Antibiotics, Vol. 8, Pages 193: Diabetic Foot Ulcers: Current Advances in Antimicrobial Therapies and Emerging Treatments Antibiotics doi: 10.3390/antibiotics8040193 Authors: Jesus Manuel Ramirez-Acuña Sergio A Cardenas-Cadena Pedro A Marquez-Salas Idalia Garza-Veloz Aurelio Perez-Favila Miguel A Cid-Baez Virginia Flores-Morales Margarita L Martinez-Fierro Diabetic foot ulcers (DFUs) are very important diabetes-related lesions that can lead to serious physical consequences...
Thu Oct 24, 2019 03:00
Antibiotics, Vol. 8, Pages 194: Antibacterial Activities, Phytochemical Screening and Metal Analysis of Medicinal Plants: Traditional Recipes Used against Diarrhea Antibiotics doi: 10.3390/antibiotics8040194 Authors: Nasir Mahmood Ruqia Nazir Muslim Khan Abdul Khaliq Mohammad Adnan Mohib Ullah Hongyi Yang The aim of this study was to explore the phytochemical composition, heavy metals analysis and the antibacterial activity of six medicinal plants i.e., Terminalia chebula...
Thu Oct 24, 2019 03:00
Antioxidants, Vol. 8, Pages 509: The Role of Magnesium in the Secondary Phase After Traumatic Spinal Cord Injury. A Prospective Clinical Observer Study Antioxidants doi: 10.3390/antiox8110509 Authors: André Sperl Raban Arved Heller Bahram Biglari Patrick Haubruck Julian Seelig Lutz Schomburg Tobias Bock Arash Moghaddam In the secondary injury phase after traumatic spinal cord injury (TSCI), oxidative stress and neuroinflammatory responses at the site of injury constitute...
Thu Oct 24, 2019 03:00
Antioxidants, Vol. 8, Pages 508: Protein Carbonylation in Patients with Myelodysplastic Syndrome: An Opportunity for Deferasirox Therapy Antioxidants doi: 10.3390/antiox8110508 Authors: Alba Rodríguez-García María Luz Morales Vanesa Garrido-García Irene García-Baquero Alejandra Leivas Gonzalo Carreño-Tarragona Ricardo Sánchez Alicia Arenas Teresa Cedena Rosa María Ayala José M. Bautista Joaquín Martínez-López María Linares Control of oxidative stress...
Thu Oct 24, 2019 03:00
Arts, Vol. 8, Pages 142: Ghosts in the Closet: Catastrophizing and Spectral Disability in Anne Charlotte Robertson’s Apologies Arts doi: 10.3390/arts8040142 Authors: Ely Anne Charlotte Robertson, who died in 2012, was a Super 8 experimental filmmaker whose primarily diaristic films record her experience with a diagnosis of manic depression and the corresponding nervous breakdowns. This article specifically addresses Robertson’s film Apologies (1983–1990), which features...
Thu Oct 24, 2019 03:00
Atmosphere, Vol. 10, Pages 644: Effect of Typhoon-Generated Cold Wake on the Subsequent Typhoon Tembin and Its Sensitivity to Horizontal Resolutions Atmosphere doi: 10.3390/atmos10110644 Authors: Moon Ha Weather research models have been used to investigate the sensitivity of simulations of Typhoon Tembin (1214) to changes in three horizontal grid spacings and the effect of the cold wake generated by Typhoon Bolaven (1215). We used modified sea surface temperature (SST) to simulate...
Thu Oct 24, 2019 03:00
Atmosphere, Vol. 10, Pages 643: Seasonal Changes in Interclone Variation Following Ozone Exposure on Three Major Gene Pools: An Analysis of Cryptomeria Japonica Clones Atmosphere doi: 10.3390/atmos10110643 Authors: Takafumi Miyama Hiroyuki Tobita Kentaro Uchiyama Kenichi Yazaki Saneyoshi Ueno Akira Uemura Asako Matsumoto Mitsutoshi Kitao Takeshi Izuta Recently, there has been a continuous increase in the concentration of tropospheric ozone in urban forests in...
Thu Oct 24, 2019 03:00
Atmosphere, Vol. 10, Pages 641: Volatile Organic Compounds in a Petrochemical Region in Arid of NW China: Chemical Reactivity and Source Apportionment Atmosphere doi: 10.3390/atmos10110641 Authors: Xiaoxiao Zhang Xiang Ding Xinming Wang Dilinuer Talifu Guo Wang Yanli Zhang Abulikemu Abulizi We measured volatile organic compounds (VOCs) during the heating, non-heating, and sandstorm periods in the air of the Dushanzi district in NW China and investigated their concentrations,...
