Publication date: January 2020Source: Magnetic Resonance Imaging, Volume 65Author(s): Yunyu Gao, Jijun Han, Yurong Zhu, Jiajia Wang, Xinhua Wei, Xuegang XinAbstractPurposeThe aim of this study was to propose a channel combination method for |B1+| mapping methods using phase difference to reconstruct |B1+| map.Theory and methodsPhase-based |B1+| mapping methods commonly consider the phase difference of two scans to measure |B1+|. Multiple receiver coils acquire a number of images and the phase difference...
Fri Oct 25, 2019 16:51
Publication date: Available online 25 October 2019Source: Magnetic Resonance ImagingAuthor(s): Frederick C. Damen, Rong-Wen Tain, Riya Thomas, Weigo Li, Leon Tai, Kejia CaiAbstractArterial spin labeling (ASL) MRI, based on endogenous contrast from blood water, is used in research and diagnosis of cerebral vascular conditions. However, artifacts due to imperfect imaging conditions such as B0-inhomogeneity (ΔB0) could lead to variations in the quantification of relative cerebral blood flow (CBF). In...
Fri Oct 25, 2019 16:51
Publication date: Available online 24 October 2019Source: Magnetic Resonance ImagingAuthor(s): Badri Karthikeyan, Swati D. Sonkawade, Saraswati Pokharel, Marilena Preda, Ferdinand Schweser, Robert Zivadinov, Minhyung Kim, Umesh C. SharmaAbstractPurposeThe conventional volumetric approaches of measuring cardiac function are load-dependent, and are not able to discriminate functional changes in the infarct, transition and remote myocardium. We examined phase-dependent regional mechanical changes in...
Fri Oct 25, 2019 16:51
Publication date: Available online 24 October 2019Source: Autoimmunity ReviewsAuthor(s): Denis Poddubnyy, Howard Amital, Andrea Rubbert-Roth
Fri Oct 25, 2019 16:44
Objectives: The aim of this study was to investigate the following: (1) the vibration pattern of the round window (RW) membrane in human cadavers during air (AC) and bone conduction (BC) stimulation at different excitation sites; (2) the effect of the stimulation on the fluid volume displacement (VD) at the RW and compare the VD between BC and AC stimulation procedures; (3) the effectiveness of cochlear stimulation by the bone implant at different excitation sites. Design: The RW membrane...
Fri Oct 25, 2019 16:39
Objectives: Recent animal studies have shown that noise exposure can cause cochlear synaptopathy without permanent threshold shift. Because the noise exposure preferentially damaged auditory nerve fibers that processed suprathreshold sounds (low-spontaneous rate fibers), it has been suggested that synaptopathy may underlie suprathreshold hearing deficits in humans. Recently, several researchers have suggested measures to identify the pathology or pathologies underlying suprathreshold hearing deficits...
Fri Oct 25, 2019 16:39
Objectives: Previous work demonstrates the importance of a high signal to noise ratio (SNR) when using transient evoked otoacoustic emissions (TEOAEs) to assay the medial olivocochlear reflex (MOCR). Increasing stimulus level provides one means to increase TEOAE SNR. However, this may come at the expense of a smaller MOCR effect. It is not clear whether the gain in SNR associated with the use of higher stimulus levels outweighs the disadvantage of a potentially smaller MOCR effect. The present...
Fri Oct 25, 2019 16:39
Objectives: Previous work has suggested that individual characteristics, including amount of hearing loss, age, and working memory ability, may affect response to hearing aid signal processing. The present study aims to extend work using metrics to quantify cumulative signal modifications under simulated conditions to real hearing aids worn in everyday listening environments. Specifically, the goal was to determine whether individual factors such as working memory, age, and degree of hearing loss...
Fri Oct 25, 2019 16:39
Objectives: The Quick Spectral Modulation Detection (QSMD) test provides a quick and clinically implementable spectral resolution estimate for cochlear implant (CI) users. However, the original QSMD software (QSMD(MySound)) has technical and usability limitations that prevent widespread distribution and implementation. In this article, we introduce a new software package EasyQSMD, which is freely available software with the goal of both simplifying and standardizing spectral resolution measurements. ...
