Natural selection can remove maladaptive genotypic variance from populations, leaving reduced phenotypic variation as a signal of its action. Hybrid populations offer a unique opportunity to study phenotypic variance before selection purifies it, as these populations can have increased genotypic and phenotypic variance than can reveal trade-offs and selection conflicts not visible, or visible to a lesser extent, in unadmixed populations. Here, we study the interactions between a fungal leaf rust...
Fri Oct 25, 2019 03:00
Human pregnancy requires the coordinated function of multiple tissues in both mother and fetus and has evolved in concert with major human adaptations. As a result, pregnancy-associated phenotypes and related disorders are genetically complex and have likely been sculpted by diverse evolutionary forces. However, there is no framework to comprehensively evaluate how these traits evolved or to explore the relationship of evolutionary signatures on trait-associated genetic variants to molecular function....
Fri Oct 25, 2019 03:00
Mass Drug Administration (MDA) is regarded as a potential strategy for locally interrupting transmission of human malaria under specific circumstances. However, insights on how MDA affects the eco-evolutionary dynamics of different Plasmodium species are not well known. We provide a computational model where the ecologically explicit life cycle of the parasite is implemented. Since the parasite inhabits two different ecological niches - human host and the mosquito - it undergoes different selection...
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Abstract Rationale Adams–Oliver syndrome (AOS) is a genetic disorder characterized by the association of aplasia cutis congenita (ACC), terminal transverse limb defect (TTLD), congenital cardiac malformation (CCM), and minor features, such as cutaneous, neurological, and hepatic abnormalities (HAs). The aim of the study is to emphasize phenotype–genotype correlations in AOS. Methods We studied 29 AOS patients. We recorded retrospectively detailed phenotype data, including clinical examination,...
Fri Oct 25, 2019 20:37
Abstract Objectives Numerous tools have been developed to characterize the morphometry of 3D models. The aim of this study was to apply these techniques to better understand the morphometric growth pattern of healthy children's mandibles. Material and Methods The study sample was composed of 480 very young children aged from 36 gestational weeks to 7 years old. The sample was divided into three subsamples according to the development stages of their deciduous dentition. Several biometric...
Fri Oct 25, 2019 17:32
Abstract Objectives The taxonomic status of isolated hominoid teeth from the Asian Pleistocene has long been controversial due to difficulties distinguishing between pongine and hominin molars given their high degree of morphometrical variation and overlap. Here, we combine nonmetric and geometric morphometric data to document a dental pattern that appears to be taxonomically diagnostic among Pongo. We focus on the protoconule, a cuspule of well‐documented evolutionary history, as well as on...
Fri Oct 25, 2019 15:44
Abstract Objective To investigate the relationship between preoperative trabecular bone structure and implant outcome based on bone morphometric bone parameters from CBCT scans. Material and Methods Twenty consecutive cases with early implant failure in the posterior region of the mandible were matched with 20 control patients with a successful implant osseointegration selected. All patients had taken a preoperative CBCT image according to a standardized acquisition protocol. On these CBCT...
Fri Oct 25, 2019 21:18
Background: Transbronchial lung cryobiopsy (TBLC) is a novel technique that has proved its diagnostic value in various diffuse parenchymal lung diseases (DPLD). However, there is substantial variability among interventional pulmonologists in procedural technique, diagnostic yield, and complication rate. Radial endobronchial ultrasound (R-EBUS) is useful for identification of ground-glass opacity lesions and can help identify target lung parenchyma. We aim to evaluate R-EBUS in TBLC histopathologic...
Tue Oct 01, 2019 03:00
Abstract Vancomycin is often used in orthopedic surgery as a local prophylaxis of bacterial infection. The aim of this work was to compare the release of vancomycin and its biologically inactive crystalline degradation products (CDP-1) during in vitro experiments from different types of local antibiotic delivery systems (bone grafts and bone cements). The concentrations of vancomycin and its crystalline degradation products were determined by high-performance liquid chromatography....
