Publication date: Available online 25 October 2019Source: Clinical ImmunologyAuthor(s): Katherine A. Murphy, Kartik Bhamidiphati, Samuel J.S. Rubin, Lucas Kipp, William H. Robinson, Tobias V. LanzAbstractInhibitory cell-surface receptors on lymphocytes, often called immune checkpoints, are powerful targets for cancer therapy. Despite their direct involvement in autoimmune pathology, they are currently not exploited therapeutically for autoimmune diseases. Understanding the receptors' expression patterns...
Mark above section as read
Publication date: Available online 25 October 2019Source: European Journal of Pharmaceutical SciencesAuthor(s): Zongwei Guo, Ting Song, Zuguang Xue, Peng Liu, Minhang Zhang, Xiaodong Zhang, Zhichao ZhangAbstractDeepening understanding of how Bcl-2 family proteins protect cancer cells from apoptosis has driven the development of ‘BH3 mimetic’ drugs that target various anti-apoptotic Bcl-2-like proteins by mimicking their natural inhibitors, the BH3-only proteins. The proof of target engagement and...
Publication date: Available online 25 October 2019Source: European Journal of Pharmaceutical SciencesAuthor(s): Jiaojiao Yu, Xiaosong Shan, Shichao Chen, Xinli Sun, Pengjin Song, Ruidong Zhao, Liandong HuAbstractIn this study, novel orally disintegrating tablets (ODTs) with multi-channel structure were designed to provide a rapid disintegration and subsequently drug dissolution. The ODTs were prepared using conventional wet compression through perforating channels with a special multi-channel mold....
Publication date: Available online 25 October 2019Source: European Journal of Pharmaceutical SciencesAuthor(s): Risto O. Juvonen, Aki T. Heikkinen, Olli Kärkkäinen, Rabia Jehangir, Juhani Huuskonen, Johanna Troberg, Hannu Raunio, Olli T. Pentikäinen, Moshe FinelAbstractBeagle dog is a standard animal model for evaluating nonclinical pharmacokinetics of new drug candidates. Glucuronidation in intestine and liver is an important first-pass drug metabolic pathway, especially for phenolic compounds....
Publication date: Available online 25 October 2019Source: European Journal of Pharmaceutical SciencesAuthor(s): Yosuke Yamamoto, Harumi Kumagai, Moe Haneda, Maria Vertzoni, Niels Ouwerkerk, Daisuke Murayama, Yoshifumi Katakawa, Kei Motonaga, Christos Reppas, Tomokazu TajiriAbstractThe main objective of this study was to investigate the mechanism of solifenacin release from a pH-responsive ion-complex oral resinate suspension under conditions simulating the environment in the upper gastrointestinal...
Publication date: Available online 25 October 2019Source: European Journal of Pharmaceutical SciencesAuthor(s): Annelies Jorritsma-Smit, Coba J. van Zanten, Jolande Schoemaker, Janneke J.M. Meulenberg, Daan J. Touw, Jos G.W. Kosterink, Hans W. Nijman, Toos Daemen, Derk P. AllersmaAbstractTherapeutic vaccination is being explored as a treatment strategy for the treatment of patients with primary or metastatic tumours. We developed a vaccine targeted to Human papillomavirus (HPV)-induced tumours based...
Mark above section as read
Publication date: Available online 25 October 2019Source: Journal of Neuroscience MethodsAuthor(s): Barilin Dkhar, Abhijeet Bhatia, Pranjal Pratim Saikia, Haphidasara PyngropeABSTRACTObjectivesResearch using rat as an in-vivo model has played an important role in otological research. The rat ear anatomy has been described; however, detailed surgical procedures to access the temporal bone are limited. The authors present a technique to approach the inner ear of rat that was standardized by cadaveric...
Mark above section as read
Abstract To understand the influence of social relationships on cardiovascular responses to stress, the present study investigated perceived affectionate support as a mediating variable explaining the association between specific attachment bonds (i.e., mother, father, partner, best friend) and cardiovascular reactivity (CVR). Utilizing a standardized stress testing protocol, 138 young adults completed measures of attachment and social support, with continuous cardiovascular measurements obtained...
