Dicer Sequencing, Whole Genome Methylation Profiling, mRNA and smallRNA Sequencing Analysis in Basal Cell Carcinoma. Cell Physiol Biochem. 2019;53(5):760-773 Authors: Sand M, Bromba A, Sand D, Gambichler T, Hessam S, Becker JC, Stockfleth E, Meyer T, Bechara FG Abstract BACKGROUND/AIMS: Perturbations in the expression of microRNAs (miRNAs) and their maturing machinery components such as Dicer have been previously described for basal cell carcinoma (BCC)....
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Related ArticlesFDG-PET/CT in the surveillance of head and neck cancer following radiotherapy. Eur Arch Otorhinolaryngol. 2019 Oct 23;: Authors: Risør LM, Loft A, Berthelsen AK, Loft FC, Madsen AR, Vogelius IR, Kjær A, Friborg J Abstract PURPOSE: To examine the time-dependent diagnostic performance of FDG-PET/CT in the follow-up of head and neck cancer (HNC) and to assess the prognostic value of PET-negative and PET-inconclusive findings. MATERIAL...
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Related ArticlesThe Pathophysiology, Presentation and Management of Ischaemic Colitis: A Systematic Review. World J Surg. 2019 Oct 23;: Authors: Demetriou G, Nassar A, Subramonia S Abstract There are currently no guidelines on the long-term management of patients after an episode of acute ischaemic colitis. Our aim was to review the literature on the pattern of presentation and the pathophysiology of this condition and to understand the current status...
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Related ArticlesIncreased Morbidity and Mortality of Emergency Laparotomy in Elderly Patients. World J Surg. 2019 Oct 23;: Authors: Chua MSH, Chan DKH Abstract BACKGROUND: There is an increasing incidence of elderly patients requiring emergency laparotomy. Our study compares the outcomes of elderly patients undergoing emergency laparotomy against the outcomes of non-elderly patients. METHODOLOGY: Patients who underwent emergency laparotomy between...
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Related ArticlesIncidence of Venous Thromboembolism Following Major Emergency Abdominal Surgery. World J Surg. 2019 Oct 23;: Authors: Balachandran R, Jensen KK, Burcharth J, Ekeloef S, Schack AE, Gögenur I Abstract BACKGROUND: In a retrospective cohort study, we looked at the incidence and risk factors of developing in-hospital venous thromboembolism (VTE) after major emergency abdominal surgery and the risk factors for developing a venous thrombosis....
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Related ArticlesStudy on the Segmentation of the Right Posterior Sector of the Liver. World J Surg. 2019 Oct 23;: Authors: Minami T, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Nagino M Abstract BACKGROUND: The border between segments VI and VII of the right posterior sector of the liver is controversial owing to lack of anatomical landmarks. This study aimed to examine the segmentation of the right posterior sector. ...
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Related ArticlesAuthor's Reply: Prophylactic Intraperitoneal Onlay Mesh Following Midline Laparotomy: Long-Term Results of a Randomized Controlled Trial. World J Surg. 2019 Oct 23;: Authors: Glauser PM PMID: 31646365 [PubMed - as supplied by publisher]
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Related ArticlesIdentifying organs at risk for radiation-induced late dysphagia in head and neck cancer patients. Clin Transl Radiat Oncol. 2019 Nov;19:87-95 Authors: Hedström J, Tuomi L, Finizia C, Olsson C Abstract Background and purpose: Dysphagia is a common, severe and dose-limiting toxicity after oncological treatment of head and neck cancer (HNC). This study aims to investigate relationships between radiation doses to structures involved in normal...
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Related ArticlesClosing the Brief Case: Laryngeal Blastomycosis Involving a Vocal Cord Implant. J Clin Microbiol. 2019 Nov;57(11): Authors: Fenwick AJ, McKittrick ND, Zhang SX PMID: 31645410 [PubMed - in process]
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Related ArticlesThe Brief Case: Laryngeal Blastomycosis Involving a Vocal Cord Implant. J Clin Microbiol. 2019 Nov;57(11): Authors: Fenwick AJ, McKittrick ND, Zhang SX PMID: 31645409 [PubMed - in process]
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Related ArticlesIncidence and outcomes of cricothyrotomy in the "cannot intubate, cannot oxygenate" situation. Medicine (Baltimore). 2019 Oct;98(42):e17713 Authors: Kwon YS, Lee CA, Park S, Ha SO, Sim YS, Baek MS Abstract Few data are available regarding factors that impact cricothyrotomy use and outcome in general hospital setting. The aim of the present study was to determine the incidence and outcomes of the patients underwent cricothyrotomy in a...
