Summary Background Preclinical studies suggested synergistic anti-tumor activity when pairing mTOR inhibitors with histone deacetylase (HDAC) inhibitors. We completed a phase I, dose-finding trial for the mTOR inhibitor everolimus combined with the HDAC inhibitor panobinostat in advanced clear cell renal cell carcinoma (ccRCC) patients. We additionally investigated expression of microRNA 605 (miR-605) in serum samples obtained from trial participants. Patients and Methods Twenty-one...
Fri Oct 25, 2019 03:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07591
Fri Oct 25, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b10418
Fri Oct 25, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07808
Fri Oct 25, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05419
Fri Oct 25, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08219
Fri Oct 25, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07902
Fri Oct 25, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06714
Fri Oct 25, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09123
Fri Oct 25, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b10981
Fri Oct 25, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08927
Fri Oct 25, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05526
Fri Oct 25, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09227
Fri Oct 25, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05776
Fri Oct 25, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b10645
Fri Oct 25, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b11200
Fri Oct 25, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08835
Fri Oct 25, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09752
Fri Oct 25, 2019 07:00
Publication date: December 2019Source: Clinical Neurophysiology, Volume 130, Issue 12Author(s): Yasuo Terao, Shin-ichi Tokushige, Satomi Inomata-Terada, Hideki Fukuda, Akihiro Yugeta, Yoshikazu UgawaAbstractObjectivePatients with Parkinson's disease (PD) and multiple system atrophy both present predominantly with parkinsonism at early stages, whereas cerebellar symptoms are largely masked in multiple system atrophy with parkinsonism (MSAP). We sought to determine whether the velocity profiles of...
Fri Oct 25, 2019 22:49
Publication date: Available online 24 October 2019Source: Clinical NeurophysiologyAuthor(s): Elias Paolo Casula, Michele Maiella, Maria Concetta Pellicciari, Francesco Porrazzini, Alessia D'Acunto, Lorenzo Rocchi, Giacomo KochAbstractObjectiveTo validate two indexes of interhemispheric signal propagation (ISP) and balance (IHB) by combining transcranial magnetic stimulation (TMS) and electroencephalography (EEG).MethodsWe used TMS-EEG to non-invasively stimulate the two hemispheres of 50 healthy...
Fri Oct 25, 2019 22:49
Publication date: Available online 24 October 2019Source: Clinical NeurophysiologyAuthor(s): Anca Adriana Arbune, Irina Popa, Ioana Mindruta, Sandor Beniczky, Cristian Donos, Andrei Daneasa, Mihai Dragoş Mălîia, Ovidiu Alexandru Băjenaru, Jean Ciurea, Andrei BarboricaAbstractObjectiveSleep is an active process with an important role in memory. Epilepsy patients often display a disturbed sleep architecture, with consequences on cognition. We aimed to investigate the effect of sleep on cortical networks’...
Fri Oct 25, 2019 22:49
Publication date: Available online 24 October 2019Source: Clinical NeurophysiologyAuthor(s): H. Tankisi
Fri Oct 25, 2019 22:49
Publication date: Available online 24 October 2019Source: Clinical NeurophysiologyAuthor(s): Luciana Pelosi, Catherine H Han, Mark J McKeage
Fri Oct 25, 2019 22:49
Publication date: Available online 24 October 2019Source: Clinical NeurophysiologyAuthor(s): Martin Regensburger
Fri Oct 25, 2019 22:49
Publication date: Available online 24 October 2019Source: Clinical NeurophysiologyAuthor(s): Edoardo Ferlazzo, Silvana Franceschetti, Sara Gasparini, Maurizio Elia, Laura Canafoglia, Chiara Pantaleoni, Michele Ascoli, Tiziana D'Agostino, Chiara Sueri, Giulia Ferrigno, Ferruccio Panzica, Vittoria Cianci, Umberto AgugliaAbstractObjectivethe clinical and neurophysiological characteristics of myoclonus in Angelman syndrome (AS) have been evaluated in single case or small cohorts, with contrasting results....
Fri Oct 25, 2019 22:49
Publication date: Available online 21 September 2019Source: Clinical NeurophysiologyAuthor(s): P. Scoppettuolo, N. Gaspard, C. Depondt, B. Legros, N. Ligot, G. NaeijeAbstractObjectiveDespite improvement in acute stroke care, almost 40% of patients with ischemic stroke present neurological deterioration. Neurological deterioration is associated with higher death and dependency rates. Neurological deterioration mechanisms are unknown, and half of neurological deterioration remains unexplained. We postulate...
