Real‐world health utility scores (HUS) in epidermal growth factor receptor mutations (EGFRm) non‐small cell lung cancer outpatients were similar between those treated by first‐ and second‐line tyrosine kinase inhibitors, which were superior to chemotherapy. Treatment‐associated toxicities corresponded to HUS of treatment groups. Abstract Background As the treatment landscape in patients with non‐small cell lung cancer (NSCLC) harboring mutations in the epidermal growth factor receptor (EGFRm)...
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Rheumatoid arthritis is a systemic, polygenic, and multifactorial syndrome characterized by erosive polyarthritis, damage to joint architecture, and presence of autoantibodies against several self-structures in the serum and synovial fluid. These autoantibodies (anticitrullinated protein/peptide antibodies (ACPAs), rheumatoid factors (RF), anticollagen type II antibodies, antiglucose-6 phosphate isomerase antibodies, anticarbamylated protein antibodies, and antiacetylated protein antibodies) have...
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There are many common causes of itchy breasts without a rash, including allergens and growth. This article looks at the causes and how to treat them.
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Information on subgroup assessments in systematic reviews (SR) of atrial fibrillation (AF) is limited. This review aims to describe subgroup analyses in AF SRs to inform the design of SRs and randomized trials...
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Treatment of bipolar disorder (BD) usually requires drug combinations. Combinations of lithium plus valproic acid (Li/VPA) and lithium plus carbamazepine (Li/CBZ) are used in clinical practice but were not pre...
Models of collaborative care and consultation liaison propose organizational changes to improve the quality of care for people with common mental disorders, such as anxiety and depression. Some literature sugg...
Following publication of the original article [1], we have been notified that one of the authors’ names is spelled incorrectly. In this Correction the incorrect and correct author name are shown.
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Gestational diabetes mellitus (GDM) leads to poor pregnancy outcomes. Strategies that improve trophoblast cell function are important methods for GDM treatment. This study aimed to investigate the expression a...
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Abstract Objectives The aim of this crossover study was to compare clinical denture base deformation with different attachments used for mandibular implant overdentures. Materials and methods Twenty‐four patients with edentulous mandibular ridges received 2 implants in the former canine regions. Three months thereafter, each patient randomly given the following implant overdentures in a crossover design: 1) Bar implant overdentures (BOD), 2) Resilient telescopic implant overdentures (TOD)...
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Abstract Tacrolimus (TAC), the mainstay of maintenance immunosuppressive agents, plays a crucial role in new‐onset diabetes after transplantation (NODAT). Previous studies investigating the diabetogenic effects of TAC have focused on the β cells of islets. In this study, we found that TAC contributed to NODAT through directly affecting hepatic metabolic homeostasis. In mice, TAC induced hypoglycemia rather than hyperglycemia during starvation via suppressing gluconeogenetic genes, suggesting the...
Abstract Kidney transplant (KT) recipients have an increased risk for urothelial carcinoma. A role for JC virus (JCV) in human cancers is not yet proved but there is an increasingly reported association between BK virus (BKV) nephropathy and renourinary neoplasms. We report a KT recipient who developed a high‐grade urothelial carcinoma 5 years after a diagnosis of JCV nephropathy and 9 years after KT. Neoplastic tissue was positive for JCV DNA by real‐time polymerase chain reaction (PCR). Immunochemical...
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Abstract We aim to characterize the kinetics of early and late microglial phenotypes after systemic inflammation in an animal model of severe sepsis and the effects of minocycline on these phenotypes. Rats were subjected to CLP, and some animals were treated with minocycline (10 ug/kg) by i.c.v. administration. Animals were killed 24 hours, 5, 10 and 30 days after sepsis induction, and serum and hippocampus were collected for subsequent analyses. Real‐time PCR was performed for M1 and M2 markers....
Abstract Recent studies indicate circular RNAs are related to dysregulation of vascular endothelial cell function, yet the underlying mechanisms have remained elusive. Here, we characterized the functional role of circular RNA USP1 (circ‐USP1) in the regulation of the blood‐tumour barrier (BTB) permeability and the potential mechanisms. In the current study, the circ‐USP1 expressing level was up‐regulated in glioma cerebral microvascular endothelial cells (GECs) of the BTB model in vitro. Knockdown...
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Abstract Long noncoding RNAs (lncRNAs) have been shown to be aberrantly expressed in oral squamous cell carcinoma (OSCC), but the biological role and function of BRAF‐activated long noncoding RNA (BANCR) in OSCC remain poorly understood. In this study, we found that the expression of BANCR was up‐regulated in OSCC tissues and cell lines compared to the negative control. The decreased expression of BANCR in vitro markedly inhibited OSCC cell proliferation, migration, and invasion while the opposite...
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A potato protein hydrolysate, APPH is a potential anti-obesity diet ingredient. Since, obesity leads to deterioration of liver function and associated liver diseases, in this study the effect of APPH on high f...
Aim of this study was to evaluate the effectiveness of scalp, tongue, and Jin’s 3-needle acupuncture for the improvement of postapoplectic aphasia.
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A 75-year-old non-atopic male had been suffering from a gastroenteritis-like illness for the last 24 hours characterized by diarrhea and malaise. He decided to take, for the first time, 4 mg of loperamide hydrochloride to assist with symptom relief. Within 30 minutes, he developed severe anaphylaxis with widespread urticaria, presyncope and acute worsening of diarrhea and vomiting. He was transported by ambulance to the hospital, where his initial blood pressure was 82/50. He was successfully resuscitated...
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The aim of this study was to evaluate the fate of preserved aortic root following supracoronary aortic replacement for acute type A aortic dissection.
Durable mechanical circulatory support device (MCSD) therapy has experienced rapid dissemination in the U.S. Few studies have evaluated geographic patterns of its dissemination based upon patient characteristics that could identify potential variation in its application.
In this case, we describe an unusual case of dual pathology: i) hypertrophic obstructive cardiomyopathy (HOCM) and ii) aortic root aneurysm. We demonstrate the advantage of a single trans aortic approach to address all components of the HOCM disease. This is illustrated in a video highlighting the main steps of the procedure.
Although surgical outcomes for anomalous left coronary artery from the pulmonary artery (ALCAPA) are excellent in the modern era with the coronary reimplantantion technique, mortality remains high in Chinese population. This study was undertaken to review the surgical management in our center and assess the midterm outcomes.
Aneurysm of the main pulmonary trunk (PAA) is a rare but severe complicating factor in patients suffering from pulmonary arterial hypertension (PAH). Many centers consider a PAA as an indication for a heart-lung transplantation. We herein aimed to summarize our institutional experience with a lung-only strategy in this complex group of patients.
In 2004, a prospective randomized trial demonstrated that, after 3 years, saphenous veins (SV) harvested with a No Touch (NT) technique had a greater patency than radial grafts for coronary bypass surgery. We now report the 8-year follow-up data of this trial.
The treatment of aortic valve disease in children and adolescents requires an individualized approach to provide a long-term solution with optimal hemodynamic profile. The role of aortic leaflet reconstruction techniques is evolving.
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Cold snare polypectomy (CSP) is associated with higher complete resection rates when compared with cold biopsy forceps (CBF) for the removal of small polyps (4-9 mm). This study aimed to evaluate self-reported polypectomy preferences and actual practice patterns among endoscopists at an academic center and to identify factors associated with the use of CSP for small polyps.
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Abstract Duplication of 15q11.2‐q13.1 (dup15q syndrome) is one of the most common copy number variations associated with autism spectrum disorders (ASD) and intellectual disability (ID). As with many neurogenetic conditions, accurate behavioral assessment is challenging due to the level of impairment and heterogeneity across individuals. Large‐scale phenotyping studies are necessary to inform future clinical trials in this and similar ID syndromes. This study assessed developmental and behavioral...
Abstract Kabuki syndrome (KS) is a disorder of epigenetic dysregulation due to heterozygous mutations in KMT2D or KDM6A, genes encoding a lysine‐specific methyltransferase or demethylase, respectively. The phenotype is highly variable, including congenital cardiac and renal anomalies, developmental delay, hypotonia, failure to thrive, short stature, and immune dysfunction. All affected individuals have characteristic facial features. As KS natural history has not been fully delineated, limited information...
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While hemorrhage can occur because of developmental venous anomalies (DVAs), there is no established opinion concerning their association with pregnancy and childbirth. In the present report, we discuss the case of a now 39-year-old woman with DVA in whom pregnancy and childbirth were successful. When she was 28, she experienced disturbance of consciousness and paralysis on the left side of the body, and brain computed tomography revealed cerebral hemorrhage coupled with subarachnoid hemorrhage.
Background: Computed tomography angiogram (CTA) derived from computed tomography perfusion (CTP) has been proposed to avoid addition of separate CT perfusion protocol for selection of large vessel occlusion in acute stroke patients. Previous studies have validated this technique for proximal large vessel occlusions. In this study, we test reliability for identifying M2 occlusions on CTA derived from CTP. Methods: Through a retrospective search of the institutional thrombectomy database, we identified...
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Ralstonia mannitolilytica is an emerging opportunistic pathogen that is associated with severe disease, including septic shock, meningitis, and renal transplant infections. Reports on this pathogen are limited, h...
Pneumocephalus and pneumorachis, presence of air inside the skull and spinal canal, are mostly seen after neurosurgical procedures and neuraxial anesthesia. They have also been described after penetrating trau...
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Chem. Commun., 2019, Accepted ManuscriptDOI: 10.1039/C9CC05797H, CommunicationLuca Polacchi, Arnaud Brosseau, Rémi Métivier, Clemence AllainAn OFF to ON mechano-responsive fluorescent polydiacetylene derivative has been prepared by photopolymerisation of a diacetylene covalently linked to a tetrazine fluorophore. This system has been studied at the nanoscale...The content of this RSS Feed (c) The Royal Society of Chemistry
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Abstract Background Intracranial interdural cyst is a rare lesion. The exact pathophysiology of these cysts remains unknown. Clinical presentation We report an infant with interdural cyst of the tentorium cerebelli. Although the cyst mimicked an arachnoid cyst on pre- and postnatal magnetic resonance images, lateral suboccipital craniotomy revealed the cyst...
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Objective The use of microvascular free tissue transfer (MVFTT) for defects of the scalp and lateral temporal bone in patients with cochlear implants (CI) is uncommon. Herein, we report our experience with the utility, indications, and outcomes for MVFTT in patients with cochlear implants. Methods A retrospective review of patients at our institution from September 2016 to December 2017 identified subjects with coexistent cochlear implant and ipsilateral MVFTT of the lateral temporal bone...
Primary laryngectomy versus salvage laryngectomy: A comparison of outcomes in the chemoradiation era
Objective To compare primary total laryngectomy (TL) versus salvage TL and analyze the functional outcomes, complications, recurrence rates, and survival. Study Design Case series with chart review. Setting Tertiary care center. Subjects and Methods Fifteen‐year retrospective analysis of 208 patients with laryngeal squamous cell carcinoma treated by TL was completed. Outcome measures included survival, swallowing rehabilitation, speech rehabilitation, complications, and assessment...
Objective Competing risk analysis is a powerful assessment for cancer risk factors and covariates. This method can better elucidate insurance status and other social determinants of health covariates in oral cavity cancer treatment, survival, and disparities. Study Design Retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) database. Methods Data regarding patient characteristics, clinical stage at diagnosis, treatment, and survival data for 20,271...
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