Publication date: Available online 25 October 2019Source: American Journal of Infection ControlAuthor(s): Sidney Bondurant, Tanya McKinney, Liza Bondurant, Lisa FitzpatrickBackgroundThis study was performed to evaluate the effectiveness of a new commercially available hand sanitizer using 0.12% benzalkonium chloride (BZK) as the active ingredient in reducing transient skin contamination with Staphylococcus aureus in health care workers (HCWs), as compared with the effectiveness of a 70% ethanol-based...
Sat Oct 26, 2019 15:52
Metabolomic Profiling to Identify Molecular Biomarkers of Cellular Response to Methotrexate In Vitro
Variation in methotrexate (MTX) efficacy represents a significant barrier to early and effective disease control in the treatment of autoimmune arthritis. We hypothesize that the utilization of metabolomic techniques will allow for an improved understanding of the biochemical basis for the pharmacological activity of MTX, and can promote the identification and evaluation of novel molecular biomarkers of MTX response. In this work, erythroblastoid cells were exposed to MTX at the physiologic concentration...
Fri Oct 25, 2019 12:42
Abstract Bruton's tyrosine kinase (BTK) is a key regulator of B‐cell receptor and Fc receptor signaling, and a rational therapeutic target for autoimmune diseases. This first‐in‐human phase I, double‐blind, placebo‐controlled trial investigated the safety, tolerability, pharmacokinetics (PK), target occupancy, and effects on QT interval of evobrutinib, a highly selective, oral inhibitor of BTK, in healthy subjects. This dose escalation trial consisted of two parts. Part 1 included 48 subjects in...
Thu Oct 24, 2019 16:58
Publication date: Available online 25 October 2019Source: Sleep MedicineAuthor(s): Elizabeth Hill, Donna Fairley, Ewan McConnell, Ian Morrison, Marta Celmina, Serafeim – Chrysovalantis Kotoulas, Renata L. RihaAbstractObjective/BackgroundThe utility of the pictorial Epworth sleepiness scale (pESS) has been assessed by only a few studies in a clinical population. Some of its questions may be inappropriate in certain patient groups. The aim of this study was to assess the utility of the pESS in the...
Sat Oct 26, 2019 15:27
Abstract Adaptation of automatic postural responses (APR) to balance perturbations might be thought to be impaired by muscle fatigue, given the associated proprioceptive and effector deficits. In this investigation, we aimed to evaluate the effect of muscular fatigue on APR adaptation over repetitive balance perturbations through support base backward translations. APR adaptation was evaluated in three epochs: (a) pre‐fatigue; (b) post‐fatigue, immediately following fatigue of the plantiflexor muscles...
Fri Oct 25, 2019 21:08
Publication date: January 2020Source: World Neurosurgery, Volume 133Author(s): Amina Guenna Holmgren, Niklas Juth, Anna Lindblad, Ann-Christin von VogelsangObjectiveTo investigate the extent to which restraint is used in neurosurgical care, under what circumstances, and how it is documented.MethodsA cross-sectional study with a mixed-methods approach was used to identify neurosurgical inpatients subjected to restraint. The data were collected in 2 phases: (1) a study-specific questionnaire was distributed...
Sat Oct 26, 2019 14:44
Publication date: December 2019Source: World Neurosurgery, Volume 132Author(s): Tsinsue Chen, George M. Mastorakos, Kyle I. Swanson, Jennifer M. Eschbacher, Kris A. SmithBackgroundChoroid plexus papillomas (CPPs) are benign World Health Organization grade I tumors that comprise 2%–4% of all brain tumors among children and less than 1% of brain tumors in adults. Most adult cases occur in the fourth ventricle, with only 1 previous report describing an adult patient with a temporal horn CPP.Case DescriptionWe...
Sat Oct 26, 2019 14:44
Cancers, Vol. 11, Pages 1663: The Actin Binding Protein Plastin-3 Is Involved in the Pathogenesis of Acute Myeloid Leukemia Cancers doi: 10.3390/cancers11111663 Authors: Arne Velthaus Kerstin Cornils Jan K. Hennigs Saskia Grüb Hauke Stamm Daniel Wicklein Carsten Bokemeyer Michael Heuser Sabine Windhorst Walter Fiedler Jasmin Wellbrock Leukemia-initiating cells reside within the bone marrow in specialized niches where they undergo complex interactions with...