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Related ArticlesPerformance of emergency surgical front of neck airway access by head and neck surgeons, general surgeons, or anaesthetists: an in situ simulation study. Br J Anaesth. 2019 11;123(5):696-703 Authors: Groom P, Schofield L, Hettiarachchi N, Pickard S, Brown J, Sandars J, Morton B Abstract BACKGROUND: The 'cannot intubate cannot oxygenate' (CICO) emergency requires urgent front of neck airway (FONA) access to prevent death. In cases reported...
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Related Articles[Minimally invasive treatment of postintubation stenosis by use of Ultra Dream Pulse Laser and steroid-mitomycin in a 4-year-old girl]. Orv Hetil. 2019 May;160(20):792-796 Authors: Szabó L, Szakács L, Rovó L Abstract Postintubation stenosis is a frequent complication of long-term endotracheal anesthesia. In the last few decades, its incidence showed an increasing tendency particularly among children and premature infants. It mostly affects...
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Related ArticlesDrug-Induced Sleep Computed Tomography-Directed Upper Airway Surgery for Obstructive Sleep Apnea: A Pilot Study. Otolaryngol Head Neck Surg. 2019 01;160(1):172-181 Authors: Lee LA, Wang CJ, Lo YL, Huang CG, Kuo IC, Lin WN, Hsin LJ, Fang TJ, Li HY Abstract OBJECTIVE: A surgical response to upper airway (UA) surgery for obstructive sleep apnea (OSA) depends on adequate correction of collapsible sites in the UA. This pilot study aimed to...
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Related ArticlesWalking but Not Talking: Laryngeal Separation as a Novel Approach to Improve Quality of Life in Bulbar Amyotrophic Lateral Sclerosis. J Pain Symptom Manage. 2018 12;56(6):e4-e5 Authors: Agne JL, Norton KP PMID: 30223015 [PubMed - indexed for MEDLINE]
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Related ArticlesOtorhinolaryngological profile and surgical intervention in patients with HIV/AIDS. Sci Rep. 2018 08 13;8(1):12045 Authors: Bao S, Shao S Abstract Little is known about the diagnosis and surgical management of head and neck conditions in patients with HIV/AIDS. This study was conducted to characterize the otorhinolaryngological (ORL) profiles, surgical interventions and outcomes in patients with HIV/AIDS. This retrospective study included...
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Re-irradiation with protons or heavy ions with focus on head and neck, skull base and brain malignancies. Br J Radiol. 2019 Oct 24;:20190516 Authors: Seidensaal K, Harrabi SB, Uhl M, Debus J Abstract Re-irradiation can offer a potentially curative solution in case of progression after initial therapy, however a second course of radiotherapy can be associated with an increased risk of severe side-effects. Particle therapy with protons and especially carbon...
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Related ArticlesCost-effectiveness of proton therapy in treating base of skull chordoma. Australas Phys Eng Sci Med. 2019 Oct 23;: Authors: Austin AM, Douglass MJJ, Nguyen GT, Dalfsen R, Le H, Gorayski P, Tee H, Penniment M, Penfold SN Abstract While proton beam therapy (PBT) can offer increased sparing of healthy tissue, it is associated with large capital costs and as such, has limited availability. Furthermore, it has not been well established whether...
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Related ArticlesChiari I Malformation and Basilar Invagination in Fibrous Dysplasia: Prevalence, Mechanisms, and Clinical Implications. J Bone Miner Res. 2018 11;33(11):1990-1998 Authors: Pan KS, Heiss JD, Brown SM, Collins MT, Boyce AM Abstract Fibrous dysplasia (FD) is a mosaic disorder of benign fibro-osseous lesions, which may be associated with extraskeletal features as part of McCune-Albright syndrome (MAS). Cranial base abnormalities, including...
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Related ArticlesMaternal environment and craniofacial growth: geometric morphometric analysis of mandibular shape changes with in utero thyroxine overexposure in mice. J Anat. 2018 07;233(1):46-54 Authors: Kesterke MJ, Judd MA, Mooney MP, Siegel MI, Elsalanty M, Howie RN, Weinberg SM, Cray JJ Abstract An estimated 3% of US pregnancies are affected by maternal thyroid dysfunction, with between one and three of every 1000 pregnancies being complicated...
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99 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2019/10/25PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Implementation of Laboratory Review of Test Builds Within the Electronic Health Record Reduces Errors. Arch Pathol Lab Med. 2019 Oct 24;: Authors: Barry C, Edmonston TB, Gandhi S, Ganti K, Kim N, Bierl C Abstract CONTEXT.—: As electronic health records (EHRs) become more ubiquitous, physicians have come to expect that laboratory data from a variety of sources will be incorporated into the EHR in a structured format. The Clinical Laboratory Improvement...
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Impact of the 2018 American Society of Clinical Oncology/College of American Pathologists HER2 Guideline Updates on HER2 Assessment in Breast Cancer With Equivocal HER2 Immunohistochemistry Results With Focus on Cases With HER2/CEP17 Ratio <2.0 and Average HER2 Copy Number â¥4.0 and <6.0. Arch Pathol Lab Med. 2019 Oct 24;: Authors: Hoda RS, Brogi E, Xu J, Ventura K, Ross DS, Dang C, Robson M, Norton L, Morrow M, Wen HY Abstract CONTEXT.—: The American...
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Targeting chronic lymphocytic leukemia with N-methylated thrombospondin-1-derived peptides overcomes drug resistance. Blood Adv. 2019 Oct 22;3(20):2920-2933 Authors: Pramil E, Herbi Bastian L, Denèfle T, Nemati F, Xiao M, Lardé E, Maloum K, Roos-Weil D, Chapiro E, Le Garff-Tavernier M, Davi F, Decaudin D, Sarfati M, Nguyen-Khac F, Merle-Béral H, Karoyan P, Susin SA Abstract Chronic lymphocytic leukemia (CLL), the most common adulthood leukemia in Western...
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Novel chemotherapeutic agent, FND-4b, activates AMPK and inhibits colorectal cancer cell proliferation. PLoS One. 2019;14(10):e0224253 Authors: Sinner HF, Johnson J, Rychahou PG, Watt DS, Zaytseva YY, Liu C, Evers BM Abstract Colorectal cancer (CRC) is the second leading cause of cancer deaths in the US with the majority of deaths due to metastatic disease. Current chemotherapeutic regimens involve highly toxic agents, which limits their utility; therefore,...
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Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer. Phytomedicine. 2019 Sep 27;65:153100 Authors: Wang Y, Tang C, Yao S, Lai H, Li R, Xu J, Wang Q, Fan XX, Wu QB, Leung EL, Ye Y, Yao X Abstract BACKGROUND: The incidence of non-small cell lung cancer (NSCLC) accounts for approximately 85-90% of lung cancer, which has been shown to be challenging for treatment owing to poorly understanding of...
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Multiple effects of CDK4/6 inhibition in cancer: from cell cycle arrest to immunomodulation. Biochem Pharmacol. 2019 Oct 21;:113676 Authors: Bonelli M, La Monica S, Fumarola C, Alfieri R Abstract Dysregulation of the cell cycle is a hallmark of cancer that leads to aberrant cellular proliferation. CDK4/6 are cyclin-dependent kinases activated in response to proliferative signaling, which induce RB hyper-phosphorylation and hence activation of E2F transcription...
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G9a promotes cell proliferation and suppresses autophagy in gastric cancer by directly activating mTOR. FASEB J. 2019 Oct 24;:fj201900233RR Authors: Yin C, Ke X, Zhang R, Hou J, Dong Z, Wang F, Zhang K, Zhong X, Yang L, Cui H Abstract As an important methyltransferase, G9a has been reported to be abnormally expressed in various human cancers and plays essential roles in tumorigenesis. However, the biologic functions and molecular mechanisms of G9a in...
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Related ArticlesIn vitro anticancer effects of esculetin against human leukemia cell lines involves apoptotic cell death, autophagy, G0/G1 cell cycle arrest and modulation of Raf/MEK/ERK signalling pathway. J BUON. 2019 Jul-Aug;24(4):1686-1691 Authors: Wang X, Yang C, Zhang Q, Wang C, Zhou X, Zhang X, Liu S Abstract PURPOSE: Esculetin is an important bioactive coumarin with amazing potential to suppress the growth of cancer cells. The present study was...
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Related ArticlesInhibition of cancer cell growth in gemcitabine-resistant pancreatic carcinoma by mangiferin phytochemical involves induction of autophagy, endogenous ROS production, cell cycle disruption, mitochondrial mediated apoptosis and suppression of cancer cell migration and invasion. J BUON. 2019 Jul-Aug;24(4):1581-1586 Authors: Yu L, Chen M, Zhang R, Jin Z Abstract PURPOSE: Pancreatic cancer causes considerable mortality across the globe and...
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Related ArticlesInhibition of endometrial carcinoma by Kaempferol is interceded through apoptosis induction, G2/M phase cell cycle arrest, suppression of cell invasion and upregulation of m-TOR/PI3K signalling pathway. J BUON. 2019 Jul-Aug;24(4):1555-1561 Authors: Lei X, Guo J, Wang Y, Cui J, Feng B, Su Y, Zhao H, Yang W, Hu Y Abstract PURPOSE: The main purpose of this study was to investigate the selective anticancer effects of Kaempferol against MFE-280...
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Related ArticlesInhibition of cancer cell growth by Tangeretin flavone in drug-resistant MDA-MB-231 human breast carcinoma cells is facilitated via targeting cell apoptosis, cell cycle phase distribution, cell invasion and activation of numerous Caspases. J BUON. 2019 Jul-Aug;24(4):1532-1537 Authors: Fan S, Xu H, Liu H, Hu Z, Xiao J, Liu H Abstract PURPOSE: In this study, the anticancer effects of a natural flavonoid-Tangeretin, were examined against...
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Related ArticlesDentatin exerts anticancer effects on human colon cancer cell lines via cell cycle arrest, autophagy, inhibition of cell migration and JAK/STAT signalling pathway. J BUON. 2019 Jul-Aug;24(4):1488-1493 Authors: Xiong W, Dong J, Kong S Abstract PURPOSE: Colon cancer is a malignant disease with significant mortality. In the present study the anticancer effects of a carbazole alkaloid, Dentatin, were examined against colon cancer cells. ...
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Related ArticlesSilencing of PPMD1 inhibits proliferation of human colon cancer cells via induction of apoptosis and cell cycle arrest. J BUON. 2019 Jul-Aug;24(4):1464-1469 Authors: Yin Z, Yi J, Nie T, Yang Z, Ding N, Du SX, Liu S, Peng T Abstract PURPOSE: Accumulating reports have shown the oncogenic properties of PPMD1 (protein phosphatase, Mg2+/Mn2+ dependent 1D) in different cancer types. This study was undertaken to explore the role and therapeutic...
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Related ArticlesMiRNA-409-5p dysregulation promotes imatinib resistance and disease progression in children with chronic myeloid leukemia. Eur Rev Med Pharmacol Sci. 2019 Oct;23(19):8468-8475 Authors: Liu YY, Jiao WY, Li T, Bao YY Abstract OBJECTIVE: To elucidate the role of miRNA-409-5p in the pathogenesis of child chronic myeloid leukemia (CML) and its potential mechanism. PATIENTS AND METHODS: Expression levels of miRNA-409-5p and NUP43 in...
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Related ArticlesMembrane-bound TNF mediates microtubule-targeting chemotherapeutics-induced cancer cytolysis via juxtacrine inter-cancer-cell death signaling. Cell Death Differ. 2019 Oct 23;: Authors: Zhang J, Yang Y, Zhou S, He X, Cao X, Wu C, Hu H, Qin J, Wei G, Wang H, Liu S, Sun L Abstract Microtubule-targeting agents (MTAs) are a class of most widely used chemotherapeutics and their mechanism of action has long been assumed to be mitotic arrest...
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Related ArticlesAn orally available tubulin inhibitor, VERU-111, suppresses triple-negative breast cancer tumor growth and metastasis and bypasses taxane resistance. Mol Cancer Ther. 2019 Oct 23;: Authors: Deng S, Krutilina RI, Wang Q, Lin Z, Parke DN, Playa HC, Chen H, Miller DD, Seagroves TN, Li W Abstract Triple-negative breast cancer (TNBC) accounts for ~15% of breast cancer cases in the United States. TNBC has poorer overall prognosis relative to...
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Related ArticlesGender differences in clinical manifestations and polysomnographic findings in Chinese patients with obstructive sleep apnea. Sleep Breath. 2019 Oct 23;: Authors: Zhang Z, Cheng J, Yang W, Zou H, Su C, Miao J Abstract PURPOSE: The gender differences in patients with obstructive sleep apnea (OSA) are not fully understood so far, as previous studies had conflicting results. No reports have addressed the differences in OSA between Chinese...
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