Abstract For the proper organization of the six-layered mammalian neocortex it is required that neurons migrate radially from their place of birth towards their designated destination. The molecular machinery underlying this neuronal migration is still poorly understood. The dynein-adaptor protein BICD2 is associated with a spectrum of human neurological diseases, including malformations of cortical development. Previous studies have shown that knockdown of BICD2 interferes with...
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Publication date: Available online 25 October 2019Source: VaccineAuthor(s): Sarah Wood Pallas, Albana Ahmeti, Winthrop Morgan, Iria Preza, Erida Nelaj, Malembe Ebama, Ann Levin, Kathryn E. Lafond, Silvia BinoAbstractBackgroundSince 2012, WHO has recommended influenza vaccination for health care workers (HCWs), which has different costs than routine infant immunization; however, few cost estimates exist from low- and middle-income countries. Albania, a middle-income country, has self-procured influenza...
Publication date: Available online 25 October 2019Source: VaccineAuthor(s): Yong-Myung Kang, Hyun-Kyu Cho, Hyun-Mi Kim, Myoung-Heon Lee, Thanh Long To, Hyun-Mi KangAbstractThe occurrence of severe outbreaks of highly pathogenic avian influenza in Korea led to establishment of a national antigen bank for emergency preparedness. Here, we developed five vaccines for this bank (clade 2.3.2.1C, clade 2.3.4.4A, B, C, and D) by reverse genetics, inactivated them with formalin, and evaluated the protective...
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SUMMARY The mid‐infrared (IR) spectra of human cystic fibrosis (CF) cells acquired by Fourier transform infrared microspectroscopy (microFTIR) were compared to those of non‐CF cells. Within the 1700‐1480cm‐1 spectral domain of amides, unsupervised explorative principal component analysis identified a few variables reflecting quantitative and qualitative vibrations arising from protein secondary structures and amino acid side chains. Their pattern reflected α‐helix to β‐sheet transitions in bronchial...
Abstract Irradiation of femtosecond (fs) pulse lasers in the visible and near‐infrared ranges have been proposed as a promising candidate for inactivating viruses. However, in order to achieve significant virus inactivation, past works have required relatively long irradiation times (1 hour or longer), even for small volumes. Given its advantages compared with other techniques, there is an urgent need to shorten the time required to inactivate viruses using fs laser technology. In this study, we...
ABSTRACT The rapid detection and identification of microorganisms is one of the most important factors in many cases of ill health. The purpose of this study was to determine the fluorescence characteristics of seven oral bacteria using emission spectra with the aim of distinguishing between the bacteria, and to compare fluorescence imaging methods for the direct assessment of oral bacteria. Fluorescence images of each bacterium were obtained under a 405‐nm light source using a two‐filter system....
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Publication date: December 2019Source: Journal of Anthropological Archaeology, Volume 56Author(s): Hadas Goldgeier, Natalie D. Munro, Leore GrosmanAbstractHilazon Tachtit Cave served as a cemetery for at least 28 individuals and an arena for interment rituals and other activities. The nature of the activities in the cave, their frequency and their recurrence over time, demonstrate that this site was an important sacred place on the Late Natufian (ca. 12,000 cal. BP) landscape of the western Galilee...
Publication date: December 2019Source: Journal of Anthropological Archaeology, Volume 56Author(s): Todd J. Kristensen, P. Gregory Hare, Ruth M. Gotthardt, Norman A. Easton, John W. Ives, Robert J. Speakman, Jeffrey T. RasicAbstractLithic provenance analyses offer means to reconstruct ancestral social relationships in Subarctic North America. We summarize sourced obsidian data from 462 archaeological sites in the Yukon and Northwest Territories, Canada, and interpret obsidian distribution through...
Publication date: December 2019Source: Journal of Anthropological Archaeology, Volume 56Author(s): Natacha BucAbstractAlthough the Paraná River wetland includes a high number of Late Holocene archaeological sites from hunter-gatherer groups which share material properties related to a common subsistence strategy, material variability can be seen in the regional scale. Through the analysis of pottery style, some authors have proposed that this could be related to the development of social limits....