Sat Oct 26, 2019 03:00
Cancers, Vol. 11, Pages 1662: Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Gastric Cancer Cancers doi: 10.3390/cancers11111662 Authors: Adriana C. Gamboa Joshua H. Winer The management of peritoneal metastases from gastric cancer origin has evolved considerably over the last three decades with the establishment of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) as efficacious therapies in carefully selected patients. Other...
Sat Oct 26, 2019 03:00
Cancers, Vol. 11, Pages 1664: IL-33 Promotes CD11b/CD18-Mediated Adhesion of Eosinophils to Cancer Cells and Synapse-Polarized Degranulation Leading to Tumor Cell Killing Cancers doi: 10.3390/cancers11111664 Authors: Sara Andreone Francesca Spadaro Carla Buccione Jacopo Mancini Antonella Tinari Paola Sestili Adriana Rosa Gambardella Valeria Lucarini Giovanna Ziccheddu Isabella Parolini Cristiana Zanetti Maria Teresa D’Urso Adele De Ninno Luca Businaro...
Sat Oct 26, 2019 03:00
Cancers, Vol. 11, Pages 1660: Targeting Apoptotic Pathways in Acute Myeloid Leukaemia Cancers doi: 10.3390/cancers11111660 Authors: Jonathan R. Sillar Anoop K. Enjeti Acute Myeloid Leukaemia is a devastating disease that continues to have a poor outcome for the majority of patients. In recent years, however, a number of drugs have received FDA approval, following on from successful clinical trial results. This parallels the characterization of the molecular landscape of Acute Myeloid...
Sat Oct 26, 2019 03:00
Cancers, Vol. 11, Pages 1658: Toxicity Profiles of Fractionated Radiotherapy, Contemporary Stereotactic Radiosurgery, and Transsphenoidal Surgery in Nonfunctioning Pituitary Macroadenomas Cancers doi: 10.3390/cancers11111658 Authors: Chia-Lun Chang Kevin Sheng-Po Yuan Alexander T.H. Wu Szu-Yuan Wu Background: Here, we compared the toxicity profiles of contemporary stereotactic radiosurgery (SRS), modern fractionated radiotherapy (FRT), and transsphenoidal surgery used to treat...
Sat Oct 26, 2019 03:00
Cancers, Vol. 11, Pages 1661: Should All Patients With HR-Positive HER2-Negative Metastatic Breast Cancer Receive CDK 4/6 Inhibitor As First-Line Based Therapy? A Network Meta-Analysis of Data from the PALOMA 2, MONALEESA 2, MONALEESA 7, MONARCH 3, FALCON, SWOG and FACT Trials Cancers doi: 10.3390/cancers11111661 Authors: Valentina Rossi Paola Berchialla Diana Giannarelli Cecilia Nisticò Gianluigi Ferretti Simona Gasparro Michelangelo Russillo Giovanna Catania Leonardo...
Sat Oct 26, 2019 03:00
Abstract Adolescence is a developmental period characterized by disruptions in sleep and changes in circadian preferences. Although adolescents with attention‐deficit/hyperactivity disorder (ADHD) are at even higher risk of sleep disruption than their peers, no study has examined whether circadian preference is associated with sleep problems and daytime sleepiness in adolescents with ADHD. This study provides an initial test of the hypothesis that greater evening preference would be associated with...
Fri Oct 25, 2019 14:32
Thu Oct 03, 2019 20:47
Corynebacterium ulcerans can colonize a wide variety of animals and also humans are infected, typically by zoonotic transmission. Symptoms range from skin ulcers or systemic infections to diphtheria-like illness....
Fri Oct 25, 2019 03:00
This small scale cross-sectional study was done to identify the common systolic blood pressure pattern (dipping or non-dipping) among type 2 diabetic men with coexisting hypertension and erectile dysfunction(E...
Fri Oct 25, 2019 03:00
Intestinal parasites are present throughout the world in varying degrees of prevalence due to many factors. The aim of this study was to determine the 5-year trend prevalence of intestinal prevalence among pat...
