IJMS, Vol. 20, Pages 5329: Expression of Adenosine Receptors in Rodent Pancreas International Journal of Molecular Sciences doi: 10.3390/ijms20215329 Authors: Hayashi Adenosine regulates exocrine and endocrine secretions in the pancreas. Adenosine is considered to play a role in acini-to-duct signaling in the exocrine pancreas. To identify the molecular basis of functional adenosine receptors in the exocrine pancreas, immunohistochemical analysis was performed in the rat, mouse, and...
Fri Oct 25, 2019 03:00
IJMS, Vol. 20, Pages 5326: Chemical Patterns of Proteasome Inhibitors: Lessons Learned from Two Decades of Drug Design International Journal of Molecular Sciences doi: 10.3390/ijms20215326 Authors: Guedes Aniceto Andrade Salvador Guedes Drug discovery now faces a new challenge, where the availability of experimental data is no longer the limiting step, and instead, making sense of the data has gained a new level of importance, propelled by the extensive incorporation...
Fri Oct 25, 2019 03:00
IJMS, Vol. 20, Pages 5325: CpWRKY71, a WRKY Transcription Factor Gene of Wintersweet (Chimonanthus praecox), Promotes Flowering and Leaf Senescence in Arabidopsis International Journal of Molecular Sciences doi: 10.3390/ijms20215325 Authors: Huang Liu Huang Ma Li Li Sui The WRKY transcription factors are one of the most important plant-specific transcription factors and play vital roles in various biological processes. However, the functions of WRKY genes in...
Fri Oct 25, 2019 03:00
IJMS, Vol. 20, Pages 5327: Wounding and UVB Light Synergistically Induce the Biosynthesis of Phenolic Compounds and Ascorbic Acid in Red Prickly Pears (Opuntia ficus-indica cv. Rojo Vigor) International Journal of Molecular Sciences doi: 10.3390/ijms20215327 Authors: Ortega-Hernández Nair Welti-Chanes Cisneros-Zevallos Jacobo-Velázquez The present study evaluated the effects of ultraviolet B (UVB) radiation and wounding stress, applied alone or combined, on the biosynthesis...
Fri Oct 25, 2019 03:00
IJMS, Vol. 20, Pages 5323: Single-Channel Properties of the ROMK-Pore-Forming Subunit of the Mitochondrial ATP-Sensitive Potassium Channel International Journal of Molecular Sciences doi: 10.3390/ijms20215323 Authors: Michał Laskowski Bartłomiej Augustynek Piotr Bednarczyk Monika Żochowska Justyna Kalisz Brian O’Rourke Adam Szewczyk Bogusz Kulawiak An increased flux of potassium ions into the mitochondrial matrix through the ATP-sensitive potassium channel (mitoKATP)...
Fri Oct 25, 2019 03:00
IJMS, Vol. 20, Pages 5322: Interplay Between MicroRNAs and Oxidative Stress in Ovarian Conditions with a Focus on Ovarian Cancer and Endometriosis International Journal of Molecular Sciences doi: 10.3390/ijms20215322 Authors: Marí-Alexandre Pellín Carcelén Agababyan Moreno-Manuel García-Oms Calabuig-Fariñas Gilabert-Estellés Ovarian cancer and endometriosis are two distinct gynaecological conditions that share many biological aspects incuding proliferation, invasion...
Fri Oct 25, 2019 03:00
IJMS, Vol. 20, Pages 5324: Recent Advances in Basic Research for Brain Arteriovenous Malformation International Journal of Molecular Sciences doi: 10.3390/ijms20215324 Authors: Barbosa Do Prado Han Oh Su Arteriovenous malformations (AVMs) are abnormal connections of vessels that shunt blood directly from arteries into veins. Rupture of brain AVMs (bAVMs) can cause life-threatening intracranial bleeding. Even though the majority of bAVM cases are sporadic without a family...
Fri Oct 25, 2019 03:00
IJMS, Vol. 20, Pages 5321: Heat Shock Proteins: Dynamic Biomolecules to Counter Plant Biotic and Abiotic Stresses International Journal of Molecular Sciences doi: 10.3390/ijms20215321 Authors: ul Haq Khan Ali Khattak Gai Zhang Wei Gong Due to the present scenario of climate change, plants have to evolve strategies to survive and perform under a plethora of biotic and abiotic stresses, which restrict plant productivity. Maintenance of plant protein functional...
Fri Oct 25, 2019 03:00
IJMS, Vol. 20, Pages 5320: Expression of A New Endogenous Retrovirus-Associated Transcript in Hodgkin Lymphoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms20215320 Authors: Jana Schneider Ines Volkmer Kristina Engel Alexander Emmer Martin S. Staege During characterization of a cDNA library from the Hodgkin lymphoma (HL) cell line L-1236, we discovered a new transcript derived from chromosome 1 at the long intergenic non-protein coding RNA 1768 (LINC01768)/colony...
Fri Oct 25, 2019 03:00
IJMS, Vol. 20, Pages 5319: The Landscape of Actionable Gene Fusions in Colorectal Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20215319 Authors: Filippo Pagani Giovanni Randon Vincenzo Guarini Alessandra Raimondi Michele Prisciandaro Riccardo Lobefaro Maria Di Bartolomeo Gabriella Sozzi Filippo de Braud Patrizia Gasparini Filippo Pietrantonio The treatment scenario of metastatic colorectal cancer (mCRC) has been rapidly enriched with...
Fri Oct 25, 2019 03:00
IJMS, Vol. 20, Pages 5317: The Protective Role of Calbindin-D9k on Endoplasmic Reticulum Stress-Induced Beta Cell Death International Journal of Molecular Sciences doi: 10.3390/ijms20215317 Authors: Changhwan Ahn Eui-Man Jung Beum-Soo An Eui-Ju Hong Yeong-Min Yoo Eui-Bae Jeung Intracellular calcium ion content is tightly regulated for the maintenance of cellular functions and cell survival. Calbindin-D9k (CaBP-9k) is responsible for regulating the distribution of cytosolic...
Fri Oct 25, 2019 03:00
IJMS, Vol. 20, Pages 5315: Autophagy Modulation in Human Thyroid Cancer Cells following Aloperine Treatment International Journal of Molecular Sciences doi: 10.3390/ijms20215315 Authors: Hui-I Yu Hui-Ching Shen Shu-Hsin Chen Yun-Ping Lim Hsiang-Hsun Chuang Tsai-Sung Tai Fang-Ping Kung Chieh-Hsiang Lu Chia-Yi Hou Ying-Ray Lee Aloperine, an alkaloid isolated from Sophora alopecuroides, exhibits multiple pharmacological activities including anti-inflammatory,...
Fri Oct 25, 2019 03:00
IJMS, Vol. 20, Pages 5313: Tackling Acute Lymphoblastic Leukemia—One Fish at a Time International Journal of Molecular Sciences doi: 10.3390/ijms20215313 Authors: Arpan A. Sinha Gilseung Park J. Kimble Frazer Despite advancements in the diagnosis and treatment of acute lymphoblastic leukemia (ALL), a need for improved strategies to decrease morbidity and improve cure rates in relapsed/refractory ALL still exists. Such approaches include the identification and implementation of...
Fri Oct 25, 2019 03:00
IJMS, Vol. 20, Pages 5318: Emerging Anticancer Potentials of Selenium on Osteosarcoma International Journal of Molecular Sciences doi: 10.3390/ijms20215318 Authors: Kok-Lun Pang Kok-Yong Chin Selenium is a trace element essential to humans and forms complexes with proteins, which exert physiological functions in the body. In vitro studies suggested that selenium possesses anticancer effects and may be effective against osteosarcoma. This review aims to summarise current evidence on...
Fri Oct 25, 2019 03:00
IJMS, Vol. 20, Pages 5314: Role of High-Mobility Group Box-1 in Liver Pathogenesis International Journal of Molecular Sciences doi: 10.3390/ijms20215314 Authors: Bilon Khambu Shengmin Yan Nazmul Huda Xiao-Ming Yin High-mobility group box 1 (HMGB1) is a highly abundant DNA-binding protein that can relocate to the cytosol or undergo extracellular release during cellular stress or death. HMGB1 has a functional versatility depending on its cellular location. While intracellular...
Fri Oct 25, 2019 03:00
IJMS, Vol. 20, Pages 5311: Comparative Genome-wide Analysis and Expression Profiling of Histone Acetyltransferase (HAT) Gene Family in Response to Hormonal Applications, Metal and Abiotic Stresses in Cotton International Journal of Molecular Sciences doi: 10.3390/ijms20215311 Authors: Muhammad Imran Sarfraz Shafiq Muhammad Ansar Farooq Muhammad Kashif Naeem Emilie Widemann Ali Bakhsh Kevin B. Jensen Richard R.-C. Wang Post-translational modifications are involved...
