Publication date: Available online 25 October 2019Source: Sleep MedicineAuthor(s): Elizabeth Hill, Donna Fairley, Ewan McConnell, Ian Morrison, Marta Celmina, Serafeim – Chrysovalantis Kotoulas, Renata L. RihaAbstractObjective/BackgroundThe utility of the pictorial Epworth sleepiness scale (pESS) has been assessed by only a few studies in a clinical population. Some of its questions may be inappropriate in certain patient groups. The aim of this study was to assess the utility of the pESS in the...
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Publication date: Available online 25 October 2019Source: American Journal of Infection ControlAuthor(s): Sidney Bondurant, Tanya McKinney, Liza Bondurant, Lisa FitzpatrickBackgroundThis study was performed to evaluate the effectiveness of a new commercially available hand sanitizer using 0.12% benzalkonium chloride (BZK) as the active ingredient in reducing transient skin contamination with Staphylococcus aureus in health care workers (HCWs), as compared with the effectiveness of a 70% ethanol-based...
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Publication date: Available online 25 October 2019Source: European Journal of Pharmaceutical SciencesAuthor(s): Zongwei Guo, Ting Song, Zuguang Xue, Peng Liu, Minhang Zhang, Xiaodong Zhang, Zhichao ZhangAbstractDeepening understanding of how Bcl-2 family proteins protect cancer cells from apoptosis has driven the development of ‘BH3 mimetic’ drugs that target various anti-apoptotic Bcl-2-like proteins by mimicking their natural inhibitors, the BH3-only proteins. The proof of target engagement and...
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Publication date: Available online 25 October 2019Source: European Journal of Pharmaceutical SciencesAuthor(s): Jiaojiao Yu, Xiaosong Shan, Shichao Chen, Xinli Sun, Pengjin Song, Ruidong Zhao, Liandong HuAbstractIn this study, novel orally disintegrating tablets (ODTs) with multi-channel structure were designed to provide a rapid disintegration and subsequently drug dissolution. The ODTs were prepared using conventional wet compression through perforating channels with a special multi-channel mold....
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Publication date: Available online 25 October 2019Source: European Journal of Pharmaceutical SciencesAuthor(s): Risto O. Juvonen, Aki T. Heikkinen, Olli Kärkkäinen, Rabia Jehangir, Juhani Huuskonen, Johanna Troberg, Hannu Raunio, Olli T. Pentikäinen, Moshe FinelAbstractBeagle dog is a standard animal model for evaluating nonclinical pharmacokinetics of new drug candidates. Glucuronidation in intestine and liver is an important first-pass drug metabolic pathway, especially for phenolic compounds....
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Publication date: Available online 25 October 2019Source: European Journal of Pharmaceutical SciencesAuthor(s): Yosuke Yamamoto, Harumi Kumagai, Moe Haneda, Maria Vertzoni, Niels Ouwerkerk, Daisuke Murayama, Yoshifumi Katakawa, Kei Motonaga, Christos Reppas, Tomokazu TajiriAbstractThe main objective of this study was to investigate the mechanism of solifenacin release from a pH-responsive ion-complex oral resinate suspension under conditions simulating the environment in the upper gastrointestinal...
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Publication date: Available online 25 October 2019Source: European Journal of Pharmaceutical SciencesAuthor(s): Annelies Jorritsma-Smit, Coba J. van Zanten, Jolande Schoemaker, Janneke J.M. Meulenberg, Daan J. Touw, Jos G.W. Kosterink, Hans W. Nijman, Toos Daemen, Derk P. AllersmaAbstractTherapeutic vaccination is being explored as a treatment strategy for the treatment of patients with primary or metastatic tumours. We developed a vaccine targeted to Human papillomavirus (HPV)-induced tumours based...
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Publication date: Available online 25 October 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Rongzhou He, Yanchen Ye, Zilun Li, Yu Jiang, Yonghui Li, Yunyan Liu, Kangjie Wang, Chen Yao
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Publication date: Available online 25 October 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Axel Haine, Martin J. Schmid, Marc Schindewolf, Armando Lenz, Sarah M. Bernhard, Heinz Drexel, Iris Baumgartner, Jörn F. DopheideObjectivesInformation on performance of different stent platforms in endovascular revascularisation of femoropopliteal lesions is controversial and scarce.MethodsInterwoven nitinol (INS, Supera) were compared with drug eluting (DES, Zilver PTx) stents...
