Publication date: December 2019Source: European Journal of Cancer, Volume 123Author(s): Margreet G. Franken, Brenda Leeneman, Maria Gheorghe, Carin A. Uyl-de Groot, John B.A.G. Haanen, Pieter H.M. van BaalAbstractBackgroundAlthough a myriad of novel treatments entered the treatment paradigm for advanced melanoma, there is lack of head-to-head evidence. We conducted a network meta-analysis (NMA) to estimate each treatment's relative effectiveness and safety.MethodsA systematic literature review (SLR)...
Fri Oct 25, 2019 12:47
Publication date: December 2019Source: European Journal of Cancer, Volume 123Author(s): A. Moya-Plana, A. Aupérin, R. Obongo, A. Baglin, F.R. Ferrand, B. Baujat, N. Saroul, O. Casiraghi, S. Vergez, P. Herman, F. Janot, J. Thariat, B. Vérillaud, L. de Gabory, S. Albert, G. Andry, E. Babin, C. Bach, J.-M. Badet, C. BadoualAbstractBackgroundHead and neck mucosal melanoma (HNMM) is aggressive and rare, with a poor prognosis because of its high metastatic potential. The two main subtypes are sinonasal...
Fri Oct 25, 2019 12:47
Publication date: December 2019Source: European Journal of Cancer, Volume 123Author(s): Saurabh Singh, Sanjay Pandey, Amanpreet Singh Chawla, Anant Narayan Bhatt, Bal Gangadhar Roy, Daman Saluja, Bilikere S. DwarakanathAbstractAccumulating evidence suggests the antiangiogenic potential of the glycolytic inhibitor 2-deoxy-D-glucose (2-DG) among the anticancerous properties of this drug. In the present studies, we investigated the antiangiogenic effects of dietary 2-DG on tumour (Lewis lung carcinoma...
Fri Oct 25, 2019 12:47
Publication date: Available online 24 October 2019Source: European Journal of CancerAuthor(s): Inkeun Park, Bong-Seog Kim, Ho Yeong Lim, Hee-Jun Kim, Hyo Jin Lee, Yoon Ji Choi, Kyong Hwa Park, Kyung Hee Lee, Shinkyo Yoon, Bumsik Hong, Jun Hyuk Hong, Hanjong Ahn, Jae Lyun LeeAbstractPurposeGemcitabine–oxaliplatin (GEMOX) demonstrated mild toxicity and promising effectiveness in patients with advanced urothelial cell cancer (UCC). We investigated the activity and safety of first-line GEMOX compared...
Fri Oct 25, 2019 12:47
Abstract Objective To investigate possible associations between disease specific survival (DSS) of oral cancer and single nucleotide polymorphisms (SNPs) in transforming growth factor beta receptor 1 (TGFBR1). Methods Using iPLEX Sequenom MassARRAY platform, three SNPs in TGFBR1 gene were genotyped in 356 newly diagnosed patients with histologically confirmed primary oral cancer. Demographic and clinical information of all cases were obtained from face‐to‐face interviews and electronic...
Fri Oct 25, 2019 12:20
Background: Implanted high-frequency spinal cord stimulators at 10 kHz (HF-SCS) have recently acquired conditional approval for magnetic resonance imaging (MRI), including retrospective application to previously implanted devices. Under certain conditions, there are greater specific absorption rate (SAR) scanning restrictions compared to some conventional alternatives. This poses technical challenges to obtain diagnostic quality imaging. Objectives: To describe our experience with 9 such scans, demonstrating...
Fri Oct 25, 2019 10:10
Abstract Objectives To validate the Hospital Anxiety and Depression Scale (HADS) and the 10‐item Perceived Stress Scale (PSS‐10) for use in patients with oral lichen planus (OLP) and to provide cross‐sectional analysis of anxiety, depressive and distress symptoms in patients with OLP. Methods Validity and reliability of both instruments were assessed in 260 participants with OLP in one tertiary Oral Medicine Centre through confirmatory factor analysis and calculation of reliability coefficients....