Thu Oct 24, 2019 03:00
Atmosphere, Vol. 10, Pages 642: Extreme Drought Events over Brazil from 2011 to 2019 Atmosphere doi: 10.3390/atmos10110642 Authors: Ana Paula M. A. Cunha Marcelo Zeri Karinne Deusdará Leal Lidiane Costa Luz Adriana Cuartas José Antônio Marengo Javier Tomasella Rita Marcia Vieira Alexandre Augusto Barbosa Christopher Cunningham João Victor Cal Garcia Elisangela Broedel Regina Alvalá Germano Ribeiro-Neto Drought-related disasters are among the natural...
Thu Oct 24, 2019 03:00
Atmosphere, Vol. 10, Pages 640: A Cloud Detection Algorithm with Reduction of Sunlight Interference in Ground-Based Sky Images Atmosphere doi: 10.3390/atmos10110640 Authors: Xin Li Zhiying Lu Qingxia Zhou Zhengyang Xu Cloud detection for ground-based sky images has attracted much attention in cloud-related fields. In this paper, we proposed a cloud detection algorithm that reduced the sunlight interference in the image. The solar location method was introduced to track the sun...
Thu Oct 24, 2019 03:00
Bioengineering, Vol. 6, Pages 99: Flow Process for Ketone Reduction Using a Superabsorber-Immobilized Alcohol Dehydrogenase from Lactobacillus brevis in a Packed-Bed Reactor Bioengineering doi: 10.3390/bioengineering6040099 Authors: Niklas Adebar Harald Gröger Flow processes and enzyme immobilization have gained much attention over the past few years in the field of biocatalytic process design. Downstream processes and enzyme stability can be immensely simplified and improved. In...
Thu Oct 24, 2019 03:00
Bioengineering, Vol. 6, Pages 98: Analysis of Pressure Distribution in Transfemoral Prosthetic Socket for Prefabrication Evaluation via the Finite Element Method Bioengineering doi: 10.3390/bioengineering6040098 Authors: Mohd Syahmi Jamaludin Akihiko Hanafusa Yamamoto Shinichirou Yukio Agarie Hiroshi Otsuka Kengo Ohnishi In this study, we estimated and validated the pressure distribution profile between the residuum and two types of prosthetic sockets for transfemoral...
Thu Oct 24, 2019 03:00
Biomolecules, Vol. 9, Pages 648: The Loop of the TPR1 Subdomain of Phi29 DNA Polymerase Plays a Pivotal Role in Primer-Terminus Stabilization at the Polymerization Active Site Biomolecules doi: 10.3390/biom9110648 Authors: del Prado Santos Lázaro Salas de Vega Bacteriophage Phi29 DNA polymerase belongs to the protein-primed subgroup of family B DNA polymerases that use a terminal protein (TP) as a primer to initiate genome replication. The resolution of the crystallographic...
Thu Oct 24, 2019 03:00
Biomolecules, Vol. 9, Pages 649: Emerging Role of Vitamin D and its Associated Molecules in Pathways Related to Pathogenesis of Thrombosis Biomolecules doi: 10.3390/biom9110649 Authors: Mohammad Mishra Ashraf Vitamin D, besides having an essential role in calcium and bone metabolism, also acts as a mediator of many non-calcemic effects through modulations of several biological responses. Vitamin D exists in its two major forms, vitamin D2, or commonly known as ergocalciferol,...
Thu Oct 24, 2019 03:00
Biomolecules, Vol. 9, Pages 647: Transcriptomic Analysis Reveals the Roles of Detoxification Systems in Response to Mercury in Chromera velia Biomolecules doi: 10.3390/biom9110647 Authors: Sharaf De Michele Sharma Fakhari Oborník Heavy metal pollution is an increasing global concern. Among heavy metals, mercury (Hg) is especially dangerous because of its massive release into the environment and high toxicity, especially for aquatic organisms. The molecular response mechanisms...
Thu Oct 24, 2019 03:00
Biomolecules, Vol. 9, Pages 646: Design of N-Terminal Derivatives from a Novel Dermaseptin Exhibiting Broad-Spectrum Antimicrobial Activity against Isolates from Cystic Fibrosis Patients Biomolecules doi: 10.3390/biom9110646 Authors: Yuan Ying Hui Wang Xinping Xi Chengbang Ma Yue Liu Mei Zhou Qiang Du James F. Burrows Minjie Wei Tianbao Chen Lei Wang Dermaseptins are an antimicrobial peptide family widely identified from the skin secretions of phyllomeudusinae...
