Cold snare polypectomy (CSP) is associated with higher complete resection rates when compared with cold biopsy forceps (CBF) for the removal of small polyps (4-9 mm). This study aimed to evaluate self-reported polypectomy preferences and actual practice patterns among endoscopists at an academic center and to identify factors associated with the use of CSP for small polyps.
11h
Publication date: Available online 25 October 2019Source: Gene Expression PatternsAuthor(s): Andrew J. Schneider, Joseph Gawdzik, Chad M. Vezina, Tracie R. Baker, Richard E. PetersonAbstractPrevious studies identified Sox9 as a critical mediator of prostate development but the precise stage when Sox9 acts had not been determined. A genetic approach was used to delete Sox9 from mouse urogenital sinus epithelium (UGE) prior to prostate specification. All prostatic bud types (anterior, dorsolateral...
23h
Contributors : Silvia Calabrese ; Alexis Sarazin ; Cusant Loïc ; Annette Niehl ; Alexander Erban ; Daphnée Brulé ; Ghislaine Recorbet ; Daniel Wipf ; Christophe Roux ; Joachim Kopka ; Thomas Boller ; Pierre-Emmanuel CourtySeries Type : Expression profiling by high throughput sequencingOrganism : Populus trichocarpa ; Rhizophagus irregularis ; Sorghum bicolorWe analyzed the impact of different phosphate levels on the regulation of plant and fungal transcriptomes.
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Contributor : Tao TanSeries Type : Expression profiling by high throughput sequencingOrganism : Macaca fascicularis ; Macaca mulattaThe induction of the primordial germ-like cells (PGCLCs) from primate pluripotent stem cells (PSCs)provides a powerful system to study the cellular and molecular mechanism underlying germline specification, which are difficult to study in vivo. However a comprehensive single cell RNA sequencing(scRNA-seq) analysis of the developmental trajectory of PGCLCs differentiation...
5h
Contributor : Jian LiuSeries Type : Expression profiling by arrayOrganism : Homo sapiensMTA1, SOX4, EZH2 and TGF-β are all potent inducers of epithelial-mesenchymal transition (EMT) in cancer; however, the signaling relationship among these molecules in EMT is poorly understood. Here, we investigated the function of MTA1 in cancer cells and demonstrated that MTA1 overexpression efficiently activates EMT. This activation resulted in a significant increase in the migratory and invasive properties...
5h
Contributors : Sara C Marques ; Linn Reinholdt ; Julie S Bødker ; Alexander Schmitz ; Jacob G Mikkelsen ; Hans E Johnsen ; Martin Bøgsted ; Karen DybkærSeries Type : Expression profiling by arrayOrganism : Homo sapiensAlthough diffuse large B-cell lymphoma (DLBCL) is a very heterogeneous disease, patients are as standard treated with a combination of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP). Since approximately 40% of patients die due to refractory disease...
5h
Abstract We would like to express our gratitude to Dr Lo for his insightful comments on our study.1 We fully acknowledge the role of endoscopic examinations in addition to variceal screening, such as to detect other upper gastrointestinal pathologies (e.g. peptic ulcer, portal hypertensive gastrolatry etc).2 Hence upper endoscopy should be offered to any cirrhotic patients who have clinical features of these pathologies, namely epigastric pain, anaemia, melaena or per rectal bleeding.
13h
Abstract Renal dysfunction is common in liver cirrhosis and it is associated with poor prognosis. However, we still have major limitations when assessing renal function in cirrhotic patients. Current available methods are biased and have a tendency to consistently overestimate glomerular filtration rates (GFR).
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Abstract ARC‐520, the first RNA interference (RNAi) therapeutic was designed to reduce all RNA transcripts derived from cccDNA, leading to a reduction in viral antigens and HBV DNA. We aimed to evaluate the depth of hepatitis B surface antigen (HBsAg) decline in response to multiple doses of ARC‐520 compared to placebo (PBO) in two randomized, multi‐center studies in nucleoside/nucleotide (NUC) experienced patients with hepatitis B e antigen negative (E‐neg) or positive (E‐pos) disease. A total...
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Methylliberine (CAS 51168-26-4), a methoxiuric acid, is a caffeine metabolite present at low levels in various Coffea plants; however, very little has been published regarding this compound and we could find no toxicological data in the public domain. Therefore, we undertook the toxicological investigation of a pure, synthetic form of methylliberine in order to evaluate its potential health hazards as a food ingredient. A (1) bacterial reverse mutation test, (2) in vitro mammalian chromosomal aberration...
9h
For a progressive multifocal liquid lens with an elastic membrane deformed by liquid pressure, to realize a reasonably power distribution, asymmetric deformation characteristics of the membrane surface are needed. Based on the asymmetric freeform surface structure, this paper proposed progressive multifocal liquid lenses focused by liquid with nonuniform thickness membranes. The structure and mathematical model of power distribution for the lens are introduced. The membrane deformation and the corresponding...
9h
The human gut-resident commensal microbiota is a unique ecosystem associated with various bodily functions, especially immunity. Gut microbiota dysbiosis plays a crucial role in autoimmune disease pathogenesis as well as in bowel-related diseases. However, the role of the gut microbiota, which causes or influences systemic immunity in autoimmune diseases, remains elusive. Aryl hydrocarbon receptor, a ligand-activated transcription factor, is a master moderator of host-microbiota interactions because...
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Purpose. To investigate whether lymphocyte nadir induced by radiation is associated with survival and explore its underlying risk factors in patients with hepatocellular carcinoma (HCC). Methods. Total lymphocyte counts were collected from 184 HCC patients treated by radiotherapy (RT) with complete follow-up. Associations between gross tumor volumes (GTVs) and radiation-associated parameters with lymphocyte nadir were evaluated by Pearson/Spearman correlation analysis and multiple linear regression....
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The separation and enrichment can be targeted to enrich in fly ash and reduce the cost of leaching and recovering of fly ash. Regarding their different properties, the single-component separation was used to obtain uncompleted burned carbon, glass microbeads, minerals, and other characteristic components from the ash. Also, the mineral composition of each component was analyzed by electron microscopy. The metal minerals were mainly concentrated in the mineral components. Besides, the electron probe...
9h
Crystal-cell interactions are a vital step toward kidney stone formation. However, its mechanisms remained unclear. Here, a protein-protein interaction (PPI) network analysis of a kidney stone revealed that the proteins were enriched in a posttranslational protein modification process in the endoplasmic reticulum (ER). The in vitro study showed that the markers of ER stress, including Bip and CHOP, were upregulated, PERK and ATF6 were activated, and XBP-1 mRNA was spliced. An ER stress-specific protein,...
9h
Long noncoding RNA (lncRNA) disorder has been found in many kinds of age-associated diseases. However, the role of lncRNA in the development of age-related hearing loss (AHL) is still largely unknown. This study sought to uncover AHL-associated lncRNAs and the function. RNA-sequencing was conducted to profile lncRNA expression in the cochlea of an early-onset AHL mouse model. RT-qPCR assay was used to validate the expression pattern of lncRNAs. ATP assay, JC-1 assay, mitochondrial probe staining,...
9h
Rheumatoid arthritis is a systemic, polygenic, and multifactorial syndrome characterized by erosive polyarthritis, damage to joint architecture, and presence of autoantibodies against several self-structures in the serum and synovial fluid. These autoantibodies (anticitrullinated protein/peptide antibodies (ACPAs), rheumatoid factors (RF), anticollagen type II antibodies, antiglucose-6 phosphate isomerase antibodies, anticarbamylated protein antibodies, and antiacetylated protein antibodies) have...
9h
This is an in vitro study conducted to observe the safety and antiscarring effects of combined application of bevacizumab (BVZ) and 5-fluorouracil (5-Fu) or BVZ and mitomycin C (MMC) during glaucoma filtration surgery (GFS). The cytotoxicity of drug combinations in human Tenon’s fibroblasts (HTFs) and human umbilical vein endothelial cells (HUVECs) was evaluated. Their effects on the levels of vascular endothelial growth factor (VEGF) in HUVECs, cell proliferation and migration in HTFs, and the expression...
9h
Purpose. To describe the surgical technique and clinical outcomes of bilensectomy (pIOL explant and phacoemulsification), followed by DMEK performed for bullous keratopathy secondary to pIOL. Methods. Seven eyes of seven patients, who developed corneal decompensation after pIOL implantation, underwent bilensectomy followed by DMEK in a two-step procedure. Main outcome measures included uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), refraction, endothelial cell density (ECD)...
9h
Metal-organic frameworks (MOFs) are an intriguing class of porous inorganic-organic hybrid networks synthesized from metal ions with multidentate organic ligands. MOFs have uniform and tunable cavities and tailorable chemistry, making them promising materials for hazardous component removal from the environment. Controllable integration of magnetic nanoparticles (NPs) and MOFs is leading to the creation of many novel multifunctional MOF-based composites, which exhibit advanced performance that is...
9h
This study investigates the shelving stability of dispersed aluminium nanoparticles in water mixtures fabricated by the conventional and the controlled bath temperature two-step methods. The nanofluids were prepared with water of pH 9 and nanoparticles of 0.1–1.0 vol.%. A bath type ultrasonicator was employed for dispersing the nanoparticles into the base fluid. The sonication process, for all as-prepared samples, lasted for 4 hours and was either device bath temperature uncontrolled or controlled...
9h
Human error is one of the most important risk factors affecting aviation safety. The original Cognitive Reliability and Error Analysis Method (CREAM) developed for the nuclear industry is reliable for human reliability quantification, but it is not fully applicable to human reliability analysis in aviation because it neglects the characteristics of long-duration flights. Here, we propose a modified CREAM method to predict human error probability in flight and provide some improvement measures for...
9h
Background. ANGPTL4 is a glycoprotein that is involved in regulating triglyceride metabolism by inhibiting LPL activity under fasting conditions. Additionally, ANGPTL4 has been suggested as a link between hypertriglyceridemia and albuminuria in the nephrotic syndrome. In this study, we examined levels of circulating ANGPTL4 in people with diabetic nephropathy (DN) and its association with established DN-associated proteins such as IGFBP1 and IGFBP4. Methods. We quantified circulating ANGPTL4, IGFBP1,...
9h
Many acupuncture therapies were used to treat spinal cord injury (SCI) and its complications. The difference in efficacy among these therapies has not been assessed. To compare the efficacy of different acupuncture therapies for SCI, we searched databases (PubMed, Embase, Cochrane Library, CNKI, and WanFang) for relevant RCTs in both English and Chinese before June 2019 that reported the association between acupuncture therapies and SCI. The RCTs were categorized according to the location of the...
9h
Foshou San is a typical gynaecological formula with wild usage in traditional Chinese medicine. Jiawei Foshou San (JFS) is a novel ingredient prescription from Foshou San with antiendometriosis effect in unclear mechanisms. To uncover the potential application and proapoptotic mechanisms of JFS, JFS ingredient-drug target-disease networks, GO enrichment, and pathway analysis were established for potential application prediction. Molecular docking and validation in vivo were investigated by the proapoptotic...
9h
Background. Central pain mimicking trigeminal neuralgia (TN) as a result of lateral medullary infarction or Wallenberg syndrome has been rarely reported. Case Report. We discuss a patient who presented with a lateral medullary infarct and shortly after developed facial pain mimicking TN. We also elaborate on the anatomical pathway of the trigeminal nerve explaining facial pain as a result of a lateral medullary lesion. Discussion. Clinicians should be aware of this typical complication of lateral...
9h
Background. Mast cell leukaemia is a unique disease among hematopoietic neoplasms, being one of the rarest leukaemia subtypes. In addition, its prompt diagnosis is usually challenging. This is due to its heterogeneity in clinical presentations and cytomorphological and immunophenotypical features together with potential associations with other hematologic neoplasms which can complicate the condition and delay accurate diagnosis. To the best of our knowledge, this is the first case report of CD4-positive...
9h
A traumatic neuroma is a well-known complication after acute trauma to a peripheral nerve; the nerve tries to re-establish continuity by an orderly growth of axons from the peripheral to distal stump through the proliferation of Schwann cells. However, this process is not always perfect, and aberrant repair gives rise to a neuroma. We present a 50-year-old female who underwent an initial colonoscopy for change in bowel habits and was found to have a 7 mm submucosal lesion in the proximal rectum....
9h
A 25-year-old woman had undergone removal of a cryptogenic tumor in the left maxillary sinus 1 year prior to presentation. The patient experienced abdominal pain for 4 days with repeated vomiting episodes; therefore, she was transferred to our hospital by an ambulance. Contrast-enhanced computed tomography revealed a 3-cm tumor in the ileocecal region, which caused small bowel obstruction. Contrast imaging of the ileus tube showed extrinsic compression of the ileocecal region. Forward-viewing linear...