Fri Oct 25, 2019 03:00
IJMS, Vol. 20, Pages 5312: The Overcrowded Crossroads: Mitochondria, Alpha-Synuclein, and the Endo-Lysosomal System Interaction in Parkinson’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms20215312 Authors: Kai-Jung Lin Kai-Lieh Lin Shang-Der Chen Chia-Wei Liou Yao-Chung Chuang Hung-Yu Lin Tsu-Kung Lin Parkinson’s disease (PD) is the second most common neurodegenerative disorder worldwide, mainly affecting the elderly. The disease progresses...
Fri Oct 25, 2019 03:00
IJMS, Vol. 20, Pages 5316: Acoustic Trauma Modulates Cochlear Blood Flow and Vasoactive Factors in a Rodent Model of Noise-Induced Hearing Loss International Journal of Molecular Sciences doi: 10.3390/ijms20215316 Authors: Sun-Ae Shin Ah-Ra Lyu Seong-Hun Jeong Tae Hwan Kim Min Jung Park Yong-Ho Park Noise exposure affects the organ of Corti and the lateral wall of the cochlea, including the stria vascularis and spiral ligament. Although the inner ear vasculature and spiral...
Fri Oct 25, 2019 03:00
IJMS, Vol. 20, Pages 5308: Sulfolobus acidocaldarius Microvesicles Exhibit Unusually Tight Packing Properties as Revealed by Optical Spectroscopy International Journal of Molecular Sciences doi: 10.3390/ijms20215308 Authors: Alexander Bonanno Robert C. Blake Parkson Lee-Gau Chong In this study, we used optical spectroscopy to characterize the physical properties of microvesicles released from the thermoacidophilic archaeon Sulfolobus acidocaldarius (Sa-MVs). The most abundant proteins...
Fri Oct 25, 2019 03:00
IJMS, Vol. 20, Pages 5310: Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology International Journal of Molecular Sciences doi: 10.3390/ijms20215310 Authors: Rinku Dutta Roukiah Khalil Ryan Green Shyam S Mohapatra Subhra Mohapatra Ashwagandha (Withania Somnifera, WS), belonging to the family Solanaceae, is an Ayurvedic herb known worldwide for its numerous beneficial health activities since ancient times. This medicinal plant provides benefits...
Fri Oct 25, 2019 03:00
IJMS, Vol. 20, Pages 5309: Comprehensive Analysis of the Chitinase Gene Family in Cucumber (Cucumis sativus L.): From Gene Identification and Evolution to Expression in Response to Fusarium oxysporum International Journal of Molecular Sciences doi: 10.3390/ijms20215309 Authors: Ezra S. Bartholomew Kezia Black Zhongxuan Feng Wan Liu Nan Shan Xiao Zhang Licai Wu Latoya Bailey Ning Zhu Changhong Qi Huazhong Ren Xingwang Liu Chitinases, a subgroup of pathogenesis-related...
Fri Oct 25, 2019 03:00
JCM, Vol. 8, Pages 1795: Chronic Kidney Disease: The Silent Epidemy Journal of Clinical Medicine doi: 10.3390/jcm8111795 Authors: Antonio Bellasi Luca Di Lullo Biagio Di Iorio Numerous observations suggest that chronic kidney disease (CKD) is an epidemic condition [...]
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JCM, Vol. 8, Pages 1794: Sexuality and Mental Health: The Need for Mutual Development and Research Journal of Clinical Medicine doi: 10.3390/jcm8111794 Authors: Angel L. Montejo Research in the field of sexuality has shown growing scientific development in recent years, although there’s a lack of well-trained professionals who could contribute to increasing its benefits. Sexuality continues to be a taboo with different interpretations and difficult delimitation of either normal...