Fri Oct 25, 2019 11:09
Objective Increasing evidence has indicated an association between immune cells infiltration in LSCC and clinical outcome. The aim of this research was tantamount to comprehensively investigate the effect of 22 tumor infiltrating immune cells (TIICs) on the prognosis of LSCC patients. Methods In our research, the CIBERSORT algorithm was utilized to calculate the proportion of 22 TIICs in 502 cases from the TCGA cohort....
Fri Oct 25, 2019 03:00
It is assumed that the sequencing of ribosomes better reflects the active microbial community than the sequencing of the ribosomal RNA encoding genes. Yet, many studies exploring microbial communities in various environments, ranging from the human gut to deep oceans, questioned the validity of this paradigm due to the discrepancies between the DNA and RNA based communities. Here, we focus on an often neglected key step in the analysis, the reverse transcription (RT) reaction. Previous studies showed...
Fri Oct 25, 2019 03:00
Background The effects of global climate change on species inhabiting marine ecosystems are of growing concern, especially for endemic species that are sensitive due to restricted distribution. One method employed for determining the effects of climate change on the distribution of these organisms is species distribution modeling. Methods We generated a model to evaluate the potential geographic distribution and breeding...
Fri Oct 25, 2019 03:00
Background The canine transmissible venereal tumor (CTVT) or Sticker’s sarcoma is a neoplastic disease affecting dogs. This disease is presented as a tumoral mass in the genital organs of both, male and female individuals. Up to date, there is no clear evidence indicating a viral agent as the causative mediator for CTVT development. Purpose The present work aims to analyze 21 samples from canines with CTVT for molecular identification of Papillomavirus DNA sequences. In addition, microbiological...
Fri Oct 25, 2019 03:00
Background The classification of hepatitis viruses still predominantly relies on ad hoc criteria, i.e., phenotypic traits and arbitrary genetic distance thresholds. Given the subjectivity of such practices coupled with the constant sequencing of samples and discovery of new strains, this manual approach to virus classification becomes cumbersome and impossible to generalize. Methods Using two well-studied hepatitis virus...
Fri Oct 25, 2019 03:00
This study aimed to investigate how elite Chinese gymnasts manage the landing impact from a backward somersault. Six international-level male gymnasts performed backward somersault tests with a synchronous collection of kinematics (250 Hz), ground reaction forces (1,000 Hz), and surface electromyography (EMG) (2,000 Hz). A 19-segment human model was developed and lower extremity joints torques were calculated by means of a computer simulation. The angles of the lower extremity joints initially extended...
Fri Oct 25, 2019 03:00
Background Because of the complex mechanisms of injury, conventional surgical treatment and early blood pressure control does not significantly reduce mortality or improve patient prognosis in cases of intracerebral hemorrhage (ICH). We aimed to identify the hub genes associated with intracerebral hemorrhage, to act as therapeutic targets, and to identify potential small-molecule compounds for treating ICH. Methods The...
Fri Oct 25, 2019 03:00
Combination of insect pathogenic fungi and microbial metabolites is a prospective method for mosquito control. The effect of the entomopathogenic fungus Metarhizium robertsii J.F. Bischoff, S.A. Rehner & Humber and avermectins on the survival and physiological parameters of Aedes aegypti (Linnaeus, 1762) larvae (dopamine concentration, glutathione S-transferase (GST), nonspecific esterases (EST), acid proteases, lysozyme-like, phenoloxidase (PO) activities) was studied. It is shown that the combination...
Fri Oct 25, 2019 03:00
During the last decade, several Bohaiornis-like enantiornithine species—and numerous specimens—have been recognized from the celebrated Jehol Biota of northwestern China. In this paper, we describe the anatomy of another “bohaiornithid” species from the 125 million-year-old Yixian Formation of Liaoning Province, China. The new taxon differs from previously recognized “bohaiornithids” on a number of characters from the forelimb and shoulder girdle. We also provide a new phylogenetic framework for...