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Publication date: Available online 25 October 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Christos Liapis, Efthymios D. Avgerinos, Hans-Henning Eckstein
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Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Wei Zhang, Shengqiang Dang, Guangjian Zhang, Haiqi He, Xiaopeng WenAbstractPurposeIL-10, IL-18 and IL-12 are reported to participate in the inflammation process. The potential influences of IL-10, IL-18 and IL-12 polymorphisms on non-small cell lung cancer (NSCLC) risk were explored in this study.MethodsSix candidate SNPs from 500 NSCLC patients and 500 controls were genotyped. The correlation between the...
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Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Zongwei Wang, Yuxian Yang, Simo Liu, Juan Feng, Yuanyuan Zhang, Jing Ke, Dong ZhaoAbstractAimsExploring the CD26 expression in peripheral blood and T cells in Hashimoto's thyroiditis with normal thyroid function. And evaluating the association between CD26 expression and TGAb and TPOAb levels.MethodsWe collected peripheral blood and thyroid tissues from healthy controls and HT patients. Then we measured circulating...
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Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Xiao Wu, Rong Xue, Hao Peng, Xiaojie Gan, Xu Lu, Wei Yan, Yizhu Tian, Xuhao Ni, Hongbin Shen, Feng Cheng, Xuehao Wang, Xiaoming Wang, Ling LuAbstractTumors escape immune attacks via various mechanisms, among which activation of regulatory pathways in effector immune cells and recruitment of immunosuppressive cells are usually employed. Traf6 is a member of the family of tumor necrosis factor receptor-associated...
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Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Christian BaillyAbstractThe drug edaravone (EDA) is prescribed for the treatment of patients with amyotrophic lateral sclerosis or after an acute cerebral infarction. This synthetic pyrazolone derivative is a potent scavenger of oxygen free radicals and also functions as a modulator of transcription factors, repressing NFκB and activating Nrf2, to regulate oxidative stress. EDA displays complementary anti-oxidative...
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Publication date: December 2019Source: Journal of Anthropological Archaeology, Volume 56Author(s): Hadas Goldgeier, Natalie D. Munro, Leore GrosmanAbstractHilazon Tachtit Cave served as a cemetery for at least 28 individuals and an arena for interment rituals and other activities. The nature of the activities in the cave, their frequency and their recurrence over time, demonstrate that this site was an important sacred place on the Late Natufian (ca. 12,000 cal. BP) landscape of the western Galilee...
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Publication date: December 2019Source: Journal of Anthropological Archaeology, Volume 56Author(s): Todd J. Kristensen, P. Gregory Hare, Ruth M. Gotthardt, Norman A. Easton, John W. Ives, Robert J. Speakman, Jeffrey T. RasicAbstractLithic provenance analyses offer means to reconstruct ancestral social relationships in Subarctic North America. We summarize sourced obsidian data from 462 archaeological sites in the Yukon and Northwest Territories, Canada, and interpret obsidian distribution through...
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Publication date: December 2019Source: Journal of Anthropological Archaeology, Volume 56Author(s): Natacha BucAbstractAlthough the Paraná River wetland includes a high number of Late Holocene archaeological sites from hunter-gatherer groups which share material properties related to a common subsistence strategy, material variability can be seen in the regional scale. Through the analysis of pottery style, some authors have proposed that this could be related to the development of social limits....
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Publication date: Available online 25 October 2019Source: Journal of Bodywork and Movement TherapiesAuthor(s): Christopher M. NorrisAbstractExercise is vital to the management of low back pain (LBP). However, research, social media, and fitness industry interests can leave therapists confused about best practice in exercise prescription for this clinical condition. The 3R’s approach to back rehabilitation is introduced as an evidence-based framework for developing patient specific exercise throughout...
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Publication date: Available online 25 October 2019Source: Journal of Bodywork and Movement TherapiesAuthor(s): Galit PazAbstractBackgroundCharcot-Marie-Tooth (CMT) disease, a progressive hereditary peripheral neuropathy, leads to muscle weakness, wasting, and sensory and motor nerve deprivation. The two main types of CMT are CMT1 (demyelinating) and CMT2 (axonal). Initial findings include foot deformities and sensory changes with progression to altered gait, diminished reflexes, and muscle wasting...
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Publication date: Available online 25 October 2019Source: Journal of Clinical VirologyAuthor(s): Elke Wollants, Leen Beller, Kurt Beuselinck, Mandy Bloemen, Katrien Lagrou, Marijke Reynders, Marc Van RanstAbstractBackgroundEnteroviruses are responsible for a wide range of clinical symptoms.Enterovirus D68 was already known to cause mild to severe respiratory infections, but in the last few years, it has also been associated with neurological symptoms and acute flaccid paralysis.ObjectivesIn this...
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Publication date: Available online 25 October 2019Source: Journal of Controlled ReleaseAuthor(s): Hyung-seung Jin, Da-som Choi, Minkyung Ko, Dongkap Kim, Dong-hee Lee, Soojin lee, Ah Young Lee, Seung Goo Kang, Soo Hyun Kim, Youngmee Jung, Youngdo Jeong, Justin J. Chung, Yoon ParkAbstractClinical data from diverse cancer types shows that the increased T cell infiltration in tumors correlates with improved patient prognosis. Acidic extracellular pH is a major attribute of the tumor microenvironment...
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Publication date: Available online 26 October 2019Source: Journal of EthnopharmacologyAuthor(s): Kenny Kuchta, Nguyen Huu Tung, Tomoe Ota, Muhareva Raekiansyah, Kristina Grötzinger, Hans Rausch, Yukihiro Shoyama, Hans Wilhelm Rauwald, Kouichi MoritaAbstractEthnopharmacological relevanceThe haemorrhagic dengue fever affects up to 500 million patients, annually causing 20.000 deaths, with no chemotherapeutic agent available. The oleoresin labdanum of Cistus creticus L. has been established as an anti-infective...
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Publication date: Available online 26 October 2019Source: Journal of EthnopharmacologyAuthor(s): Jia-xin Cheng, Bo-dou Zhang, Wan-fang Zhu, Chao-feng Zhang, Yi-min Qin, Masahiko Abe, Toshihiro Akihisa, Wen-yuan Liu, Feng Feng, Jie ZhangAbstractEthnopharmacological relevanceFicus hispida L.f. (Moraceae) has long been used as a traditional medicine in India, China, Sri Lanka, Australia, and Myanmar in the treatment of diarrhea, ulcer, anemia, diabetes, inflammation, and cancer.Aim of the review: This...
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Publication date: Available online 26 October 2019Source: Journal of EthnopharmacologyAuthor(s): Zi Hui Ni, Li Wu, Ke Xin Cao, Xi Qiong Zhang, Dan Yu Wang, Yu Wei Zeng, Lin Lin Liang, Xian Dan Qiu, Run Sheng Guo, Hai Bo Cheng, Zhi Peng ChenAbstractEthnopharmacological relevanceDahuang Zhechong pill (DHZCP) is a commonly used traditional Chinese medicine for the treatment of hepatocarcinoma.Aim of the studyPrevious studies have found that DHZCP can exert anti-hepatocarcinoma effects and reverse drug...
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Publication date: Available online 25 October 2019Source: Journal of EthnopharmacologyAuthor(s): Rentsen Badamjav, Dolgor Sonom, Yunhao Wu, Yuanyuan Zhang, Junping Kou, Boyang Yu, Fang LiAbstractEthnopharmacological relevanceThalictrum minus L., a Mongolian folk medicinal plant, was applied for the treatment of bacterial and fungal infection, tuberculosis and lung inflammation.Aim of the study: The present work aims to elucidate the protective effects of Thalictrum minus L.(TML) against lipopolysaccharide...
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Publication date: Available online 25 October 2019Source: Journal of EthnopharmacologyAuthor(s): Rui Li, Yang Zhang, Yucheng Wang, Kejia Huang, Qianye Yang, Tiantian Zhang, Kun Xie, Jian Li, Qi ZhaoAbstractEthnopharmacological relevanceFritillariae cirrhosae (FC), referred to‘Chuan beimu'in China. As an important edible and medicinal plant, the bulbs of F.cirrhosae is used traditionally in the treatment of pulmonary diseases associated with lung heat, inflammation and tumors. In the study, we investigated...
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Publication date: Available online 25 October 2019Source: Journal of EthnopharmacologyAuthor(s): Anindita Banerjee, Siddhartha Singh, Shilpi Kumari Prasad, Sourav Kumar, Oly Banerjee, Tapan Seal, Sandip Mukherjee, Bithin Kumar MajiAbstractEthnopharmacological relevanceTinospora sinensis Lour. (Merr.) belongs to the family Menispermaceae and its stem extract have been used traditionally in broad aspects of therapeutic remedies including debility, dyspepsia, fever, jaundice, ulcer, bronchitis, urinary...
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Publication date: 15 February 2020Source: Journal of Hazardous Materials, Volume 384Author(s): Ningyuan Zhu, Chunquan Li, Lingjun Bu, Cilai Tang, Sichu Wang, Pengfei Duan, Lunguang Yao, Jun Tang, Dionysios D. Dionysiou, Yonghong WuAbstractAn innovative advanced oxidation process was successfully developed to photocatalytic-degradation of estrone through the synergistic effect of biochar and Bi/Bi2O3 in bismuth-containing photocatalytic biochar (BiPB). The highest reaction rate constant (kobs) of...