Fri Oct 25, 2019 03:00
Design polymorphic microsatellite loci that will be useful for studies of the genetic diversity, gene-flow and reproduction in the Japanese endemic conifer Thuja standishii and test the transferability of these l...
Fri Oct 25, 2019 03:00
Staphylococcus aureus and S. epidermidis as opportunistic pathogens, notable for their frequency and severity of infections are recognized as the most usual reasons for medical device-associated infections that s...
Fri Oct 25, 2019 03:00
Publication date: Available online 25 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): A. Ockerman, M. Vanhaverbeke, I. Miclotte, A. Belmans, T. Vanassche, C. Politis, R. Jacobs, P. VerhammeAbstractBleeding after dental extraction in patients treated with non-vitamin K oral anticoagulants (NOAC) may lead to unplanned reinterventions and interruption of anticoagulation, thereby exposing patients to a risk of thromboembolism. We have designed a study (EXTRACT-NOAC) to...
Sat Oct 26, 2019 13:56
Abstract Genomic testing of adolescents is increasing yet engaging them in decision making is not routine. We assessed decisional conflict in adolescents and a parent making independent decisions about actual genomic testing results and factors that influenced their choices. We enrolled 163 dyads consisting of an adolescent (13‐17 years) not selected based on a specific clinical indication and one parent. After independently choosing categories of conditions to learn for the adolescent,...
Sat Oct 26, 2019 12:08
Publication date: Available online 25 October 2019Source: Gene Expression PatternsAuthor(s): Andrew J. Schneider, Joseph Gawdzik, Chad M. Vezina, Tracie R. Baker, Richard E. PetersonAbstractPrevious studies identified Sox9 as a critical mediator of prostate development but the precise stage when Sox9 acts had not been determined. A genetic approach was used to delete Sox9 from mouse urogenital sinus epithelium (UGE) prior to prostate specification. All prostatic bud types (anterior, dorsolateral...
Sat Oct 26, 2019 13:47
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Abstract Objectives Assess sexual function, menopausal symptoms, and depression in women with BRCA mutations associated with oophorectomy and menopause status Methods Women age 40 and older with BRCA mutations completed a questionnaire with validated measures of sexual activity, menopausal symptoms, depression, and cancer worry. These measures were compared between those with intact ovaries and those who had undergone pre‐ or post‐menopausal risk‐reducing salpingo‐oophorectomy (RRSO). ...
Sat Oct 26, 2019 12:29
Abstract Objective Designing salient digital health interventions requires theoretically‐based formative research and user‐center design with stakeholder input throughout impacting content and technology design. mychoice is a theory‐based, stakeholder‐guided digital health tool to improve clinical trial informed decision making, particularly among African American patients. Methods mychoice was developed by: 1) mixed‐methods formative research, including in‐depth interviews (n=16) and surveys...
Sat Oct 26, 2019 11:14
Abstract Objective Prostate cancer (PCa) is the most prevalent form of cancer among men and has one of the most favorable survival rates among all cancers. Here we examine the association between depression and anxiety symptoms in a population‐based sample of men. Methods A cross‐sectional analysis was conducted on a subsample of 6,585 male participants aged 49‐69 from the 2009‐2015 survey cycle of the Atlantic PATH. Mild, moderate or severe depression or anxiety indicators were primary...
Fri Oct 25, 2019 22:44
Fri Oct 25, 2019 22:43
Abstract Objective The current study aims to explore the trend of Internet health information seeking (IHIS) in cancer survivors, and the relationship between four dimensions of digital divide (e.g., mental access, material access, skills access, and usage access) and IHIS. Methods Data from three iterations (2011, 2013, 2017) of Health Information National Trends Survey were analyzed. Only cancer survivors (2011: n=563; 2013: n=459; 2017: n=504) were included. ANOVA and multivariate regressions...
Fri Oct 25, 2019 22:43
Abstract Objective Few patient‐reported outcome measures (PROMs) have been developed that adequately measure the patient‐experience following diagnosis and treatment of melanoma. Building on previous research, which developed the European Organisation for Research and Treatment of Cancer [EORTC] Quality of Life Module [QLQ‐MEL38], the aim of this study was to further test the hypothesised domain structure and psychometric properties of the Phase 3 module, in a new larger sample of melanoma patients....
Fri Oct 25, 2019 11:09
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