Related ArticlesStaphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4+ T cells in cutaneous T-cell lymphoma. Oncoimmunology. 2019;8(11):e1641387 Authors: Blümel E, Willerslev-Olsen A, Gluud M, Lindahl LM, Fredholm S, Nastasi C, Krejsgaard T, Surewaard BGJ, Koralov SB, Hu T, Persson JL, Bonefeld CM, Geisler C, Iversen L, Becker JC, Andersen MH, Woetmann A, Buus TB, Ødum N Abstract Staphylococcus aureus is implicated in disease...
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Related ArticlesTrial watch: dendritic cell vaccination for cancer immunotherapy. Oncoimmunology. 2019;8(11):e1638212 Authors: Sprooten J, Ceusters J, Coosemans A, Agostinis P, De Vleeschouwer S, Zitvogel L, Kroemer G, Galluzzi L, Garg AD Abstract Dendritic- cells (DCs) have received considerable attention as potential targets for the development of anticancer vaccines. DC-based anticancer vaccination relies on patient-derived DCs pulsed with a source...
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Related ArticlesEnhancing direct cytotoxicity and response to immune checkpoint blockade following ionizing radiation with Wee1 kinase inhibition. Oncoimmunology. 2019;8(11):e1638207 Authors: Patel P, Sun L, Robbins Y, Clavijo PE, Friedman J, Silvin C, Van Waes C, Cook J, Mitchell J, Allen C Abstract Tumor cells activate the G2/M cell cycle checkpoint in response to ionizing radiation (IR) and effector immune cell-derived granzyme B to facilitate repair...
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Related ArticlesEvidence for interaction of the NLRP3 inflammasome and Bruton's tyrosine kinase in tumor-associated macrophages: implications for myeloid cell production of interleukin-1beta. Oncoimmunology. 2019;8(11):1659704 Authors: Benner B, Scarberry L, Stiff A, Duggan MC, Good L, Lapurga G, Butchar JP, Tridandapani S, Carson WE Abstract An inflammatory microenvironment has been shown to play an important role in the growth and metastasis of tumors....
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Related ArticlesA theranostic PSMA ligand for PET imaging and retargeting of T cells expressing the universal chimeric antigen receptor UniCAR. Oncoimmunology. 2019;8(11):1659095 Authors: Arndt C, Feldmann A, Koristka S, Schäfer M, Bergmann R, Mitwasi N, Berndt N, Bachmann D, Kegler A, Schmitz M, Puentes-Cala E, Soto JA, Ehninger G, Pietzsch J, Liolios C, Wunderlich G, Kotzerke J, Kopka K, Bachmann M Abstract Chimeric antigen receptor (CAR) T cells have...
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Related ArticlesSuppression of tumor antigen presentation during aneuploid tumor evolution contributes to immune evasion. Oncoimmunology. 2019;8(11):1657374 Authors: Tripathi R, Modur V, Senovilla L, Kroemer G, Komurov K Abstract Anti-tumor immune responses impede tumor formation, and cancers have evolved many mechanisms of immune evasion. Confirming earlier findings, we show that human tumors with high chromosomal instability (CIN+) are significantly...
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A poly-neoantigen DNA vaccine synergizes with PD-1 blockade to induce T cell-mediated tumor control.
Related ArticlesA poly-neoantigen DNA vaccine synergizes with PD-1 blockade to induce T cell-mediated tumor control. Oncoimmunology. 2019;8(11):1652539 Authors: Tondini E, Arakelian T, Oosterhuis K, Camps M, van Duikeren S, Han W, Arens R, Zondag G, van Bergen J, Ossendorp F Abstract The combination of immune-stimulating strategies has the potency to improve immunotherapy of cancer. Vaccination against neoepitopes derived from patient tumor material...
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Related ArticlesIrreversible electroporation of locally advanced pancreatic cancer transiently alleviates immune suppression and creates a window for antitumor T cell activation. Oncoimmunology. 2019;8(11):1652532 Authors: Scheffer HJ, Stam AGM, Geboers B, Vroomen LGPH, Ruarus A, de Bruijn B, van den Tol MP, Kazemier G, Meijerink MR, de Gruijl TD Abstract Purpose: Local tumor ablation through irreversible electroporation (IRE) may offer a novel therapeutic...
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Related ArticlesAnti-tumoral potential of a human granulysin-based, CEA-targeted cytolytic immunotoxin. Oncoimmunology. 2019;8(11):1641392 Authors: Ibáñez-Pérez R, Guerrero-Ochoa P, Al-Wasaby S, Navarro R, Tapia-Galisteo A, De Miguel D, Gonzalo O, Conde B, Martínez-Lostao L, Hurtado-Guerrero R, Sanz L, Anel A Abstract Granulysin is a protein present in the granules of human cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, with cytolytic activity...
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Related ArticlesClinical evidence that immunogenic cell death sensitizes to PD-1/PD-L1 blockade. Oncoimmunology. 2019;8(10):e1637188 Authors: Kepp O, Zitvogel L, Kroemer G Abstract In preclinical in vivo models of cancer, the induction of immunogenic cell death (ICD) sensitizes to subsequent immunotherapy. Several clinical trials now confirm that pretreatment with ICD-inducing anthracyclines sensitizes to immune checkpoint blockade targeting PD-1 and...
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Related ArticlesCD80 expression promotes immune surveillance in Barrett's metaplasia. Oncoimmunology. 2019;8(10):e1636618 Authors: Scarpa M, Fassan M, Kotsafti A, Realdon S, Dall'Olmo L, Morbin T, Cavallin F, Saadeh L, Cagol M, Alfieri R, Castoro C, Rugge M, Castagliuolo I, Scarpa M Abstract Esophageal adenocarcinoma (EAC) is the final step of a pathway starting with esophageal reflux disease, Barrett's metaplasia and Barrett's dysplasia. Positive costimulatory...
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Related ArticlesMetformin as an archetype immuno-metabolic adjuvant for cancer immunotherapy. Oncoimmunology. 2019;8(10):e1633235 Authors: Verdura S, Cuyàs E, Martin-Castillo B, Menendez JA Abstract The development of a single immuno-metabolic adjuvant capable of modulating, in the appropriate direction and intensity, the complex antagonistic and symbiotic interplays between tumor cells, immune cells, and the gut microbiota may appear pharmacologically...
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Related ArticlesConstitutively active GSK3β as a means to bolster dendritic cell functionality in the face of tumour-mediated immune suppression. Oncoimmunology. 2019;8(10):e1631119 Authors: López González M, Oosterhoff D, Lindenberg JJ, Milenova I, Lougheed SM, Martiáñez T, Dekker H, Quixabeira DCA, Hangalapura B, Joore J, Piersma SR, Cervera-Carrascon V, Santos JM, Scheper RJ, Verheul HMW, Jiménez CR, Van De Ven R, Hemminki A, Van Beusechem VW, De Gruijl TD ...
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Related ArticlesExpression of MHC class I, HLA-A and HLA-B identifies immune-activated breast tumors with favorable outcome. Oncoimmunology. 2019;8(10):e1629780 Authors: Noblejas-López MDM, Nieto-Jiménez C, Morcillo García S, Pérez-Peña J, Nuncia-Cantarero M, Andrés-Pretel F, Galán-Moya EM, Amir E, Pandiella A, Győrffy B, Ocana A Abstract Antigen recognition by MHC class I molecules is a key step for the initiation of the immune response. We hypothesized...
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Related ArticlesIncreased CMTM6 can predict the clinical response to PD-1 inhibitors in non-small cell lung cancer patients. Oncoimmunology. 2019;8(10):e1629261 Authors: Koh YW, Han JH, Haam S, Jung J, Lee HW Abstract CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) plays a crucial role in the stability of the programmed death-ligand 1 (PD-L1). However, there has been no previous study of CMTM6 in non-small cell lung cancer (NSCLC) and its...
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Related ArticlesMiRNA expression patterns are associated with tumor mutational burden in lung adenocarcinoma. Oncoimmunology. 2019;8(10):e1629260 Authors: Lv Y, Huang Z, Lin Y, Fang Y, Chen Z, Pan L, Zhang Y, Xu Z Abstract Background: Tumor mutational burden (TMB) has emerged as an independent biomarker to predict patient responses to treatment with immune checkpoint inhibitors (ICIs) for lung adenocarcinoma (LUAD). MicroRNAs (miRNAs) have a crucial...
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Related ArticlesAutoinducer-2 of gut microbiota, a potential novel marker for human colorectal cancer, is associated with the activation of TNFSF9 signaling in macrophages. Oncoimmunology. 2019;8(10):e1626192 Authors: Li Q, Peng W, Wu J, Wang X, Ren Y, Li H, Peng Y, Tang X, Fu X Abstract Objectives: The interaction between the quorum sensing (QS) molecules of gut microbiota and the immunity of colorectal cancer (CRC) has not been investigated before....
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Related ArticlesEnhancement of diagnostic performance in lung cancers by combining CEA and CA125 with autoantibodies detection. Oncoimmunology. 2019;8(10):e1625689 Authors: Zang R, Li Y, Jin R, Wang X, Lei Y, Che Y, Lu Z, Mao S, Huang J, Liu C, Zheng S, Zhou F, Wu Q, Gao S, Sun N, He J Abstract Objectives: Although low-dose computed tomography has been confirmed to have meaningful diagnostic utility, lung cancer is still the leading cause of cancer-related...
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Related ArticlesIntratumorally delivered formulation, INT230-6, containing potent anticancer agents induces protective T cell immunity and memory. Oncoimmunology. 2019;8(10):e1625687 Authors: Bloom AC, Bender LH, Tiwary S, Pasquet L, Clark K, Jiang T, Xia Z, Morales-Kastresana A, Jones JC, Walters I, Terabe M, Berzofsky JA Abstract The benefits of anti-cancer agents extend beyond direct tumor killing. One aspect of cell death is the potential to release...
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Related ArticlesCaloric restriction promotes the stemness and antitumor activity of T lymphocytes. Oncoimmunology. 2019;8(10):e1616153 Authors: Pietrocola F, Kroemer G Abstract Recent findings have shed new light on the mechanisms through which tumor-infiltrating lymphocytes (TILs) maintain their cytotoxic potential in the context of checkpoint blockade or adoptive transfer therapies. As a consequence of the ionic unbalance occurring in the tumor microenvironment,...
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Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Fri Oct 25, 2019 10:00
Tissue Engineering Part A, Ahead of Print.
Fri Oct 25, 2019 10:00
Abstract To investigate the effects of photobiomodulation applied to respiratory muscles on lung function, thoracoabdominal mobility, respiratory muscle strength, and functional capacity in COPD patients. This is a randomized double-blind crossover clinical trial. Twelve male COPD patients participated in the study. Participants were randomly allocated to receive two photobiomodulation sessions, 1 week apart: (1) an effective photobiomodulation session applied at the main respiratory...
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Related Articles[Recent advances in nephronectin]. Sheng Li Xue Bao. 2019 Oct 25;71(5):799-805 Authors: Qian GQ, Yang NB, Shi JJ Abstract Nephronectin (NPNT) is a novel extracellular matrix protein and a new ligand of integrin α8β1. Recent studies showed that NPNT is highly expressed in kidney, lung, thyroid, etc, and it may play an important role in many pathological conditions. NPNT is involved in the process of kidney development and acute kidney...
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Related Articles[Caveolin-1: oxidative stress target in tumor cells]. Sheng Li Xue Bao. 2019 Oct 25;71(5):792-798 Authors: Wang WH, Li HY, Qu C, Zhang YJ, Zou W Abstract Aberrant oxidative metabolism in cells is one of the hallmarks of cancer. Overproduction of reactive species promotes carcinogenesis by inducing genetic mutations and activating oncogenic pathways, and thus, antioxidant therapy is considered as an important strategy for cancer prevention...
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Related Articles[Research advances in relationship between biological clock and cardiovascular diseases]. Sheng Li Xue Bao. 2019 Oct 25;71(5):783-791 Authors: Jiang TT, Ji S, Yang GR, Chen LH Abstract Circadian rhythms widely exist in living organisms, and they are regulated by the biological clock. Growing evidence has shown that circadian rhythms are tightly related to the physiological function of the cardiovascular system, including blood pressure,...
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Related Articles[Advance in effect of aerobic exercise on immune system and autoimmune diseases]. Sheng Li Xue Bao. 2019 Oct 25;71(5):769-782 Authors: Xie Y, Wang JP Abstract Autoimmune diseases are a kind of chronic diseases with unclear etiology, which has the characteristics of repetition and difficulty to cure completely. Aerobic exercise, as an effective intervention method for chronic diseases, has also received extensive attention in the field...
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Related Articles[The brain imaging studies of obstructive sleep apnea: evidence from resting-state EEG and fMRI]. Sheng Li Xue Bao. 2019 Oct 25;71(5):760-768 Authors: Wan XY, Zhao WR, Wu XR, Chen XY, Lei X Abstract Obstructive sleep apnea (OSA) is a common clinic sleep disorder, and characterized by obstruction of upper airway during sleep, resulting in sleep fragmentation and intermittent hypoxemia. We reviewed the brain imaging studies in OSA patients...
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Related Articles[Influence of general anesthetic exposure in developing brain on cognition and the underlying mechanisms]. Sheng Li Xue Bao. 2019 Oct 25;71(5):749-759 Authors: Zhao X, Hao LJ, Zhang YT, Zhang Y, Zhang C Abstract With the evolution of medical techniques and technology, an increasing number of infants, neonates, and fetuses are exposed to general anesthesia for clinical diagnostic and therapeutic process. The neurotoxic effects of general...
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Related Articles[Involvement of intrathecal activation of MrgC receptor in pathological pain and morphine tolerance]. Sheng Li Xue Bao. 2019 Oct 25;71(5):741-748 Authors: Li YP, Jiang JP Abstract Rodent MrgC receptor (Mas-related G-protein-coupled receptor subtype C) shares 65% sequence homology and similarities in terms of expression pattern and binding profile with human Mas-related gene X receptor 1 (hMrgX1). Therefore, researchers generally explore...
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Related Articles[Research progress on neural mechanism of peripheral inflammation in Parkinson's disease]. Sheng Li Xue Bao. 2019 Oct 25;71(5):732-740 Authors: Liu YT, Sun MH, Cai CW, Ren C, Niu HC Abstract Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by loss of dopaminergic (DA) neurons in the dense part of the substantia nigra (SNpc). Postmortem analysis of PD patients and experimental animal studies found...
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Related Articles[Anti-injury effect of hydrogen-enriched water in a rat model of liver injury induced by aflatoxin B1]. Sheng Li Xue Bao. 2019 Oct 25;71(5):725-731 Authors: Hu HL, Gao J, Guo WJ, Zhou FH, Liu HY, Su CC Abstract The purpose of this study was to investigate the anti-injury effect and protective mechanism of hydrogen-enriched water in a rat model of acute liver injury induced by aflatoxin B1 (AFB1). Healthy male Sprague-Dawley (SD) rats...
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Related Articles[IL-6 inhibits colonic longitudinal muscle contraction by inactivating L-type calcium channel in rats with pancreatitis]. Sheng Li Xue Bao. 2019 Oct 25;71(5):717-724 Authors: Tang Y, Liang SW, Quan XJ, Luo HS, Liu Y Abstract The aim of this study was to investigate the effect of interleukin 6 (IL-6) on the contraction of colon longitudinal muscle strips in rats with acute pancreatitis (AP) and its underlying mechanism. Rat AP model was...
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Related Articles[Differences of brain pathological changes and cognitive function after bilateral common carotid artery occlusion between Sprague-Dawley and Wistar rats]. Sheng Li Xue Bao. 2019 Oct 25;71(5):705-716 Authors: Sun W, Geng Y, Chen YT, Tang XH, Zhang YJ, Gu SH, Xie JJ, Zhang ZA, Tian XS Abstract The aim of the present study was to investigate the differences of the pathological changes and cognitive function after bilateral common carotid...
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Related Articles[Activation of the JAK/STAT signal pathway may be involved in DNA damage of A549 cells induced by X-ray]. Sheng Li Xue Bao. 2019 Oct 25;71(5):698-704 Authors: Peng LQ, Li CH, Mao B Abstract The aim of this study was to investigate the relationship between the effects of different doses of X-rays on DNA damage and JAK/STAT signaling pathway activation in A549 cells. The A549 cells were radiated with X-rays at doses of 2, 4, and 8 Gy. The...
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Related ArticlesFerroptosis was involved in the oleic acid-induced acute lung injury in mice. Sheng Li Xue Bao. 2019 Oct 25;71(5):689-697 Authors: Zhou H, Li F, Niu JY, Zhong WY, Tang MY, Lin D, Cui HH, Huang XH, Chen YY, Wang HY, Tu YS Abstract The aim of the present study was to investigate the role of ferroptosis in acute lung injury (ALI) mouse model induced by oleic acid (OA). ALI was induced in the mice via the lateral tail vein injection of pure...
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Related ArticlesDual role of polyamines in heart ischemia/reperfusion injury through regulation of mitochondrial permeability transition pore. Sheng Li Xue Bao. 2019 Oct 25;71(5):681-688 Authors: Chen HY, Jia XL, Zhao SQ, Zheng WH, Mei ZG, Yang HW, Zhang SZ Abstract Polyamines (putrescine, spermidine, and spermine) are essential polycations that play important roles in various physiological and pathophysiological processes in mammalian cells. The study...
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Related ArticlesOtorhinolaryngological profile and surgical intervention in patients with HIV/AIDS. Sci Rep. 2018 08 13;8(1):12045 Authors: Bao S, Shao S Abstract Little is known about the diagnosis and surgical management of head and neck conditions in patients with HIV/AIDS. This study was conducted to characterize the otorhinolaryngological (ORL) profiles, surgical interventions and outcomes in patients with HIV/AIDS. This retrospective study included...
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