Mark above section as read
Publication date: Available online 25 October 2019Source: Journal of Bodywork and Movement TherapiesAuthor(s): Christopher M. NorrisAbstractExercise is vital to the management of low back pain (LBP). However, research, social media, and fitness industry interests can leave therapists confused about best practice in exercise prescription for this clinical condition. The 3R’s approach to back rehabilitation is introduced as an evidence-based framework for developing patient specific exercise throughout...
Publication date: Available online 25 October 2019Source: Journal of Bodywork and Movement TherapiesAuthor(s): Galit PazAbstractBackgroundCharcot-Marie-Tooth (CMT) disease, a progressive hereditary peripheral neuropathy, leads to muscle weakness, wasting, and sensory and motor nerve deprivation. The two main types of CMT are CMT1 (demyelinating) and CMT2 (axonal). Initial findings include foot deformities and sensory changes with progression to altered gait, diminished reflexes, and muscle wasting...
Mark above section as read
Publication date: Available online 25 October 2019Source: International Journal of PsychophysiologyAuthor(s): Fanny Grisetto, Yvonne N. Delevoye-Turrell, Clémence RogerAbstractAggressive behaviors in pathological and healthy populations have been largely related to poor cognitive control functioning. However, few studies have investigated the influence of aggressive traits (i.e., aggressiveness) on cognitive control. In the current study, we investigated the effects of aggressiveness on cognitive...
Publication date: Available online 25 October 2019Source: International Journal of PsychophysiologyAuthor(s): Nick Beligiannis, Jan W. Van StrienAbstractPrevious event-related potential studies have reported enhanced Early Posterior Negativity (EPN) in response to snake pictures compared to pictures of other animals. This EPN snake effect may be partly driven by specific snake skin patterns. In this study, by using blurred pictures to make these patterns less visible, we explored whether the relative...
Publication date: Available online 25 October 2019Source: International Journal of PsychophysiologyAuthor(s): Timm Rosburg, Michael Weigl, Gunnar DeuringAbstractIt is as yet unresolved to what extent the pre-attentive detection of auditory deviance is modulated by emotion. The current event-related potential study was designed to investigate simultaneously the auditory and the visual mismatch negativity (MMN), as well as the impact of emotion on the auditory MMN. Thirty healthy participants saw sequences...
Mark above section as read
Abstract Motivational interviewing (MI) is an effective means of facilitating behavior change in a variety of health conditions. However, given its origins in western psychology, its utility in ethnic populations is unclear. Our objective was to examine the effectiveness of MI and its components in people of varying ethnicities and how they may experience MI. We undertook a narrative systematic review of the literature, searching only peer-reviewed research up until February, 2019...
Mark above section as read
Publication date: Available online 25 October 2019Source: PeptidesAuthor(s): M.A. Nauck, H. Holle, M. Kahle, A. Tytko, C.F. Deacon, J.J. Holst, J.J. MeierAbstractBackground, aimsIn patients with type 2 diabetes, the lost insulinotropic effect of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) is more apparent after continuous versus bolus administration. To test whether the difference might be explained by rapid tachyphylaxis in response to elevated concentrations of GIP,...
Mark above section as read
SATURDAY, Oct. 26, 2019 -- Allergies and asthma can turn Halloween into fright night, so parents must be vigilant. Some fun-sized candy bars have no labels to alert about possible food allergens, such as peanuts, said Dr. Todd Mahr, president of the...
Mark above section as read
Publication date: Available online 25 October 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Tamir Dean Anver, Lida Mirzai, Peng Li, Kathlyn Powell, Peter D. WaiteAbstractPurposeUse cone-beam computed tomography (CBCT) analysis to assess the long term radiographic outcomes of early secondary alveolar bone grafting.Patients and MethodsThe most recent post-operative CBCT of 79 alveolar cleft patients that underwent of anterior iliac crest bone grafting (AICBG) by a single surgeon over...
Publication date: Available online 25 October 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Warley Luciano Fonseca Tavares, Francielen Oliveira Fonseca, Lucas Moreira Maia, Vinícius de Carvalho Machado, Nelson Renato França Alves Silva, Gil Moreira Junior, Antônio Paulino Ribeiro SobrinhoAbstractWhen conventional endodontic treatment resources are depleted, endodontic surgery becomes an alternative treatment for apical periodontitis to remove unreachable infected areas and seal...