Fri Oct 25, 2019 16:39
Objectives: This study tested listeners with a cochlear implant (CI) in one ear and acoustic hearing in the other ear, to assess their ability to localize sound and to understand speech in collocated or spatially separated noise or speech maskers. Design: Eight CI listeners with contralateral acoustic hearing ranging from normal hearing to moderate sensorineural hearing loss were tested. Localization accuracy was measured in five of the listeners using stimuli that emphasized the separate...
Fri Oct 25, 2019 16:39
Objectives: To evaluate the influence of auditory cues on postural sway in normal-hearing (NH) individuals, hearing-impaired individuals with vestibular impairment (HIVL), or hearing-impaired (HI) individuals without vestibular impairment. Design: Thirty-two participants received a hearing and a vestibular evaluation (vHIT, oVEMP, cVEMP) and then were separated in to three groups (NH, HI, HIVL). All participants had to stand on a force platform in four postural conditions (A: EO/firm, B:...
Fri Oct 25, 2019 16:39
Objectives: Research suggests that the speech perception of children using bone conduction amplification improves if the device is coupled to an implanted abutment rather than to a softband. The purpose of the present study was to determine if the benefit of direct stimulation via an abutment is limited to small improvements in speech perception or if similar or greater benefits occur for other auditory tasks important for learning and communication. Design: Fourteen children (7 to 15 years...
Fri Oct 25, 2019 16:39
Objective: The reliability of the electrically evoked compound action potential (eCAP) threshold depends on its precision and accuracy. The precision of the eCAP threshold reflects its variability, while the accuracy of the threshold shows how close it is to the actual value. The objective of this study was to determine the test/retest variability of the eCAP threshold in Advanced Bionics cochlear implant users, which has never been reported before. We hypothesized that the test/retest variability...
Fri Oct 25, 2019 16:39
Objectives: While fundamental frequency (F0) cues are important to both lexical tone perception and multitalker segregation, F0 cues are poorly perceived by cochlear implant (CI) users. Adding low-frequency acoustic hearing via a hearing aid in the contralateral ear may improve CI users’ F0 perception. For English-speaking CI users, contralateral acoustic hearing has been shown to improve perception of target speech in noise and in competing talkers. For tonal languages such as Mandarin Chinese,...
Fri Oct 25, 2019 16:39
This article introduces the Consumer Ear Disease Risk Assessment (CEDRA) tool. CEDRA is a brief questionnaire designed to screen for targeted ear diseases. It offers an opportunity for consumers to self-screen for disease before seeking a hearing device and may be used by clinicians to help their patients decide the appropriate path to follow in hearing healthcare. Here we provide highlights of previously published validation in the context of a more thorough description of CEDRA’s development and...
Fri Oct 25, 2019 16:39
Objectives: The mechanisms underlying age-related changes in speech perception are still unclear, most likely multifactorial and often can be difficult to parse out from the effects of hearing loss. Age-related changes in temporal resolution (i.e., the ability to track rapid changes in sounds) have long been associated with speech perception declines exhibited by many older individuals. The goals of this study were as follows: (1) to assess age-related changes in temporal resolution in cochlear...
Fri Oct 25, 2019 16:39
Objectives: Serial recall of digits is frequently used to measure short-term memory span in various listening conditions. However, the use of digits may mask the effect of low quality auditory input. Digits have high frequency and are phonologically distinct relative to one another, so they should be easy to identify even with low quality auditory input. In contrast, larger item sets reduce listener ability to strategically constrain their expectations, which should reduce identification accuracy...
Fri Oct 25, 2019 16:39
Objective: The stimuli used to evoke otoacoustic emissions (OAEs) are typically calibrated based on the total SPL measured at the probe microphone. However, due to the acoustics of the ear-canal space (i.e., standing-wave interference), this method can underestimate the stimulus pressure reaching the tympanic membrane at certain frequencies. To mitigate this effect, stimulus calibrations based on forward pressure level (FPL) can be applied. Furthermore, the influence of ear-canal acoustics on...
Fri Oct 25, 2019 16:39
Objectives: An increasing number of severe-profoundly deaf adult unilateral cochlear implant (CI) users receive bimodal stimulation; that is, they use a conventional acoustic hearing aid (HA) in their nonimplanted ear. The combination of electric and contralateral acoustic hearing provides additional benefits to hearing and also to general health-related quality of life compared with unilateral CI use. Bilateral CI is a treatment alternative to both unilateral CI and bimodal stimulation in some...