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Abstract Background Acute T-cell lymphoblastic leukaemia (T-ALL) is an aggressive disorder derived from immature thymocytes. The variability observed in clinical responses on this type of tumours to treatments, the high toxicity of current protocols and the poor prognosis of patients with relapse or refractory make it urgent to find less toxic and more effective therapies in the context of a personalized medicine of precision. ...
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Abstract Background Non-small cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor (EGFR) mutations often develop brain metastases. Treatment with EGFR-tyrosine kinase inhibitors (TKIs) has shown the effectiveness; however, knowledge of the clinical factors associated with outcomes in NSCLC patients with EGFR mutations remains limited. Methods...
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Abstract Background and objectives The survival rate of patients with advanced oesophageal cancer is very low and can vary significantly, even among patients with the same TNM stage. It is important to look for indicators that are economical and readily available to predict overall survival. The aim of this study was to determine whether lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR) could be potential...
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Abstract To study the clinical presentation, management and mechanism of fractured outer metallic tracheostomy tube presenting as tracheobronchial foreign body. A retrospective chart review patients with fracture outer metallic tracheostomy tube. Data regarding the patients’ demographic data, diagnosis, clinical presentation, type of tracheostomy tube and site of fracture were analyzed. Total 4 cases of fracture outer metallic tracheostomy tube were found. There were 3 males and...
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Publication date: Available online 26 October 2019Source: Addictive BehaviorsAuthor(s): Nicholas C. Glodosky, Carrie CuttlerAbstractYoung adults in the U.S. report high levels of stress which are known to contribute to depression and anxiety. Regular cannabis users frequently cite coping with stress as their primary motivation for use. However, research indicates that coping motives are associated with potentially negative outcomes, including cannabis-related problems and negative affect. Therefore,...
Publication date: Available online 25 October 2019Source: Addictive BehaviorsAuthor(s): Matt Vassar, Sam Jellison, Hannah Wendelbo, Cole WayantAbstractIntroductionTransparent, open scientific research practices aim to improve the validity and reproducibility of research findings. A key component of open science is the public sharing of data and metadata that constitute the basis for research findings.MethodsWe conducted a 6 year cross-sectional investigation of the rates and methods of data sharing...
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Publication date: Available online 25 October 2019Source: BiomaterialsAuthor(s): Zhao Wang, Tao Jia, Qianqian Sun, Ye Kuang, Bin Liu, Mengshu Xu, Hui Zhu, Fei He, Shili Gai, Piaoping YangAbstractThe current conventional photo-therapeutic agents often show low therapy efficacy because of their single treatment model, the limited penetration depth of excitation light and hypoxia in the tumor microenvironment (TME). Herein, a new type of phthalocyanine manganese (MnPcE4) photosensitizer with strong...
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Publication date: Available online 25 October 2019Source: Clinical TherapeuticsAuthor(s): Bereket Molla Tigabu, Majid Davari, Abbas Kebriaeezadeh, Mojtaba Mojtahedzadeh, Kourosh Sadeghi, Farhad Najmeddin, Zahra Jahangard-RafsanjaniAbstractPurposeAlbumin-based fluid therapy in septic shock is a matter of debate and criticism. The aim of this study was to assess the cost-effectiveness of albumin therapy in patients with septic shock.MethodsA retrospective cohort study was conducted in Imam Khomeini,...
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Abstract Background Thymic carcinoma has been classified into 12 subtypes, thymic lymphoepithelioma-like carcinoma (LELC) is a type of them, and has a pathological organization similar to that of lymphoepithelioma, an undifferentiated type of nasopharyngeal carcinoma. According to a report from the International Thymic Malignancy Interest Group (ITMIG), thymic LELC is a rare tumor and accounts for 6% of all thymic carcinoma cases....
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Abstract Microecology is an emerging discipline in recent years. The female reproductive tract is an important microecological region, and its microecological environment can directly affect women’s cervical health. This meta-analysis aimed to analyze the effects of vaginal microecology on Human papillomavirus (HPV) infection and cervical intraepithelial neoplasia (CIN). PubMed and Web of Science were systematically searched for eligible publications from January 2000 to December...