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JCM, Vol. 8, Pages 1793: The Circulating GRP78/BiP Is a Marker of Metabolic Diseases and Atherosclerosis: Bringing Endoplasmic Reticulum Stress into the Clinical Scenario Journal of Clinical Medicine doi: 10.3390/jcm8111793 Authors: Josefa Girona Cèlia Rodríguez-Borjabad Daiana Ibarretxe Joan-Carles Vallvé Raimon Ferré Mercedes Heras Ricardo Rodríguez-Calvo Sandra Guaita-Esteruelas Neus Martínez-Micaelo Núria Plana Lluís Masana Background: Glucose-regulated...
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JCM, Vol. 8, Pages 1792: Plasma Levels of Retinol Binding Protein 4 Relate to Large VLDL and Small LDL Particles in Subjects with and without Type 2 Diabetes Journal of Clinical Medicine doi: 10.3390/jcm8111792 Authors: Hanna Wessel Ali Saeed Janette Heegsma Margery A. Connelly Klaas Nico Faber Robin P. F. Dullaart Background: Retinol binding protein 4 (RBP4) carries retinol in plasma, but is also considered an adipokine, as it is implicated in insulin resistance in mice....
Fri Oct 25, 2019 03:00
JCM, Vol. 8, Pages 1790: The Predictive Accuracy of the General Movement Assessment for Cerebral Palsy: A Prospective, Observational Study of High-Risk Infants in a Clinical Follow-Up Setting Journal of Clinical Medicine doi: 10.3390/jcm8111790 Authors: Ragnhild Støen Lynn Boswell Raye-Ann de Regnier Toril Fjørtoft Deborah Gaebler-Spira Espen Ihlen Cathrine Labori Marianne Loennecken Michael Msall Unn Inger Möinichen Colleen Peyton Annamarie Russow Michael...
Fri Oct 25, 2019 03:00
JCM, Vol. 8, Pages 1791: C-Reactive Protein and Neutrophil/Lymphocytes Ratio: Prognostic Indicator for Doubling overall survival Prediction in Pancreatic Cancer Patients Journal of Clinical Medicine doi: 10.3390/jcm8111791 Authors: Schlick Magnes Huemer Ratzinger Weiss Pichler Melchardt Greil Egle : Background: Despite modern chemotherapy regimens, survival of patients with locally advanced/metastatic pancreatic cancer remains dismal. Long-term survivors...
Fri Oct 25, 2019 03:00
JCM, Vol. 8, Pages 1788: High Myopia and Its Associated Factors in JPHC-NEXT Eye Study: A Cross-Sectional Observational Study Journal of Clinical Medicine doi: 10.3390/jcm8111788 Authors: Mori Kurihara Uchino Torii Kawashima Sasaki Ozawa Yamagishi Iso Sawada Tsugane Yuki Tsubota The increasing prevalence of high myopia has been noted. We investigated the epidemiological characteristics and the related factors of high myopia in a Japanese...
Fri Oct 25, 2019 03:00
JCM, Vol. 8, Pages 1789: Potential Therapeutic Targets of Quercetin and Its Derivatives: Its Role in the Therapy of Cognitive Impairment Journal of Clinical Medicine doi: 10.3390/jcm8111789 Authors: Jakaria Azam Jo Kim Dash Choi Quercetin (QC) is a flavonoid and crucial bioactive compound found in a variety of vegetables and fruits. In preclinical studies, QC has demonstrated broad activity against several diseases and disorders. According to recent investigations,...
Fri Oct 25, 2019 03:00
JCM, Vol. 8, Pages 1786: Endoscopic Ultrasound-Guided Treatment of Gastric Varices Using Coils and Cyanoacrylate Glue Injections: Results after 1 Year of Experience Journal of Clinical Medicine doi: 10.3390/jcm8111786 Authors: Sławomir Kozieł Katarzyna Pawlak Łukasz Błaszczyk Mateusz Jagielski Anna Wiechowska-Kozłowska Background and Aims: Gastric varices (GVs) occur in 20% of patients with portal hypertension. GVs are associated with a 65% risk of bleeding over the course...
Fri Oct 25, 2019 03:00
JCM, Vol. 8, Pages 1787: The Effect of Adjustment of Endotracheal Tube Cuff Pressure during Scarless Remote Access Endoscopic and Robotic Thyroidectomy on Laryngo-Pharyngeal Complications: Prospective Randomized and Controlled Trial Journal of Clinical Medicine doi: 10.3390/jcm8111787 Authors: Chang-Hoon Koo Hye-Min Sohn Eun-Su Choi June-Yong Choi Ah-Young Oh Young-Tae Jeon Jung-Hee Ryu Scarless remote access endoscopic and robotic thyroidectomy has been recently performed...
