Ajith Sivadasan, Mathew Alexander, Sanjith Aaron, Vivek Mathew, Shalini Nair, Karthik Muthusamy, AT Prabhakar, Rohit N Benjamin, Atif Shaikh, Gideon RynjahAnnals of Indian Academy of Neurology 2019 22(4):464-471 Introduction: There is scarce literature regarding the clinical course, comorbidities and long-term outcomes after myasthenic crisis (MC). The natural history of myasthenia gravis (MG) in this subset remains uncertain. Methods: The study included a cohort admitted with MC (2007–2017) in...
Fri Oct 25, 2019 00:00
Veer Bahadur Singh, Harish KumarAnnals of Indian Academy of Neurology 2019 22(4):519-520
Fri Oct 25, 2019 00:00
Jagarlapudi M. K. MurthyAnnals of Indian Academy of Neurology 2019 22(4):472-473
Fri Oct 25, 2019 00:00
Akella Radha Rama Devi, Lokesh Lingappa, Shaik Mohammad NaushadAnnals of Indian Academy of Neurology 2019 22(4):523-524
Fri Oct 25, 2019 00:00
Hamidreza Jahanbani-Ardakani, Fereshteh Alsahebfosoul, Masoud Etemadifar, Seyed-Hossein AbtahiAnnals of Indian Academy of Neurology 2019 22(4):474-476 Background: Multiple sclerosis (MS) is a chronic demyelinating disorder of central nervous system. Although the definite pathogenesis of MS has not been understood, crucial role of environmental and genetic risk factors has been proposed. Propose: To determine the serum level of interleukin-18 (IL-18) as well as gene polymorphisms of IL-18 (rs1946518,...
Fri Oct 25, 2019 00:00
Nataraja Pillai Venugopal, Sherin Kummararaj, Govindaraj KummararajAnnals of Indian Academy of Neurology 2019 22(4):526-526
Fri Oct 25, 2019 00:00
Sucharita Ray, Kamalesh Chakravarty, Heena Kathuria, Vivek LalAnnals of Indian Academy of Neurology 2019 22(4):477-481 Introduction: Stroke mimics are some of the common causes of misdiagnosis of stroke, with an attendant surfeit of finances and resources. Aim: We attempt to discuss some of the common neurological conditions mimicking stroke in the emergency. Methods: We reviewed the articles in English discussing stroke mimics in the last 5 years of publication. Purpose of the Review: We discuss...
Fri Oct 25, 2019 00:00
Indu Ghanshyam Bhana, Mahendra Chourasiya, Soaham Dilip DesaiAnnals of Indian Academy of Neurology 2019 22(4):529-530
Fri Oct 25, 2019 00:00
Hiroyuki Todo, Katsuya Nishida, Ryuki Ando, Hiroshi Yamasaki, Naonobu Futamura, Itaru FunakawaAnnals of Indian Academy of Neurology 2019 22(4):482-484 Background: Although muscle ultrasound (MUS) is known to facilitate the diagnosis and evaluation of the severity of amyotrophic lateral sclerosis (ALS), the number of fasciculation has been scarcely examined as a predictive marker of the prognosis in ALS. Objective: The objective of this study was to examine the predictive value of fasciculation...
Fri Oct 25, 2019 00:00
Manish Modi, Rajveer Singh, Manoj Kumar Goyal, Jitender Gairolla, Gagandeep Singh, Vivek Rishi, JS Thakur, RK Sehgal, Vivek Kumar Garg, Niranjan Khandelwal, Parampreet S Kharbanda, S Prabhakar, Vivek LalAnnals of Indian Academy of Neurology 2019 22(4):533-533
Fri Oct 25, 2019 00:00
Davide Sattin, Nirmal Surya, Caterina Pistarini, Paolo Tonin, Hitav Someshwar, Milena Caputo, Matilde LeonardiAnnals of Indian Academy of Neurology 2019 22(4):485-487 The epidemiological data of Indian patients with disorders of consciousness (DOC), specifically vegetative state and minimally conscious state, have not been investigated. The present study sought to explore the current state of the art in India for patients with DOC promoting a pilot survey. An ad hoc questionnaire was sent to a...
Fri Oct 25, 2019 00:00
Sinan Eliaçik, Ömer Önder Savas, Erdal Komut, Funda Uysal TanAnnals of Indian Academy of Neurology 2019 22(4):536-537
Fri Oct 25, 2019 00:00
Mahesh Kamate, Mayank DetrojaAnnals of Indian Academy of Neurology 2019 22(4):488-489
Fri Oct 25, 2019 00:00
Banshi Lal Kumawat, Pankaj Kumar Saini, Chandra Mohan Sharma, Manisha Sharma, LS ManuAnnals of Indian Academy of Neurology 2019 22(4):539-540
Fri Oct 25, 2019 00:00
Arunmozhimaran Elavarasi, Balachandran ManiAnnals of Indian Academy of Neurology 2019 22(4):490-490
Fri Oct 25, 2019 00:00
Yatin Sagvekar, Virti Shah, Anshu Rohatgi, Neha Pandita, Rahul Sharma, Rajeswari Rajan, Dhrumil ShahAnnals of Indian Academy of Neurology 2019 22(4):543-545
Fri Oct 25, 2019 00:00
Objectives: Given the relative novelty of stereotactic body radiation therapy as a treatment modality low-risk and intermediate-risk prostate cancer, little data exist evaluating dosimetry and its impact on patient-reported quality of life (PR-QOL) metrics. Herein, we present an interim analysis of a phase II clinical trial of PR-QOL and dosimetric correlates. Methods: Patients with biopsy-proven low-risk or intermediate-risk prostate cancer, prostate volume ≤100 cm3, and life expectancy...
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Objectives: To investigate local control and functional outcome following state-of-the-art fractionated stereotactic radiotherapy (FSRT) for paragangliomas of the head and neck. Methods: In total, 40 consecutive patients with paragangliomas of the head and neck received conventionally FSRT from 2003 to 2016 at the Department of Radiation Oncology of the University Hospital Erlangen. Local control, toxicities, and functional outcome were examined during follow-up. In total, 148 magnetic resonance...
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No abstract available
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Objectives: Thick melanomas, defined as ≥4 mm in thickness, represent ~5% of new melanoma diagnoses and have been associated with poor overall survival (OS). Ultrathick melanomas, those lesions ≥8 mm in thickness, have been associated with worse survival. We sought to compare prognostic factors for thick and ultrathick melanoma. Methods: Retrospective analysis of a prospective database of all patients receiving an operation for melanoma, June 2005 to December 2016 was performed. Multivariate...
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Objectives: Cancer patients with comorbid diabetes have a 50% increased risk of all-cause mortality compared with cancer patients without diabetes. Less attention to diabetes management (glucose control, medication adherence, and diabetes self-management behaviors) during active cancer treatment is hypothesized as an explanation for worse outcomes among diabetic cancer patients. The objective of this systematic review is to determine and quantify how a cancer diagnosis impacts diabetes management. ...
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Objectives: Although adolescents and young adults (AYA) suffer disproportionately from cutaneous melanoma (CM), little is known regarding the burden of CM leading to hospitalization in AYA. The objective of this study was to elucidate sociodemographic/hospitalization characteristics of AYA CM inpatients, determine which factors lead to the greater length of stay (LOS) and cost of care for AYA CM inpatients, and evaluate trends in the prevalence, LOS, and cost of care for AYA CM hospitalizations. ...
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Objectives: In endometrial cancer, the appropriate sequence of adjuvant chemotherapy (aCT) and adjuvant radiation therapy (aRT) is unclear. We aim evaluated whether early chemotherapy is associated with improved overall survival (OS) and cancer-specific survival (CSS). Methods: Endometrial cancer patients that received aCT and aRT were selected from the SEER-Medicare database. Early chemotherapy was defined as receiving aCT before aRT, with or without additional aCT (“sandwich” regimens)....
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Objectives: Current National Comprehensive Cancer Network (NCCN) guidelines support systemic therapy based on mutational status in stage IV non–small cell lung cancer (NSCLC), with stereotactic body radiation therapy (SBRT) reserved for oligoprogression. We aimed to evaluate the cost-effectiveness of the routine addition of SBRT to upfront therapy in stage IV NSCLC by mutational subgroup. Materials and Methods: A Markov state transition model was constructed to perform a cost-effectiveness...
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Objectives: Insulin-like growth factor-methotrexate (IGF-MTX) is a conjugate of methotrexate and 765IGF, a variant of IGF-1 with high affinity for insulin-like growth factor type 1 receptor. The study aim was to determine the maximum tolerated dose of IGF-MTX in refractory solid organ and hematologic malignancies expressing insulin-like growth factor type 1 receptor. Materials and Methods: This phase I trial used a modified toxicity probability interval design with 5 cohort dose levels, and...
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Objectives: The discovery of tyrosine kinase inhibitors (TKI) has remarkably improved the clinical course of patients with non–small cell lung cancer driven by Epidermal Growth Factor Receptor (EGFR) mutations. However, virtually in all cases, the disease resurfaces in a TKI-resistant form that is mainly linked to an acquired EGFR-T790M mutation, a MET amplification, or small cell lung cancer (SCLC) transformation. Third-generation TKIs are able to block tumor growth through an irreversible binding...
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No abstract available
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Background: Although lobectomy is the standard of care in stage I non–small cell lung cancer (NSCLC), medical comorbidities increase surgical risk in elderly patients. No population-based studies compare short-term mortality (STM) for surgery (STM-S), radiation (STM-R), and observation (STM-O) in elderly patients with stage I NSCLC. Methods: A total of 60,466 biopsy-proven stage I NSCLC cases diagnosed between 2004 and 2012 were retrieved from the Surveillance, Epidemiology, and End Results...