Fri Oct 25, 2019 16:39
Objectives: Although the educational achievement gap between people without hearing loss and people with hearing loss is well-documented, few studies are based on large, nonclinical samples. The present study aims to investigate the educational attainment among Norwegian adults diagnosed with sensorineural hearing loss as children, compared with a matched control group of people without hearing loss. Design: A prospective cohort design was applied. Between 1954 and 1986, the children in the...
Fri Oct 25, 2019 16:39
Objectives: The aims of this study were as follows: (a) to describe audiologists’ practices toward auditory training (AT) for adult cochlear implant (CI) users with a postlingual hearing loss; and (b) to assess the cost of different AT methods for clients and service providers in comparison with no AT delivery. Design: A survey was distributed to approximately 230 Australian CI audiologists to investigate the range, magnitude, and rationale of AT practices adopted as part of rehabilitation...
Fri Oct 25, 2019 16:39
Objectives: Cochlear implant (CI) users frequently report poor sound quality while listening to music, although the specific parameters responsible for this loss of sound quality remain poorly understood. Audio compression, which reduces the dynamic range (DR) for a given sound, is a ubiquitous component of signal processing used by both CI and hearing aid technology. However, the relative impact of compression for acoustic and electric hearing on music perception has not been well studied, an...
Fri Oct 25, 2019 16:39
Objectives: The purpose of this study was to assess the factor structure, reliability, and validity of the Fear of Tinnitus Questionnaire (FTQ); a brief self-report measure of people’s fears about potential cognitive, emotional, behavioral, and social consequences of living with tinnitus. Design: Five hundred eighty-eight Dutch-speaking adults with tinnitus completed an online battery of questionnaires measuring tinnitus-related distress, fear, catastrophizing, and quality of life. The sample...
Fri Oct 25, 2019 16:39
Objectives: To examine maturation of neural discriminative responses to an English vowel contrast from infancy to 4 years of age and to determine how biological factors (age and sex) and an experiential factor (amount of Spanish versus English input) modulate neural discrimination of speech. Design: Event-related potential (ERP) mismatch responses (MMRs) were used as indices of discrimination of the American English vowels [ε] versus [I] in infants and children between 3 months and 47 months...
Fri Oct 25, 2019 16:39
Publication date: Available online 24 October 2019Source: Pathology - Research and PracticeAuthor(s): Yan Wang, Yanming Wu, Jue Li, Jialong Li, Guowei CheAbstractPurposeTo explore the association of thyroid transcription factor-1 (TTF-1) expression status with clinicopathological characteristics and survival of patients with small cell lung cancer (SCLC).MethodsA comprehensive literature search was conducted to identify potentially relevant studies in several electronic databases, including EMBASE,...
Fri Oct 25, 2019 16:21
Publication date: Available online 24 October 2019Source: International Journal of PsychophysiologyAuthor(s): Taylor Hornung, Wen-Hsuan Chan, Ralph-Axel Müller, Jeanne Townsend, Brandon KeehnAbstractBackgroundPrior studies using a variety of methodologies have reported inconsistent dopamine (DA) findings in individuals with autism spectrum disorder (ASD), ranging from dopaminergic hypo- to hyper-activity. Theta-band power derived from scalp-recorded electroencephalography (EEG), which may be associated...
Fri Oct 25, 2019 16:19
Publication date: Available online 24 October 2019Source: International Journal of PsychophysiologyAuthor(s): Michael J. Imburgio, Annmarie MacNamaraAbstractCognitive reappraisal is a higher order emotion regulation strategy, the effects of which can be measured using the late positive potential (LPP), an event-related potential that is larger for emotional versus neutral stimuli. Whereas the lab provides a relatively predictable and calm environment in which to engage in reappraisal, outside of...
Fri Oct 25, 2019 16:19
Publication date: Available online 24 October 2019Source: International Journal of PsychophysiologyAuthor(s): Sven Hoffmann, Lea Teresa Jendreizik, Ulrich Ettinger, Sylvain LabordeAbstractDetecting errors is crucial for adapting one’s own actions. Moreover, behavior is often optimized by adapting to maladaptive actions, i.e. errors. In this regard, recent studies and models of error monitoring point to an involvement of emotional states in error monitoring. A psychophysiological correlate of the...