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Publication date: Available online 25 October 2019Source: Journal of ProteomicsAuthor(s): Huanying Pang, Wanxin Li, Weijie Zhang, Shihui Zhou, Rowena Hoare, Sean J. Monaghan, Jichan Jian, Xiangmin LinAbstractIt is well known that lysine acetylation (Kace) modification is a common post-translational modification (PTM) that plays an important role in multiple biological and pathological functions in bacteria. However, few studies have focused on lysine acetylation modification in aquatic pathogens...
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Publication date: Available online 25 October 2019Source: Journal of ProteomicsAuthor(s): MaríaCeleste Ferrari, Micaela Cerletti, Roberto A. Paggi, Christian Troetschel, Ansgar Poetsch, Rosana De CastroGraphical abstract
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Publication date: Available online 25 October 2019Source: Journal of VoiceAuthor(s): Matthias Echternach, Catalina Högerle, Marie Köberlein, Patrick Schlegel, Michael Döllinger, Bernhard Richter, Marie-Anne KainzSummaryIntroductionIt is generally assumed that when singing across the region where registration events for untrained voices occur (the passaggio), singers modify the voice production system in order to avoid changes of voice quality. In this context, it has been postulated that nasalance...
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Publication date: Available online 26 October 2019Source: Materials & DesignAuthor(s): Yunan Lin, Rongrong Chen, Yanjun Zhang, Zhu Lin, Qi Liu, Jingyuan Liu, Yanli Wang, Liangtian Gao, Jun WangAbstractPorous organosilica intercalated graphene oxide (p-GA) was synthesized via the two-step polymerization method using 1-(2-aminoethyl)-3- aminopropyltrimethoxysilane as monomer. The average pore diameter of p-GA was calculated to be 4.42 nm with the Barret–Joyner–Halenda (BJH) algorithm. Amino and...
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Publication date: Available online 26 October 2019Source: Palaeogeography, Palaeoclimatology, PalaeoecologyAuthor(s): Diego A. Kietzmann, Roberto A. ScassoAbstractWe report Upper Jurassic–Lower Cretaceous (Kimmeridgian-Berriasian) calcispheres from the Ameghino (Nordenskjöld) Formation at high palaeolatitudes on the northern part of the Antarctic Peninsula. The Ameghino Formation generally contains a relatively poorly preserved association of calcispheres, which are often recrystallized or replaced...
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Publication date: Available online 25 October 2019Source: Palaeogeography, Palaeoclimatology, PalaeoecologyAuthor(s): Xiaojuan Sun, Christoph Heubeck, Michael Steiner, Ben YangAbstractTerreneuvian strata from the western Yangtze Platform host diverse assemblages of small shelly fossils (SSFs), which are key for understanding the Cambrian Bioradiation Event and have been the objects of numerous geochemical studies to understand environmental factors during Fortunian and Cambrian Age 2. The region...
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Publication date: Available online 25 October 2019Source: PeptidesAuthor(s): M.A. Nauck, H. Holle, M. Kahle, A. Tytko, C.F. Deacon, J.J. Holst, J.J. MeierAbstractBackground, aimsIn patients with type 2 diabetes, the lost insulinotropic effect of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) is more apparent after continuous versus bolus administration. To test whether the difference might be explained by rapid tachyphylaxis in response to elevated concentrations of GIP,...
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Publication date: Available online 25 October 2019Source: VaccineAuthor(s): Sarah Wood Pallas, Albana Ahmeti, Winthrop Morgan, Iria Preza, Erida Nelaj, Malembe Ebama, Ann Levin, Kathryn E. Lafond, Silvia BinoAbstractBackgroundSince 2012, WHO has recommended influenza vaccination for health care workers (HCWs), which has different costs than routine infant immunization; however, few cost estimates exist from low- and middle-income countries. Albania, a middle-income country, has self-procured influenza...
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Publication date: Available online 25 October 2019Source: VaccineAuthor(s): Yong-Myung Kang, Hyun-Kyu Cho, Hyun-Mi Kim, Myoung-Heon Lee, Thanh Long To, Hyun-Mi KangAbstractThe occurrence of severe outbreaks of highly pathogenic avian influenza in Korea led to establishment of a national antigen bank for emergency preparedness. Here, we developed five vaccines for this bank (clade 2.3.2.1C, clade 2.3.4.4A, B, C, and D) by reverse genetics, inactivated them with formalin, and evaluated the protective...
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Information on subgroup assessments in systematic reviews (SR) of atrial fibrillation (AF) is limited. This review aims to describe subgroup analyses in AF SRs to inform the design of SRs and randomized trials...
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