Fri Oct 25, 2019 03:00
Bacopa monnieri is a medicinal herb that is increasing in demand in Thailand. However, the lack of high-bacoside cultivars has limited pharmaceutical utilization and production. Here, chromosome doubling in B. monnieri was attempt to improve biomass and bacoside content in its seedling. Nodal segments were treated with colchicine (0, 0.025, 0.05, 0.075, 0.1, and 0.5% w/v) for 24 or 48 h before transferring to multiple shoot induction medium (1/2 MS medium supplemented with 0.2 mg L−1 BAP). Of 326...
Fri Oct 25, 2019 03:00
Abstract To evaluate erythropoietin-producing hepatocellular carcinoma (Eph)/Eph receptor-interaction protein (ephrin) expression in oral squamous cell carcinoma (OSCC) and oral epithelial precursor lesions (OEPLs), EphA2, EphB4, and ephrinB2 were examined and compared with microvessel density (MVD) and lymphatic vessel density (LVD). Samples from 73 OSCC and 43 OEPLs patients were immunohistochemically analyzed with antibodies against EphA2, EphB4, ephrinB2, CD34, and D2-40. Results...
Fri Oct 25, 2019 03:00
Background: Medical history, thoracentesis, and imaging features are usually the first steps in the investigation of a possible malignant pleural effusion (MPE). Unfortunately, the diagnostic yield of thoracentesis in this situation is suboptimal even if the procedure is repeated, especially in the context of malignant pleural mesothelioma (MPM). The next step for confirming the diagnosis, if clinically appropriate, is thoracoscopy, but not all patients are fit to undergo this procedure, so the diagnosis...
Fri Oct 25, 2019 09:48
Abstract Aberrant expression of Forkhead box C1 (FOXC1) promotes tumor metastasis in multiple human malignant tumors. However, the upstream modulating mode and downstream molecular mechanism of FOXC1 in metastasis of colorectal cancer (CRC) remain unclear. Herein, we describe a systematic analysis of FOXC1 expression and prognosis in CRC performed on our clinical data and public databases, which indicated that FOXC1 upregulation in CRC samples was significantly associated with poor prognosis. FOXC1...
Thu Oct 24, 2019 20:39
Pluripotent stem cells — which have the ability to differentiate into any cell type in the body — have enormous potential for regenerative medicine and for uncovering the developmental biology underlying health and disease. New advances in stem-cell technologies are crucial for understanding the…
Thu Oct 24, 2019 03:00
Abstract Maternal inheritance of mitochondrial DNA (mtDNA) was originally thought to prevent any response to selection on male phenotypic variation attributable to mtDNA, resulting in a male‐biased mtDNA mutation load (‘mother’s curse’). However, the theory underpinning this claim implicitly assumes that a male’s mtDNA has no effect on the fitness of females he comes into contact with. If such ‘mitochondrially‐encoded indirect genetics effects’ (mtIGEs) do in fact exist, and there is relatedness...
Thu Oct 24, 2019 21:46
Abstract Background Micropapillary and plasmacytoid variants of urothelial carcinoma (UC) exhibit very aggressive clinical behavior. To date, only a small number of cytology cases have been reported in either of these variants. Herein, we report 15 cases of UC with combined micropapillary and plasmacytoid features based on urine cytology. Methods We performed a retrospective analysis of all patients with carcinoma of bladder with predominant plasmacytoid and micropapillary histology who...
Thu Oct 24, 2019 21:35
Abstract Objective The current study evaluated perceived barriers to care for parents of children with cancer and the mediating effect of illness uncertainty (IU; uncertainty from the ambiguity or unpredictability of the illness), on the relationship between barriers and parental psychological distress. We hypothesized that greater barriers to care would be related to higher levels of IU, and in turn higher anxiety, depression, and posttraumatic stress symptom (PTSS) ratings. Methods As...
Thu Oct 24, 2019 20:43
Abstract Objective It was previously determined that group‐based face‐to‐face Mindfulness‐based Cognitive Therapy (MBCT) and individual internet‐based MBCT (eMBCT) are equally efficacious compared to treatment as usual (TAU) in reducing psychological distress. In this study the incremental cost‐utility of both interventions compared to TAU was assessed. Methods This cost‐effectiveness study included 245 self‐referred heterogeneous cancer patients with psychological distress who were randomized...
Thu Oct 24, 2019 20:43
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου