- Breath-hold compressed-sensing 3D MR cholangiopancreatography compared to free-breathing 3D MR cholangiopancreatography: prospective study of image quality and diagnostic performance in pancreatic disordersAbstract Purpose To compare image quality and diagnostic performance of three magnetic resonance cholangiopancreatography (MRCP) protocols in patients with suspected pancreatic abnormalities: free-breathing standard 3D-MRCP (STD), free-breathing compressed sensing 3D-MRCP (CS), and CS 3D-MRCP with acquisition during a single breath-hold > 20 s (BH-CS).
PeerJ Computer Science
- A novel GIS-based ensemble technique for flood susceptibility mapping using evidential belief function and support vector machine: Brisbane, AustraliaIn this study, we propose and test a novel ensemble method for improving the accuracy of each method in flood susceptibility mapping using evidential belief function (EBF) and support vector machine (SVM). The outcome of the proposed method was compared with the results of each method. The proposed method was implemented four times using different SVM kernels. Hence, the efficiency of each SVM kernel was also assessed. First, a bivariate statisti
- Genome-wide analysis of basic helix–loop–helix superfamily members related to anthocyanin biosynthesis in eggplant (Solanum melongena L.)The basic helix–loop–helix (bHLH) superfamily is considered the second largest transcription factor (TF) family. It plays regulatory roles in the developmental processes of plants and in their defense responses. In recent years, many bHLH superfamily genes have been identified and characterized in herbaceous and woody plants. However, the comprehensive genomic and functional analyses of these genes in eggplant (Solanum melongena L.) have not been
- Characterization of dengue cases among patients with an acute illness, Central Department, ParaguayBackground In 2018, Paraguay experienced a large dengue virus (DENV) outbreak. The primary objective of this study was to characterize dengue cases in the Central Department, where the majority of cases occur, and identify factors associated with DENV infection. Methods Patients were enrolled from January-May 2018 if they presented with a suspected arboviral illness.
- Environmental fate of the anti-parasitic ivermectin in an aquatic micro-ecological system after a single oral administrationBackground Ivermectin (IVM) has been widely used in the aquaculture industry since its efficacy against parasites. However, the degradation of IVM was very slow in aquatic environments and the environmental fate of IVM in a complete aquatic system was still not clear. Therefore, comparable studies in a complete aquatic system were merited and helped to elucidate the environmental fate and effects of IVM.
BioMed Research International
- Quality Characteristics and Functional and Antioxidant Capacities of Algae-Fortified Fish Burgers Prepared from Common Barbel (Barbus barbus)Introduction. Algae have been used as natural ingredients to produce new canned fish burgers prepared from minced flesh of common barbel. In this research, the impact of the addition of Cystoseira compressa and Jania adhaerens at concentrations of 0.5, 1, and 1.5% w/v on the texture and sensory characteristics of fish burgers were investigated. Results. Compared to controls, fish burgers containing 1% algae had better texture and sensory properti
Lasers in Surgery and Medicine
- The Comparison of Thermal Effects of a 1940‐nm Tm:fiber Laser and 980‐nm Diode Laser on Cortical Tissue: Stereotaxic Laser Brain SurgeryBackground and Objectives The thermal damage on adjacent healthy structures is always an unwanted consequence of continuous‐wave laser irradiation of soft tissues. To propose a laser as an effective alternative to traditional surgical tools, this photothermal damage due to heat conduction must be taken into account with a detailed laser dosimetry study. Two candidate lasers; a 980‐nm diode and 1940‐nm Tm:fiber were selected for this study. Despi
BMC Research Notes
- The effect of training and awareness of subtle control on the frequency of hand hygiene among intensive care unit nursesThis study aimed to determine the effect of awareness of subtle control after training on the hand hygiene compliance among nurses in intensive care units (ICUs). The study was conducted in two ICUs of a traum...
- Combinations of Alchornea cordifolia, Cassytha filiformis and Pterocarpus santalinoides in diarrhoegenic bacterial infectionsThis study examines the rationale, if any, behind combining the extracts from the fruits of Alchornea cordifolia and Pterocarpus santalinoides and aerial parts of Cassytha filiformis in the traditional treatment ...