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AbstractThe microbial habitat on leaf surfaces, also called the phyllosphere, is a selective environment for bacteria, harbouring specific phyllosphere bacterial communities (PBCs). These communities influence plant health, plant-community diversity, ecosystem functioning and ecosystem services. Host plants in an urban environment accommodate different PBCs than those in non-urban environments, but previous studies did not address individual urban factors. In this study, the PBC composition and diversity...
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Abstract Background Stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT) are well established local treatment approaches in several cancer settings. Although SBRT is still under investigation for spinal metastases, promising results in terms of a high effectiveness and optimal tolerability have been recently published on this topic. For spinal SBRT, one of the most relevant issues is represented by the inter-observer...
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Abstract Background Previous research revealed that luteolin could improve the activation of alkaline phosphatase (ALP) and osteocalcin in mouse osteoblasts. We aimed to determine the effect of luteolin on osteogenic differentiation of periodontal ligament cells (PDLCs). Methods Cultured human PDLCs (HPDLCs) were treated by luteolin at 0.01,...
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Publication date: Available online 26 October 2019Source: Biosensors and BioelectronicsAuthor(s): Yanjie Chen, Shupei Zhang, Hong Dai, Zhensheng Hong, Yanyu LinAbstractA flexible two-step photoelectrochemical (PEC)–colorimetric immunoassay was proposed for ultrasensitive detection of lipolysis stimulated lipoprotein receptor (LSR) which is found to be closely related to ovarian cancer (OC). In this paper, the Cu nanoclusters (CuNCs) enhanced multiple mixed TiO2 mesocrystals junction (MMMJ) was fabricated...
Publication date: Available online 25 October 2019Source: Biosensors and BioelectronicsAuthor(s): Jhih-Cheng Wang, Yu-Ching Tung, Keishi Ichiki, Hiroaki Sakamoto, Tai-Hua Yang, Shin-ichiro Suye, Han-Sheng ChuangAbstractThe rapid and robust detection of infectious bacteria is vital in sepsis treatment because of their ability to reveal multi-drug resistance. This study presents culture-free and self-driving DNA nanosensors by combining diffusometry and oligonucleotide probes to rapidly detect a lethal...
Publication date: Available online 25 October 2019Source: Biosensors and BioelectronicsAuthor(s): Hazal Kutluk, Richard Bruch, Gerald Urban, Can DincerAbstractMicroRNAs (miRNAs) are important biomarkers for the early detection of various diseases, especially cancer. Therefore, there is a continuing interest in different biosensing strategies that allow for the point-of-care measurement of miRNAs. Almost all miRNA sensors utilize cross-hybridization of the target miRNA with a capture probe for the...
Publication date: Available online 25 October 2019Source: Biosensors and BioelectronicsAuthor(s): Yangxia Han, Jia Chen, Zhan Li, Hongli Chen, Hongdeng QiuAbstractAlkaline phosphatase (ALP) is a membrane-bound enzyme widely present in biological tissues and is extensively used as a biomarker in clinical diagnosis because abnormal ALP levels in organisms are often closely related to many diseases. In order to meet the urgent needs of human health and the development of precision medicine, the classic...
Publication date: Available online 25 October 2019Source: Biosensors and BioelectronicsAuthor(s): Pablo Gallay, Marcos Eguílaz, Gustavo RivasAbstractWe are reporting an original supramolecular architecture based on a rationally designed new nanohybrid with enhanced peroxidase-like activity and site-specific biorecognition properties using avidin-functionalized multi-walled carbon nanotubes (MWCNTs-Av) and Ru nanoparticles (RuNPs). The nanohybrid-electrochemical interface was obtained by drop-coating...
Publication date: Available online 25 October 2019Source: Biosensors and BioelectronicsAuthor(s): Yuanfeng Pang, Jinmaio Shi, Xingsheng Yang, Chongwen Wang, Zhiwei Sun, Rui XiaoAbstractCircling exosomal PD-L1 can be expected as a predictor for the clinical responds of anti-PD-1/PD-L1 therapy. Here, we present a simple method integrating capture and analysis of exosomal PD-L1 directly from serum. Firstly, Fe3O4@TiO2 nanoparticles were used to enrich exosomes through the binding of TiO2 shell and hydrophilic...
