional singers and if so, if it has a stabilizing effect on vocal fold oscillation patterns, is not yet fully...
Fri Oct 25, 2019 03:00
Localization and characterization of thyroid microcalcifications: A histopathological study. PLoS One. 2019;14(10):e0224138 Authors: Guerlain J, Perie S, Lefevre M, Perez J, Vandermeersch S, Jouanneau C, Huguet L, Frochot V, Letavernier E, Weil R, Rouziere S, Bazin D, Daudon M, Haymann JP Abstract Thyroid calcification is frequent in thyroid nodules. The aim of our study was to evaluate the prevalence of calcifications in thyroid tissue samples of patients...
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Prediagnostic BMI and thyroid cancer incidence in the PLCO trial. Future Oncol. 2019 Oct;15(30):3451-3456 Authors: Abdel-Rahman O Abstract Aim: To assess the correlation between prediagnostic BMI and thyroid cancer risk within the prostate, lung, colorectal and ovary (PLCO) trial. Methods: PLCO trial participants without a history of thyroid cancer before study enrollment who have complete information about prediagnostic BMI were included. Multivariable...
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Related ArticlesBlockade of ErbB2 and PD-L1 using a bispecific antibody to improve targeted anti-ErbB2 therapy. Oncoimmunology. 2019;8(11):e1648171 Authors: Mittal D, Vijayan D, Neijssen J, Kreijtz J, Habraken MMJM, Van Eenennaam H, Van Elsas A, Smyth MJ Abstract A significant proportion of human epidermal growth factor receptor 2 (Her2/ErbB2)-positive metastatic breast cancer patients are refractory to Her2-targeted trastuzumab-like therapy. Some of...
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Autophagy: A Novel Mechanism Involved in the Anti-Inflammatory Abilities of Probiotics. Cell Physiol Biochem. 2019;53(5):774-793 Authors: Zaylaa M, Alard J, Kassaa IA, Peucelle V, Boutillier D, Desramaut J, Rosenstiel P, Nguyen HTT, Dabboussi F, Pot B, Grangette C Abstract BACKGROUND/AIMS: Deregulation of the complex interaction among host genetics, gut microbiota and environmental factors on one hand and aberrant immune responses on the other hand,...
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