- Maternal and fetal outcomes of cesarean delivery and factors associated with its unfavorable management outcomes; in Ayder Specialized Comprehensive Hospital, Mekelle, Tigray, Ethiopia, 2017This study aimed to determine the unfavorable outcomes and to assess factors contribute to the unfavorable management outcomes after cesarean deliveries in Ayder Specialized Comprehensive Hospital, Mekelle, Ti...
- Mycobacterium indicus pranii therapy induces tumor regression in MyD88- and TLR2-dependent mannerMycobacterium indicus pranii (MIP) is an atypical mycobacterium species with potent antitumor efficacy. Macrophages and dendritic cells (DCs) are antigen-presenting cells, playing key roles in the activation of a...
Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία
- Παιδικός Καρκίνος: Αισιόδοξα μηνύματα από τα φάρμακα για ενήλικεςΘεραπευτικά για τα παιδιά με επιθετικές μορφές καρκίνου θα μπορούσαν να είναι ορισμένα αντικαρκινικά φάρμακα που σήμερα χορηγούνται σε ενήλικες. Αυτό έδειξε μελέτη που δημοσιεύθηκε στο European Journal of Cancer. Εξετάζοντας τη γενετική σύσταση ενός παιδικού όγκου οι επιστήμονες βρήκαν πως μπορούν να τον αντιστοιχίσουν με υπάρχουσα φαρμακευτική αγωγή που χορηγείται μόνο στους ενήλικες με καρκίνο. Η έρευνα φέρνει ελπίδα για εκατοντάδες παιδιά για
- Αλλεργίες: Το τρόφιμο που μειώνει κατά 40% το πρόβλημα στα παιδιάΤα παιδιά μπορεί να απεχθάνονται συνήθως τα ψάρια και να δυσανασχετούν όταν πρέπει να τα φάνε, ωστόσο μελέτη που δημοσιεύεται στο Nutrients δείχνει ότι τα παιδιά που τρώνε ψάρια ή ιχθυέλαιο από την ηλικία των 12 μηνών περίπου έχουν σημαντικά μειωμένη συχνότητα εκζέματος, συριγμού και άσθματος σε ηλικία έξι ετών. Η μειωμένη συχνότητα κυμαινόταν από 28 έως 40%. «Συγκρίναμε παιδιά που έτρωγαν ψάρια τουλάχιστον μια φορά την εβδομάδα μέχρι την ηλικί
- Αυτό είναι το καλύτερο φάρμακο για την καρδιά και το άγχοςΗ τακτική σωματική άσκηση είναι εξαιρετικά ωφέλιμη για όλους τους ασθενείς με καρδιαγγειακά νοσήματα ανεξαρτήτως ηλικίας, σύμφωνα με μελέτη που δημοσιεύθηκε στο Canadian Journal of Cardiology. Οι ερευνητές από το Γαλλικό Πανεπιστήμιο της Βουργουνδίας υποστηρίζουν ότι οι ασθενείς που ωφελούνται περισσότερο από την καρδιακή αποκατάσταση είναι εκείνοι που αρχικά είχαν την μεγαλύτερη σωματική εξασθένηση. Ως γνωστόν, οι ηλικιωμένοι ασθενείς διατρέχο
- Η πρωτεΐνη που φρενάρει τη νόσο ΑλτσχάιμερΒιολόγοι από το Πανεπιστήμιο της Καλιφόρνια, Irvine, που αναζητούσαν νέες προσεγγίσεις για τη μελέτη τη νόσου Αλτσχάιμερ ανέδειξαν ένα εξαιρετικά σημαντικό εύρημα σχετικά με τη μάχη κατά της φλεγμονής που συνδέεται με την ασθένεια, όπως αναφέρεται στη σχετική δημοσίευση στο Proceeding of the National Academy of Sciences. Η ανακάλυψη των ερευνητών σχετικά με το ρόλο της πρωτεΐνης TOM-1 κάνει την ανατροπή όσον αφορά στην εξέταση των διαδικασιών τη
- Optimizing drug selection in psychopharmacology based on 40 significant CYP2C19- and CYP2D6-biased adverse drug reactions of selective serotonin reuptake inhibitorsBackground Selective serotonin reuptake inhibitors (SSRIs) are among the most widely prescribed class of drugs in the practice of psychiatry. Cytochrome P450 (CYP) 2C19 and CYP2D6 are established as clinically relevant drug metabolizing enzymes (DMEs) that influence the pharmacokinetics of SSRIs and may either be grouped as being primarily metabolized by CYP2C19 or CYP2D6. The aim of this study is to test the hypothesis that the primary drug me
- Improved annotation of Lutzomyia longipalpis genome using bioinformatics analysisLutzomyia longipalpis, a sand fly, is a vector-spreading pathogenic protozoan in the New World. MicroRNA (miRNA) is evolutionarily-conserved non-coding RNA, which plays critical roles in various biological processes. To date, the functions of most proteins in L. longipalpis are unknown, and few studies have addressed the roles of miRNAs in this species. In the present study, we re-annotated the protein-coding genes and identified several miRNAs u
- Solvent polarity mediates phytochemical yield and antioxidant capacity of Isatis tinctoriaSecondary metabolites have been extensively used in the treatment of various health problems. The role of solvent polarity on the phytochemical isolation and antioxidant capacity of Isatis tinctoria (woad) is elusive. In the present study, 14 solvents with different polarity were used in the extraction and total phenolic and flavonoid content (TPC and TFC) investigation. Ferricyanide, phosphomolybdenum, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) me
SAGE-Journals: Journal of International Medical Research: Table of Contents
- Metabonomics window into plateau hypoxiaJournal of International Medical Research, Ahead of Print.
- Comparative study of xuesaitong injection and compound salvia miltiorrhizae injection in the treatment of acute cerebral infarction: a meta-analysisJournal of International Medical Research, Ahead of Print.
bioRxiv Subject Collection: Evolutionary Biology
- Agent-based Modeling of Asian Corn Borer Resistance to BT Corn [NEW RESULTS]We present ABM-IRM, an agent-based modeling approach to insect resistance management. ABM-IRM is one of the agent-based models that we have developed to simulate the insect resistance of Asian Corn Borer (ACB) to BT corn. The model was implemented using NetLogo, an agent-based programming environment (Wilensky, 1999). We created our model using simple rules to find emergent patterns (Wilensky and Rand, 2015) based on refuge types and pyramid BT e
- Evolution of Gene Expression and Splicing in Parallel Cold-Adapted Fly Populations [NEW RESULTS]Changes in gene regulation at multiple levels may comprise an important share of the molecular changes underlying adaptive evolution in nature. However, few studies have assayed within- and between-population variation in gene regulatory traits at a transcriptomic scale, and therefore inferences about the characteristics of adaptive regulatory changes have been elusive. Here, we assess quantitative trait differentiation in gene expression levels
- Amitosis confers benefits of sex in the absence of sex to Tetrahymena [NEW RESULTS]Sex appears to be the most successful reproductive strategy in eukaryotes despite its many costs. While a complete explanation for sex's success remains elusive, several evolutionary benefits of sex have been identified, such as, the purging of deleterious mutations, the accumulation of beneficial mutations, and an advantage in biotic interactions. It is predicted that, by forgoing these benefits, asexual lineages are evolutionary dead-ends due t
- Dynamical Systems Modeling of Bt Resistant Cornborer Population Dynamics [NEW RESULTS]Mathematical models provide insights for the design and optimization of strategies to control disease epidemics and evolution of pesticide resistance in crops. Here, we present a simple mathematical model to investigate the population dynamics of non-Bt resistant and Bt resistant cornborers in a field with refuge. In the presence of refuge, it is expected that the population of Bt resistant pests will decline due to the dilution effect (non-Bt re
- Paulinella micropora KR01 holobiont genome assembly for studying primary plastid evolution [NEW RESULTS]The widespread algal and plant (Archaeplastida) plastid originated >1 billion years ago, therefore relatively little can be learned about plastid integration during the initial stages of primary endosymbiosis by studying these highly derived species. Here we focused on a unique model for endosymbiosis research, the photosynthetic amoeba Paulinella micropora KR01 (Rhizaria) that underwent a more recent independent primary endosymbiosis about 124 M
- Evolutionary branching in distorted trait spaces [NEW RESULTS]Biological communities are thought to have been evolving in trait spaces that are not only multi-dimensional, but also distorted in a sense that mutational covariance matrices among traits depend on the parental phenotypes of mutants. Such a distortion may affect diversifying evolution as well as directional evolution. In adaptive dynamics theory, diversifying evolution through ecological interaction is called evolutionary branching. This study a
- Regional differences in gene regulation may underlie patterns of sensitivity to novel insecticides in Colorado potato beetle [NEW RESULTS]Agricultural insect pests frequently exhibit geographic variation in levels of insecticide resistance, which are often presumed to be due to the intensity of insecticide use for pest management. However, regional differences in the evolution of resistance to novel insecticides suggests that other factors are influencing rates of adaptation. We examined LC50 bioassay data spanning 15 years and six insecticides (abamectin, imidacloprid, spinosad, c
