Colon cancer therapy by focusing on colon cancer stem cells and their tumor microenvironment. J Cell Physiol. 2019 Oct 24;: Authors: Jahanafrooz Z, Mosafer J, Akbari M, Hashemzaei M, Mokhtarzadeh A, Baradaran B Abstract Despite many advances and optimization in colon cancer treatment, tumor recurrence and metastases make the development of new therapies necessary. Colon cancer stem cells (CCSCs) are considered as the main triggering factor of cancer...
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Aligning requirements of training and assessment in radiation treatment planning in the era of competency-based medical education. Int J Radiat Oncol Biol Phys. 2019 Oct 19;: Authors: Moideen N, de Metz C, Kalyvas M, Soleas E, Egan R, Dalgarno N Abstract PURPOSE: Radiation treatment planning (RTP) is a unique skill that requires interdisciplinary collaboration among radiation oncologists (ROs), dosimetrists, and medical physicists (MP) to train and assess...
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Integrated Analysis of mRNA-miRNA-lncRNA ceRNA Network in Human HR+/Her-2- Breast Cancer and Triple Negative Breast Cancer. J Comput Biol. 2019 Oct 24;: Authors: Jia X, Shi Y, Zhu Y, Meng W, He L, Jia Y, Tong Z Abstract Breast cancer is a heterogeneous disease highly diverse in different subtypes, including hormone receptor positive and hormone receptor negative subtypes with variable malignancy, therapy regimen, and different prognosis. In this study,...
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Chemotherapy-induced peripheral neurotoxicity: A multifaceted, still unsolved issue. J Peripher Nerv Syst. 2019 Oct;24 Suppl 2:S6-S12 Authors: Cavaletti G, Alberti P, Argyriou AA, Lustberg M, Staff NP, Tamburin S, Toxic Neuropathy Consortium of the Peripheral Nerve Society Abstract Chemotherapy-induced peripheral neurotoxicity (CIPN) is a potentially dose-limiting side effect of several commonly used cytotoxic chemotherapy agents. The main pharmacological...
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Prediagnostic BMI and thyroid cancer incidence in the PLCO trial. Future Oncol. 2019 Oct;15(30):3451-3456 Authors: Abdel-Rahman O Abstract Aim: To assess the correlation between prediagnostic BMI and thyroid cancer risk within the prostate, lung, colorectal and ovary (PLCO) trial. Methods: PLCO trial participants without a history of thyroid cancer before study enrollment who have complete information about prediagnostic BMI were included. Multivariable...
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Related ArticlesIs stereotactic body radiotherapy an alternative to surgery in early stage non small cell lung cancer? J BUON. 2019 Jul-Aug;24(4):1619-1625 Authors: Yaprak G, Ozan Seseogullari O, Dogan Akaslan B, Isik N Abstract PURPOSE: To determine local control and overall survival of patients with medically inoperable early-stage non-small cell lung cancer (NSCLC) treated with stereotactic ablative radiotherapy. METHODS: Included were a...
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Related ArticlesImmune checkpoint inhibitors in mCRPC - rationales, challenges and perspectives. Oncoimmunology. 2019;8(11):e1644109 Authors: Taghizadeh H, Marhold M, Tomasich E, Udovica S, Merchant A, Krainer M Abstract The advancement of immune-therapeutics in cancer treatment has proven to be promising in various malignant diseases. However, in castration resistant prostate cancer (mCRPC) major Phase III trials have been unexpectedly disappointing....
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Related ArticlesTrial watch: dendritic cell vaccination for cancer immunotherapy. Oncoimmunology. 2019;8(11):e1638212 Authors: Sprooten J, Ceusters J, Coosemans A, Agostinis P, De Vleeschouwer S, Zitvogel L, Kroemer G, Galluzzi L, Garg AD Abstract Dendritic- cells (DCs) have received considerable attention as potential targets for the development of anticancer vaccines. DC-based anticancer vaccination relies on patient-derived DCs pulsed with a source...
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Related ArticlesEarly toxicity and treatment outcomes of extended field-intensity modulated radiotherapy for cervical cancer patients with para-aortic nodal metastasis. Ecancermedicalscience. 2019;13:957 Authors: Gupta M, Chopra S, Kunder S, Dheera A, Sampathirao D, Engineer R, Ghosh J, Gurram L, Mahantshetty U, Gupta S, Shrivastava S Abstract Objective: Extended-field radiotherapy (EFRT) with concurrent chemotherapy represents standard treatment in...
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Related ArticlesEffect of radiation dose to the periventricular zone and subventricular zone on survival in anaplastic gliomas. Ecancermedicalscience. 2019;13:956 Authors: Valiyaveettil D, Malik M, Joseph DM Abstract Purpose: Evidence suggests a correlation of subventricular zone (SVZ) irradiation on survival. Most of the data have been analysed in glioblastoma patients. The aim of this study is to analyse the dose to the subventricular and periventricular...
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Related ArticlesIdentification of genes of four malignant tumors and a novel prediction model development based on PPI data and support vector machines. Cancer Gene Ther. 2019 Oct 23;: Authors: Li M, Wang P, Zhang N, Guo L, Feng YM Abstract Triple-negative breast cancer (TNBC), colon adenocarcinoma (COAD), ovarian cancer (OV), and glioblastoma multiforme (GBM) are common malignant tumors, in which significant challenges are still faced in early diagnosis,...
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Related ArticlesAcetyl-CoA carboxylase (ACC) as a therapeutic target for metabolic syndrome and recent developments in ACC1/2 inhibitors. Expert Opin Investig Drugs. 2019 Oct;28(10):917-930 Authors: Chen L, Duan Y, Wei H, Ning H, Bi C, Zhao Y, Qin Y, Li Y Abstract Introduction: Acetyl-CoA Carboxylase (ACC) is an essential rate-limiting enzyme in fatty acid metabolism. For many years, ACC inhibitors have gained great attention for developing therapeutics...
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Related ArticlesPharmacotherapy for liposarcoma: current state of the art and emerging systemic treatments. Expert Opin Pharmacother. 2019 Aug;20(12):1503-1515 Authors: Suarez-Kelly LP, Baldi GG, Gronchi A Abstract Introduction: Liposarcomas are a heterogeneous group of soft tissue tumors that arise from adipose tissue and are one of the most common soft tissue sarcomas found in adults. Liposarcomas are subclassified into four subtypes with distinct...
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Related ArticlesEpidemiology and cost of cervical cancer care and prevention in Apulia (Italy), 2007/2016. Ann Ig. 2018 Nov-Dec;30(6):490-501 Authors: Bianchi FP, Gallone MS, Fortunato F, Boccalini S, Martinelli D, Prato R, Tafuri S Abstract BACKGROUND: According to recent estimates, cervical cancer is worldwide the second most common cancer in females and the fourth overall. The number of deaths for cervical cancer is around 7.5% of all female cancer...
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Related ArticlesImpact of the human papillomavirus status on the development of high-grade cervical intraepithelial neoplasia in women negative for intraepithelial lesions or malignancy at the baseline: A 9-year Swedish nested case-control follow-up study. Cancer. 2019 01 15;125(2):239-248 Authors: Fröberg M, Östensson E, Belkić K, Oštrbenk A, Poljak M, Mints M, Arbyn M, Andersson S Abstract BACKGROUND: The causal relation between high-risk human papillomavirus...
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Related ArticlesUsing PARP Inhibitors in the Treatment of Patients With Ovarian Cancer. Curr Treat Options Oncol. 2018 11 15;19(12):1 Authors: Kurnit KC, Coleman RL, Westin SN Abstract OPINION STATEMENT: Use of poly(ADP-ribose) polymerase (PARP) inhibitors has greatly increased over the past 5 years. With several new Food and Drug Administration (FDA) approvals, three PARP inhibitors have entered into standard of care treatment for epithelial ovarian...
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Bronchogenic cyst of the neck in an elder patient: A case report. Int J Surg Case Rep. 2019 Oct 12;64:128-132 Authors: Santos I, Barros J, Lopes T, Mesquita M, Barroso L, Amado I Abstract INTRODUCTION: Bronchogenic cysts are rare malformations, mostly diagnosed in children. We report the rare case of a neck bronchogenic cyst diagnosed in an elderly patient. PRESENTATION OF CASE: The patient complained of a long-standing submental mass. The diagnostic...
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The recommended treatment for cutaneous squamous cell cancer (CuSCC) of the head and neck is Mohs surgical excision or wide local excision. Excision is recommended to a gross surgical margin of 4–6 mm however ...
Fri Oct 25, 2019 03:00
146 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/10/25PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Related ArticlesReduction En-masse of Inguinal Hernia with Incarcerated Bowel: Report of a Rare Case. Am J Case Rep. 2019 Oct 24;20:1562-1565 Authors: Baik J, Lee Y Abstract BACKGROUND Reduction en-masse of an inguinal hernia is a very uncommon condition in which a hernia sac migrates into the preperitoneal space containing an incarcerated bowel loop. CASE REPORT A 76-year-old male patient with a 4-year history of reducible left inguinal hernia complained...
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Related ArticlesProgress in regulatory peptide research. Ann N Y Acad Sci. 2019 Oct 23;: Authors: Zhang L, Eiden LE Abstract The field of regulatory peptide research has developed significant momentum owing to several recent converging trends. Dozens of peptide-based drugs have been approved by the U.S. Food and Drug Administration in the past decade, the majority for the treatment of metabolic disorders, including diabetes. These are the "tip of the...
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TAZ encodes tafazzin, a transacylase essential for cardiolipin formation and central to the etiology of Barth syndrome. Gene. 2019 Oct 21;:144148 Authors: Garlid AO, Schaffer CT, Kim J, Bhatt H, Guevara-Gonzalez V, Ping P Abstract Tafazzin, which is encoded by the TAZ gene, catalyzes transacylation to form mature cardiolipin and shows preference for the transfer of a linoleic acid (LA) group from phosphatidylcholine (PC) to monolysocardiolipin (MLCL)...
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Related ArticlesRadioembolization with 90Y Resin Microspheres of Neuroendocrine Liver Metastases After Initial Peptide Receptor Radionuclide Therapy. Cardiovasc Intervent Radiol. 2019 Oct 23;: Authors: Braat AJAT, Ahmadzadehfar H, Kappadath SC, Stothers CL, Frilling A, Deroose CM, Flamen P, Brown DB, Sze DY, Mahvash A, Lam MGEH Abstract PURPOSE: Peptide receptor radionuclide therapy (PRRT) and radioembolization are increasingly used in neuroendocrine...
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Related ArticlesA systematic review of treatment outcomes in localised and metastatic spermatocytic tumors of the testis. J Cancer Res Clin Oncol. 2019 Oct 23;: Authors: Grogg JB, Schneider K, Bode PK, Wettstein MS, Kranzbühler B, Eberli D, Sulser T, Beyer J, Hermanns T, Fankhauser CD Abstract INTRODUCTION: Because spermatocytic tumors of the testis are rare, only limited evidence exists regarding the malignant potential and the optimal management of...
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Related ArticlesThe landscape of somatic mutation in normal colorectal epithelial cells. Nature. 2019 Oct;574(7779):532-537 Authors: Lee-Six H, Olafsson S, Ellis P, Osborne RJ, Sanders MA, Moore L, Georgakopoulos N, Torrente F, Noorani A, Goddard M, Robinson P, Coorens THH, O'Neill L, Alder C, Wang J, Fitzgerald RC, Zilbauer M, Coleman N, Saeb-Parsy K, Martincorena I, Campbell PJ, Stratton MR Abstract The colorectal adenoma-carcinoma sequence has provided...
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Related ArticlesHistone H3K36I mutation in a metastatic histiocytic tumor of the skull and response to sarcoma chemotherapy. Cold Spring Harb Mol Case Stud. 2019 Oct;5(5): Authors: Snuderl M, Dolgalev I, Heguy A, Walsh MF, Benayed R, Jungbluth AA, Ladanyi M, Karajannis MA Abstract Recurrent somatic missense mutations in histone H3 genes have been identified in subsets of pediatric cancers. H3K36 histone mutations have recently been recognized as oncogenic...
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Related Articles[Leiomyosarcoma of the splenic vein]. Khirurgiia (Mosk). 2019;(10):82-87 Authors: Akhaladze GG, Grebenkin EN, Goncharov SV, Stanoevich US, Abramov AA, Kolesnikov RV, Ragimov VA, Ivanova OA, Makhambetov AZ Abstract Vascular leiomyosarcoma (LMS) is an extremely rare disease. Venous lesion is approximately 5 times more common than arterial. LMS is usually found in retroperitoneal veins and in inferior vena cava. Lesion of the splenic vein...
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Related ArticlesEndometrial carcinoma complicated by malignant pericardial effusion: A case report on the therapeutic regimen. Medicine (Baltimore). 2019 Oct;98(42):e17584 Authors: Liu G, Zhang Q, Li Z, Chen X, Zhang N, Zhang J Abstract RATIONALE: High-stage endometrial carcinoma is an aggressive tumor with a high propensity for distant spread. However, metastases to the pericardium are rare in gynecological cancer, and are usually fatal. PATIENT...
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Related ArticlesGiant paravertebral schwannoma near the lumbar nerve roots with bone destruction: A case report. Medicine (Baltimore). 2019 Oct;98(42):e17341 Authors: Chen H, Xu Q, Zhan P, Liu Y, Dai M, Zhang B Abstract RATIONALE: Schwannomas grow slowly, originating from the Schwann cells of the nerve sheath. Schwannomas of cranial origin have the highest incidence, followed by intraspinal schwannomas. However, paravertebral schwannoma is rare, and...
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Related ArticlesCirculating Tumor Cells: High-Throughput Imaging of CTCs and Bioinformatic Analysis. Recent Results Cancer Res. 2020;215:89-104 Authors: Keomanee-Dizon K, Shishido SN, Kuhn P Abstract Circulating tumor cells (CTCs) represent novel biomarkers, since they are obtainable through a simple and noninvasive blood draw or liquid biopsy. Here, we review the high-definition single-cell analysis (HD-SCA) workflow, which brings together modern methods...
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Related ArticlesCirculating Tumor Cell Enrichment Technologies. Recent Results Cancer Res. 2020;215:25-55 Authors: Boya M, Chu CH, Liu R, Ozkaya-Ahmadov T, Sarioglu AF Abstract Circulating tumor cells (CTCs) are responsible for the metastatic spread of cancer and therefore are extremely valuable not only for basic research on cancer metastasis but also as potential biomarkers in diagnosing and managing cancer in the clinic. While relatively non-invasive...
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Related ArticlesLeptomeningeal Metastases in Renal Cell Carcinoma at Initial Diagnosis: 2 Case Reports and Literature Review. Cancer Invest. 2019;37(9):501-505 Authors: Dridi M, Bouleftour W, Rivoirard R, Dal Col P, Langrand-Escure J, Vassal C, Guillot A Abstract Leptomeningeal metastasis (LM) in solid tumors are rare, even more in renal cell carcinoma (RCC). To date there is a lack of consensual treatment modalities of leptomeningeal metastasis. Furthermore,...
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