Objectives/Hypothesis The incidence of cognitive impairment (CI) in the elderly general population is 10% to 20%. The incidence of CI in the elderly laryngology treatment–seeking population is unknown, and CI may impact decision making for elective medical/surgical treatment and negatively impact the outcome of voice/swallowing therapy. We sought to determine the prevalence of CI in elderly patients who are seeking laryngology care and to evaluate the feasibility of administering a cognitive screening...
Sinus, cold, and allergy remedies comprise the most widely used sector of the over‐the‐counter (OTC) drug market. Direct‐to‐consumer advertising (DTCA) of pharmaceutical products has increased over the past 30 years, including the promotion of OTC drugs. The influence of DTCA on OTC sinonasal remedies comprises several positive and negative effects. Favorable aspects of this influence include empowerment and promotion of autonomy among patients, avoidance of low‐value clinical encounters, self‐directed...
Mark above section as read
The purpose of this systematic review was to evaluate implant survival in irradiated nasal, auricular, orbital sites and to compare them with non-irradiated respective sites. Four electronic databases and seven related journals were searched until December and March 2018, respectively. A total of 7892 articles were identified, 18 of which were included in this review; one non-randomized clinical trial, two prospective cohort, eight retrospective cohort and seven cross-sectional studies. Using the...
Mark above section as read
Ticagrelor is an antiplatelet agent used for treatment of coronary artery disease [1] and it reversibly inhibits platelet function via P2Y12 receptor [2]. There is limited literature on intravenous thrombolysis for ischemic stroke in patients taking ticagrelor. Two cases of symptomatic intracranial hemorrhage and one case of retropharyngeal hematoma have been reported [2,3]. It is likely that more patients taking ticagrelor will present with acute ischemic stroke who may otherwise be eligible for...
Mark above section as read
K-singular value decomposition (K-SVD) is a frequently used dictionary learning (DL) algorithm that iteratively works between sparse coding and dictionary updating. The sparse coding process generates sparse c...
Mark above section as read
Abstract We would like to express our gratitude to Dr Lo for his insightful comments on our study.1 We fully acknowledge the role of endoscopic examinations in addition to variceal screening, such as to detect other upper gastrointestinal pathologies (e.g. peptic ulcer, portal hypertensive gastrolatry etc).2 Hence upper endoscopy should be offered to any cirrhotic patients who have clinical features of these pathologies, namely epigastric pain, anaemia, melaena or per rectal bleeding.
Abstract Renal dysfunction is common in liver cirrhosis and it is associated with poor prognosis. However, we still have major limitations when assessing renal function in cirrhotic patients. Current available methods are biased and have a tendency to consistently overestimate glomerular filtration rates (GFR).
Abstract ARC‐520, the first RNA interference (RNAi) therapeutic was designed to reduce all RNA transcripts derived from cccDNA, leading to a reduction in viral antigens and HBV DNA. We aimed to evaluate the depth of hepatitis B surface antigen (HBsAg) decline in response to multiple doses of ARC‐520 compared to placebo (PBO) in two randomized, multi‐center studies in nucleoside/nucleotide (NUC) experienced patients with hepatitis B e antigen negative (E‐neg) or positive (E‐pos) disease. A total...
Mark above section as read
Should hospitals stock Andexxa? EMCrit Project by Scott Weingart.
Mark above section as read
Abstract Transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) is widely used to study the reactivity and connectivity of brain regions for clinical or research purposes. The electromagnetic pulse of the TMS device generates at the instant of administration an artifact of large amplitude and a duration up to tens of milliseconds that overlaps with brain activity. Methods for TMS artifact correction have been developed to remove the artifact and recover...
Mark above section as read
Background Accurate preoperative assessment of the pathological grade of hepatocellular carcinoma (HCC) could greatly benefit prognostic predictions. Purpose To assess and compare the diagnostic accuracy of the apparent diffusion coefficient (ADC) and tissue diffusivity (D) for the noninvasive pathological grading of HCC. Study Type Meta‐analysis. Data Sources PubMed/Medline, EMBASE, the Web of Science, and the Cochrane Library were searched to find related original articles published...
