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Publication date: Available online 26 October 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Adi Primov-Fever, Ory MadgarRecurrent laryngeal papillomatosis is a viral (human papillomavirus) disease that causes the growth of epithelial verrucous lesions. Patients with laryngeal papillomatosis undergo multiple surgeries due to the tendency of the lesions to reoccur and cause recurrent voice and breathing problems. The goal of the surgical treatment is to remove the...
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Abstract Background Land use change has a significant impact on ecosystem services in watershed systems. The upper part of Qiantang River, Kaihua Country has experienced land-use changes over the past 15 years, but the effect of these changes on ecosystem services remains unknown. Objective This study evaluates land-use changes in response to ecological protection...
Abstract Transport sector of Pakistan contributes more than one half to the national energy consumption. This sector is dominated by road transportation and mainly relies on fossil fuels. The country is going through rapid unplanned urbanization, which can lead to detrimental health and ecological consequences by intensifying road transport energy consumption. Therefore, the current study investigates the effect of urbanization on road sector energy consumption controlling for...
Abstract Acid mine drainage is one of the main environmental hazards to ecosystems worldwide and it is directly related to mining activities. In Ecuador, such acidic-metallic waters are drained to rivers without treatment. In this research, we tested a laboratory combined (Ca-Mg) Dispersed Alkaline Substrate (DAS) system as an alternative to remediate acid drainage from the Zaruma-Portovelo gold mining site, at El Oro, Ecuador. The system worked at low and high flow hydraulic rates...
Abstract Fenton’s reaction-based chemical oxidation is in principle a method that can be utilized for all organic fuel residues thus making it a potential all-purpose, multi-contaminant, in situ application for cases in which storage and distribution of different types of fuels have resulted in contamination of soil or groundwater. Since peroxide breakdown reactions are also expected to lead to a physical transport of the target compound, this secondary physical removal, or rebound...
Abstract Using the hologram quantitative structure-activity relationship (HQSAR) method, a quantitative model of the structure-activity relationship between the genotoxicity of quinolones towards gram-negative bacteria and structure of quinolones is constructed. A series of novel quinolones are designed, and 4 environmentally friendly quinolone derivatives are finally selected, because of their enhanced genotoxicity towards gram-negative/positive bacteria, decreased bioconcentration...
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Abstract Background As an important means of communication, exosomes play an important role in the development of hepatocellular carcinoma (HCC). Methods Bioinformatics analysis, dual-luciferase reporter assays, methylation-specific quantitative PCR, and ChIP-PCR analysis were used to gain insight into the underlying mechanism of miR-21 in HCC....
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Abstract Background Return to sport (RTS) criteria are widely being used to identify anterior cruciate ligament reconstructed (ACLR) athletes ready to return to sportive activity and reduce risk of ACL re-injury. However, studies show a high rate of ACL re-injury in athletes who passed RTS criteria. This indicates that the current RTS criteria might not be sufficient to determine return to sport time in ACLR athletes. Previous studies...
Abstract Background Several risk factors for adult acquired flatfoot deformity (AAFD) have been identified in literature. To this date, little attention has been paid to the lateral ligament complex and its influence on AAFD, although its anatomic course and anatomic studies suggest a restriction to flatfoot deformity. The aim of this study was to assess the influence of the anterior talofibular ligament (ATFL) on AAFD and on radiologic...
Abstract Background Multiple published studies quantitatively analysing the diagnostic value of MRI, MR arthrography (MRA) and CT arthrography (CTA) for labral lesions of the shoulder have had inconsistent results. The aim of this meta-analysis was to systematically compare the diagnostic performance of MRI, MRA, CTA and CT. Methods Two databases,...
Abstract Background Cyamella,the sesamoid bones of the popliteus muscle, are rare in humans. Snapping knee is an uncommon problem which can be difficult to diagnose. Case presentation In this case, we report a 24-year-old male with snapping knee caused by symptomatic cyamella in the popliteus tendon. A large cyamella was identified upon surgery...
Abstract Background Hip dysplasia is common among children with cerebral palsy (CP), particularly in spastic CP. It can result in pain, reduced function and quality of life. However, the burden of hip dysplasia among children with CP in llow-and middle-income countries (LMICs) like Bangladesh is unknown. We aimed to define the burden of hip dysplasia among children with spastic CP in Bangladesh. ...
Abstract Background In 2005, the German Association of Occupational Accident Insurance Funds (DGUV) defined radiological evaluation criteria for the assessment of degenerative occupational diseases of the lumbar spine. These include the measurement of intervertebral osteochondrosis and classification of vertebral osteosclerosis, antero-lateral and posterior spondylosis, and spondyloarthritis via plain radiography. The measures currently...
Abstract Background There are inconsistencies in findings regarding the relationship of occupational loading with spinal degeneration or structural damage. Thus, a systematic review was conducted to determine the current state of knowledge on the association of occupational loading and spine degeneration on imaging. Methods We performed electronic...
Abstract Background Occult and missed surgical neck fractures can be found in patients diagnosed with isolated greater tuberosity (GT) fracture during the follow up period. The purpose of this study was to retrospectively assess the incidence rate of occult and missed surgical neck fractures in those initially diagnosed with isolated GT fracture. Methods ...
Abstract Background Rates of total knee arthroplasty (TKA) procedures in younger, more medically complex patients have dramatically increased over the last several decades. No study has examined categorization of lower and higher functioning subgroups within the TKA patient population. Our study aimed to determine preoperative characteristics of younger patients who are lower functioning following TKA. ...
Abstract Background Exercise therapy is recommended for knee osteoarthritis (OA), but the underlying mechanisms of pain relief are not fully understood. The purpose of this study was to explore the effects of exercise on muscle perfusion assessed by dynamic contrast enhanced MRI (DCE-MRI) and its association with changes in pain in patients with knee OA. Methods ...
Abstract Background To perform medial open-wedge high tibial osteotomy (OWHTO), surgeons expose the medial-proximal tibia by releasing or cutting the superficial layer of the medial collateral ligament (sMCL). Biomechanically, the sMCL provides primary restraint against valgus forces. Therefore, any release of the sMCL can cause valgus instability of the knee joint. The purpose of this study was to assess valgus laxity after release...
Abstract Background To determine the longitudinal construct validity of assessing hand OA progression on digital photographs over 7 years compared with progression determined from radiographs, clinical features and change in symptoms. Methods Participants were community-dwelling older adults (≥50 years) in North Staffordshire, UK. Standardized...
Abstract Background Knee osteoarthritis (KOA) is a prevalent form of chronic joint disease associated with functional restrictions and pain. Activity limitations negatively impact social connectedness and psychological well-being, reducing the quality of life (QoL) of patients. The purpose of this review is to summarize the existing information on QoL in KOA patients and share the reported individual factors, which may influence...
Abstract Background The global burden of chronic pain is growing with implications for both an ageing workforce and employers. Many obstacles are faced by people with chronic pain in finding employment and returning to work after a period of absence. Few studies have explored obstacles to return-to-work (RTW) from workers’ and employers’ perspectives. Here we explore views of both people in pain and employers about challenges to...
Abstract Background The Eclipse® (Eclipse® is a trademark of Arthrex, Naples, Florida) stemless shoulder prosthesis offers the surgeon the advantage of bone stock preservation and at the same time avoids the drawbacks of a resurfacing arthroplasty. Previous studies have shown radiographic changes on serial follow up of the Eclipse prosthesis. This study attempts to assess the significance of these radiographic changes and effect...
Abstract Objective Acupuncture therapy for chronic low back pain (CLBP) has received increasing attention. Nevertheless, the evidence of efficacy and safety of random controlled trials (RCTs) remains controversial. Acupuncture as a complex intervention influenced by many factors, its effectiveness in treating chronic low back pain in the real world is unknown. We will develop a network-based registry study to evaluate the effectiveness...
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Abstract Objective Anterior urethral anomalies (AUA) which present as anterior urethral valve, stenosis or atresia, are a rare cause for congenital urinary tract obstruction. We present our AUA prenatal diagnosis case series. Methods Fetuses presenting with prenatal findings suggestive for AUA according to post‐natal reported clinical and imaging signs (urinary tract dilatation, dilated bladder, enlarged edematous fetal penis, dilatation of the fetal urethra and diverticula) were followed...
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Abstract Recently, neutrophil extracellular traps (NETs), three-dimensional structures formed of neutrophil enzymes such as neutrophil elastase (NE) and nuclear components (DNA), have been associated with progression in different types of cancer. However, data remain scarce in breast cancer. Thus, the aim of this study was to associate NETs with clinical stages of breast cancer. A prospective analysis was performed in 45 plasma samples of female patients with newly diagnosed breast...
Abstract Thirty-one cases of low-grade renal cell carcinoma (RCC) with clear cells and tubulopapillary/papillary architecture were analyzed retrospectively with immunohistochemical and genetic markers to gain more experience with the differential diagnosis of such cases. All samples coexpressed CK7 and CA9; the TFE3 or TFEB reactions were negative; the CD10 and the AMACR stainings were negative in 27 cases and 30 cases, respectively. The FISH assays for papillary RCC, available...
Abstract Ewing sarcoma is a rare tumor developed in bone and soft tissues of children and teenagers. This entity is biologically led by a chromosomal translocation, typically including EWS and FLI1 genes. Little is known about Ewing sarcoma predisposition, although the role of environmental factors, ethnicity and certain polymorphisms on Ewing sarcoma susceptibility has been studied during the last few years. Its prevalence among cancer predisposition syndromes has also been thoroughly...
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IJMS, Vol. 20, Pages 5344: Autosomal Dominant Retinitis Pigmentosa Due to Class B Rhodopsin Mutations: An Objective Outcome for Future Treatment Trials International Journal of Molecular Sciences doi: 10.3390/ijms20215344 Authors: Alexander Sumaroka Artur V. Cideciyan Jason Charng Vivian Wu Christian A. Powers Bhavya S. Iyer Brianna Lisi Malgorzata Swider Samuel G. Jacobson Gene therapy for adRP due to RHO mutations was recently shown to prevent photoreceptor...
IJMS, Vol. 20, Pages 5343: Discrimination of DNA Methylation Signal from Background Variation for Clinical Diagnostics International Journal of Molecular Sciences doi: 10.3390/ijms20215343 Authors: Robersy Sanchez Xiaodong Yang Thomas Maher Sally A. Mackenzie Advances in the study of human DNA methylation variation offer a new avenue for the translation of epigenetic research results to clinical applications. Although current approaches to methylome analysis have been helpful...
IJMS, Vol. 20, Pages 5341: Renal Ca2+ and Water Handling in Response to Calcium Sensing Receptor Signaling: Physiopathological Aspects and Role of CaSR-Regulated microRNAs International Journal of Molecular Sciences doi: 10.3390/ijms20215341 Authors: Marianna Ranieri Calcium (Ca2+) is a universal and vital intracellular messenger involved in a diverse range of cellular and biological processes. Changes in the concentration of extracellular Ca2+ can disrupt the normal cellular activities...
IJMS, Vol. 20, Pages 5342: The Impact of Chemotherapy on the Ovaries: Molecular Aspects and the Prevention of Ovarian Damage International Journal of Molecular Sciences doi: 10.3390/ijms20215342 Authors: Charlotte Sonigo Isabelle Beau Nadine Binart Michaël Grynberg Cancer treatment, such as chemotherapy, induces early ovarian follicular depletion and subsequent infertility. In order to protect gametes from the gonadotoxic effects of chemotherapy, several fertility preservation...
IJMS, Vol. 20, Pages 5340: Serotonin 5-HT4 Receptor Agonists Improve Facilitation of Contextual Fear Extinction in An MPTP-Induced Mouse Model of Parkinson’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms20215340 Authors: Ishii Kinoshita Muroi Previously, we found that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s disease (PD) model mice (PD mice) showed facilitation of hippocampal memory extinction via reduced cyclic...
IJMS, Vol. 20, Pages 5339: What Does the History of Research on the Repair of DNA Double-Strand Breaks Tell Us?—A Comprehensive Review of Human Radiosensitivity International Journal of Molecular Sciences doi: 10.3390/ijms20215339 Authors: Elise Berthel Mélanie L. Ferlazzo Clément Devic Michel Bourguignon Nicolas Foray Our understanding of the molecular and cellular response to ionizing radiation (IR) has progressed considerably. This is notably the case for the repair and...
IJMS, Vol. 20, Pages 5337: Insight into Mechanobiology: How Stem Cells Feel Mechanical Forces and Orchestrate Biological Functions International Journal of Molecular Sciences doi: 10.3390/ijms20215337 Authors: Chiara Argentati Francesco Morena Ilaria Tortorella Martina Bazzucchi Serena Porcellati Carla Emiliani Sabata Martino The cross-talk between stem cells and their microenvironment has been shown to have a direct impact on stem cells’ decisions about proliferation,...
IJMS, Vol. 20, Pages 5334: Development of an Efficient Protocol to Obtain Transgenic Coffee, Coffea arabica L., Expressing the Cry10Aa Toxin of Bacillus thuringiensis International Journal of Molecular Sciences doi: 10.3390/ijms20215334 Authors: Eliana Valencia-Lozano José L. Cabrera-Ponce Miguel A. Gómez-Lim Jorge E. Ibarra This report presents an efficient protocol of the stable genetic transformation of coffee plants expressing the Cry10Aa protein of Bacillus thuringiensis....
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