Fri Oct 25, 2019 03:00
Fri Oct 25, 2019 19:59
Future Oncology, Ahead of Print.
Fri Oct 25, 2019 15:08
Future Oncology, Ahead of Print.
Fri Oct 25, 2019 14:45
Future Oncology, Ahead of Print.
Fri Oct 25, 2019 14:38
Future Oncology, Ahead of Print.
Fri Oct 25, 2019 14:21
Future Oncology, Ahead of Print.
Fri Oct 25, 2019 14:12
Future Oncology, Ahead of Print.
Fri Oct 25, 2019 04:56
Future Oncology, Ahead of Print.
Fri Oct 25, 2019 04:38
Abstract Purpose The proportion of acute symptomatic lacunar infarction lesions that undergo cavitation and the factors influencing cavity formation are yet unclear, particularly in the Chinese population. Hence, we investigated changes in the diameter of acute lacunar infarction lesions and identified the risk factors for the progression of these lesions. Methods ...
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Related ArticlesUpregulation of intratumoral HLA class I and peritumoral Mx1 in ulcerated melanomas. Oncoimmunology. 2019;8(11):e1660121 Authors: Verver D, Poirier-Colame V, Tomasic G, Cherif-Rebai K, Grunhagen DJ, Verhoef C, Suciu S, Robert C, Zitvogel L, Eggermont AMM Abstract Before the era of immune checkpoint blockade, a meta-analysis encompassing fifteen trials reported that adjuvant IFN-α significantly reduces the risk of relapse and improves...
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Related ArticlesAberrant upregulation of PDK1 in ovarian cancer cells impairs CD8+ T cell function and survival through elevation of PD-L1. Oncoimmunology. 2019;8(11):e1659092 Authors: Wang JJ, Siu MK, Jiang YX, Leung TH, Chan DW, Cheng RR, Cheung AN, Ngan HY, Chan KK Abstract Blockade of the programmed cell death 1(PD-1)/PD-1 ligand-1(PD-L1) pathway has been exploited therapeutically in many cancer types. Upregulation of PD-L1 in tumor cells contributes...
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Related ArticlesA synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice. Oncoimmunology. 2019;8(11):e1657375 Authors: Lévesque S, Le Naour J, Pietrocola F, Paillet J, Kremer M, Castoldi F, Baracco EE, Wang Y, Vacchelli E, Stoll G, Jolly A, De La Grange P, Zitvogel L, Kroemer G, Pol JG Abstract We have recently shown that chemotherapy with immunogenic cell death (ICD)-inducing agents...
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Related ArticlesLurbinectedin synergizes with immune checkpoint blockade to generate anticancer immunity. Oncoimmunology. 2019;8(11):e1656502 Authors: Xie W, Forveille S, Iribarren K, Sauvat A, Senovilla L, Wang Y, Humeau J, Perez-Lanzon M, Zhou H, Martínez-Leal JF, Kroemer G, Kepp O Abstract Systemic treatment with the active transcription inhibitor lurbinectedin aims at inducing tumor cell death in hyperproliferative neoplasms. Here we show that cell...
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Related ArticlesApoptotic caspases inhibit abscopal responses to radiation and identify a new prognostic biomarker for breast cancer patients. Oncoimmunology. 2019;8(11):e1655964 Authors: Rodriguez-Ruiz ME, Buqué A, Hensler M, Chen J, Bloy N, Petroni G, Sato A, Yamazaki T, Fucikova J, Galluzzi L Abstract Caspase 3 (CASP3) has a key role in the execution of apoptosis, and many cancer cells are believed to disable CASP3 as a mechanism of resistance to...
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Related ArticlesExtracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response. Oncoimmunology. 2019;8(11):e1655370 Authors: Sosnowska A, Czystowska-Kuzmicz M, Golab J Abstract Expression of arginase-1 (ARG1) is an immunosuppressive feature of tumor microenvironment that leads to depletion of ʟ-arginine, a nutrient required for T-cells expansion. Ovarian carcinoma cells release extracellular vesicles...
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Related ArticlesApoptotic caspases cut down the immunogenicity of radiation. Oncoimmunology. 2019;8(11):e1655364 Authors: Buqué A, Rodriguez-Ruiz ME, Fucikova J, Galluzzi L Abstract Caspases are known for their ability to precipitate apoptosis. Our findings indicate that accelerating the terminal inactivation of cells dying in response to radiation therapy limit their immunogenicity as a consequence of reduced type I interferon secretion. Thus, caspase...
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Related ArticlesPre-surgical oncolytic virotherapy improves breast cancer outcomes. Oncoimmunology. 2019;8(11):e1655363 Authors: Mullins-Dansereau V, Petrazzo G, Geoffroy K, Béland D, Bourgeois-Daigneault MC Abstract Oncolytic viruses (OVs) are a novel class of cancer biotherapeutics with the ability to kill cancers and trigger anti-tumor immunity. Using murine models of cancer in pre-clinical proof-of-concept studies, we found that neoadjuvant OV administration...
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Related ArticlesPDL1 expression is associated with longer postoperative, survival in adrenocortical carcinoma. Oncoimmunology. 2019;8(11):e1655362 Authors: Billon E, Finetti P, Bertucci A, Niccoli P, Birnbaum D, Mamessier E, Bertucci F Abstract Adrenocortical carcinomas (ACCs) are heterogeneous cancers associated with a very poor prognosis. The improvement of prognostic tools and systemic therapy are urgently needed. Targeting the immune system using...
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Related ArticlesHuman Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors. Oncoimmunology. 2019;8(11):e1655360 Authors: Kaffes I, Szulzewsky F, Chen Z, Herting CJ, Gabanic B, Velázquez Vega JE, Shelton J, Switchenko JM, Ross JL, McSwain LF, Huse JT, Westermark B, Nelander S, Forsberg-Nilsson K, Uhrbom L, Maturi NP, Cimino PJ, Holland EC, Kettenmann H, Brennan CW, Brat DJ, Hambardzumyan D ...
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Related ArticlesMacrophages induce CD47 upregulation via IL-6 and correlate with poor survival in hepatocellular carcinoma patients. Oncoimmunology. 2019;8(11):e1652540 Authors: Chen J, Zheng DX, Yu XJ, Sun HW, Xu YT, Zhang YJ, Xu J Abstract CD47 is known to be involved in phagocyte-mediated tumor clearance; however, its expression, clinical significance, and regulatory mechanism in hepatocellular carcinoma (HCC) remain poorly understood. In the present...
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Related ArticlesThe impact of CTLA-4 blockade and interferon-α on clonality of T-cell repertoire in the tumor microenvironment and peripheral blood of metastatic melanoma patients. Oncoimmunology. 2019;8(11):e1652538 Authors: Khunger A, Rytlewski JA, Fields P, Yusko EC, Tarhini AA Abstract Patients with metastatic melanoma were treated with tremelimumab and interferon-α (IFN) in a previously reported clinical trial [NCT00610857]. Responses were assessed...
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Related ArticlesCombined chemotherapy and allogeneic human Vγ9Vδ2 T lymphocyte-immunotherapies efficiently control the development of human epithelial ovarian cancer cells in vivo. Oncoimmunology. 2019;8(11):e1649971 Authors: Joalland N, Lafrance L, Oullier T, Marionneau-Lambot S, Loussouarn D, Jarry U, Scotet E Abstract Epithelial ovarian cancer (EOC) represents 5% of human gynecologic cancers in the world, is heterogeneous and highly invasive with...
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Related ArticlesDocking protein-1 promotes inflammatory macrophage signaling in gastric cancer. Oncoimmunology. 2019;8(11):e1649961 Authors: Li T, Li B, Sara A, Ay C, Leung WY, Zhang Y, Dong Y, Liang Q, Zhang X, Weidner P, Gutting T, Behrens HM, Röcken C, Sung JJ, Ebert MP, Yu J, Burgermeister E Abstract Docking protein-1 (DOK1) is a tumor suppressor frequently lost in malignant cells, however, it retains the ability to control activities of immune receptors...
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Related ArticlesBlockade of ErbB2 and PD-L1 using a bispecific antibody to improve targeted anti-ErbB2 therapy. Oncoimmunology. 2019;8(11):e1648171 Authors: Mittal D, Vijayan D, Neijssen J, Kreijtz J, Habraken MMJM, Van Eenennaam H, Van Elsas A, Smyth MJ Abstract A significant proportion of human epidermal growth factor receptor 2 (Her2/ErbB2)-positive metastatic breast cancer patients are refractory to Her2-targeted trastuzumab-like therapy. Some of...
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Related ArticlesPolyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile. Oncoimmunology. 2019;8(11):e1648170 Authors: De Groot R, Van Loenen MM, Guislain A, Nicolet BP, Freen-Van Heeren JJ, Verhagen OJHM, Van Den Heuvel MM, De Jong J, Burger P, Van Der Schoot CE, Spaapen RM, Amsen D, Haanen JBAG, Monkhorst K, Hartemink KJ, Wolkers MC Abstract Non-small cell lung...
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Related ArticlesT cell receptor next-generation sequencing reveals cancer-associated repertoire metrics and reconstitution after chemotherapy in patients with hematological and solid tumors. Oncoimmunology. 2019;8(11):e1644110 Authors: Simnica D, Akyüz N, Schliffke S, Mohme M, V Wenserski L, Mährle T, Fanchi LF, Lamszus K, Binder M Abstract The dynamics of immunoaging and the onset of immunoparesis in healthy individuals and cancer patients has been...
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Related ArticlesImmune checkpoint inhibitors in mCRPC - rationales, challenges and perspectives. Oncoimmunology. 2019;8(11):e1644109 Authors: Taghizadeh H, Marhold M, Tomasich E, Udovica S, Merchant A, Krainer M Abstract The advancement of immune-therapeutics in cancer treatment has proven to be promising in various malignant diseases. However, in castration resistant prostate cancer (mCRPC) major Phase III trials have been unexpectedly disappointing....
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Related ArticlesClinical impact of T cells, B cells and the PD-1/PD-L1 pathway in muscle invasive bladder cancer: a comparative study of transurethral resection and cystectomy specimens. Oncoimmunology. 2019;8(11):e1644108 Authors: Wahlin S, Nodin B, Leandersson K, Boman K, Jirström K Abstract In patients with muscle invasive bladder cancer (MIBC), neoadjuvant chemotherapy (NAC) prior to radical cystectomy has improved survival but there is an urgent...
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Related ArticlesSepsis inhibits tumor growth in mice with cancer through Toll-like receptor 4-associated enhanced Natural Killer cell activity. Oncoimmunology. 2019;8(11):e1641391 Authors: Vigneron C, Mirouse A, Merdji H, Rousseau C, Cousin C, Alby-Laurent F, Mira JP, Chiche JD, Llitjos JF, Pène F Abstract Sepsis-induced immune dysfunctions are likely to impact on malignant tumor growth. Sequential sepsis-then-cancer models of tumor transplantation in...
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Related ArticlesDexamethasone differentially depletes tumour and peripheral blood lymphocytes and can impact the efficacy of chemotherapy/checkpoint blockade combination treatment. Oncoimmunology. 2019;8(11):e1641390 Authors: Aston WJ, Hope DE, Cook AM, Boon L, Dick I, Nowak AK, Lake RA, Lesterhuis WJ Abstract Dexamethasone is a synthetic glucocorticoid commonly used for the prevention and management of side effects in cancer patients undergoing chemotherapy....
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