Κυριακή 27 Οκτωβρίου 2019


Stigma and its correlates in people living with lung cancer: A cross‐sectional study from China
Abstract Objectives This study aimed to examine the level of stigma and identify the correlates of stigma among lung cancer patients in China. Methods In total, 283 lung cancer patients were recruited from a tertiary cancer center in China by the convenience sampling method and completed a demographic, disease‐related information and situational characteristics questionnaire and self‐reported measures assessing stigma, state self‐esteem and coping self‐efficacy. Results The mean stigma...
Psycho-Oncology
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A call to action for expanded sleep research in pediatric oncology: A position paper on behalf of the International Psycho‐Oncology Society Pediatrics Special Interest Group
Abstract Sleep and circadian rhythms are closely related to physical and psychosocial well‐being. However, sleep and circadian rhythm disruptions are often overlooked in children with cancer, as they are frequently considered temporary side effects of therapy that resolve when treatment ends. Yet, evidence from adult oncology suggests a bidirectional relationship wherein cancer and its treatment disrupt sleep and circadian rhythms, which are associated with negative health outcomes such as poor...
Psycho-Oncology
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Content comparison of unmet needs self‐report measures used in patients with head and neck cancer: a systematic review
Abstract Objective Morbidity from head and neck cancers (HNCs) and their treatment is significant, given their proximity to anatomical sites impacting facial appearance and function. Assessing the needs of HNC patients throughout their cancer journey is critical to informing quality care and improving quality of life. We aimed to identify available unmet needs measures in the HNC setting and appraise their content and psychometric properties. Methods We conducted a systematic search of...
Psycho-Oncology
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Impact of fear of cancer recurrence on survival among lymphoma patients
Abstract Objective This study aimed to evaluate FCR among lymphoma patients who completed treatment and its impact on survival and quality of life (QOL). Methods In this prospective cohort study, 467 lymphoma patients were included who completed treatment with curative intent between Feb 2012 and March 2017. FCR was measured using a question from the Korean version of the QOL in Cancer Survivors Questionnaire. QOL and general health and functioning were measured using the EORTC QLQ‐C30....
Psycho-Oncology
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Using Smart‐Messaging to Enhance Mindfulness‐Based Cognitive Therapy for Cancer Patients: A Mixed Methods Proof of Concept Evaluation
Abstract Objective Depression and anxiety lead to reduced treatment adherence, poorer quality of life, and increased care costs amongst cancer patients. Mindfulness‐Based Cognitive Therapy (MBCT) is an effective treatment, but dropout reduces potential benefits. Smart‐message reminders can prevent dropout and improve effectiveness. However, smart‐messaging is untested for MBCT in cancer. This study evaluates smart‐messaging to reduce dropout and improve effectiveness in MBCT for cancer patients...
Psycho-Oncology
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Using GRADE methodology to assess innovation of new medicinal products in Italy
Abstract Aim In April 2017 the Italian Medicine Agency (AIFA) has developed new criteria to grant any new medicinal product with an innovative designation. The aim of this study is to describe this new model and how it works. Methods A retrospective descriptive analysis was performed on the results of the assessment process of innovativeness of new medicinal products (or therapeutic indications) based on the AIFA's new Innovation criteria (therapeutic need, added therapeutic value and quality...
British Journal of Clinical Pharmacology
1m
The association of the optimal bolus of dexmedetomidine with its favorable hemodynamic outcomes in adults surgical patients under general anesthesia
Abstract Background Dexmedetomidine is highly specific alpha 2‐adrenoceptor agonist. A single bolus of dexmedetomidine can achieve clinical therapeutic effect. Therefore, it is essential to know the safety margin between the clinical effectiveness dosages of dexmedetomidine and its side effect. Methods A total of 42 patients underwent elective thyroidectomy were enrolled in this study. Dexmedetomidine was given as a single bolus injection 30 min towards the end of surgery. The up‐and‐down...
British Journal of Clinical Pharmacology
1m
Investigating the clinical factors and co‐medications associated with circulating levels of atorvastatin and its major metabolites in secondary prevention
Abstract Aims The lipid‐lowering drug, atorvastatin (ATV), is one of the most commonly prescribed medications worldwide. The aim of this study was to comprehensively investigate and characterise the clinical factors and co‐medications associated with circulating levels of ATV and its metabolites in secondary prevention clinical practice. Methods The plasma concentrations of ATV, 2‐hydroxy (2‐OH) ATV, ATV lactone (ATV L) and 2‐OH ATV L were determined in patients one month after hospitalisation...