- Senescence and entrenchment in evolution of amino acid sites [NEW RESULTS]Amino acid propensities at a site change in the course of protein evolution. This may happen for two reasons. Changes may be triggered by substitutions at epistatically interacting sites elsewhere in the genome; alternatively, they may arise due to environmental changes that are external to the genome. Here, we design a framework for distinguishing between these alternatives. Using analytical modelling and simulations, we show that they cause opp
- Intragenic Recombination Influences Rotavirus Diversity and Evolution [NEW RESULTS]Because of their replication mode and segmented dsRNA genome, homologous recombination is assumed to be rare in the rotaviruses. We analyzed 23,627 complete rotavirus genome sequences available in the NCBI Virus Variation database and found numerous instances of homologous recombination, some of which prevailed across multiple sequenced isolates. In one case, recombination may have generated a novel rotavirus VP1 lineage. We also found strong evi
- Fine-scale position effects shape the distribution of inversion breakpoints in Drosophila melanogaster [NEW RESULTS]Chromosomal inversions are among the primary drivers of genome structure evolution in a wide range of natural populations. While there is an impressive array of theory and empirical analyses that has identified conditions under which inversions can be positively selected, comparatively little data is available on the fitness impacts of these genome structural rearrangements themselves. Because inversion breakpoints can interrupt functional elemen
- Disentangling Sources of Gene Tree Discordance in Phylotranscriptomic Datasets: A Case Study from Amaranthaceae s.l. [NEW RESULTS]Phylogenomic datasets have become common and fundamental to understanding the phylogenetic relationships of recalcitrant groups across the Tree of Life. At the same time, working with large genomic or transcriptomic datasets requires special attention to the processes that generate gene tree discordance, such as data processing and orthology inference, incomplete lineage sorting, hybridization, model violation, and uninformative gene trees. Metho
- Evolution of the DAN gene family in vertebrates [NEW RESULTS]The DAN gene family (DAN, Differential screening-selected gene Aberrant in Neuroblastoma) is a group of genes that is expressed during development and plays fundamental roles in limb bud formation and digitation, kidney formation and morphogenesis and left-right axis specification. During adulthood the expression of these genes are associated to diseases, including cancer. Although most of the attention to this group of genes has been dedicated t
- Evaluating the boundaries of marine biogeographic regions of the Southwestern Atlantic using halacarid mites (Halacaridae), meiobenthic organisms with a low dispersal potential [NEW RESULTS]Aim: We evaluated traditional biogeographic boundaries of coastal marine regions in SW Atlantic using DNA sequence data from common, rocky-shore inhabiting, marine mites of the genera Agauopsis and Rhombognathus, family Halacaridae. Methods: We investigated geographic population genetic structure using CO1 gene sequences, estimated divergence times using a multigene dataset and absolute time-calibrated molecular clock analyses, and performed envi
- Parallel and non-parallel changes of the gut microbiota during trophic diversification in repeated young adaptive radiations of sympatric cichlid fish [NEW RESULTS]Recent increases in understanding the ecological and evolutionary roles of microbial communities has underscored their importance for their hosts biology. Yet, little is known about gut microbiota dynamics during early stages of ecological diversification and speciation. We studied the gut microbiota of extremely young adaptive radiations of Nicaraguan crater lake cichlid fish (Amphilophus cf. citrinellus) to test the hypothesis that parallel evo
- Range expansion shifts clonal interference patterns in evolving populations [NEW RESULTS]The movement of a population through space can have profound impacts on its evolution, as observed theoretically, experimentally, and clinically. Furthermore, it has been observed that mutants emerging at the spreading front develop higher frequencies in the population than their counterparts further from the front. Here we use fundamental arguments from population genetics regarding expected time scales of beneficial mutant establishment and fix
- New tracheal stainless steel stent pilot study: twelve month follow-up in a rabbit modelBackground Canine tracheal collapse is a complex airway pathology without promising treatment results. Currently nitinol stents are the best surgical option; however, some professionals are doubting if stent placement is the best option due to the associated complications. Objective Determine the technical feasibility, safety, and long-term follow-up after the implan
- Combined effects of water temperature, grazing snails and terrestrial herbivores on leaf decomposition in urban streamsThe decomposition of organic matter in freshwaters, such as leaf litter, can affect global nutrient (e.g., carbon) cycling. This process can be influenced by fast urbanization through increased water temperature, reduced aquatic diversity and changed leaf litter quality traits. In this study, we performed a mesocosm experiment to explore the individual and combined effects of warming (8°C higher and ambient), the presence versus absence of grazin
- Norrisanima miocaena, a new generic name and redescription of a stem balaenopteroid mysticete (Mammalia, Cetacea) from the Miocene of CaliforniaRorqual whales are among the most species rich group of baleen whales (or mysticetes) alive today, yet the monophyly of the traditional grouping (i.e., Balaenopteridae) remains unclear. Additionally, many fossil mysticetes putatively assigned to either Balaenopteridae or Balaenopteroidea may actually belong to stem lineages, although many of these fossil taxa suffer from inadequate descriptions of fragmentary skeletal material. Here we provide a
- Spatio-temporal variation in oxidative status regulation in a small mammalLife-history allocation trade-offs are dynamic over time and space according to the ecological and demographical context. Fluctuations in food availability can affect physiological trade-offs like oxidative status regulation, reflecting the balance between pro-oxidant production and antioxidant capacity. Monitoring the spatio-temporal stability of oxidative status in natural settings may help understanding its importance in ecological and evoluti
- Effects of ferulic acid esterase-producing Lactobacillus fermentum and cellulase additives on the fermentation quality and microbial community of alfalfa silageBackground Alfalfa (Medicago sativa) is an important forage material widely used for animal feed production. Ensiling is an effective method for preserving alfalfa, but it has shown some limitations in the production of high-quality alfalfa silage due to its low water soluble carbohydrates (WSC) content and high buffering capacity. Lactic acid bacteria (LAB) and cellulase are often used as silage additives to promote the ensiling
- Cognitive performance in distinct groups of children undergoing epilepsy surgery—a single-centre experienceBackground We aimed first to describe trends in cognitive performance over time in a large patient cohort (n = 203) from a single tertiary centre for paediatric epilepsy surgery over the period of 16 years divided in two (developing—pre-2011 vs. established—post-2011). Secondly, we tried to identify subgroups of epilepsy surgery candidates with distinctive epilepsy-related characteristics that associate with their pre- and post-s
- Exogenous application of nitric oxide donors regulates short-term flooding stress in soybeanShort-term water submergence to soybean (Glycine max L.) create hypoxic conditions hindering plant growth and productivity. Nitric oxide (NO) is considered a stress-signalling and stress-evading molecule, however, little is known about its role during flooding stress. We elucidated the role of sodium nitroprusside (SNP) and S-nitroso L-cysteine (CySNO) as NO donor in modulation of flooding stress-related bio-chemicals and genetic determinants of
- MicroRNA-205-5p inhibits three-dimensional spheroid proliferation of ErbB2-overexpressing breast epithelial cells through direct targeting of CLCN3We previously reported that microRNA-205-5p (miR-205-5p) is significantly decreased in the ErbB2-overexpressing breast epithelial cell line MCF10A-ErbB2 compared with control cells. In this study, we identified a direct target of miR-205-5p, chloride voltage-gated channel 3 (CLCN3). CLCN3 expression was induced by ErbB2 overexpression; this induced expression was then reduced to control levels by the transfection of the miR-205-5p precursor. In R
- Plastome of mycoheterotrophic Burmannia itoana Mak. (Burmanniaceae) exhibits extensive degradation and distinct rearrangementsPlastomes of heterotrophs went through varying degrees of degradation along with the transition from autotrophic to heterotrophic lifestyle. Here, we identified the plastome of mycoheterotrophic species Burmannia itoana and compared it with those of its reported relatives including three autotrophs and one heterotroph (Thismia tentaculata) in Dioscoreales. B. itoana yields a rampantly degraded plastome reduced in size and gene numbers at the adva
- Endemism and diversity of small mammals along two neighboring Bornean mountainsMountains offer replicated units with large biotic and abiotic gradients in a reduced spatial scale. This transforms them into well-suited scenarios to evaluate biogeographic theories. Mountain biogeography is a hot topic of research and many theories have been proposed to describe the changes in biodiversity with elevation. Geometric constraints, which predict the highest diversity to occur in mid-elevations, have been a focal part of this discu
- Fluctuation and diversity of Hydromedusae (Hydrozoa, Cnidaria) in a highly productive region of the Gulf of Mexico inferred from high frequency plankton samplingHydrozoa medusae undergo blooms and seasonal fluctuations; however the drivers of such fluctuations are unknown. To understand how medusa populations fluctuate in response to seasonal factors such as temperature, salinity, dissolved oxygen, and chlorophyll a, and to enhance our taxonomic knowledge of Hydrozoa in Galveston Bay (TX), we performed frequent plankton sampling from September 2015 to September 2016. We collected 1,321 medusae in 190 sam
- Identification of crucial genes in abdominal aortic aneurysm by WGCNABackground Abdominal aortic aneurysm (AAA) is the full thickness dilation of the abdominal aorta. However, few effective medical therapies are available. Thus, elucidating the molecular mechanism of AAA pathogenesis and exploring the potential molecular target of medical therapies for AAA is of vital importance. Methods Three expression datasets (GSE7084, GSE47472 and GSE57691) were downloaded from the Gene Expression Omnibus (GEO). T
- Effect on hand kinematics when using assistive devices during activities of daily livingAssistive devices (ADs) are products intended to overcome the difficulties produced by the reduction in mobility and grip strength entailed by ageing and different pathologies. Nevertheless, there is little information about the effect that the use of these devices produces on hand kinematics. Thus, the aim of this work is to quantify this effect through the comparison of kinematic parameters (mean posture, ROM, median velocity and peak velocity)
- Bees may drive the reproduction of four sympatric cacti in a vanishing coastal mediterranean-type ecosystemBackground Sympatric congeneric plants might share pollinators, or each species might avoid competition by evolving specialized traits that generate partitions in pollinator assemblages. In both cases, pollen limitation (a decrease in the quality and quantity of compatible reproductive pollen) can occur, driving the plant mating system to autogamy as a mechanism of reproductive assurance. We assessed the relationships between pollinator assembl
- Complete mitochondrial genome sequence of Labriocimbex sinicus, a new genus and new species of Cimbicidae (Hymenoptera) from ChinaLabriocimbex sinicus Yan & Wei gen. et sp. nov. of Cimbicidae is described. The new genus is similar to Praia Andre and Trichiosoma Leach. A key to extant Holarctic genera of Cimbicinae is provided. To identify the phylogenetic placement of Cimbicidae, the mitochondrial genome of L. sinicus was annotated and characterized using high-throughput sequencing data. The complete mitochondrial genome of L. sinicus was obtained with a length of 15,405 bp
- Integrative transcriptome data mining for identification of core lncRNAs in breast cancerBackground Cumulative evidence suggests that long non-coding RNAs (lncRNAs) play an important role in tumorigenesis. This study aims to identify lncRNAs that can serve as new biomarkers for breast cancer diagnosis or screening. Methods First, the linear fitting method was used to identify differentially expressed genes from the breast cancer RNA expression profiles i
Τετάρτη 9 Οκτωβρίου 2019
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