Κυριακή 27 Οκτωβρίου 2019



Immunomodulatory receptors are differentially expressed in B and T cell subsets relevant to autoimmune disease
Publication date: Available online 25 October 2019Source: Clinical ImmunologyAuthor(s): Katherine A. Murphy, Kartik Bhamidiphati, Samuel J.S. Rubin, Lucas Kipp, William H. Robinson, Tobias V. LanzAbstractInhibitory cell-surface receptors on lymphocytes, often called immune checkpoints, are powerful targets for cancer therapy. Despite their direct involvement in autoimmune pathology, they are currently not exploited therapeutically for autoimmune diseases. Understanding the receptors' expression patterns...
Clinical Immunology
18h

Using CETSA assay and a mathematical model to reveal dual Bcl-2/Mcl-1 inhibition and on-target mechanism for ABT-199 and S1
Publication date: Available online 25 October 2019Source: European Journal of Pharmaceutical SciencesAuthor(s): Zongwei Guo, Ting Song, Zuguang Xue, Peng Liu, Minhang Zhang, Xiaodong Zhang, Zhichao ZhangAbstractDeepening understanding of how Bcl-2 family proteins protect cancer cells from apoptosis has driven the development of ‘BH3 mimetic’ drugs that target various anti-apoptotic Bcl-2-like proteins by mimicking their natural inhibitors, the BH3-only proteins. The proof of target engagement and...
ScienceDirect Publication: European Journal of Pharmaceutical Sciences
19h

Preparation and evaluation of novel multi-channel orally disintegrating tablets
Publication date: Available online 25 October 2019Source: European Journal of Pharmaceutical SciencesAuthor(s): Jiaojiao Yu, Xiaosong Shan, Shichao Chen, Xinli Sun, Pengjin Song, Ruidong Zhao, Liandong HuAbstractIn this study, novel orally disintegrating tablets (ODTs) with multi-channel structure were designed to provide a rapid disintegration and subsequently drug dissolution. The ODTs were prepared using conventional wet compression through perforating channels with a special multi-channel mold....
ScienceDirect Publication: European Journal of Pharmaceutical Sciences
19h

In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs
Publication date: Available online 25 October 2019Source: European Journal of Pharmaceutical SciencesAuthor(s): Risto O. Juvonen, Aki T. Heikkinen, Olli Kärkkäinen, Rabia Jehangir, Juhani Huuskonen, Johanna Troberg, Hannu Raunio, Olli T. Pentikäinen, Moshe FinelAbstractBeagle dog is a standard animal model for evaluating nonclinical pharmacokinetics of new drug candidates. Glucuronidation in intestine and liver is an important first-pass drug metabolic pathway, especially for phenolic compounds....
ScienceDirect Publication: European Journal of Pharmaceutical Sciences
19h

The mechanism of solifenacin release from a pH-responsive ion-complex oral suspension in the fasted upper gastrointestinal lumen
Publication date: Available online 25 October 2019Source: European Journal of Pharmaceutical SciencesAuthor(s): Yosuke Yamamoto, Harumi Kumagai, Moe Haneda, Maria Vertzoni, Niels Ouwerkerk, Daisuke Murayama, Yoshifumi Katakawa, Kei Motonaga, Christos Reppas, Tomokazu TajiriAbstractThe main objective of this study was to investigate the mechanism of solifenacin release from a pH-responsive ion-complex oral resinate suspension under conditions simulating the environment in the upper gastrointestinal...
ScienceDirect Publication: European Journal of Pharmaceutical Sciences
19h

GMP manufacturing of Vvax001, a therapeutic anti-HPV vaccine based on recombinant viral particles
Publication date: Available online 25 October 2019Source: European Journal of Pharmaceutical SciencesAuthor(s): Annelies Jorritsma-Smit, Coba J. van Zanten, Jolande Schoemaker, Janneke J.M. Meulenberg, Daan J. Touw, Jos G.W. Kosterink, Hans W. Nijman, Toos Daemen, Derk P. AllersmaAbstractTherapeutic vaccination is being explored as a treatment strategy for the treatment of patients with primary or metastatic tumours. We developed a vaccine targeted to Human papillomavirus (HPV)-induced tumours based...
ScienceDirect Publication: European Journal of Pharmaceutical Sciences
19h

Manuscript title: Improved postauricular surgical approach to the round window of rats
Publication date: Available online 25 October 2019Source: Journal of Neuroscience MethodsAuthor(s): Barilin Dkhar, Abhijeet Bhatia, Pranjal Pratim Saikia, Haphidasara PyngropeABSTRACTObjectivesResearch using rat as an in-vivo model has played an important role in otological research. The rat ear anatomy has been described; however, detailed surgical procedures to access the temporal bone are limited. The authors present a technique to approach the inner ear of rat that was standardized by cadaveric...
Journal of Neuroscience Methods
19h
Perceived social support mediates the association between attachment and cardiovascular reactivity in young adults
Abstract To understand the influence of social relationships on cardiovascular responses to stress, the present study investigated perceived affectionate support as a mediating variable explaining the association between specific attachment bonds (i.e., mother, father, partner, best friend) and cardiovascular reactivity (CVR). Utilizing a standardized stress testing protocol, 138 young adults completed measures of attachment and social support, with continuous cardiovascular measurements obtained...
Psychophysiology
19h
Back rehabilitation – the 3R’s approach
Publication date: Available online 25 October 2019Source: Journal of Bodywork and Movement TherapiesAuthor(s): Christopher M. NorrisAbstractExercise is vital to the management of low back pain (LBP). However, research, social media, and fitness industry interests can leave therapists confused about best practice in exercise prescription for this clinical condition. The 3R’s approach to back rehabilitation is introduced as an evidence-based framework for developing patient specific exercise throughout...
ScienceDirect Publication: Journal of Bodywork and Movement Therapies
19h
Massage Therapy Treatment and Outcomes in a Patient with Charcot-Marie-Tooth Disease: A Case Report
Publication date: Available online 25 October 2019Source: Journal of Bodywork and Movement TherapiesAuthor(s): Galit PazAbstractBackgroundCharcot-Marie-Tooth (CMT) disease, a progressive hereditary peripheral neuropathy, leads to muscle weakness, wasting, and sensory and motor nerve deprivation. The two main types of CMT are CMT1 (demyelinating) and CMT2 (axonal). Initial findings include foot deformities and sensory changes with progression to altered gait, diminished reflexes, and muscle wasting...
ScienceDirect Publication: Journal of Bodywork and Movement Therapies
19h

Efficient but less active monitoring system in individuals with high aggressive predispositions
Publication date: Available online 25 October 2019Source: International Journal of PsychophysiologyAuthor(s): Fanny Grisetto, Yvonne N. Delevoye-Turrell, Clémence RogerAbstractAggressive behaviors in pathological and healthy populations have been largely related to poor cognitive control functioning. However, few studies have investigated the influence of aggressive traits (i.e., aggressiveness) on cognitive control. In the current study, we investigated the effects of aggressiveness on cognitive...
International Journal of Psychophysiology
19h

Blurring attenuates the early posterior negativity in response to snake stimuli
Publication date: Available online 25 October 2019Source: International Journal of PsychophysiologyAuthor(s): Nick Beligiannis, Jan W. Van StrienAbstractPrevious event-related potential studies have reported enhanced Early Posterior Negativity (EPN) in response to snake pictures compared to pictures of other animals. This EPN snake effect may be partly driven by specific snake skin patterns. In this study, by using blurred pictures to make these patterns less visible, we explored whether the relative...
International Journal of Psychophysiology
19h

Enhanced processing of facial emotion for target stimuli
Publication date: Available online 25 October 2019Source: International Journal of PsychophysiologyAuthor(s): Timm Rosburg, Michael Weigl, Gunnar DeuringAbstractIt is as yet unresolved to what extent the pre-attentive detection of auditory deviance is modulated by emotion. The current event-related potential study was designed to investigate simultaneously the auditory and the visual mismatch negativity (MMN), as well as the impact of emotion on the auditory MMN. Thirty healthy participants saw sequences...
International Journal of Psychophysiology
19h
Motivational Interviewing in Ethnic Populations
Abstract Motivational interviewing (MI) is an effective means of facilitating behavior change in a variety of health conditions. However, given its origins in western psychology, its utility in ethnic populations is unclear. Our objective was to examine the effectiveness of MI and its components in people of varying ethnicities and how they may experience MI. We undertook a narrative systematic review of the literature, searching only peer-reviewed research up until February, 2019...
Latest Results for Journal of Immigrant and Minority Health
19h

No evidence of tachyphylaxis for insulinotropic actions of Glucose-Dependent Insulinotropic Polypeptide (GIP) in subjects with type 2 diabetes, their first-degree relatives, or in healthy subjects
Publication date: Available online 25 October 2019Source: PeptidesAuthor(s): M.A. Nauck, H. Holle, M. Kahle, A. Tytko, C.F. Deacon, J.J. Holst, J.J. MeierAbstractBackground, aimsIn patients with type 2 diabetes, the lost insulinotropic effect of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) is more apparent after continuous versus bolus administration. To test whether the difference might be explained by rapid tachyphylaxis in response to elevated concentrations of GIP,...
ScienceDirect Publication: Peptides
19h

Halloween Can Be Frightful for Kids With Allergies, Asthma
SATURDAY, Oct. 26, 2019 -- Allergies and asthma can turn Halloween into fright night, so parents must be vigilant. Some fun-sized candy bars have no labels to alert about possible food allergens, such as peanuts, said Dr. Todd Mahr, president of the...
Drugs.com - Daily MedNews
19h

Long Term Post-Operative Cone Beam Commuted Tomography Analysis of Secondary Bone Grafting in 79 Patients with Unrepaired Alveolar Clefts
Publication date: Available online 25 October 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Tamir Dean Anver, Lida Mirzai, Peng Li, Kathlyn Powell, Peter D. WaiteAbstractPurposeUse cone-beam computed tomography (CBCT) analysis to assess the long term radiographic outcomes of early secondary alveolar bone grafting.Patients and MethodsThe most recent post-operative CBCT of 79 alveolar cleft patients that underwent of anterior iliac crest bone grafting (AICBG) by a single surgeon over...
Oral and Maxillofacial Surgery
19h

Apicoecto-Guide 3D: optimizing access for apicoectomies
Publication date: Available online 25 October 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Warley Luciano Fonseca Tavares, Francielen Oliveira Fonseca, Lucas Moreira Maia, Vinícius de Carvalho Machado, Nelson Renato França Alves Silva, Gil Moreira Junior, Antônio Paulino Ribeiro SobrinhoAbstractWhen conventional endodontic treatment resources are depleted, endodontic surgery becomes an alternative treatment for apical periodontitis to remove unreachable infected areas and seal...
Oral and Maxillofacial Surgery
19h

Endoscopic Infraorbital Microdissection for Localized V2 Trigeminal Neuralgia
Publication date: Available online 25 October 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Max Ward, Neil Majmundar, Antonios Mammis, Boris PaskhoverAbstractBackgroundTrigeminal neuralgia is a chronic and debilitating syndrome characterized by short paroxysms of lancinating facial pain. Patients may be medically managed; however, in cases of medically refractory trigeminal neuralgia surgical management is often required.ObjectiveTo present and describe the technique for endoscopic...
Oral and Maxillofacial Surgery
19h
Periauricular wrinkles removed with voltaic arc dermabrasion (Atmospheric Plasma technique)
Abstract Background In recent literature, different approaches have been proposed to improve the long‐lasting treatment of age‐related alterations on the human face with decreased invasiveness and side effects such as scar tissue. Voltaic arc dermabrasion is a minimally painful procedure that does not create discomfort to the patient and requires no anaesthesia. Aims The aim of this investigation was to evaluate the voltaic arc technique for the treatment of skin wrinkles in the periauricular...
Journal of Cosmetic Dermatology
19h
Follicular pancreatitis: A rare pancreatic inflammatory pseudotumor
Publication date: Available online 25 October 2019Source: Clinical ImagingAuthor(s): W. James Tom, Xiangdong Xu, Noushin Vahdat, Fiona Cassidy, Lejla AganovicAbstractInflammatory pseudotumors imitate neoplasms on imaging but actually represent focal inflammation. We report a case of follicular pancreatitis, which is a recently recognized distinct form of mass-forming focal chronic pancreatitis pathologically characterized by lymphoid infiltration with abundant reactive germinal centers. In our patient,...
Clinical Imaging
19h

Vascularized Ameloblastoma: A Case Report and Clinicopathologic Review of 18 Cases From The Literature
Publication date: Available online 26 October 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Esther L.B. Childers, Lekidelu Taddasse-Heath, Andrea Bonnick, Tammey NaabAbstractThe notable features of ameloblastoma do not typically include prominent vascularity. However, rarely, vascular ameloblastoma has been described under a variety of names. We present a case of vascularized ameloblastoma that had a bloody return on FNA. The English literature had a total of...
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
19h

Upper Cervical Spine Abnormalities as a Radiographic Index in the Diagnosis and Treatment of Temporomandibular Disorders
Publication date: Available online 25 October 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Ji Rak Kim, Jung Hwan Jo, Jin Woo Chung, Ji Woon ParkAbstractObjectiveTo investigate clinical characteristics and treatment outcomes of patients with temporomandibular disorders (TMD) according to the presence of upper cervical spine abnormalities and craniofacial morphology.Study DesignClinical examinations were conducted on 43 TMD patients. Upper cervical spine characteristics...
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
19h
TLR9 expression is associated with PD-L1 expression and indicates a poor prognosis in patients with peripheral T-cell lymphomas
Publication date: Available online 25 October 2019Source: Pathology - Research and PracticeAuthor(s): Jingrong Qian, Hongxue Meng, Bowen Lv, Jie Wang, Yingying Lu, Shu Zhao, Wenhui LiAbstractToll-like receptor9 (TLR9), a member of pattern recognition receptors, play an important role in tumor immunologic surveillance. However, the clinical impact of TLR9 and programmed cell death-ligand 1 (PD-L1) in peripheral T-cell lymphomas (PTCL) remains unclear. In this study, we examined the expression of TLR9...
ScienceDirect Publication: Pathology - Research and Practice
19h
Effect heterogeneity and variable selection for standardizing causal effects to a target population
Abstract The participants in randomized trials and other studies used for causal inference are often not representative of the populations seen by clinical decision-makers. To account for differences between populations, researchers may consider standardizing results to a target population. We discuss several different types of homogeneity conditions that are relevant for standardization: Homogeneity of effect measures, homogeneity of counterfactual outcome state transition parameters,...
http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=10654&channel-name=European+Journal+of+Epidemiology
20h
The Effect of Nasalance on Vocal Fold Oscillation Patterns During the Male Passaggio
Publication date: Available online 25 October 2019Source: Journal of VoiceAuthor(s): Matthias Echternach, Catalina Högerle, Marie Köberlein, Patrick Schlegel, Michael Döllinger, Bernhard Richter, Marie-Anne KainzSummaryIntroductionIt is generally assumed that when singing across the region where registration events for untrained voices occur (the passaggio), singers modify the voice production system in order to avoid changes of voice quality. In this context, it has been postulated that nasalance...
ScienceDirect Publication: Journal of Voice
20h

Acetylome profiling of <em>Vibrio alginolyticus</em> reveals its role in bacterial virulence
Publication date: Available online 25 October 2019Source: Journal of ProteomicsAuthor(s): Huanying Pang, Wanxin Li, Weijie Zhang, Shihui Zhou, Rowena Hoare, Sean J. Monaghan, Jichan Jian, Xiangmin LinAbstractIt is well known that lysine acetylation (Kace) modification is a common post-translational modification (PTM) that plays an important role in multiple biological and pathological functions in bacteria. However, few studies have focused on lysine acetylation modification in aquatic pathogens...
ScienceDirect Publication: Journal of Proteomics
20h

The LonB protease modulates the degradation of CetZ1 involved in rod-shape determination in <em>Haloferax volcanii</em>
Publication date: Available online 25 October 2019Source: Journal of ProteomicsAuthor(s): MaríaCeleste Ferrari, Micaela Cerletti, Roberto A. Paggi, Christian Troetschel, Ansgar Poetsch, Rosana De CastroGraphical abstract
ScienceDirect Publication: Journal of Proteomics
20h
Electrostatic interactions of alkaline earth cations with 1,2-dimyristoyl- sn -glycero-3-phosphatidic acid (DMPA) model membranes at neutral and acidic pH
Abstract The binding of alkaline earth cations Mg2+, Ca2+, and Sr2+ (M2+) to unilamellar 1,2-dimyristoyl-sn-glycero-3-phosphatidic acid (DMPA) vesicles was analysed by pH potentiometry, differential scanning calorimetry (DSC), isothermal titration calorimetry (ITC) and FT-IR spectroscopy. The binding of alkaline earth cations induces deprotonation of the DMPA headgroup even at very low concentration of divalent cations (~ 100 µM). The amount of deprotonated DMPA was measured by...
Latest Results for European Biophysics Journal
20h
Effect of lipid saturation on amyloid-beta peptide partitioning and aggregation in neuronal membranes: molecular dynamics simulations
Abstract Aggregation of amyloid- \(\beta \) (Aβ) peptides, cleaved from the amyloid precursor protein, is known as a precursor of the Alzheimer’s disease (AD). It is also known that Alzheimer’s disease is characterized by a substantial decrease of the amount of polyunsaturated lipids in the neuronal membranes of the frontal gray matter. To get insight into possible interconnection of these...
Latest Results for European Biophysics Journal
21h
Study of the complex coacervation mechanism between ovalbumin and the strong polyanion PSSNa: influence of temperature and pH
Abstract We studied the complex between ovalbumin and long flexible poly-(sodium 4-styrene sulfonate) as a function of pH and temperature. We used various techniques [turbidimetry, conductometry, dynamic light scattering, viscosimetry, and ultra-small-angle light scattering (USALS)] to fully characterize the coacervate complex. Different phases of complexation versus temperature were determined by turbidimetric analysis (pHc, pHϕ1, and pHϕ2). The optimal protein/polyelectrolyte...
Latest Results for European Biophysics Journal
22h
Incidence of Colorectal Cancer and Adenomatous Polyps After a Two-Step Screening in Isfahan Province, Iran in 2018
Abstract Purpose The aim of this study was to estimate the incidence of colorectal cancers in Iran. The results of this study are based on a screening program that is being implemented in Isfahan province. Material and Methods In this study, about 137,000 people were screened for colorectal cancer and adenomatous polyps in 2 steps during the year 2018. ...
Latest Results for Journal of Gastrointestinal Cancer
20h

Using a multimodal near-infrared spectroscopy and MRI to quantify gray matter metabolic rate for oxygen: A hypothermia validation study
Publication date: Available online 25 October 2019Source: NeuroImageAuthor(s): Mada Hashem, Qiong Zhang, Ying Wu, Thomas W. Johnson, Jeff F. DunnAbstractNon-invasive quantitative imaging of cerebral oxygen metabolism (CMRO2) in small animal models is crucial to understand the role of oxidative metabolism in healthy and diseased brains. In this study, we developed a multimodal method combining near-infrared spectroscopy (NIRS) and MRI to non-invasively study oxygen delivery and consumption in the...
NeuroImage
20h
Time to take a new approach to oral health care
Every year in the United States 52 MILLION school hours are lost because children have cavities.  TWO out of THREE adults have dental disease and we know many of these oral health problems impact systemic body health by exacerbating chronic inflammatory... Read More ›
Ultimate Oral Health Guide
20h

Commensal Correlation Network Between Segmentation and Direct Area Estimation for Bi-ventricle Quantification
Publication date: Available online 25 October 2019Source: Medical Image AnalysisAuthor(s): Gongning Luo, Suyu Dong, Wei Wang, Kuanquan Wang, Shaodong Cao, Clara Tam, Henggui Zhang, Joanne Howey, Pavlo Ohorodnyk, Shuo LiAbstractAccurate and automated cardiac bi-ventricle quantification based on cardiac magnetic resonance (CMR) image is a very crucial procedure for clinical cardiac disease diagnosis. Two traditional and commensal tasks, i.e., bi-ventricle segmentation and direct ventricle function...
Medical Image Analysis
20h
Most Popular NEJM Group Feature This Week: Amoxicillin for Chronic Low Back Pain? Are You Kidding Me? In Defense of a Controversial Clinical Trial
Here's the most clicked-on item we featured from NEJM Group this week, in case you missed it the first time around: HIV and ID...
NEJM Journal Watch: Physician's First Watch RSS Feed
20h
Inhibition of TUG1/miRNA-299-3p Axis Represses Pancreatic Cancer Malignant Progression via Suppression of the Notch1 Pathway
Abstract Background and Aims Taurine-upregulated gene 1 (TUG1) is reported to be upregulated and contributes to the progression of Pancreatic cancer (PC) by serving as an oncogene. Our aims were to explore the precise mechanism of TUG1 involved in PC pathogenesis. Methods TUG1 and miR-299-3p expression profiles were measured by qRT-PCR. The direct interaction between...
Latest Results for Digestive Diseases and Sciences
20h
UK Patients of Bangladeshi Descent with Crohn’s Disease Respond Less Well to TNF Antagonists Than Caucasian Patients
Abstract Background Patients with inflammatory bowel disease are currently managed with the assumption that trial data are applicable to all ethnic groups. Previous studies demonstrate differences in disease severity and phenotype of Asian patients with Crohn’s disease (CD), including Bangladeshi Asians within the UK. No study has evaluated the impact of ethnicity on response to anti-TNFs. ...
Latest Results for Digestive Diseases and Sciences
22h
Location, location, location: Lessons from airway epithelial anion channels
The Journal of Physiology
20h

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