9h
Kallmann syndrome (KS)/Idiopathic hypogonadotropic hypogonadism (IHH) is characterized by hypogonadotropic hypogonadism and anosmia or hyposmia due to the abnormal migration of olfactory and gonadotropin releasing hormone producing neurons. Multiple genes have been implicated in KS/IHH. Sequential testing of these genes utilising Sanger sequencing is time consuming and not cost effective. The introduction of parallel multigene panel sequencing of small gene panels for the identification of causative...
9h
The ketogenic diet, a diet high in fat and extremely low in carbohydrates, has recently gained momentum and is increasingly employed by patients in order to lose weight. We report a case of an otherwise healthy 47-year-old male who developed seizures and hypoglycemia shortly after initiating this diet. Biochemical testing confirmed hyperinsulinemic hypoglycemia and a subsequent abdomen MRI showed a pancreatic mass. The tumor was ultimately excised with pathology confirming an insulinoma. It was felt...
9h
We describe a case of a 24-year-old overweight woman who presented with hirsutism, secondary amenorrhea, clitoromegaly, and symptoms of diabetes mellitus (DM). While a diagnosis of polycystic ovary syndrome (PCOS) with its associated metabolic disturbances was initially considered, serum total testosterone, androstenedione, and 17-hydroxyprogesterone (17-OHP) measured by liquid chromatography tandem mass spectrometry (LC-MS/MS) were significantly increased. As 17-OHP did not increase upon ACTH (Synacthen)...
9h
Phaeochromocytomas and paragangliomas are rare catecholamine-secreting tumours arising from the adrenal medulla or sympathetic paraganglia. It is known that 20–30% of all cases occur as a result of germline variants in several well known genes. The TMEM127 gene was recently identified as a new phaeochromocytoma susceptibility gene. However, until a larger sample of cases is available, the prevalence, genotype-phenotype correlation, and a clear predominant biochemical pattern of TMEM127-related PCC,...
9h
Background. Implant placement in defective anterior maxilla poses a great challenge regarding functional and aesthetic outcomes. Therefore, it requires predictable alveolar ridge augmentation. Deproteinized bovine bone mineral (DBBM) particle has commonly been used for bone grafting. However, it is associated with low resorption rates which potentially compromise the outcome of horizontal augmentation in conjunction with implant placement. Aims. This study is aimed at evaluating the stability of...
9h
We describe a patient with a major depression and a newly discovered Brugada syndrome, who was successfully treated with 35 electroconvulsive therapy sessions using succinylcholine as muscle relaxant. We discuss the use of succinylcholine in patients with Brugada syndrome.
9h
Numerical Study on Zonal Disintegration of Deep Rock Mass Using Three-Dimensional Bonded Block Model
Zonal disintegration, a phenomenon of fractured zones and intact zones distributed alternately in deep rock mass, is different from the excavation-damaged zone of shallow rock mass. In this study, bonded block model of 3DEC was employed to study the fracture mode and origination condition of zonal disintegration. Initiation, propagation, and coalescence progress of fracture around the roadway boundary under different triaxial stress conditions are elaborated. Numerical simulation demonstrated that...
9h
This study aimed to explore the safe and efficient top-coal caving mining under thin topsoil of shallow coal seam (SCS) and realize the optimization of hydraulic support. Numerical simulation and theoretical analysis were used to reveal the stress distribution of the topsoil, the structure characteristics of the main roof blocks, and the development of the roof subsidence convergence. Step subsidence of the initial fractured main roof after sliding destabilization frequently existed, which seriously...
9h
Utility tunnel is a kind of underground tunnel structure that carries more than two types of public utility lines, and the utility tunnels built by the prefabricated method have been adopted in many modern cities due to their easy maintenance and environmental protection capabilities. However, knowledge about the seismic performance of the prefabricated utility tunnel and pipelines inside is quite limited. In this paper, a prefabricated utility tunnel newly built in Xi’an, China, is taken as the...
9h
The particle breakage property under loading is an important factor affecting the nonlinearity of the shear strength and stress-strain curves of coarse-grained soils. The macromechanical behaviors of coarse granular materials under consolidation and drainage shearing were tested by using a large true triaxial apparatus. The particle breakage mechanism has been analyzed by the fluctuation change of stress-strain curve and particle composition change. It was shown that the particle shape is an extremely...
9h
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