Background Quantitative diffusion MRI is a promising technique for evaluating peripheral nerve integrity but low signal‐to‐noise ratio (SNR) can impede measurement accuracy. Purpose To evaluate principal component analysis (PCA) and generalized spherical deconvolution (genSD) denoising techniques to improve within‐subject reproducibility and peripheral nerve conspicuity. Study Type Prospective. Subjects Seven healthy volunteers and three peripheral neuropathy patients. Field...
Background Glioblastoma (GBM) is the most aggressive primary brain tumor, characterized by a heterogeneous and abnormal vascularity. Subtypes of vascular habitats within the tumor and edema can be distinguished: high angiogenic tumor (HAT), low angiogenic tumor (LAT), infiltrated peripheral edema (IPE), and vasogenic peripheral edema (VPE). Purpose To validate the association between hemodynamic markers from vascular habitats and overall survival (OS) in glioblastoma patients, considering...
Background In mitral valve dysfunction, noninvasive measurement of transmitral blood flow is an important clinical examination. Flow imaging of the mitral valve, however, is challenging, since it moves in and out of the image plane during the cardiac cycle. Purpose To more accurately measure mitral flow, a slice‐following MRI phase contrast sequence is proposed. This study aimed to implement such a sequence, validate its slice‐following functionality in a phantom and healthy subjects, and...
Mark above section as read
Publication date: Available online 25 October 2019Source: Seminars in OrthodonticsAuthor(s): Lysle E. Johnston
Mark above section as read
Polo-like kinase 3 (PLK3) has been documented as a tumor suppressor in several types of malignancies. However, the role of PLK3 in colorectal cancer (CRC) progression and glucose metabolism remains to be known.
Mark above section as read
Carbon fluxes in the cryosphere are hardly assessed yet but are crucial regarding climate change. Here we show a novel prototype device that captures the phototrophic potential in supraglacial environments based on laser-induced fluorescence emission (L.I.F.E.) technology offering high spectral and spatial resolution data under in situ conditions.
Conducting in vitro experiments to reflect in vivo conditions as adequately as possible is not an easy task. The use of primary cell cultures is an important step toward understanding cell biology in a whole organism. The provided protocol outlines how to successfully grow and culture embryonic mouse cerebellar neurons.
Here we present a training and testing system where a trainee can complete manual vascular reconstruction in vitro individually using a magnetic anchoring technique. The system can also be used to test the quality of reconstruction.
Here, we present a protocol to establish a replicable conductive hearing loss induction via surgical tympanic membrane puncture and verification by otoscope visualization and behavioral assessment by clap startle.
Mark above section as read
Publication date: Available online 25 October 2019Source: Journal of Human EvolutionAuthor(s): Guido Bataille, Armando Falcucci, Yvonne Tafelmaier, Nicholas J. Conard
Mark above section as read
Publication date: Available online 25 October 2019Source: Behavioural Brain ResearchAuthor(s): Sakineh Alizadeh Golsorkhdan, Mahdi Eskandarian Boroujeni, Abbas Aliaghaei, Mohammad Amin Abdollahifar, Afshar Ramezanpour, Reza Nejatbakhsh, Iraj Jafari Anarkooli, Elahe Barfi, Mohammad Javad FridoniAbstractMethamphetamine (METH) is a strong psychostimulant drug which can essentially affect different brain regions. Hippocampus as one of main components of limbic system plays key roles in processing of...
Mark above section as read
Pulmonary lobectomy has been a well-established curative treatment method for localized lung cancer. After left upper pulmonary lobectomy, the upward displacement of remaining lower lobe causes the distortion ...
The activation of stretch-activated channels (SACs) in cardiac myocytes, which changes the phases of action potential repolarization, is proven to be highly efficient for the conversion of atrial fibrillation....
Quantitative ultrasound has been used for the assessment of cancellous bone status. The attenuation mechanisms of cancellous bone, however, have not been well understood, because the microstructure of cancello...
Mark above section as read
Abstract Schistosomiasis is a neglected chronic parasitic disease with a significant lasting morbidity. Currently, praziquantel (PZQ) is the most efficient drug for schistosomiasis worldwide. However, the possibility of the occurrence of resistance to PZQ is increasing. Therefore, there is a vital need to find new antischistosomal drugs or to increase the efficacy of the existing ones. Omeprazole is a proton pump inhibitor which is reported to have antiparasitic properties. Thus,...
Chrysomya bezziana : a case report in a dog from Southern China and review of the Chinese literature
Abstract Chrysomya bezziana is an obligate, myiasis-causing fly in humans and warm-blooded animals throughout the tropical and subtropical Old World. We report a case of cutaneous myiasis due to C. bezziana in a dog from Guangxi province in China. A total of 35 maggots were removed from the lesions. Direct sequencing of the mitochondrial cytochrome b gene showed that the specimen belonged to haplotype CB_bezz02, which was previously reported in Malaysia and the Gulf region. This...
Mark above section as read
Publication date: Available online 25 October 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): A. Sayan, V. Ilankovan
Publication date: Available online 25 October 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): C.W. Yong, J.L. Lum, A. Makmur, J.E. Seet, A.A.T. LimAbstractAcinic cell adenocarcinoma (ACA) is a malignant epithelial neoplasm of the salivary glands. The patient reported herein presented with an unusual case of a metastatic ACA originating from the right parapharyngeal region, which eventually metastasized to the ipsilateral cavernous sinus and the contralateral mandibular...
Mark above section as read
Abstract Aging is associated with increased oxidative stress in vascular endothelial and smooth muscle cells, which contribute to the development of a wide range of diseases affecting the circulatory system in older adults. There is growing evidence that in addition to increased production of reactive oxygen species (ROS), aging critically impairs pathways determining cellular resilience to oxidative stressors. In young organisms, the evolutionarily conserved nuclear factor-erythroid-2-related...
15h
Mark above section as read
Abstract Objectives Partial loss of hippocampal striation (PLHS) is recently described in 3 T and 7 T MR imaging as a sensitive indicator of hippocampal sclerosis. Primary objective: We described the demographic characteristics of the population with seizure disorder having PLHS at 1.5 T MR imaging and tried to see the relation of PLHS to the classic signs of hippocampal sclerosis. Secondary objective: PLHS was also looked for in...
Mark above section as read
Publication date: December 2019Source: Ultrasound in Medicine & Biology, Volume 45, Issue 12Author(s):
Publication date: December 2019Source: Ultrasound in Medicine & Biology, Volume 45, Issue 12Author(s):
Publication date: December 2019Source: Ultrasound in Medicine & Biology, Volume 45, Issue 12Author(s):
Publication date: December 2019Source: Ultrasound in Medicine & Biology, Volume 45, Issue 12Author(s):
Publication date: Available online 25 October 2019Source: Ultrasound in Medicine & BiologyAuthor(s): Adam Kositsky, Basílio A.M. Gonçalves, Lauri Stenroth, Rod S. Barrett, Laura E. Diamond, David J. SaxbyAbstractThe purpose of this study was to determine the reliability and validity of ultrasonography for measurement of hamstring muscle and semitendinosus (ST) tendon cross-sectional area (CSA). On two consecutive days, muscle anatomical CSA (ACSA) and ST tendon CSA were measured at standardized...
Publication date: Available online 25 October 2019Source: Ultrasound in Medicine & BiologyAuthor(s): Wei Dong, Pengying Wu, Di Zhou, Jixiu Huang, Mengfan Qin, Xinxing Yang, Mingxi Wan, Yujin ZongAbstractThe PIK3 CA gene encodes the p110α protein subunit and is one of the most efficient cancer genes in solid and hematological tumors including hepatocellular carcinoma (HCC). There are currently ongoing therapies against tumors based on PIK3 CA inhibition. Because microRNAs (miRNAs) play an important...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου