Employer-Mandated Obstructive Sleep Apnea Treatment and Healthcare Cost Savings among Truckers. Sleep. 2019 Oct 24;: Authors: Burks SV, Anderson JE, Panda B, Haider R, Ginader T, Sandback N, Pokutnaya D, Toso D, Hughes N, Haider HS, Brockman R, Toll A, Solberg N, Eklund J, Cagle M, Hickman JS, Mabry E, Berger M, Czeisler CA, Kales SN Abstract OBJECTIVE: To evaluate the effect of an employer-mandated obstructive sleep apnea (OSA) diagnosis and treatment...
Susceptibility of Cervical Spinal Stenosis to Hypoxic Ischemic Cord Injury. World Neurosurg. 2019 Oct 21;: Authors: Shah LM, Bisson EF Abstract BACKGROUND: The adult spinal cord is typically resistant to hypoxic ischemic injury (HII) because of collateral blood supply; however, congenital or acquired stenosis may result in baseline maximal vasodilatation, such as superimposed hemodynamic stresses, that cannot be accommodated, leaving the spinal cord...
Comprehensive management of obstructive sleep apnea by telemedicine: Clinical improvement and cost-effectiveness of a Virtual Sleep Unit. A randomized controlled trial. PLoS One. 2019;14(10):e0224069 Authors: Lugo VM, Garmendia O, Suarez-Girón M, Torres M, Vázquez-Polo FJ, Negrín MA, Moraleda A, Roman M, Puig M, Ruiz C, Egea C, Masa JF, Farré R, Montserrat JM Abstract INTRODUCTION: Obstructive sleep apnea (OSA) is a prevalent disease associated with...
Genioglossus muscle responses to resistive loads in severe OSA patients and healthy controls. J Appl Physiol (1985). 2019 Oct 24;: Authors: Ruehland WR, Rochford PD, Pierce RJ, Trinder JA, Jordan AS, Cori JM, O'Donoghue FJ Abstract This study aimed to determine whether there was impairment of genioglossus neuromuscular responses to small negative pressure respiratory stimuli, close to the conscious detection threshold, in obstructive sleep apnea (OSA)....
Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, and Heart Failure with Preserved Ejection Fraction: A Cardiopulmonary Perspective. Am J Respir Crit Care Med. 2019 Oct 24;: Authors: Mehmood M PMID: 31647719 [PubMed - as supplied by publisher]
The Effects of Obstructive Sleep Apnea on Risk factors for Cardiovascular diseases. Ear Nose Throat J. 2019 Oct 24;:145561319882548 Authors: Jung JH, Park JW, Kim DH, Kim ST Abstract INTRODUCTION: Obstructive sleep apnea (OSA) is known to cause variety of cardiovascular diseases. OBJECTIVE: The aim of this study was to examine the correlation between polysomnography (PSG) and risks factor for coronary heart disease in patients suspected to have...
Related ArticlesFeasibility of automated detection of sleep apnea using implantable pacemakers and defibrillators: a comparison with simultaneous polysomnography recording. J Interv Card Electrophysiol. 2019 Oct 23;: Authors: Della Rocca DG, Albanese M, Placidi F, Forle GB, Di Biase L, Ribatti V, Santini L, Izzi F, Cicchini L, Lovecchio M, Valsecchi S, Lavalle C, Natale A, Mercuri NB, Romigi A Abstract PURPOSE: Sleep-related breathing disorders (SRBD)...
Related ArticlesGender differences in clinical manifestations and polysomnographic findings in Chinese patients with obstructive sleep apnea. Sleep Breath. 2019 Oct 23;: Authors: Zhang Z, Cheng J, Yang W, Zou H, Su C, Miao J Abstract PURPOSE: The gender differences in patients with obstructive sleep apnea (OSA) are not fully understood so far, as previous studies had conflicting results. No reports have addressed the differences in OSA between Chinese...
Related Articles[The brain imaging studies of obstructive sleep apnea: evidence from resting-state EEG and fMRI]. Sheng Li Xue Bao. 2019 Oct 25;71(5):760-768 Authors: Wan XY, Zhao WR, Wu XR, Chen XY, Lei X Abstract Obstructive sleep apnea (OSA) is a common clinic sleep disorder, and characterized by obstruction of upper airway during sleep, resulting in sleep fragmentation and intermittent hypoxemia. We reviewed the brain imaging studies in OSA patients...
Related ArticlesDe novo ZBTB7A variant in a patient with macrocephaly, intellectual disability, and sleep apnea: implications for the phenotypic development in 19p13.3 microdeletions. J Hum Genet. 2019 Oct 23;: Authors: Ohishi A, Masunaga Y, Iijima S, Yamoto K, Kato F, Fukami M, Saitsu H, Ogata T Abstract Interstitial microdeletions at chromosome 19p13.3 are frequently associated with a constellation of clinical features including macrocephaly, characteristic...
Related ArticlesOrthodontic Removable Appliance with Posterior Bite Plane Use is not Associated with Developing Sleep-Disordered Breathing Symptoms in Healthy Children. J Dent Child (Chic). 2019 Sep 15;86(3):145-149 Authors: Changsiripun C, Tokavanich N, Almeida FR Abstract Purpose: The purpose of this study was to assess the development of sleep-disordered breathing (SDB) symptoms and the relationship between the amount of increased vertical dimension...
Related ArticlesDiagnostic Accuracy of Positive Airway Pressure Device for Sleep Apnea Detection in Acute Stroke Patients. Stroke. 2019 Oct 24;:STROKEAHA119027141 Authors: Camilo MR, Machado LA, Castilho CM, Sander HH, Eckeli AL, Fernandes RF, Leite JP, Pontes-Neto OM Abstract Background and Purpose- Sleep apnea has been associated with a poor outcome in acute stroke patients. Polysomnography is the gold standard diagnostic method for sleep apnea, but...
Related ArticlesCase report by Toce and co-authors: Have all the reasons for poor morphine glucuronidation been addressed? Br J Clin Pharmacol. 2019 04;85(4):859-860 Authors: Finel M, Järvinen E PMID: 30737810 [PubMed - indexed for MEDLINE]
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Long-term swallowing outcomes following type 1 laryngeal cleft injection. Int J Pediatr Otorhinolaryngol. 2019 Oct 15;128:109731 Authors: Miller AL, Caloway C, Hersh CJ, Hartnick CJ Abstract INTRODUCTION: Interarytenoid injection augmentation (IIA) during initial diagnostic endoscopy for aspiration and dysphagia has been described as both a diagnostic and therapeutic technique in the evaluation of type 1 laryngeal cleft (LC-1). IIA is additionally hypothesized...
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Related ArticlesHighlights from the Current Issue: January 2019. Otolaryngol Head Neck Surg. 2019 01;160(1):6-7 Authors: Krouse JH PMID: 30798738 [PubMed - indexed for MEDLINE]
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Ventriloquist Illusion Produced With Virtual Acoustic Spatial Cues and Asynchronous Audiovisual Stimuli in Both Young and Older Individuals. Multisens Res. 2019 Jan 01;32(8):745-770 Authors: Stawicki M, Majdak P, Başkent D Abstract Ventriloquist illusion, the change in perceived location of an auditory stimulus when a synchronously presented but spatially discordant visual stimulus is added, has been previously shown in young healthy populations to be...
TRIP13 interference inhibits the proliferation and metastasis of thyroid cancer cells through regulating TTC5/p53 pathway and epithelial-mesenchymal transition related genes expression. Biomed Pharmacother. 2019 Oct 21;120:109508 Authors: Yu L, Xiao Y, Zhou X, Wang J, Chen S, Peng T, Zhu X Abstract This study aimed to investigate the effect of interfering thyroid hormone receptor interacting protein 13 (TRIP13) expression on the proliferation, apoptosis...
Patritumab or placebo, with cetuximab plus platinum therapy in recurrent or metastatic squamous cell carcinoma of the head and neck: A randomised phase II study. Eur J Cancer. 2019 Oct 21;123:36-47 Authors: Forster MD, Dillon MT, Kocsis J, Remenár É, Pajkos G, Rolland F, Greenberg J, Harrington KJ Abstract BACKGROUND: The fully human monoclonal antibody patritumab blocks HER3 activation, a resistance mechanism to cetuximab, induced by heregulin (HRG)....
The Tripod Concept of the Upper Nasal Third. JAMA Facial Plast Surg. 2019 Oct 24;: Authors: Hetzler L, Givens V, Sykes J Abstract Importance: The tripod theory of the upper nasal third parallels the concept of the well-known nasal tip tripod. We are evaluating the idea that one can simply alter the upper nasal angles reliably without the complex physics associated with the nasal tip to achieve a pleasing cosmetic result. Objective: To describe...
Machine Learning by Ultrasonography for Genetic Risk Stratification of Thyroid Nodules. JAMA Otolaryngol Head Neck Surg. 2019 Oct 24;:1-6 Authors: Daniels K, Gummadi S, Zhu Z, Wang S, Patel J, Swendseid B, Lyshchik A, Curry J, Cottrill E, Eisenbrey J Abstract Importance: Thyroid nodules are common incidental findings. Ultrasonography and molecular testing can be used to assess risk of malignant neoplasm. Objective: To examine whether a model...
Postoperative Antibiotic Use Among Patients Undergoing Functional Facial Plastic and Reconstructive Surgery. JAMA Facial Plast Surg. 2019 Oct 24;: Authors: Olds C, Spataro E, Li K, Kandathil C, Most SP Abstract Importance: Best practices for antibiotic use after facial plastic and reconstructive procedures have been the subject of much debate, and there is a need for large-scale data to guide further development of evidence-based guidelines for antibiotic...
Transglutaminase 3 is expressed in basal cell carcinoma of the skin. Eur J Dermatol. 2019 Oct 23;: Authors: Smirnov A, Anemona L, Montanaro M, Mauriello A, Annicchiarico-Petruzzelli M, Campione E, Melino G, Candi E Abstract Transglutaminase 3 (TG3) belongs to a family of Ca2+-dependent enzymes which catalyse protein crosslinking. TG3 is important for proper development of the skin and hair shaft, and knock-out mice for the Tgm3 gene are sensitive to...
Re-irradiation with protons or heavy ions with focus on head and neck, skull base and brain malignancies. Br J Radiol. 2019 Oct 24;:20190516 Authors: Seidensaal K, Harrabi SB, Uhl M, Debus J Abstract Re-irradiation can offer a potentially curative solution in case of progression after initial therapy, however a second course of radiotherapy can be associated with an increased risk of severe side-effects. Particle therapy with protons and especially carbon...
Association between pathological invasion patterns and late lymph node metastases in patients with surgically treated clinical No early oral tongue carcinoma. Head Neck. 2019 Oct 24;: Authors: Hori Y, Kubota A, Yokose T, Furukawa M, Matsushita T, Oridate N Abstract BACKGROUND: This study evaluated the combination of tumor budding and depth (BD model) and worst pattern of invasion (WPOI) as histopathological prognostic factors in clinical N0 early oral...
Efficacy of EPA-enriched supplement compared with standard formula on body weight changes in malnourished patients with head and neck cancer undergone surgery: a randomized study. Head Neck. 2019 Oct 24;: Authors: Jantharapattana K, Orapipatpong O Abstract BACKGROUND: Eicosapentaenoic acid (EPA) containing nutritional supplement can reverse weight loss and increase lean body mass in a perioperative period of patients with head and neck cancer. To study...
Efficacy and cost-utility of the eHealth application 'Oncokompas', supporting patients with incurable cancer in finding optimal palliative care, tailored to their quality of life and personal preferences: a study protocol of a randomized controlled trial. BMC Palliat Care. 2019 Oct 23;18(1):85 Authors: Schuit AS, Holtmaat K, Hooghiemstra N, Jansen F, Lissenberg-Witte BI, Coupé VMH, van Linde ME, Becker-Commissaris A, Reijneveld JC, Zijlstra JM, Sommeijer DW, Eerenstein...
Gene Expression Analysis to Investigate Biological Networks Underlying Nasal Inflammatory Dysfunctions Induced by Diesel Exhaust Particles Using an In Vivo System. Ann Otol Rhinol Laryngol. 2019 Oct 24;:3489419883289 Authors: Kim HS, Kim BG, Park S, Kim N, Jang AS, Seo YR, Park MK Abstract OBJECTIVES: Diesel exhaust particles (DEP)s are notorious ambient pollutants composed of a complex mixture of a carbon core and diverse chemical irritants. Several...
Related ArticlesSPLUNC1 and MLL3 regulate cancer stem cells in nasopharyngeal carcinoma. J BUON. 2019 Jul-Aug;24(4):1700-1705 Authors: Bian S, Wang Z, Chen Y, Li R Abstract PURPOSE: Nasopharyngeal carcinoma (NPC) is one of the common types of cancer that originate from the nasopharyngeal region. Recurrence and early metastasis represent major problems associated with NPC mortality. These are mainly caused by various molecular changes that take place...
Related ArticlesHistochemical Approach for Simultaneous Detection of Ectonucleotidase and Alkaline Phosphatase Activities in Tissues. Methods Mol Biol. 2020;2041:107-116 Authors: Losenkova K, Paul M, Irjala H, Jalkanen S, Yegutkin GG Abstract Studies on pathophysiology and the therapeutic potential of extracellular ATP and other purines represent an important and rapidly evolving field. The integral response of the cell is determined by multiple factors,...
Related ArticlesFDG-PET/CT in the surveillance of head and neck cancer following radiotherapy. Eur Arch Otorhinolaryngol. 2019 Oct 23;: Authors: Risør LM, Loft A, Berthelsen AK, Loft FC, Madsen AR, Vogelius IR, Kjær A, Friborg J Abstract PURPOSE: To examine the time-dependent diagnostic performance of FDG-PET/CT in the follow-up of head and neck cancer (HNC) and to assess the prognostic value of PET-negative and PET-inconclusive findings. MATERIAL...
Related ArticlesIdentifying organs at risk for radiation-induced late dysphagia in head and neck cancer patients. Clin Transl Radiat Oncol. 2019 Nov;19:87-95 Authors: Hedström J, Tuomi L, Finizia C, Olsson C Abstract Background and purpose: Dysphagia is a common, severe and dose-limiting toxicity after oncological treatment of head and neck cancer (HNC). This study aims to investigate relationships between radiation doses to structures involved in normal...
Related ArticlesEnhancing direct cytotoxicity and response to immune checkpoint blockade following ionizing radiation with Wee1 kinase inhibition. Oncoimmunology. 2019;8(11):e1638207 Authors: Patel P, Sun L, Robbins Y, Clavijo PE, Friedman J, Silvin C, Van Waes C, Cook J, Mitchell J, Allen C Abstract Tumor cells activate the G2/M cell cycle checkpoint in response to ionizing radiation (IR) and effector immune cell-derived granzyme B to facilitate repair...
Related ArticlesEnhanced photothermal hemostasis using dual wavelengths in an in vivo leporine kidney model. Biomed Opt Express. 2019 Oct 01;10(10):5198-5206 Authors: Kim SW, Hwang J, Xuan J, Hasenberg T, Kang HW Abstract The current study investigated the hemostatic effect of dual wavelengths on in vivo leporine kidney tissue using 532-nm and 980-nm laser systems. Three irradiation modes, 532 nm, 980 nm, and dual (532 and 980 nm) modes, were compared...
Related ArticlesRapid screening of copy number variations in STRC by droplet digital PCR in patients with mild-to-moderate hearing loss. Hum Genome Var. 2019;6:41 Authors: Ito T, Kawashima Y, Fujikawa T, Honda K, Makabe A, Kitamura K, Tsutsumi T Abstract Copy number variations (CNVs) are commonly reported in STRC, the causal gene for DFNB16. Various techniques are used clinically for CNV detection, and droplet digital PCR (ddPCR) provides highly precise...
Related ArticlesClinical characteristics with long-term follow-up of four Okinawan families with moderate hearing loss caused by an OTOG variant. Hum Genome Var. 2019;6:37 Authors: Ganaha A, Kaname T, Yanagi K, Tono T, Higa T, Suzuki M Abstract We describe the clinical features of four Japanese families with moderate sensorineural hearing loss due to the OTOG gene variant. We analyzed 98 hearing loss-related genes in patients with hearing loss originally...
Related ArticlesSynchronous peritoneal carcinomatosis from a buccal squamous cell carcinoma: a case report focusing on possible metastatic mechanisms and novel therapeutic modalities. Ecancermedicalscience. 2019;13:954 Authors: Fan FS, Yang CF Abstract A 53-year-old male patient was diagnosed with squamous cell carcinoma of buccal mucosa with synchronous diffuse peritoneal carcinomatosis, a very rare presentation for oral cancer. His disease was highly...
Related ArticlesCombined CT radiomics of primary tumor and metastatic lymph nodes improves prediction of loco-regional control in head and neck cancer. Sci Rep. 2019 Oct 23;9(1):15198 Authors: Bogowicz M, Tanadini-Lang S, Guckenberger M, Riesterer O Abstract Loco-regional control (LRC) is a major clinical endpoint after definitive radiochemotherapy (RCT) of head and neck cancer (HNC). Radiomics has been shown a promising biomarker in cancer research,...
Related ArticlesPrimary Ewing's sarcoma of the temporal bone: a rare entity and review of the literature. BMJ Case Rep. 2019 Oct 23;12(10): Authors: Vishnoi JR, Kumar V, Srivastava K, Misra S Abstract Ewing's sarcoma (ES) is the second most common malignant primary bone tumour in children and adolescents. It primarily affects the diaphysis of long bones and pelvis. ES arising from temporal bone is extremely rare. To date, 43 such cases have been described...
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