Publication date: Available online 25 October 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Max Ward, Neil Majmundar, Antonios Mammis, Boris PaskhoverAbstractBackgroundTrigeminal neuralgia is a chronic and debilitating syndrome characterized by short paroxysms of lancinating facial pain. Patients may be medically managed; however, in cases of medically refractory trigeminal neuralgia surgical management is often required.ObjectiveTo present and describe the technique for endoscopic...
Mark above section as read
Abstract Background In recent literature, different approaches have been proposed to improve the long‐lasting treatment of age‐related alterations on the human face with decreased invasiveness and side effects such as scar tissue. Voltaic arc dermabrasion is a minimally painful procedure that does not create discomfort to the patient and requires no anaesthesia. Aims The aim of this investigation was to evaluate the voltaic arc technique for the treatment of skin wrinkles in the periauricular...
Mark above section as read
Publication date: Available online 25 October 2019Source: Clinical ImagingAuthor(s): W. James Tom, Xiangdong Xu, Noushin Vahdat, Fiona Cassidy, Lejla AganovicAbstractInflammatory pseudotumors imitate neoplasms on imaging but actually represent focal inflammation. We report a case of follicular pancreatitis, which is a recently recognized distinct form of mass-forming focal chronic pancreatitis pathologically characterized by lymphoid infiltration with abundant reactive germinal centers. In our patient,...
Mark above section as read
Publication date: Available online 26 October 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Esther L.B. Childers, Lekidelu Taddasse-Heath, Andrea Bonnick, Tammey NaabAbstractThe notable features of ameloblastoma do not typically include prominent vascularity. However, rarely, vascular ameloblastoma has been described under a variety of names. We present a case of vascularized ameloblastoma that had a bloody return on FNA. The English literature had a total of...
Publication date: Available online 25 October 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Ji Rak Kim, Jung Hwan Jo, Jin Woo Chung, Ji Woon ParkAbstractObjectiveTo investigate clinical characteristics and treatment outcomes of patients with temporomandibular disorders (TMD) according to the presence of upper cervical spine abnormalities and craniofacial morphology.Study DesignClinical examinations were conducted on 43 TMD patients. Upper cervical spine characteristics...
Mark above section as read
Publication date: Available online 25 October 2019Source: Pathology - Research and PracticeAuthor(s): Jingrong Qian, Hongxue Meng, Bowen Lv, Jie Wang, Yingying Lu, Shu Zhao, Wenhui LiAbstractToll-like receptor9 (TLR9), a member of pattern recognition receptors, play an important role in tumor immunologic surveillance. However, the clinical impact of TLR9 and programmed cell death-ligand 1 (PD-L1) in peripheral T-cell lymphomas (PTCL) remains unclear. In this study, we examined the expression of TLR9...
Mark above section as read
Abstract The participants in randomized trials and other studies used for causal inference are often not representative of the populations seen by clinical decision-makers. To account for differences between populations, researchers may consider standardizing results to a target population. We discuss several different types of homogeneity conditions that are relevant for standardization: Homogeneity of effect measures, homogeneity of counterfactual outcome state transition parameters,...
20h
Mark above section as read
Publication date: Available online 25 October 2019Source: Journal of VoiceAuthor(s): Matthias Echternach, Catalina Högerle, Marie Köberlein, Patrick Schlegel, Michael Döllinger, Bernhard Richter, Marie-Anne KainzSummaryIntroductionIt is generally assumed that when singing across the region where registration events for untrained voices occur (the passaggio), singers modify the voice production system in order to avoid changes of voice quality. In this context, it has been postulated that nasalance...
Mark above section as read
Publication date: Available online 25 October 2019Source: Journal of ProteomicsAuthor(s): Huanying Pang, Wanxin Li, Weijie Zhang, Shihui Zhou, Rowena Hoare, Sean J. Monaghan, Jichan Jian, Xiangmin LinAbstractIt is well known that lysine acetylation (Kace) modification is a common post-translational modification (PTM) that plays an important role in multiple biological and pathological functions in bacteria. However, few studies have focused on lysine acetylation modification in aquatic pathogens...