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We previously showed that alterations in mTOR pathway genes were correlated with response to rapalog therapy in metastatic renal cell carcinoma (mRCC), when the analysis focused on extremes of response. Herein, we expand on the prior cohort and examine genetic correlations with rapalog response in a dataset not selected for extremes of response. Tumors from 58 patients from the phase III trial of temsirolimus and 51 local mRCC patients treated with rapalogs were studied. Somatic mutations were investigated...
Fri Oct 25, 2019 17:30
Brain-infiltrating leukocytes contribute to multiple sclerosis (MS) and autoimmune encephalomyelitis and likely play a role in traumatic brain injury, seizure, and stroke. Brain-infiltrating leukocytes are also primary targets for MS disease-modifying therapies. However, no method exists for non-invasively visualizing these cells in a living organism. 1-(2'-deoxy-2'-18F-fluoroarabinofuranosyl) cytosine (18F-FAC) is a PET radiotracer that measures deoxynucleoside salvage and accumulates preferentially...
Fri Oct 25, 2019 19:13
Inflammation contributes to ventricular remodeling after myocardial ischemia, but its role in non-ischemic heart failure is poorly understood. Local tissue inflammation is difficult to assess serially during pathogenesis. While 18F-fluorodeoxyglucose (FDG) accumulates in inflammatory leukocytes which may identify inflammation in the myocardial microenvironment, it remains unclear whether this imaging technique can isolate diffuse leukocytes in pressure overload heart failure. We aimed to evaluate...
Fri Oct 25, 2019 19:13
Neuroendocrine-like trans-differentiation of prostate cancer adenocarcinomas correlates with serum levels of Chromogranin A (CgA) and drives treatment resistance. Aim of this work was to evaluate whether CgA could serve as a response predictor for 177Lu-PSMA617 radio-ligand therapy (PSMA-RLT) in comparison to the established tumor markers. Methods: 100 consecutive patients with metastasized castration resistant prostate cancer (mCRPC) scheduled for PSMA-RLT were evaluated for prostate specific...
Fri Oct 25, 2019 19:13
C-X-C motif chemokine receptor 4 (CXCR4) is expressed on the surface of various cell types involved in atherosclerosis, with a particularly rich receptor expression on macrophages and T cells. First pilot studies with 68Ga-Pentixafor, a novel CXCR4-directed positron emission tomography (PET) tracer, have shown promise to non-invasively image inflammation within atherosclerotic plaques. The aim of this retrospective study was to investigate the performance of 68Ga-Pentixafor PET/computed tomography...
Fri Oct 25, 2019 19:13
Purpose: Tumor infiltrating lymphocytes (TILs) are associated with benefit to trastuzumab and chemotherapy in early-stage HER2+ breast cancer (BC) patients. The predictive value of TILs, TIL subsets, and other immune cells in patients receiving chemotherapy-sparing lapatinib plus trastuzumab (LT) treatment is unclear. Experimental Design: H&E-stained slides (n=59) were used to score stromal (s-)TILs from pre-treatment biopsies of patients enrolled in the neoadjuvant TBCRC006 trial of 12-week...
Fri Oct 25, 2019 15:53
Abstract Malignant melanoma metastases are chameleons of histopathology. In 4 primary malignant melanomas and 20 melanoma metastases expression of S-100, HMB-45 and melan-A as melanoma markers and CD56, synaptophysin and chromogranin-A as neuroendocrine markers was retrospectively analyzed. While all primary tumors expressed all 3 melanoma markers 7/20 of melanoma metastases had lost at least one melanoma marker, one had lost all three markers. Conversely about half of the samples...
Fri Oct 25, 2019 03:00
Publication date: Available online 25 October 2019Source: Practical Radiation OncologyAuthor(s): Roland Teboh Forbang, Senthamizhchelvan Srinivasan, Sweet Ping Ng, Maureen L. Aliru, Joseph M. HermanAbstractPurpose/ObjectivesActive Breathing Coordinator (ABC) (Elekta AB, Crawley, UK) is a motion management strategy for radiation treatment. During setup, aligning the patient to the bony spine alone does not necessarily lead to an accurate alignment to soft tissue targets and further adjustment is necessary....
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Publication date: Available online 24 October 2019Source: Practical Radiation OncologyAuthor(s): Bram D. Vermeulen, Paul M. Jeene, Jasmijn Sijben, Robin Krol, Heidi Rütten, Johannes A. Bogers, Pètra M. Braam, Peter D. SiersemaAbstractBackground and purposeClinical evidence regarding optimal radiation dose for palliation of dysphagia from esophageal cancer is generally lacking. In an effort to investigate optimal radiation dose, we assessed two different radiation schedules for palliation of dysphagia.Materials...
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Related ArticlesCase study: cochlear implantation in cochlear otospongiosis. Cochlear Implants Int. 2019 Oct 23;:1-5 Authors: Marfatia H, Shah K, Pareek A, Chatterjee C, Goyal P Abstract Objective and importance: Cochlear implantation can be performed successfully in patients with otospongiosis of the temporal bone with the potential for excellent audiological outcomes and high patient satisfaction. The purpose of this case report is to highlight the...
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