Thu Oct 24, 2019 03:00
Biomolecules, Vol. 9, Pages 644: Pharmacology Study of the Multiple Angiogenesis Inhibitor RC28-E on Anti-Fibrosis in a Chemically Induced Lung Injury Model Biomolecules doi: 10.3390/biom9110644 Authors: Xiangying Kou Yeying Sun Shenjun Li Weihua Bian Zhihao Liu Daolai Zhang Jing Jiang Background: Disease-related injury in any organ triggers a complex cascade of cellular and molecular responses that culminate in tissue fibrosis, inflammation, and angiogenesis simultaneously....
Thu Oct 24, 2019 03:00
Biomolecules, Vol. 9, Pages 645: Anthocyanins from Hibiscus syriacus L. Inhibit Melanogenesis by Activating the ERK Signaling Pathway Biomolecules doi: 10.3390/biom9110645 Authors: Wisurumuni Arachchilage Hasitha Maduranga Karunarathne Ilandarage Menu Neelaka Molagoda Sang Rul Park Jeong Woon Kim Oh-Kyu Lee Hae Yun Kwon Matan Oren Yung Hyun Choi Hyung Won Ryu Sei-Ryang Oh Wol Soon Jo Kyoung Tae Lee Gi-Young Kim Hibiscus syriacus L. exhibited promising...
Thu Oct 24, 2019 03:00
Brain Sciences, Vol. 9, Pages 290: Autonomic Stress Response and Perceived Effort Jointly Inform on Dual Tasking in Aging Brain Sciences doi: 10.3390/brainsci9110290 Authors: Giancarlo Condello Roberta Forte Pablo Monteagudo Barbara Ghinassi Angela Di Baldassarre Laura Capranica Caterina Pesce The study investigated, through neuroendocrinological, subjective and behavioral assessments, how aging individuals cope with locomotor-cognitive dual-tasking and whether physical...
Thu Oct 24, 2019 03:00
Brain Sciences, Vol. 9, Pages 291: Effects of Methylphenidate on Cognitive Function in Adults with Traumatic Brain Injury: A Meta-Analysis Brain Sciences doi: 10.3390/brainsci9110291 Authors: Chien Chien Liu Wu Chang Wu This meta-analysis evaluated the effects of methylphenidate (MPH) on cognitive outcome and adverse events in adults with traumatic brain injuries (TBI). We searched PubMed, EMBASE, and PsycINFO for randomized controlled trials (RCTs) published before...
Thu Oct 24, 2019 03:00
Cancers, Vol. 11, Pages 1642: Efficacy, Safety, and Tolerability of Approved Combination BRAF and MEK Inhibitor Regimens for BRAF-Mutant Melanoma Cancers doi: 10.3390/cancers11111642 Authors: Hamid Cowey Offner Faries Carvajal No head-to-head studies exist comparing BRAF inhibitor/MEK inhibitor (BRAFi/MEKi) combination treatments for BRAF-mutant melanoma. A side-by-side analysis of randomized phase III trials is presented that evaluated dabrafenib/trametinib, vemurafenib/cobimetinib,...
Thu Oct 24, 2019 03:00
Cancers, Vol. 11, Pages 1641: Tumor BRCA Test for Patients with Epithelial Ovarian Cancer: The Role of Molecular Pathology in the Era of PARP Inhibitor Therapy Cancers doi: 10.3390/cancers11111641 Authors: Fumagalli Tomao Betella Rappa Calvello Bonanni Bernard Peccatori Colombo Viale Barberis Guerini-Rocco The PARP inhibitor olaparib has been approved in the maintenance setting of platinum-sensitive epithelial ovarian cancer patients with...
Thu Oct 24, 2019 03:00
Cancers, Vol. 11, Pages 1643: Genomic-Destabilization-Associated Mutagenesis and Clonal Evolution of Cells with Mutations in Tumor-Suppressor Genes Cancers doi: 10.3390/cancers11111643 Authors: Yoshioka Matsuno Hyodo Fujimori The development of cancer is driven by genomic instability and mutations. In general, cancer develops via multiple steps. Each step involves the clonal evolution of cells with abrogated defense systems, such as cells with mutations in cancer-suppressor...
Thu Oct 24, 2019 03:00
Cancers, Vol. 11, Pages 1639: Antiplatelet Agents for Cancer Prevention: Current Evidences and Continuing Controversies Cancers doi: 10.3390/cancers11111639 Authors: Corinne Frere Manon Lejeune Pierre Kubicek Dorothée Faille Zora Marjanovic the Groupe Francophone Thrombose et Cancer Over the past two decades, aspirin has emerged as a promising chemoprotective agent to prevent colorectal cancer (CRC). In 2016, the mounting evidence supporting its chemoprotective effect,...
Thu Oct 24, 2019 03:00
Cancers, Vol. 11, Pages 1638: Long Noncoding RNAs in Acute Myeloid Leukemia: Functional Characterization and Clinical Relevance Cancers doi: 10.3390/cancers11111638 Authors: Morgane Gourvest Pierre Brousset Marina Bousquet Acute Myeloid Leukemia (AML) is the most common form of leukemia in adults with an incidence of 4.3 per 100,000 cases per year. Historically, the identification of genetic alterations in AML focused on protein-coding genes to provide biomarkers and to understand...
Thu Oct 24, 2019 03:00
Cancers, Vol. 11, Pages 1636: Clinical Significance of Various Drug-Sensitivity Markers in Patients with Surgically Resected Pulmonary Pleomorphic Carcinoma Cancers doi: 10.3390/cancers11111636 Authors: Hisao Imai Kimihiro Shimizu Osamu Kawashima Hideki Endoh Kazuyoshi Imaizumi Yasuhiro Goto Mitsuhiro Kamiyoshihara Masayuki Sugano Ryohei Yamamoto Shigebumi Tanaka Atsushi Fujita Yoshihito Kogure Yukio Seki Akira Mogi Tetsunari Oyama Koichi Minato...
Thu Oct 24, 2019 03:00
Cancers, Vol. 11, Pages 1637: Galeterone and The Next Generation Galeterone Analogs, VNPP414 and VNPP433-3β Exert Potent Therapeutic Effects in Castration-/Drug-Resistant Prostate Cancer Preclinical Models In Vitro and In Vivo Cancers doi: 10.3390/cancers11111637 Authors: Andrew K. Kwegyir-Afful Senthilmurugan Ramalingam Vidya P. Ramamurthy Puranik Purushottamachar Francis N. Murigi Tadas S. Vasaitis Weiliang Huang Maureen A. Kane Yuji Zhang Nicholas Ambulos Sudhir...
Thu Oct 24, 2019 03:00
Cancers, Vol. 11, Pages 1640: Anti-Proliferative Effects of an Extra-Virgin Olive Oil Extract Enriched in Ligstroside Aglycone and Oleocanthal on Human Liver Cancer Cell Lines Cancers doi: 10.3390/cancers11111640 Authors: De Stefanis Scimè Accomazzo Catti Occhipinti Bertea Costelli Oleocanthal and ligstroside aglycone are olive oil-derived polyphenols. The former interferes with tumor growth with minor or no cytotoxicity on non-tumorigenic primary cell lines....
Thu Oct 24, 2019 03:00
Cancers, Vol. 11, Pages 1631: Understanding and Targeting Apoptotic Pathways in Ovarian Cancer Cancers doi: 10.3390/cancers11111631 Authors: Linah F. Al-Alem Andrew T. Baker Unnati M. Pandya Eric L. Eisenhauer Bo R. Rueda Ovarian cancer cells evade the immune system as well as chemotherapeutic and/or biologic treatments through inherent or acquired mechanisms of survival and drug resistance. Depending on the cell type and the stimuli, this threshold can range from external...
Thu Oct 24, 2019 03:00
Cancers, Vol. 11, Pages 1632: The Role of Post-Neoadjuvant Chemotherapy Tumor Volume for Prognostication and Treatment Guidance in Loco-Regionally Advanced Nasopharyngeal Carcinoma Cancers doi: 10.3390/cancers11111632 Authors: Fo-Ping Chen Dan-Wan Wen Feng Li Li Lin Jia Kou Wei-Hong Zheng Li Li Guan-Qun Zhou Ying Sun The value of post-neoadjuvant chemotherapy (NACT) tumor volume for prognostication in loco-regionally advanced nasopharyngeal carcinoma (LA-NPC)...
Thu Oct 24, 2019 03:00
Cancers, Vol. 11, Pages 1634: PIK3CA Cooperates with KRAS to Promote MYC Activity and Tumorigenesis via the Bromodomain Protein BRD9 Cancers doi: 10.3390/cancers11111634 Authors: Catherine M. Bell Philipp Raffeiner Jonathan R. Hart Peter K. Vogt Tumor formation is generally linked to the acquisition of two or more driver genes that cause normal cells to progress from proliferation to abnormal expansion and malignancy. In order to understand genetic alterations involved in this...
