American Society for Stereotactic and Functional Neurosurgery
- Mechanisms and Risk Factors Contributing to Visual Field Deficits following Stereotactic Laser AmygdalohippocampotomySelective laser amygdalohippocampotomy (SLAH) is a minimally invasive surgical treatment for medial temporal lobe epilepsy. Visual field deficits (VFDs) are a significant potential complication. The objective of this study was to determine the relationship between VFDs and potential mechanisms of injury to the optic radiations and lateral geniculate nucleus. We performed a retrospective cross-sectional analysis of 3 patients (5.2%) who developed
Annals of Neurology
- Genetic Landscape of Epilepsy of Infancy with Migrating Focal SeizuresObjective Epilepsy of infancy with migrating focal seizures (EIMFS) is one of the most severe developmental and epileptic encephalopathies. We delineate the genetic causes and genotype–phenotype correlations of a large EIMFS cohort. Methods Phenotypic and molecular data were analyzed on patients recruited through an international collaborative study. Results We ascertained 135 patients from 128 unrelated families. Ninety‐three of 135
- Annals of Neurology: Volume 86, Number 5, November 2019A fluorescence photomicrograph showing human astrocytes derived from induced pluripotent stem cells, from a patient with Vanishing White Matter disease. They are stained red with glial fibrillary acidic protein (GFAP) immunohistochemistry, and the nuclei are stained blue with DAPI. See Leferink et al. on pp. 780–792, in this issue for details. ANN NEUROL 2019;86:1–1
- Enhanced oxidative stress contributes to worse prognosis and delayed neurofunctional recovery after striatal intracerebral hemorrhage in 5XFAD miceAbstract Although Alzheimer's disease (AD) is associated with an increased risk of intracerebral hemorrhage (ICH) caused by hypertension and cerebral amyloid angiopathy, the precise clinical course after hypertensive ICH in AD patients is still unknown. In this study, we investigated how striatal ICH, a frequent site for hypertensive ICH, affected the prognosis of AD. We employed 17‐ and 18‐month‐old male 5XFAD (5X) mice and littermate (LT) con
- Cell‐type specific visualization and biochemical isolation of endogenous synaptic proteins in miceAbstract In recent years, the remarkable molecular complexity of synapses has been revealed, with over 1000 proteins identified in the synapse proteome. Although it is known that different receptors and other synaptic proteins are present in different types of neurons, the extent of synapse diversity across the brain is largely unknown. This is mainly due to the limitations of current techniques. Here we report an efficient method for the purifi
- Nicotine smoking concentrations modulateGABAergic synaptic transmission in murine medial prefrontal cortexbyactivation ofα7* and β2* nicotinicreceptorsAbstract Nicotine is the major addictive component of cigarettes, reaching a brain concentration of ~300 nM during smoking of a single cigarette. The prefrontal cortex (PFC) mechanisms underlying temporary changes of working memory during smoking are incompletely understood. Here, we investigated whether 300 nM nicotine modulates γ amino‐butyric acid (GABA)ergic synaptic transmission from pyramidal neurons of the output layer (V) of the murine m
Journal of NeuroEngineering and Rehabilitation - Latest Articles
- Reducing the energy cost of walking in older adults using a passive hip flexion deviceElevated energy cost is a hallmark feature of gait in older adults. As such, older adults display a general avoidance of walking which contributes to declining health status and risk of morbidity. Exoskeletons...
Journal of Neuroscience Methods
- Test–retest reliability of spatial patterns from resting-state functional MRI using the restricted Boltzmann machine and hierarchically organized spatial patterns from the deep belief networkPublication date: Available online 15 October 2019Source: Journal of Neuroscience MethodsAuthor(s): Hyun-Chul Kim, Hojin Jang, Jong-Hwan LeeAbstractBackgroundRestricted Boltzmann machines (RBMs), including greedy layer-wise trained RBMs as part of a deep belief network (DBN), have the ability to identify spatial patterns (SPs; functional networks) in resting-state fMRI (rfMRI) data. However, there has been little research on (1) the reproducibili
- Optimizing cell encapsulation condition in ECM-Collagen I hydrogels to support 3D neuronal culturesPublication date: Available online 15 October 2019Source: Journal of Neuroscience MethodsAuthor(s): Doris Lam, Heather A. Enright, Sandra K.G. Peters, Monica L. Moya, David A. Soscia, Jose Cadena, Javier A. Alvarado, Kristen S. Kulp, Elizabeth K. Wheeler, Nicholas O. FischerABSTRACTBackgroundThe emergence of three-dimensional (3D) cell culture in neural tissue engineering has significantly elevated the complexity and relevance of in vitro systems
- Implantable Wireless Device for Study of Entrapment NeuropathyPublication date: Available online 15 October 2019Source: Journal of Neuroscience MethodsAuthor(s): Ronit Malka, Diego L. Guarin, Suresh Mohan, Iván Coto Hernández, Pavel Gorelik, Ofer Mazor, Tessa Hadlock, Nate JowettAbstractBackgroundDisease processes causing increased neural compartment pressure may induce transient or permanent neural dysfunction. Surgical decompression can prevent and reverse such nerve damage. Owing to insufficient evidence
Latest Results for Child's Nervous System
- Imaging diagnosis of ventriculomegaly: fetal, neonatal, and pediatricAbstract Ventriculomegaly is the term used to describe abnormal enlargement of ventricles in the brain. Neuroimaging, whether it is by ultrasound, computed tomography, or magnetic resonance imaging, is the key to its identification and can help to diagnose its cause and guide management in many cases. The implementation of the imaging modalities and potential differential considerations varies from the fetus, infant, and pediat
NeuroReport - Published Ahead-of-Print
- Age effect on functional connectivity changes of right anterior insula after partial sleep deprivationNeuroimaging studies revealed that emotion and cognition dysfunction after sleep deprivation is associated with the disturbance of the salience network. However, the age effect on the functional connectivity changes of the network after sleep deprivation remains unclear. The current study investigated the functional connectivity changes of the right anterior insula after partial sleep deprivation in young and old adults by using resting-state fun
- Motivational effects on brain activity: need for closure moderates the impact of task uncertainty on engagement-related P3bNeed for cognitive closure (NFC), that is, individual’s aversion toward uncertainty and the desire to reduce it quickly usually manifests in effort minimizing cognitive strategies. Recent studies, however, demonstrated that it is also linked with laborious processing when the task itself induces uncertainty. Although this pattern was observed when testing behaviors and cardiovascular activity, it has never been tested on a neurocognitive level. T
- Attention shifting and subliminal cueing under high attentional load: an EEG study using emotional facesEmotional expressions and attentional processes interact such that emotion increases perceptual sensitivity in modality-specific brain areas leading to more efficient processing of the stimulus. In the current study, we asked the question of whether the emotional expressions can be processed subliminally when faces are attended but the emotional expression is irrelevant. We presented angry and neutral male and female faces supraliminally and subl
- Protective effects of polygalasaponin F on oxidative stress and apoptosis-induced ischemic myocardial injury in neonatal rats with hypoxic-ischemic brain damageThe aim of the present study was to evaluate the role of polygalasaponin F on ischemic myocardial injury in neonatal rats with hypoxic-ischemic brain damage. A primary in-vitro myocardial cell oxygen-glucose deprivation/reperfusion model and an in-vivo middle cerebral artery occlusion model were established. The results demonstrated that polygalasaponin F protects myocardium in hypoxic-ischemic brain injury. The mechanisms of its protective effec
- Patterns of electrical brain activation in response to socially-disputed perceptual judgmentsIn recent years, neuroscience has begun to investigate brain responses to social stimuli. To date, however, the effects of social feedback on attentional and perceptual processes remain unclear. In this study, participants were asked to judge the hues of distinct, or ambiguously coloured stimuli, and to indicate their confidence ratings. Alleged social feedback was then provided, either endorsing or disputing the participants’ responses. Particip
- Alterations of functional connectivity between thalamus and cortex before and after decompression in cervical spondylotic myelopathy patients: a resting-state functional MRI studyObjective: Cervical spondylotic myelopathy is regarded as a chronic, special incomplete spinal cord injury, so the sensory components transmitted to thalamus decreased after distal spinal cord injury, which lead the disturbance of thalamus-cortex circuits, which might explain the alterations of clinical function of cervical spondylotic myelopathy patients. However, for lack of effective methods to evaluate the disturbance circuits and how the
- Clinical and Optic Disc Characteristics of Patients Showing Visual Recovery in Leber Hereditary Optic NeuropathyBackground: The visual prognosis in Leber hereditary optic neuropathy (LHON) is generally poor. However, some individuals can have spontaneous visual recovery (VR) in one or both eyes by a mechanism that is not yet clearly understood. The purpose of this study was to determine whether certain clinical and optic disc features are associated with VR in patients with LHON. Methods: We retrospectively examined 80 eyes of 40 patients with LHON
- Referral Patterns in Neuro-OphthalmologyBackground: Neuro-ophthalmologists specialize in complex, urgent, vision- and life-threatening problems, diagnostic dilemmas, and management of complex work-ups. Access is currently limited by the relatively small number of neuro-ophthalmologists, and consequently, patients may be affected by incorrect or delayed diagnosis. The objective of this study is to analyze referral patterns to neuro-ophthalmologists, characterize rates of misdiagnoses
- Enhanced Depth Imaging Optical Coherence Tomography of Optic Nerve Head Drusen in ChildrenBackground: To assess the utility of enhanced depth imaging optical coherence tomography (EDI-OCT), compared with other conventional imaging modalities, for detecting and characterizing optic nerve head drusen (ONHD) in children. Methods: We report a retrospective cross-sectional case series of consecutive pediatric patients (age ≤16 years) with ONHD confirmed using B-scan ultrasonography. All eyes were evaluated using spectral-domain OCT
- Catastrophic Allergic Fungal Sinusitis: A Report of Two CasesBackground: Allergic fungal rhinosinusitis (AFRS) is a common condition in which sinusitis develops as an IgE-mediated response to common sinonasal fungal organisms. If that response leads to blockage of sinus ostia, bone expansion and erosion by expansive cysts containing dense inspissated debris may occur with the potential for critical neurovascular compression including damage to the anterior visual pathway. Methods: Review of clinica
- Rapidly Sequential Vision From Loss Posterior Ischemic Optic Neuropathy Due to Methicillin-Susceptible Staphylococcus Aureus BacteremiaAbstract: A 63-year-old man with a history of high-grade bladder cancer was admitted to the intensive care unit (ICU) with renal failure and methicillin-susceptible Staphylococcus aureus bacteremia originating from his nephrostomy tube. While in the ICU, he had painless, severe loss of vision in the right eye followed by his left eye 12 hours later. Visual acuity was no light perception in each eye. He was anemic, and before each eye lost visi
- Causes of Horner Syndrome: A Study of 318 PatientsBackground: Some reports have indicated that when a cause for Horner syndrome can be determined, it is most often chest and neck tumors and stroke. Others have suggested that Horner syndrome is more frequently caused by surgical procedures in the neck and chest. These differences may be explained by disparate accrual methods. Therefore, we decided to compare the cause of Horner syndrome in cases where the diagnosis was confirmed by apraclonidi
- Magnetic Resonance Imaging Abnormalities of the Optic Nerve Sheath and Intracranial Internal Carotid Artery in Giant Cell ArteritisBackground: Giant cell arteritis (GCA) is an important diagnostic consideration in elderly patients with vision changes. Superficial temporal artery biopsy (TAB) has long been considered the gold standard diagnostic approach for GCA, but MRI has gained interest as an alternative diagnostic modality. Although most of the literature has focused on imaging abnormalities of branches of the external carotid artery, there have been a few reports of
- FGF-21 ameliorates essential hypertension of SHR via baroreflex afferent functionPublication date: Available online 15 October 2019Source: Brain Research BulletinAuthor(s): Pei Chen, Xu Bing, Yan Feng, Ke-Xin Li, Zhuo Liu, Xun Sun, Xiao-Long Lu, Lu-Qi Wang, Yu-Wen Chen, Xiong-Xiong Fan, Xin-Ling Yang, Ning Wang, Quo-Fen Qiao, Bai-Yan LiAbstractHypertension is a common complication of metabolic abnormalities associated with cardiovascular system and characterized by sexual dimorphism in mammals. Fibroblast growth factor-21 (FG
- <em>Neuros</em><em>urgical Operative Atlas: Vascular Neurosurgery, 3rd Edition</em> R. Loch Macdonald Thieme Medical Publishers, Inc. 2019 1-288 pages $274.99 ISBN 9781626231108Publication date: January 2020Source: World Neurosurgery, Volume 133Author(s): Leonard H. Verhey, Justin A. Singer
- SYNERGISTIC THERAPIES FOR RECURRENT MALIGNANT GLIOMASPublication date: Available online 15 October 2019Source: World NeurosurgeryAuthor(s): Joshua E. Simon, Vikram C. Prabhu, Kevin Barton, Ewa Borys, Erika Piedras-Renteria, Edward Melian
- Microsurgical Management of Intracranial Aneurysms after Flow Diversion failurePublication date: Available online 15 October 2019Source: World NeurosurgeryAuthor(s): Giovanni Grasso, Fabio Torregrossa
- Mechanical thrombectomy of distal occlusions using ADAPT compared to new generation of mini – 017 microcatheter compatible – stent retrievers: a meta-analysisPublication date: Available online 15 October 2019Source: World NeurosurgeryAuthor(s): G. Barchetti, F. Cagnazzo, E. Raz, G. Barbagallo, G. Toccaceli, S. Peschillo
- Paulus of Aegina and the historical origins of spine surgeryPublication date: Available online 15 October 2019Source: World NeurosurgeryAuthor(s): Kevin Jang, Jeffrey V. Rosenfeld, Antonio Di IevaAbstractPaulus of Aegina (625-690 AD) was the last of the prolific Byzantine physicians. His works consolidated and extended the knowledge of his predecessors, with pioneering efforts to improve the surgical management of spinal injuries. In this paper, we review the literature to present an overview of the remar
- Persistent Trigeminal Artery: Neuroanatomical and Clinical Relevance.Publication date: Available online 15 October 2019Source: World NeurosurgeryAuthor(s): Gaurav Tyagi, Nishanth Sadashiva, Subhas Konar, Aravind Gowda, Jitender Saini, Dhaval Shukla, Bhagavatula Indira DeviAbstractIntroductionPersistent trigeminal artery (PTA) is the most common remnant of primitive circulation communicating the developing carotid and vertebrobasilar junction. Although discovered incidentally, an altered hemodynamic may lead to an
- Artificial Discs in Cervical Disc Replacement: A Meta-Analysis for Comparison of Long-term OutcomesPublication date: Available online 15 October 2019Source: World NeurosurgeryAuthor(s): Waseem Wahood, Yagiz Ugur Yolcu, Panagiotis Kerezoudis, Anshit Goyal, Mohammed Ali Alvi, Brett A. Freedman, Mohamad BydonAbstractBackgroundCervical disc replacement(CDR) has emerged as an alternative to anterior cervical discectomy and fusion for the surgical treatment of degenerative cervical disc disease. Although comparison of the two techniques has been stu
Πέμπτη 17 Οκτωβρίου 2019
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