Fri Oct 25, 2019 16:19
Publication date: Available online 24 October 2019Source: Journal of ProteomicsAuthor(s): Zhun Liu, Shaobin Yu, Shuting Ye, Zhimin Shen, Lei Gao, Ziyang Han, Peipei Zhang, Fei Luo, Sui Chen, Mingqiang KangAbstractOesophageal squamous cell carcinoma (ESCC) is an aggressive malignancy and a leading cause of cancer-related death worldwide. Lack of effective early diagnosis strategies and ensuing complications from tumour metastasis account for the majority of ESCC death. Thus, identification of key...
Fri Oct 25, 2019 16:13
Publication date: Available online 24 October 2019Source: Journal of ProteomicsAuthor(s): Shaolan Yang, Hui Li, Sarabjit Bhatti, Suping Zhou, Yong Yang, Tara Fish, Theodore W. ThannhauserAbstractThis paper reports a laser capture microdissection-tandem mass tag-quantitative proteomics analysis of Al-sensitive cells in root tips. Cherry tomato (Solanum lycopersicum var. cerasiforme ‘LA2710’) seedlings were treated under 15 μM Al3+ activity for 13 d. Root-tip longitudinal fresh frozen tissue sections...
Fri Oct 25, 2019 16:13
Publication date: Available online 24 October 2019Source: Journal of ProteomicsAuthor(s): Jimena Alvarez Hayes, Kristin Surmann, Yanina Lamberti, Maren Depke, Vishnu Dhople, Bruno Blancá, Esperanza Ruiz, Branislav Vecerek, Frank Schmidt, Uwe Völker, María Eugenia RodriguezAbstractB. pertussis is the etiological agent of whooping cough, a highly contagious respiratory disease which remains uncontrolled worldwide. Understanding how this pathogen responds to the environmental changes and adapts to different...
Fri Oct 25, 2019 16:13
Publication date: Available online 24 October 2019Source: Journal of ProteomicsAuthor(s): Yumin Kan, Qingyang Lyu, Na Jiang, Sining Han, Jianqiang Li, Saul Burdman, Laixin LuoAbstractAcidovorax citrulli, the causal agent of bacterial fruit blotch (BFB) disease, infects cucurbit crops including watermelon and melon. This bacterium can enter the viable but nonculturable (VBNC) state following exposure to copper sulfate. Moreover, copper-induced VBNC A. citrulli cells can be resuscitated by EDTA. In...
Fri Oct 25, 2019 16:13
Publication date: Available online 24 October 2019Source: Journal of ProteomicsAuthor(s): Renee Jean-Toussaint, Yuzhen Tian, Amrita Datta Chaudhuri, Norman J. Haughey, Ahmet Sacan, Seena K. AjitAbstractExosomes are 30–150 nm extracellular vesicles mediating intercellular communication. Disease states can alter exosome composition affecting the message carried and thereby, its functional impact. The objective of this study was to identify proteins present in these vesicles in a mouse model of neuropathic...
Fri Oct 25, 2019 16:13
Publication date: Available online 24 October 2019Source: Medical HypothesesAuthor(s): Richa Saxena, Neal L. Weintraub, Yaoliang TangAbstractIschemic cardiac preconditioning protects the heart during myocardial infarction by activating critical cardioprotective genes such as eNOS, SOD, and HO-1. Clinical trials only show marginal effects of conventional preconditioning strategies, however, in part due to transient activation of cardioprotective genes. Recent studies have shown that N6-methyladenosine...
Fri Oct 25, 2019 15:58
Condition: Hereditary Hemorrhagic TelangiectasiaInterventions: Drug: Timolol Gel; Drug: Placebo GelSponsors: Washington University School of Medicine; Institute of Clinical and Translational Sciences (ICTS)Recruiting
Fri Oct 25, 2019 15:58
Condition: Disease Free SurvivalInterventions: Drug: bevacizumab; Drug: DDP; Drug: Docetaxel; Radiation: radiotherapySponsor: Fourth Military Medical UniversityRecruiting
Fri Oct 25, 2019 15:58
Condition: Head and Neck Squamous Cell CarcinomaIntervention: Drug: HPV E6-specific TCR-T cell with anti-PD1 auto-secreted elementSponsors: Xinqiao Hospital of Chongqing; TCRCure Biopharma LtdRecruiting
Fri Oct 25, 2019 15:58
Conditions: Thyroid Neoplasms; Genetic Susceptibility; Radiation ExposureIntervention: Sponsor: Institut National de la Santé Et de la Recherche Médicale, FranceRecruiting
Fri Oct 25, 2019 15:58
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