Σάββατο 26 Οκτωβρίου 2019


An RNA guanine quadruplex regulated pathway to TRAIL-sensitization by DDX21 [Article]
DDX21 is a newly discovered RNA G-quadruplex (rG4) binding protein with no known biological rG4 targets. In this study we used label-free proteomic MS/MS to identify 26 proteins that are expressed at significantly different levels in cells expressing wild type DDX21 relative to an rG4 binding deficient DDX21 (M4). Data are available via ProteomeXchange with identifier PXD013501.From this list we validate MAGED2 as a protein that is regulated by DDX21 through rG4 in its 5’UTR. MAGED2 protein levels,...
RNA In Advance
Fri Oct 25, 2019 17:19
Risperidone-induced tardive akathisia: A rare antipsychotic side effect with management issues
Biswa Ranjan Mishra, Rajeev Ranjan, Debadatta Mohapatra, Santanu NathAnnals of Indian Academy of Neurology 2019 22(4):499-501 Akathisia is a movement disorder, a common extrapyramidal side effect that has been reported to occur primarily with antipsychotics and some neurological conditions. It is manifested by a subjective feeling of inner restlessness along with objective evidence of motoric restlessness. Tardive akathisia (TA) is rare, and there is very sparse literature available as regards...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Neuromyelitis optica spectrum disorder with vertical gaze palsy and hypersomnolence
Jomal Mathew, Madhukar Mohan, Ashok MenonAnnals of Indian Academy of Neurology 2019 22(4):530-532
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Plasmapheresis for NMOSD: Not a rescue therapy anymore!?
Rohit Bhatia, Radhakrishna Pedapati, Siddharth ChopraAnnals of Indian Academy of Neurology 2019 22(4):371-372
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Dengue fever with facial palsy: A rare neurological manifestation
Vijay Sardana, Rahi Kiran BhattiproluAnnals of Indian Academy of Neurology 2019 22(4):517-519
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Critical appraisal of guidelines for evaluation and certification of specified neurological disabilities
Inder Puri, Govind Singh, Rajendra Kumar Acharya, Divya GoswamiAnnals of Indian Academy of Neurology 2019 22(4):373-376 New disability law called “Rights of Persons with Disabilities Act 2016” has been acted in 2016. The United Nations' Convention for Rights of Persons with Disabilities is the sole of this new act. Of the total 21 categories, three new neurological legal disability categories such as chronic neurological conditions, Parkinson disease (PD), and multiple sclerosis have been notified...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Seronegative autoimmune encephalitis – A diagnostic and therapeutic dilemma
M NetravathiAnnals of Indian Academy of Neurology 2019 22(4):369-370
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Diagnostic utility of human leukocyte antigen B*15:02 screening in severe carbamazepine hypersensitivity syndrome
Youssef Moutaouakkil, Badr Adouani, Yahia Cherrah, Jamal Lamsaouri, Yassir BouslimanAnnals of Indian Academy of Neurology 2019 22(4):377-383 Background: Despite many studies suggesting an association between human leukocyte antigen (HLA)-B*15:02 and carbamazepine (CBZ)-induced severe cutaneous adverse drug reactions essentially toxic epidermal necrolysis (TEN) and Stevens–Johnson syndrome (SJS), the evidence of association in different populations and the degree of association remain uncertain....
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Extensor plantar response: The examination technique makes a crucial difference
Sarma R. K. GosalaAnnals of Indian Academy of Neurology 2019 22(4):513-513
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
William osler and harvey williams cushing: Friendship around neurosurgery
Marleide da Mota GomesAnnals of Indian Academy of Neurology 2019 22(4):384-388 William Osler was a mentor for the younger William Harvey Cushing and they intermingled careers and friendship for the rest of their lives. They shared a common interest in the anatomy and pathology of neurological disorders, and in the history of medicine. Their behavior was, however, sharply different: Osler was the revered physician, full of wisdom and good humor, and Cushing, the prestigious surgeon, in a perennial...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Expanding the spectrum of polymerase gamma-related ataxia
Harsh Vardhan Gupta, Kayla Karlowski, Tekalign BurkaAnnals of Indian Academy of Neurology 2019 22(4):525-525
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Plasma exchange as a first line therapy in acute attacks of neuromyelitis optica spectrum disorders
BL Kumawat, Reenu Choudhary, CM Sharma, Deepak Jain, Ashwini HiremathAnnals of Indian Academy of Neurology 2019 22(4):389-394 Background and Aims: Neuromyelitis optica spectrum disorder (NMOSD) is a demyelinating disorder of central nervous system with deleterious effects. At present Intravenous corticosteroids are used for the relapse as the first line of treatment, but with only a class evidence III-IV. Having an underlying humoral immune mechanism in the pathogenesis of NMOSD and as it is rightly...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Secondary narcolepsy masquerading as obstructive sleep apnea
Sachin Sureshbabu, Ajay Asranna, Sudhir Peter, Sobhana Chindripu, Gaurav K MittalAnnals of Indian Academy of Neurology 2019 22(4):537-538
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Epidemiologic features, risk factors, and outcomes of respiratory infection in patients with acute stroke
Lunlin Mao, Xiaobo Liu, Peng Zheng, Saiping WuAnnals of Indian Academy of Neurology 2019 22(4):395-400 Objective: The objective of this study is to explore risk factors for stroke-associated pneumonia (SAP) and their impact on prognosis. Materials and Methods: The data collected from a retrospective review of 257 patients with acute cerebral infarction between January 2014 and December 2016 were included in this study. Data were collected for clinical, demographic, and coexisting parameters. Univariate...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
A preventable ataxia: Cerebrotendinous xanthomatosis
Bhagya Shaji, B Srikumar, Dileep RamachandranAnnals of Indian Academy of Neurology 2019 22(4):493-496 Cerebrotendinous xanthomatosis is an autosomal recessive inborn error of metabolism that is an often missed but treatable cause of hereditary ataxia. We report a case of cerebrotendinous xanthomatosis (CTX) that was diagnosed only after the development of cognitive decline and adult onset ataxia in a 35-year-old man. He had poor scholastic performance in childhood followed by gradually progressive...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Antibody negative autoimmune encephalitis- Does it differ from definite one?
Sunil Pradhan, Animesh Das, Ananya Das, Madhura MulmuleyAnnals of Indian Academy of Neurology 2019 22(4):401-408 Context: Autoimmune encephalitis (AE) is an emerging cause of non-infective encephalitis, presentations of which vary widely. Traditionally the diagnosis of AE is based on detection of antibodies in a patient with clinical picture suggestive of AE. Aim: To evaluate the clinical characteristics and response to immunotherapy in patients with antibody negative autoimmune encephalitis and...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Phencyclidine: A rare cause of saccadic intrusions
MN Shameer Nijam, Narmathey Thambirajah, Dhanushka Vithanawasam, Kumarangie Vithanage, Damith S Liyanage, I Kishara Gooneratne, Sunethra SenanayakeAnnals of Indian Academy of Neurology 2019 22(4):503-505 Saccadic intrusions such as opsoclonus and ocular flutter are often due to a paraneoplastic or a parainfectious condition. Toxins/drugs may rarely cause them. Herein, we report a rare case of ocular flutter/opsoclonus due to phencyclidine (PCP) toxicity. Our patient is a 21-year-old male who presented...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Is dementia in Parkinson' disease related to chronic stress, anxiety, and depression?
Anita Pal, Nishi Pegwal, Madhuri Behari, Ratna SharmaAnnals of Indian Academy of Neurology 2019 22(4):409-413 Objectives: Stress, anxiety, and depression are known to be associated with the development of neurodegenerative disorders through interactions with the underlying pathophysiology. We hypothesized that the presence of these symptoms contributes to cognitive disturbances and dementia in Parkinson's disease (PD). The present study aimed to investigate the levels of stress, anxiety, and depression...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Infection and epilepsy: Current dilemma
Deepti VibhaAnnals of Indian Academy of Neurology 2019 22(4):514-515
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Lateralized periodic discharges are predictive of seizures in patients with intracerebral hemorrhage
Sushma Yerram, Nakul Katyal, Aarti Sarwal, Pravin George, Christopher R NeweyAnnals of Indian Academy of Neurology 2019 22(4):414-418 Background: Patients with intracerebral hemorrhages (ICHs) have higher incidence of seizures. Previous studies have suggested that location and size of hemorrhage may increase epileptogenicity. We aim to evaluate seizure development risk factors from clinical examination, imaging, and continuous electroencephalography (cEEG) in critically ill patients with ICH. Methods:...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Myotonic dystrophy type 1 complicated by colonic obstruction due to a bezoar
Aaron de Souza, Sanjeev GuptaAnnals of Indian Academy of Neurology 2019 22(4):520-523
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Evaluation of symptoms of depression and anxiety in adolescents with epilepsy in a tertiary-level medical center in Serbia
Ksenija Ervin Gebauer-Bukurov, Zeljka Dragomir Nikolasevic, Dragica Stevan Hajder, Zeljko Dragan Zivanovic, Vojislava Vojislav Bugarski IgnjatovicAnnals of Indian Academy of Neurology 2019 22(4):419-425 Backgrounds: Even though epilepsy is the most common neurological disorder in adolescence; studies of adolescents with epilepsy are scarce. Objective: To evaluate whether adolescents with epilepsy are more likely to develop anxiety and depressive symptoms than their healthy peers and to determine...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Tuberculous encephalitis with aphemia detected only by 18F-fluorodeoxyglucose-positron emission tomography
Boby Varkey Maramattom, Joe Thomas, Surya JosephAnnals of Indian Academy of Neurology 2019 22(4):527-529
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Abnormal subcortical volumes and cortical thickness in Parkinson's disease with impulse control disorders
Shweta Prasad, Venkateswara Reddy Reddam, Albert Stezin, Ravi Yadav, Jitender Saini, Pramod Kumar PalAnnals of Indian Academy of Neurology 2019 22(4):426-431 Background: The occurrence of impulse control disorders (ICDs) in Parkinson's disease (PD) is frequently attributed to dopamine replacement therapy. However, not all patients who receive medication develop ICDs. Recent imaging studies have suggested specific neuroanatomical abnormalities in patients with PD and ICD. Objectives: This study...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Management of benign paroxysmal positional vertigo not attributed to the posterior semicircular canal: A case series
Petros V Vlastarakos, John Plioutas, Nikolaos S Tsilis, Thomas P NikolopoulosAnnals of Indian Academy of Neurology 2019 22(4):533-535
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Urinary symptoms in patients with Parkinson's disease and progressive supranuclear palsy: Urodynamic findings and management of bladder dysfunction
Anupam Gupta, UK Rashmi Krishnan, Sushruth Nageshkumar, Pramod Kumar Pal, Meeka Khanna, Arun B TalyAnnals of Indian Academy of Neurology 2019 22(4):432-436 Objective: The objective of this study is to observe urinary symptoms in patients with Parkinson's disease (PD) and progressive supranuclear palsy (PSP) and advice bladder dysfunction management based on urodynamic study (UDS) findings. Patients and Methods: Twenty-two patients (12 males) with PD and PSP (15 and 7, respectively) with urinary...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Subacute myelopathy: Think beyond neuromyelitis optica spectrum disorder
Ananthanarayanan Kasinathan, Renu Suthar, Sameer Vyas, Arushi Gahlot Saini, Naveen Sankhyan, Savita AttriAnnals of Indian Academy of Neurology 2019 22(4):541-542
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Pregabalin and amitriptyline as monotherapy or as low-dose combination in patients of neuropathic pain: A randomized, controlled trial to evaluate efficacy and safety in an Eastern India teaching hospital
Sourav Chakrabarty, Samar Biswas, Tamoghna Maiti, Abhijit Das, Ananya Mandal, Prasun BanerjeeAnnals of Indian Academy of Neurology 2019 22(4):437-441 Objectives: The main objective is to compare efficacy and safety of pregabalin and amitriptyline monotherapy with their low-dose combination in patients of neuropathic pain (NeuP). Methodology: In this parallel-group, open-label interventional study at the Neurology Outpatient Department of Bankura Sammilani Medical College, a total of 147 patients...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Delayed propriospinal myoclonus following dorsal spinal cord surgery
Vijay Sardana, Sunil Kumar SharmaAnnals of Indian Academy of Neurology 2019 22(4):491-493 Cerebral disorders are known to be associated with myoclonus, but spinal pathologies have received little attention as a causative factor in movement disorders. Propriospinal myoclonus (PSM) is a rare hyperkinetic movement disorder caused by activity of a spinal pattern generator localized in a few segments of the spinal cord, spreading to other intraspinal segments via propriospinal pathways. Majority of...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Central disorders of hypersomnolence in children and adults: A comparative study from South India
Madhukar Trivedi, Sapna Erat Sreedharan, Shana N Nair, CA Anees, JP Unnikrishnan, PS Sarma, Ashalatha RadhakrishnanAnnals of Indian Academy of Neurology 2019 22(4):442-446 Background: Narcolepsy and idiopathic hypersomnolence (IHS) are rare disorders. In Western populations, the reported prevalence of narcolepsy is 0.02%–0.05%. In Indian subcontinent, there are few reports on narcolepsy and none on IHS so far. Here, we compared the clinical and polysomnographic profile of narcolepsy/IHS among the...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Adult-onset isolated hemichorea revealing iatrogenic hypoparathyroidism and bilateral basal ganglia calcification
Karan Desai, Priyanka Walzade, Sangeeta Hasmukh Ravat, Pankaj A AgarwalAnnals of Indian Academy of Neurology 2019 22(4):496-499 Isolated hemichorea (HC) in adults has a relatively restricted differential diagnosis including stroke of contralateral basal ganglia nuclei, nonketotic hyperglycemia, and basal ganglia toxoplasmosis in HIV infection. Hypoparathyroidism-related basal ganglia calcification can potentially cause neurological problems, including movement disorders, that are usually bilateral...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Prevalence of malnutrition in Parkinson's disease and correlation with gastrointestinal symptoms
Birinder Singh Paul, Tejinder Singh, Gunchan Paul, Dinesh Jain, Gagandeep Singh, Sandeep Kaushal, Rajoo Singh ChhinaAnnals of Indian Academy of Neurology 2019 22(4):447-452 Background: Parkinson's disease (PD) patients are at a higher risk of malnutrition with the overall prevalence estimated to be 3%–60%, but there are limited data in India regarding nutritional assessment of PD. Aim: This study aims to assess nutritional status of PD patients and correlate the disease factors and gastrointestinal...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Treatment of catatonia in Parkinson's disease with electroconvulsive therapy
Vinutha Ramesh, Ashish Sharma, Veenita Sharma, Aditya SomaniAnnals of Indian Academy of Neurology 2019 22(4):501-503 Parkinson's disease (PD) is known to have associated nonmotor manifestations including psychiatric symptoms such as depression and psychosis. Catatonia has been reported extremely rarely in patients of PD. The case described here is a rare example of catatonia in a patient with PD with psychosis. Treatment with electroconvulsive therapy (ECT) brought improvement in symptoms of both...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Long-term mortality risk of people with epilepsy who underwent seizure monitoring
Shishir N Duble, VS Nandini, Ashalatha Radhakrishnan, Ramshekhar Menon, Ajith Cherian, P Sankara Sarma, Sanjeev V ThomasAnnals of Indian Academy of Neurology 2019 22(4):453-457 Aim: The aim is to study survival outcome and sudden unexpected death in epilepsy (SUDEP) of people with epilepsy who underwent epilepsy monitoring. Subjects and Methods: Between 2000 and 2004, 558 persons were admitted to the epilepsy monitoring unit of SCTIMST who fulfilled the selection criteria. Their survival status...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Multiple neurologic deficits and cognitive decline in a young woman
Arunmozhimaran Elavarasi, Jacob George, Mehar Chand Sharma, Kalpana Kumari, Ajay Garg, Awadh Kishor Pandit, Abhishek Satapathy, Vinay GoyalAnnals of Indian Academy of Neurology 2019 22(4):506-512 We present the clinicopathologic conference of a 34-year-old lady with history of facial palsy 14 years ago who developed new deficits of mononeuritis multiplex, maculopapular rash, pancytopenia, splenomegaly, lung involvement and cognitive decline rapidly over three years. Investigations revealed pancytopenia,...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Familial Creutzfeldt-Jakob disease in an Indian kindred
Sarosh M Katrak, Apoorva Pauranik, Shrinivas B Desai, Simon Mead, Jon Beck, Sebastian Brandner, John CollingeAnnals of Indian Academy of Neurology 2019 22(4):458-461 It is now known that the inherited prion disease is caused by over 60 different mutations in the Prion protein (PRNP) gene. Four missense mutations at codons 102, 178, 200 and 210, account for over 95% of these cases. In this study we describe, a large Indian family with familial Creutzfeldt Jakob Disease (fCJD). One affected member...
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Differential diagnoses of amyotrophic lateral sclerosis are more variegated than anticipated
Josef FinstererAnnals of Indian Academy of Neurology 2019 22(4):513-513
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Familial CJD- A brief commentary
Satish Chandra, Anita Mahadevan, SK ShankarAnnals of Indian Academy of Neurology 2019 22(4):462-463
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00
Reversal of anticoagulation effect of dabigatran with idarucizumab, for thrombolysis in acute ischemic stroke: Inimicus inimico amicus
Boby V Maramattom, Joe ThomasAnnals of Indian Academy of Neurology 2019 22(4):515-517
Annals of Indian Academy of Neurology : 2015 - 18(2)
Fri Oct 25, 2019 00:00

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