British Journal of Clinical Pharmacology
1m
Deletion of Voltage-Dependent Anion Channel 1 knocks mitochondria down triggering metabolic rewiring in yeast
Abstract The Voltage-Dependent Anion-selective Channel (VDAC) is the pore-forming protein of mitochondrial outer membrane, allowing metabolites and ions exchanges. In Saccharomyces cerevisiae, inactivation of POR1, encoding VDAC1, produces defective growth in the presence of non-fermentable carbon source. Here, we characterized the whole-genome expression pattern of a VDAC1-null strain (Δpor1) by microarray analysis, discovering that the expression of mitochondrial genes was completely...
Latest Results for Cellular and Molecular Life Sciences
23h
The RNA–RNA base pairing potential of human Dicer and Ago2 proteins
Abstract The ribonuclease Dicer produces microRNAs (miRNAs) and small interfering RNAs that are handed over to Ago proteins to control gene expression by targeting complementary sequences within transcripts. Interestingly, a growing number of reports have demonstrated that the activity of Dicer may extend beyond the biogenesis of small regulatory RNAs. Among them, a report from our latest studies revealed that human Dicer facilitates base pairing of complementary sequences present...
Latest Results for Cellular and Molecular Life Sciences
23h
GSK343 induces programmed cell death through the inhibition of EZH2 and FBP1 in osteosarcoma cells
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Cancer Biology & Therapy: Table of Contents: Taylor and Francis
23h
Major challenges in accurate mutation detection of multifocal lung adenocarcinoma by next-generation sequencing
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Cancer Biology & Therapy: Table of Contents: Taylor and Francis
23h
SEMA4D under the posttranscriptional regulation of HuR and miR-4319 boosts cancer progression in esophageal squamous cell carcinoma
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Cancer Biology & Therapy: Table of Contents: Taylor and Francis
23h
Addition of decellularized extracellular matrix of porcine nasal cartilage improves cartilage regenerative capacities of PCL-based scaffolds in vitro
Abstract Composite scaffolds can improve regenerative capacities of scaffolds in various tissue-engineering approaches. In order to generate a 3D printable scaffold that is capable of cartilage regeneration, decellularized extracellular matrix (DECM) of porcine nasal cartilage was added to 3D printed polycaprolactone (PCL) scaffolds. Subsequently, scaffolds (PCL, PCL/DECM and DECM) were seeded with human primary nasoseptal chondrocytes and differentiated with cartilage inductive...
Latest Results for Journal of Materials Science: Materials in Medicine
23h
The Effects of Completing Mandalas on Mood, Anxiety, and State Mindfulness
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Art Therapy: Table of Contents: Taylor and Francis
23h
A Review of "Art Therapy for Psychosis: Theory and Practice"
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Art Therapy: Table of Contents: Taylor and Francis
23h
A Review of "Positive Art Therapy Theory and Practice: Integrating Positive Psychology with Art Therapy"
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Art Therapy: Table of Contents: Taylor and Francis
23h
Identification of a novel large EPCAM-MSH2 duplication, concurrently with LOHs in chromosome 20 and X, in a family with Lynch syndrome
Abstract Background Lynch syndrome (LS) is associated with germline mutations in one of the mismatch repair genes or EPCAM. The majority of the causative alterations are point mutations. Large genomic rearrangements represent only 5–20%. Hypothetically, the allelic imbalance, like the loss of heterozygosity, may be another high penetrance risk factor. Case presentation ...
Latest Results for International Journal of Colorectal Disease
23h
Posterior-Wall Myocardial Infarction
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The New England Journal of Medicine: Search Results in Emergency Medicine
23h
Workers Age 55 and over Working with Pain. A Descriptive Interpretive Study
Abstract Purpose In most industrialized countries, the share of workers in the age 55+ age group is increasing while there is a shortage of young workers. Although data suggest that at least one in five older workers suffers from chronic musculoskeletal pain, most will continue working despite pain. The objective of this study is to explore factors associated with staying at work for workers with musculoskeletal pain. Methods An interpretive descriptive method was used. Semi-structured...
Latest Results for Journal of Occupational Rehabilitation
23h
Informational needs for participation in bioequivalence studies: the perspectives of experienced volunteers
Abstract Purpose The present study aimed to determine the extent of information that healthy volunteers need in an informed consent form (ICF) to support their decision whether to participate in a bioequivalence study, a type of clinical studies involving the testing of pharmacokinetic equivalence of a generic drug with a brand-name drug in volunteer subjects. Methods...
Latest Results for European Journal of Clinical Pharmacology
23h
Improving self-efficacy for hearing aid self-management: the early delivery of a multimedia-based education programme in first-time hearing aid users
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International Journal of Audiology: Table of Contents: Taylor and Francis
23h

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