Condition: Advanced Gastric and Gastro-esophageal Junction AdenocarcinomaIntervention: Drug: sintilimabSponsors: Chinese Academy of Medical Sciences; Chinese PLA General Hospital; Beijing Friendship Hospital; Beijing HospitalNot yet recruiting
Fri Oct 25, 2019 15:58
Publication date: December 2019Source: Journal of Human Evolution, Volume 137Author(s): Lawrence M. Fatica, Sergio Almécija, Shannon C. McFarlin, Ashley S. HammondAbstractGorillas occupy habitats that range in elevation from 0 to 3850 m. Populations at higher elevations tend to be less arboreal than lowland populations. Variation in habitat-specific behaviors among closely related populations makes gorillas a unique model to study the relationship between locomotion and morphology. The pelvis reflects...
Fri Oct 25, 2019 15:57
Abstract Cochlear implantation (CI) is used for rehabilitation of children with bilateral severe to profound sensorineural hearing loss. Recently, treatment of such children has been influenced by diagnostic technological advances. Infants and toddlers are now increasingly included for CI. The primary aim of this study was to determine the effects of ‘age at CI’ on CI outcome. The primary aim of this study was to determine the effects of ‘age at CI’ on CI outcome. In this prospective...
Fri Oct 25, 2019 03:00
The Journal of Antibiotics, Published online: 25 October 2019; doi:10.1038/s41429-019-0252-2Identification of actinomycin D as a specific inhibitor of the alternative pathway of peptidoglycan biosynthesis
Fri Oct 25, 2019 03:00
Publication date: Available online 24 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Soumya Mukherjee, Joseph Wood, Imran Liaquat, Simon R. Stapleton, Andrew J. MartinAbstractObjectiveThe role of repeat resection for recurrent glioblastoma multiforme (rGBM) is unclear. This large comparative cohort study assessed overall survival (OS), survival since recurrence (SSR), quality of life, and complications in reoperated versus non-reoperated patients for rGBM.Patients and methodsAll...
Fri Oct 25, 2019 15:40
Publication date: Available online 24 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Yin-Dan Yao, Ao-Fei Liu, Han-Cheng Qiu, Ji Zhou, Chen Li, Qi Wang, Jin Lv, Wei-Jian JiangAbstractObjectivesThe optimal treatment of symptomatic non-acute atherosclerotic intracranial large artery occlusion (ILAO) beyond 24 hours from onset remains uncertain. We investigate the outcomes of late endovascular recanalization for symptomatic non-acute atherosclerotic ILAO.Patients and methodsFrom September...
Fri Oct 25, 2019 15:40
Publication date: Available online 24 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Jose F. Dominguez, Piyush Kalakoti, Xintong Chen, Kaisen Yao, Nam K. Lee, Smit Shah, Meic Schmidt, Chad Cole, Chirag Gandhi, Fawaz Al-Mufti, Christian A. BowersAbstractObjectiveThe Medicaid patient population and health care costs for spine surgeries among these patients have increased since 2010. Hospital length of stay (LOS) contributes appreciably to hospital costs for patients undergoing primary...
Fri Oct 25, 2019 15:40
Publication date: Available online 25 October 2019Source: Ultrasound in Medicine & BiologyAuthor(s): Antonios N. Pouliopoulos, Shih-Ying Wu, Mark T. Burgess, Maria Eleni Karakatsani, Hermes A.S. Kamimura, Elisa E. KonofagouAbstractFocused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening is currently being investigated in clinical trials. Here, we describe a portable clinical system with a therapeutic transducer suitable for humans, which eliminates the need for in-line magnetic resonance...
Fri Oct 25, 2019 15:36
Publication date: Available online 24 October 2019Source: Journal of Neuroscience MethodsAuthor(s): Ulrike Erb, Christian Schwerk, Horst Schroten, Michael KarremannAbstractAcute lymphoblastic leukaemia represents the most common paediatric malignancy. Although survival rates approach up to 90% in children, investigation of leukaemic infiltration into the central nervous system (CNS) is essential due to the presence of ongoing fatal complications. Recent in vitro studies mostly employed models of...
Fri Oct 25, 2019 15:34
Publication date: Available online 24 October 2019Source: Journal of Neuroscience MethodsAuthor(s): Gabriela Santana-Chávez, Paola Rodriguez-Moreno, Mónica López-Hidalgo, Rafael Olivares-Moreno, Yunuen Moreno-López, Gerardo Rojas-PiloniAbstractBackgroundUnderstanding the configuration of neural circuits and the specific role of distinct cortical neuron types involved in behavior, requires the study of structure-function and connectivity relationships with single cell resolution in awake behaving...
Fri Oct 25, 2019 15:34
Publication date: Available online 24 October 2019Source: Brain Research BulletinAuthor(s): Fatemeh Farokhi-Sisakht, Saeed Sadigh-Eteghad, Gisou Mohaddes, Abbas Ebrahimi-Kalan, Pouran Karimi, Mehdi FarhoudiAbstractThe present study aimed to evaluate the preventive role of physical and cognitive training separately or in combination on memory dysfunction, inflammatory factors and apoptotic markers in the hippocampal-ischemia model of rat. The ischemia model was established by infusion of endothelin-1...
Fri Oct 25, 2019 15:12
Publication date: Available online 24 October 2019Source: Brain Research BulletinAuthor(s): Xiu-Qi Bao, Lu Wang, Han-Yu Yang, Li-Yan Hou, Qing-Shan Wang, Dan ZhangAbstractGlial cell line-derived neurotrophic factor (GDNF) has neurotrophic activity for the survival of dopaminergic neurons, which is under active investigation for Parkinson’s disease (PD) therapy. FLZ is a potential new drug for PD treatment. However, it is unclear whether neurotrophic activity contributes to the neuroprotective effects...
Fri Oct 25, 2019 15:12
Publication date: Available online 24 October 2019Source: Acta HistochemicaAuthor(s): Sandra Kostic, Brandon Williams, Samy Ksouri, Leon Hardung, Natalija Filipovic, Lejla Ferhatovic Hamzic, Livia Puljak, Nasrollah Ghahramani, Katarina VukojevicAbstractBackgroundDiabetic nephropathy is a progressive condition which develops for many years. We analyzed expression of Snail and serum response factor (SRF), epithelial-mesenchymal transition (EMT) regulatory transcription factors with a key role in renal...
Fri Oct 25, 2019 15:02
Summary Using a nap design, we have recently shown that training at a complex cognitive task at bedtime improves objective sleep quality by reducing sleep fragmentation. In order to extend our findings to nighttime sleep, here we assess the impact of a multi‐componential cognitive task at bedtime on the subsequent sleep episode of subjects reporting habitual bad sleep, allegedly characterized by high sleep fragmentation. In a within‐subjects design, 20 subjective bad sleepers underwent polysomnographic...
Fri Oct 25, 2019 14:29
Thu Oct 03, 2019 20:47
Abstract Primary ciliary dyskinesia (PCD) is a rare genetic disorder of motile cilia dysfunction generally inherited as an autosomal recessive disease. Genetic testing is increasingly considered an early step in the PCD diagnostic workflow. We used targeted panel next generation sequencing (NGS) for genetic screening of 33 Egyptian families with highly clinically suspected PCD. All variants prioritized were Sanger confirmed in the affected individuals and correctly segregated within the...
Thu Oct 24, 2019 20:22
Abstract Objective Little is known regarding food anaphylaxis in infancy. We aimed to describe specificities of food anaphylaxis in infants (≤12 months) as compared to preschool children (1‐6 years). Methods We conducted a retrospective study of all food anaphylaxis cases recorded by the Allergy Vigilance Network from 2002 to 2018, in preschool children focusing on infants. Results Of 1951 food anaphylaxis reactions, 61 (3%) occurred in infants and 386 (20%) in preschool children....
Fri Oct 25, 2019 12:42
Nature Communications, Published online: 25 October 2019; doi:10.1038/s41467-019-12822-1The kagome lattice is increasingly known as a host for correlated topological electronic states. Here, Ye et al. report quantum de Haas-van Alphen oscillations of a ferromagnetic kagome material Fe3Sn2, where bulk electronic Dirac fermions are found to be modulated by rotation of the magnetic moment.
Fri Oct 25, 2019 03:00
Nature Communications, Published online: 25 October 2019; doi:10.1038/s41467-019-12803-4Elastic mapping of individual layers of the cornea with elastography uses Lamb waves, which are dependent on the thickness of each layer and the direction of propagation. Here the authors present Reverberant 3D Optical Coherence Elastography to measure elasticity of single layers using waves propagating in all directions.
Fri Oct 25, 2019 03:00
Nature Communications, Published online: 25 October 2019; doi:10.1038/s41467-019-12871-6Gale Crater on Mars has been demonstrated to have once hosted water, but its chemistry is still under debate. Here the authors use mineralogical rock compositions and show the once saline character of Gale Crater—a result of warmer climate periods during the Hesperian period.
Fri Oct 25, 2019 03:00
Nature Communications, Published online: 25 October 2019; doi:10.1038/s41467-019-12640-5ERCC1 is involved in a number of DNA repair pathways including nucleotide excision repair. Here the authors showed that reduced transcription in Ercc1-deficient mouse livers and cells increases ATP levels, suppressing glycolysis and rerouting glucose into the pentose phosphate shunt that generates reductive stress.
Fri Oct 25, 2019 03:00
Nature Communications, Published online: 25 October 2019; doi:10.1038/s41467-019-12791-5Previous studies on astrocyte development have led to controversial results due to a lack of pertinent tools. Here, authors analyze large numbers of astrocyte clones generated by nearby cortical progenitors using the MAGIC Markers strategy and ChroMS 3D imaging, and show that clonally-related astrocytes organize in a non-stereotyped manner and that cortical astrocyte subtypes are not intrinsically specified.
Fri Oct 25, 2019 03:00
Nature Communications, Published online: 25 October 2019; doi:10.1038/s41467-019-12930-yThe mechanism of force production by invadopodia is unclear. Here, the authors show that cell surface MT1-MMP when in contact with collagen, induces Arp2/3 branched actin polymerisation on the concave side of invadopodia, which generates a pushing force along with collagen cleavage by MT1-MMP to invade.
Fri Oct 25, 2019 03:00
Nature Communications, Published online: 25 October 2019; doi:10.1038/s41467-019-12617-4Electrochromic devices have a range of applications as switchable shutters. Here the authors report a hybrid device that uses complementary electrochromic molecules immobilized on nanoporous electrodes to concurrently achieve fast colouration and bleaching with high contrast over a broad spectral range.
Fri Oct 25, 2019 03:00
Nature Communications, Published online: 25 October 2019; doi:10.1038/s41467-019-12770-wSupramolecular interactions may be responsible for higher degree of efficiency and selectivity in homogeneous catalysis. Here, the authors exploit the concept of supramolecular catalysis to develop a domino rhodium-catalyzed hydroformylation of α-alkynoic acids followed by Michael addition of nucleophiles.
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Bone formation requires the replenishment of the osteoblast from a progenitor or stem cell population, which must be recruited, expanded, and differentiated to ensure continued anabolism. How this occurs and whether it is altered in the osteoporotic environment is poorly understood. Furthermore, given that emerging treatments for osteoporosis are targeting this progenitor population, it is critical to determine the regenerative capacity of this cell type in the setting of osteoporosis. Human bone...
Fri Oct 25, 2019 09:46
Bone grafting is the second most common tissue transplantation procedure worldwide. One of the alternative methods for bone repair under investigation is a tissue-engineered bone substitute. An ideal property of tissue-engineered bone substitutes is osteoinductivity, defined as the ability to stimulate primitive cells to differentiate into a bone-forming lineage. In the current study, we use a decellularization and oxidation protocol to produce a porcine bone scaffold and examine whether it possesses...
Fri Oct 25, 2019 09:45
Publication date: Available online 24 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): E. Samara, E. Twohig
Fri Oct 25, 2019 13:19
Publication date: Available online 24 October 2019Source: Revista Española de Medicina Nuclear e Imagen MolecularAuthor(s): A.M. García Vicente, J. Pérez-Beteta, G.A. Jiménez Londoño, M. Amo-Salas, F.J. Pena Pardo, M. Villena Martín, J.M. Borrás Moreno, Á. Soriano CastrejónResumenObjetivoEl objetivo fue doble, valorar el acuerdo interobservador en la segmentación tumoral y la búsqueda de una metodología fiable y aplicable en la segmentación de gliomas usando PET/TC con 18F-fluorocolina.Material y...
Fri Oct 25, 2019 13:02
Abstract Background and objective The ideal delivery of radiation to the surgical cavity of brain metastases (BMs) remains the subject of debate. Risks of local failure (LF) and radiation necrosis (RN) have prompted a reappraisal of the timing and/or modality of this critical component of BM management. IORT delivered at the time of resection for BMs requiring surgery offers the potential for improved local control (LC) afforded by the...
Fri Oct 25, 2019 03:00
Imaging of a patiеnt undеrgoing cardiac arrеst is not common but thе abnormal hеmodynamics duе to thе pump failurе havе charactеristic imaging fеaturеs on CT-scan. Thе main imaging fеaturеs includе stasis and pooling of blood in thе dеpеndеnt organs of thе body, thе infеrior vеna cava, thе right rеnal vеin, thе right hеpatic vеin and thе right hеpatic parеnchyma. Knowlеdgе of thеsе signs is еssеntial in ordеr to start rеsuscitating thе patiеnt and can havе important survival implications. Wе rеport...
Fri Oct 25, 2019 11:33
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