Fri Oct 25, 2019 03:00
JCM, Vol. 8, Pages 1783: Nitric Oxide and Biological Mediators in Pediatric Chronic Rhinosinusitis and Asthma Journal of Clinical Medicine doi: 10.3390/jcm8111783 Authors: Valentina Agnese Ferraro Stefania Zanconato Eugenio Baraldi Silvia Carraro Background: In the context of the so-called unified airway theory, chronic rhinosinusitis (CRS) and asthma may coexist. The inflammation underlying these conditions can be studied through the aid of biomarkers. Main body: We described...
Fri Oct 25, 2019 03:00
JCM, Vol. 8, Pages 1784: Efficacy of HE4, CA125, Risk of Malignancy Index and Risk of Ovarian Malignancy Index to Detect Ovarian Cancer in Women with Presumed Benign Ovarian Tumours: A Prospective, Multicentre Trial Journal of Clinical Medicine doi: 10.3390/jcm8111784 Authors: Vincent Dochez Mélanie Randet Céline Renaudeau Jérôme Dimet Aurélie Le Thuaut Norbert Winer Thibault Thubert Edouard Vaucel Hélène Caillon Guillaume Ducarme Background: Presumed benign...
Fri Oct 25, 2019 03:00
JCM, Vol. 8, Pages 1785: Influence of Transfusion on the Risk of Acute Kidney Injury: ABO-Compatible versus ABO-Incompatible Liver Transplantation Journal of Clinical Medicine doi: 10.3390/jcm8111785 Authors: Je Hyuk Yu Yongsuk Kwon Jay Kim Seong-Mi Yang Won Ho Kim Chul-Woo Jung Kyung-Suk Suh Kook Hyun Lee ABO-incompatible liver transplantation (ABO-i LT) is associated with a higher risk of acute kidney injury (AKI) compared to ABO-compatible liver transplantation...
Fri Oct 25, 2019 03:00
JCM, Vol. 8, Pages 1782: Induced Pluripotent Stem Cells as Vasculature Forming Entities Journal of Clinical Medicine doi: 10.3390/jcm8111782 Authors: Antonio Palladino Isabella Mavaro Carmela Pizzoleo Elena De Felice Carla Lucini Paolo de Girolamo Paolo A. Netti Chiara Attanasio Tissue engineering (TE) pursues the ambitious goal to heal damaged tissues. One of the most successful TE approaches relies on the use of scaffolds specifically designed and fabricated to...
Fri Oct 25, 2019 03:00
JCM, Vol. 8, Pages 1781: Histopathological Verification of the Diagnostic Performance of the EU-TIRADS Classification of Thyroid Nodules—Results of a Multicenter Study Performed in a Previously Iodine-Deficient Region Journal of Clinical Medicine doi: 10.3390/jcm8111781 Authors: Katarzyna Dobruch-Sobczak Zbigniew Adamczewski Ewelina Szczepanek-Parulska Bartosz Migda Kosma Woliński Agnieszka Krauze Piotr Prostko Marek Ruchała Andrzej Lewiński Wiesław Jakubowski Marek...
Fri Oct 25, 2019 03:00
JCM, Vol. 8, Pages 1780: Delayed Intracranial Hemorrhage in Patients with Head Trauma and Antithrombotic Therapy Journal of Clinical Medicine doi: 10.3390/jcm8111780 Authors: Anna Antoni Elisabeth Schwendenwein Harald Binder Martin Schauperl Philip Datler Stefan Hajdu Background: Delayed intracranial hemorrhage can occur up to several weeks after head trauma and was reported more frequently in patients with antithrombotic therapy. Due to the risk of delayed intracranial...
Fri Oct 25, 2019 03:00
JFB, Vol. 10, Pages 47: Biomechanical Effects of a New Macrogeometry Design of Dental Implants: An In Vitro Experimental Analysis Journal of Functional Biomaterials doi: 10.3390/jfb10040047 Authors: Sergio Alexandre Gehrke Leticia Pérez-Díaz Patricia Mazón Piedad N. De Aza The purpose of the present study was to measure and compare the insertion torque, removal torque, and the implant stability quotient by resonance frequency analysis in different polyurethane block densities...
Fri Oct 25, 2019 03:00
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