Thu Oct 24, 2019 03:00
Cancers, Vol. 11, Pages 1633: The Role of Merlin/NF2 Loss in Meningioma Biology Cancers doi: 10.3390/cancers11111633 Authors: Sungho Lee Patrick J. Karas Caroline C. Hadley James C. Bayley V A. Basit Khan Ali Jalali Alex D. Sweeney Tiemo J. Klisch Akash J. Patel Mutations in the neurofibromin 2 (NF2) gene were among the first genetic alterations implicated in meningioma tumorigenesis, based on analysis of neurofibromatosis type 2 (NF2) patients who not only develop...
Thu Oct 24, 2019 03:00
Cancers, Vol. 11, Pages 1635: SLUG Directs the Precursor State of Human Brain Tumor Stem Cells Cancers doi: 10.3390/cancers11111635 Authors: Charles Chesnelong Xiaoguang Hao Orsolya Cseh Alice Yijun Wang H. Artee Luchman Samuel Weiss In glioblastoma (GBM), brain tumor stem cells (BTSCs) encompass heterogenous populations of multipotent, self-renewing, and tumorigenic cells, which have been proposed to be at the root of therapeutic resistance and recurrence. While the functional...
Thu Oct 24, 2019 03:00
Cancers, Vol. 11, Pages 1628: Glutamine Metabolism in Brain Tumors Cancers doi: 10.3390/cancers11111628 Authors: Siva Kumar Natarajan Sriram Venneti Altered metabolism is a hallmark of cancer cells. Tumor cells rewire their metabolism to support their uncontrolled proliferation by taking up nutrients from the microenvironment. The amino acid glutamine is a key nutrient that fuels biosynthetic processes including ATP generation, redox homeostasis, nucleotide, protein, and lipid synthesis....
Thu Oct 24, 2019 03:00
Cancers, Vol. 11, Pages 1629: The Expression/Methylation Profile of Adipogenic and Inflammatory Transcription Factors in Adipose Tissue Are Linked to Obesity-Related Colorectal Cancer Cancers doi: 10.3390/cancers11111629 Authors: Hatim Boughanem Amanda Cabrera-Mulero Pablo Hernández-Alonso Borja Bandera-Merchán Alberto Tinahones Francisco José Tinahones Sonsoles Morcillo Manuel Macias-Gonzalez Obesity is well accepted as crucial risk factor that plays a critical...
Thu Oct 24, 2019 03:00
Cancers, Vol. 11, Pages 1630: Applications of Bioinformatics in Cancer Cancers doi: 10.3390/cancers11111630 Authors: Chad Brenner This series of 25 articles (22 original articles, 3 reviews) is presented by international leaders in bioinformatics and biostatistics [...]
Thu Oct 24, 2019 03:00
Cancers, Vol. 11, Pages 1627: Myeloid-Derived Suppressor Cells and Pancreatic Cancer: Implications in Novel Therapeutic Approaches Cancers doi: 10.3390/cancers11111627 Authors: Anita Thyagarajan Mamdouh Salman A. Alshehri Kelly L.R. Miller Catherine M. Sherwin Jeffrey B. Travers Ravi P. Sahu Pancreatic ductal adenocarcinoma (PDAC) remains a devastating human malignancy with poor prognosis and low survival rates. Several cellular mechanisms have been linked with pancreatic...
Thu Oct 24, 2019 03:00
Cells, Vol. 8, Pages 1315: Intracellular Redox-Balance Involvement in Temozolomide Resistance-Related Molecular Mechanisms in Glioblastoma Cells doi: 10.3390/cells8111315 Authors: Dico Salvatore Martelli Ronchi Diceglie Lucignani Ottobrini Glioblastoma (GBM) is the most common astrocytic-derived brain tumor in adults, characterized by a poor prognosis mainly due to the resistance to the available therapy. The study of mitochondria-derived oxidative stress, and...
Thu Oct 24, 2019 03:00
Cells, Vol. 8, Pages 1316: Prokaryotic Aquaporins Cells doi: 10.3390/cells8111316 Authors: Tong Hu Zhu Dong Aquaporins are integral membrane proteins that facilitate the diffusion of water and other small, uncharged solutes across the cellular membrane and are widely distributed in organisms from humans to bacteria. However, the characteristics of prokaryotic aquaporins remain largely unknown. We investigated the distribution and sequence characterization of aquaporins in...
Thu Oct 24, 2019 03:00
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