Fri Oct 25, 2019 22:49
Publication date: Available online 19 September 2019Source: Clinical NeurophysiologyAuthor(s): Claudio Babiloni, Robert J. Barry, Erol Başar, Katarzyna J. Blinowska, Andrzej Cichocki, Wilhelmus H.I.M. Drinkenburg, Wolfgang Klimesch, Robert T. Knight, Fernando Lopes da Silva, Paul Nunez, Robert Oostenveld, Jaeseung Jeong, Roberto Pascual-Marqui, Pedro Valdes-Sosa, Mark HallettAbstractIn 1999, the International Federation of Clinical Neurophysiology (IFCN) published “IFCN Guidelines for topographic...
Fri Oct 25, 2019 22:49
Publication date: Available online 24 October 2019Source: Journal of VoiceAuthor(s): Ali Dehqan, Kirrie J. BallardSummaryIntroductionMuscle tension dysphonia (MTD) is used as a clinical and diagnostic descriptive label for a diverse range of vocal fold behaviors caused by increased tension of the (para) laryngeal musculature. These increased tension can occur in the cricothyroid muscle and in the ‘‘visor’’ mechanism, contributing to voice problems. The main goal of this study is to determine whether...
Fri Oct 25, 2019 22:46
Voice assistants are quickly becoming a popular consumer tool that allows users to access libraries of skills, including games, news, and reminders. Last month, Los Angeles-based Frontive Health launched its smart personal health platform to help patients more easily adhere to their care regimens by leveraging Amazon Echo’s voice assistant. Utilizing a “less is more” approach to collating medication instructions, pre-, and post-procedure protocols, and lifestyle modifications, Frontive’s...
Fri Oct 25, 2019 22:37
Operative Experience, a healthcare simulation company based in Maryland, is releasing the first anatomically accurate female combat casualty simulator. The device can mimic a variety of conditions, including airway and breathing problems, severe wounds, and broken bones, and can be used to practice emergency medicine for those conditions. Since men mostly comprise the medics in the military, some, because of their young age or other reasons, may be unfamiliar or uncomfortable with the female...
Fri Oct 25, 2019 19:27
ClaroNav Kolahi , a company based in Toronto, Canada, won European regulatory approval for its Navient Cranial navigation system, a product designed to make neurosurgical navigation easy, intuitive, and space-efficient in the OR. Navient Cranial can be used in open or percutaneous procedures to help locate surgical targets within the brain and wherever stereotactic neurosurgery is used. It doesn’t require mounting of spherical markers and there are no cables to connect/disconnect....
Fri Oct 25, 2019 18:04
Researchers based in South Korea and Hong Kong have developed a method to create biomimetic blood vessels by directly 3D printing vascular cells and bioinks containing collagen and vascular tissue extracellular matrix components. The resulting constructs closely mimic natural blood vessels, suggesting that such techniques could pave the way for custom vascular grafts to treat various cardiovascular diseases. Vascular grafts typically involve removing a healthy blood vessel and implanting it...
Fri Oct 25, 2019 16:40
Odontocetes (toothed whales) are the most species-rich marine mammal lineage. The catalyst for their evolutionary success is echolocation - a form of biological sonar that uses high-frequency sound, produced i...
Thu Oct 24, 2019 03:00
Abstract Rationale Several findings indicate that early-life dysfunction of N-methyl-d-aspartate (NMDA) receptors might cause schizophrenia-like abnormalities in adulthood that might be induced by impairments in epigenetic regulation. Objectives In the present study, we investigated whether postnatal blockade of NMDA receptors (within the first 3 weeks of...
Fri Oct 25, 2019 03:00
Abstract A breast screening event was conducted during the homecoming festivities of a historically Black university located in a rural county in Mississippi. Two healthcare providers performed clinical breast exams for 26 African American women during the event. This was a prime opportunity to make breast screening accessible for non-elderly African American women.
Fri Oct 25, 2019 03:00
Abstract Disparities in cancer screening and care in rural communities warrant the need to determine effective ways to reach, engage, and educate the community residents. The purpose of this cross-sectional study was to pilot methods to engage rural residents in colorectal cancer (CRC) research and education activities and assess knowledge of CRC guidelines, symptoms, and screening behaviors in this sample. The community-engaged research approach was employed to develop and distribute...
Fri Oct 25, 2019 03:00
Bacterial pathogens secrete proteins into the host that target crucial biological processes. Identifying the host pathways targeted by bacterial effector proteins is key to addressing molecular pathogenesis. Here, a method using a modified yeast suppressor and toxicity screen to elucidate host pathways targeted by toxic bacterial effector proteins is described.
Fri Oct 25, 2019 22:02
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