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SummarySelf-learning healthcare systems are becoming a reality. As boundaries between research and healthcare delivery become increasingly blurred, there is an emerging opportunity to accelerate learning through the cyclical integration and analysis of patient phenotype, treatment and clinical outcome. Opportunities already exist to save money through the more efficient use of targeted and immune-based therapies Morgillo et al. [11], Zhao et al. [21], Keenan et al. [5], with a self-learning healthcare...
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Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Wei Zhang, Shengqiang Dang, Guangjian Zhang, Haiqi He, Xiaopeng WenAbstractPurposeIL-10, IL-18 and IL-12 are reported to participate in the inflammation process. The potential influences of IL-10, IL-18 and IL-12 polymorphisms on non-small cell lung cancer (NSCLC) risk were explored in this study.MethodsSix candidate SNPs from 500 NSCLC patients and 500 controls were genotyped. The correlation between the...
Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Zongwei Wang, Yuxian Yang, Simo Liu, Juan Feng, Yuanyuan Zhang, Jing Ke, Dong ZhaoAbstractAimsExploring the CD26 expression in peripheral blood and T cells in Hashimoto's thyroiditis with normal thyroid function. And evaluating the association between CD26 expression and TGAb and TPOAb levels.MethodsWe collected peripheral blood and thyroid tissues from healthy controls and HT patients. Then we measured circulating...
Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Xiao Wu, Rong Xue, Hao Peng, Xiaojie Gan, Xu Lu, Wei Yan, Yizhu Tian, Xuhao Ni, Hongbin Shen, Feng Cheng, Xuehao Wang, Xiaoming Wang, Ling LuAbstractTumors escape immune attacks via various mechanisms, among which activation of regulatory pathways in effector immune cells and recruitment of immunosuppressive cells are usually employed. Traf6 is a member of the family of tumor necrosis factor receptor-associated...
Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Christian BaillyAbstractThe drug edaravone (EDA) is prescribed for the treatment of patients with amyotrophic lateral sclerosis or after an acute cerebral infarction. This synthetic pyrazolone derivative is a potent scavenger of oxygen free radicals and also functions as a modulator of transcription factors, repressing NFκB and activating Nrf2, to regulate oxidative stress. EDA displays complementary anti-oxidative...
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Évolution de la pollution atmosphérique urbaine dans 13 grandes villes françaises entre 2008 et 2015
Publication date: Available online 25 October 2019Source: Revue des Maladies RespiratoiresAuthor(s): F. Amrani, J. Prud’homme, C. Maesano, I. Annesi-MaesanoRésuméContexteLa pollution atmosphérique est un enjeu majeur de santé publique et constitue une préoccupation majeure en France et dans le monde. Preuve en est que la pollution de l’air est l’une des 1re préoccupations environnementales des français. Le but de cette étude fut d’établir un suivi des concentrations réelles de différents polluants...
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Abstract Objectives Partial loss of hippocampal striation (PLHS) is recently described in 3 T and 7 T MR imaging as a sensitive indicator of hippocampal sclerosis. Primary objective: We described the demographic characteristics of the population with seizure disorder having PLHS at 1.5 T MR imaging and tried to see the relation of PLHS to the classic signs of hippocampal sclerosis. Secondary objective: PLHS was also looked for in...
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Publication date: Available online 26 October 2019Source: Hearing ResearchAuthor(s): Dongming Wang, Yun Zhou, Jixuan Ma, Lili Xiao, Limin Cao, Min Zhou, Weijia Kong, Zhichao Wang, Wenzhen Li, Meian He, Xiaomin Zhang, Huan Guo, Jing Yuan, Weihong ChenAbstractThe association between shift work and hearing loss is unclear. We aimed to evaluate this association in a Chinese population independently and in combination with occupational noise. A total of 11,196 participants of the Dongfeng-Tongji cohort...
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The use of integrated robotic technology to quantify the spectrum of motor symptoms of Parkinson’s Disease (PD) has the potential to facilitate objective assessment that is independent of clinical ratings. The...
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