Publication date: Available online 25 October 2019Source: Journal of ProteomicsAuthor(s): MaríaCeleste Ferrari, Micaela Cerletti, Roberto A. Paggi, Christian Troetschel, Ansgar Poetsch, Rosana De CastroGraphical abstract
Mark above section as read
Abstract The binding of alkaline earth cations Mg2+, Ca2+, and Sr2+ (M2+) to unilamellar 1,2-dimyristoyl-sn-glycero-3-phosphatidic acid (DMPA) vesicles was analysed by pH potentiometry, differential scanning calorimetry (DSC), isothermal titration calorimetry (ITC) and FT-IR spectroscopy. The binding of alkaline earth cations induces deprotonation of the DMPA headgroup even at very low concentration of divalent cations (~ 100 µM). The amount of deprotonated DMPA was measured by...
Abstract Aggregation of amyloid- \(\beta \) (Aβ) peptides, cleaved from the amyloid precursor protein, is known as a precursor of the Alzheimer’s disease (AD). It is also known that Alzheimer’s disease is characterized by a substantial decrease of the amount of polyunsaturated lipids in the neuronal membranes of the frontal gray matter. To get insight into possible interconnection of these...
Abstract We studied the complex between ovalbumin and long flexible poly-(sodium 4-styrene sulfonate) as a function of pH and temperature. We used various techniques [turbidimetry, conductometry, dynamic light scattering, viscosimetry, and ultra-small-angle light scattering (USALS)] to fully characterize the coacervate complex. Different phases of complexation versus temperature were determined by turbidimetric analysis (pHc, pHϕ1, and pHϕ2). The optimal protein/polyelectrolyte...
Mark above section as read
Abstract Purpose The aim of this study was to estimate the incidence of colorectal cancers in Iran. The results of this study are based on a screening program that is being implemented in Isfahan province. Material and Methods In this study, about 137,000 people were screened for colorectal cancer and adenomatous polyps in 2 steps during the year 2018. ...
Mark above section as read
Publication date: Available online 25 October 2019Source: NeuroImageAuthor(s): Mada Hashem, Qiong Zhang, Ying Wu, Thomas W. Johnson, Jeff F. DunnAbstractNon-invasive quantitative imaging of cerebral oxygen metabolism (CMRO2) in small animal models is crucial to understand the role of oxidative metabolism in healthy and diseased brains. In this study, we developed a multimodal method combining near-infrared spectroscopy (NIRS) and MRI to non-invasively study oxygen delivery and consumption in the...
Mark above section as read
Every year in the United States 52 MILLION school hours are lost because children have cavities. TWO out of THREE adults have dental disease and we know many of these oral health problems impact systemic body health by exacerbating chronic inflammatory... Read More ›
Mark above section as read
Publication date: Available online 25 October 2019Source: Medical Image AnalysisAuthor(s): Gongning Luo, Suyu Dong, Wei Wang, Kuanquan Wang, Shaodong Cao, Clara Tam, Henggui Zhang, Joanne Howey, Pavlo Ohorodnyk, Shuo LiAbstractAccurate and automated cardiac bi-ventricle quantification based on cardiac magnetic resonance (CMR) image is a very crucial procedure for clinical cardiac disease diagnosis. Two traditional and commensal tasks, i.e., bi-ventricle segmentation and direct ventricle function...
Mark above section as read
Here's the most clicked-on item we featured from NEJM Group this week, in case you missed it the first time around: HIV and ID...
Mark above section as read
Abstract Background and Aims Taurine-upregulated gene 1 (TUG1) is reported to be upregulated and contributes to the progression of Pancreatic cancer (PC) by serving as an oncogene. Our aims were to explore the precise mechanism of TUG1 involved in PC pathogenesis. Methods TUG1 and miR-299-3p expression profiles were measured by qRT-PCR. The direct interaction between...
Abstract Background Patients with inflammatory bowel disease are currently managed with the assumption that trial data are applicable to all ethnic groups. Previous studies demonstrate differences in disease severity and phenotype of Asian patients with Crohn’s disease (CD), including Bangladeshi Asians within the UK. No study has evaluated the impact of ethnicity on response to anti-TNFs. ...
Mark above section as read
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου