Cancers, Vol. 11, Pages 1616: Epigenetic Reprogramming for Targeting IDH-Mutant Malignant Gliomas Cancers doi: 10.3390/cancers11101616 Authors: Jong-Whi Park Şevin Turcan Targeting the epigenome has been considered a compelling treatment modality for several cancers, including gliomas. Nearly 80% of the lower-grade gliomas and secondary glioblastomas harbor recurrent mutations in isocitrate dehydrogenase (IDH). Mutant IDH generates high levels of 2-hydroxyglutarate (2-HG) that inhibit...
Tue Oct 22, 2019 03:00
Cancers, Vol. 11, Pages 1617: MPT0G612, a Novel HDAC6 Inhibitor, Induces Apoptosis and Suppresses IFN-γ-Induced Programmed Death-Ligand 1 in Human Colorectal Carcinoma Cells Cancers doi: 10.3390/cancers11101617 Authors: Chen Lin Liao Liou Chen Colorectal cancer (CRC) is the third most common cancer and the leading cause of cancer-associated death worldwide. Histone deacetylases (HDACs) have been implicated in regulating complex cellular mechanisms to influence tumor...
Tue Oct 22, 2019 03:00
Cancers, Vol. 11, Pages 1618: A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer Cancers doi: 10.3390/cancers11101618 Authors: Braicu Buse Busuioc Drula Gulei Raduly Rusu Irimie Atanasov Slaby Ionescu Berindan-Neagoe The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch from extracellular signals to intracellular responses. Alterations of signaling cascades are found in various diseases,...
Tue Oct 22, 2019 03:00
Cancers, Vol. 11, Pages 1614: Recent Advances in Nuclear Imaging of Receptor Expression to Guide Targeted Therapies in Breast Cancer Cancers doi: 10.3390/cancers11101614 Authors: Salvatore Caprio Hill Sarnella Roviello Zannetti Breast cancer remains the most frequent cancer in women with different patterns of disease progression and response to treatments. The identification of specific biomarkers for different breast cancer subtypes has allowed the development of...
Tue Oct 22, 2019 03:00
Cancers, Vol. 11, Pages 1615: Size and Shape Filtering of Malignant Cell Clusters within Breast Tumors Identifies Scattered Individual Epithelial Cells as the Most Valuable Histomorphological Clue in the Prognosis of Distant Metastasis Risk Cancers doi: 10.3390/cancers11101615 Authors: Velicko Vranes Nemanja Rajković Xingyu Li Konstantinos N. Plataniotis Nataša Todorović Raković Jelena Milovanović Ksenija Kanjer Marko Radulovic Nebojša T. Milošević Survival and...
Tue Oct 22, 2019 03:00
Cancers, Vol. 11, Pages 1612: Identification of a Synergistic Multi-Drug Combination Active in Cancer Cells via the Prevention of Spindle Pole Clustering Cancers doi: 10.3390/cancers11101612 Authors: Andrea Weiss Morgan Le Roux-Bourdieu Marloes Zoetemelk George M. Ramzy Magdalena Rausch Daniela Harry Marijana Miljkovic-Licina Katayoun Falamaki Bernard Wehrle-Haller Patrick Meraldi Patrycja Nowak-Sliwinska A major limitation of clinically used cancer drugs...
Tue Oct 22, 2019 03:00
Cancers, Vol. 11, Pages 1613: MicroRNA 452 Regulates Cell Proliferation, Cell Migration, and Angiogenesis in Colorectal Cancer by Suppressing VEGFA Expression Cancers doi: 10.3390/cancers11101613 Authors: Ji Su Mo Won Cheol Park Suck-Chei Choi Ki Jung Yun Soo-Cheon Chae The human microRNA 452 (MIR452) was identified as a colorectal cancer (CRC)-associated micro RNA (miRNA) by miRNA expression profiling of human CRC tissues versus normal colorectal tissues. It was significantly...
Tue Oct 22, 2019 03:00
Cancers, Vol. 11, Pages 1610: The Epithelial to Mesenchymal Transition Promotes Glutamine Independence by Suppressing GLS2 Expression Cancers doi: 10.3390/cancers11101610 Authors: Esmeralda Ramirez-Peña James Arnold Vinita Shivakumar Robiya Joseph Geraldine Vidhya Vijay Petra den Hollander Neeraja Bhangre Paul Allegakoen Rishika Prasad Zachary Conley José M. Matés Javier Márquez Jeffrey T. Chang Suhas Vasaikar Rama Soundararajan Arun Sreekumar Sendurai...
Tue Oct 22, 2019 03:00
Cancers, Vol. 11, Pages 1611: Screening a Broad Range of Solid and Haematological Tumour Types for CD70 Expression Using a Uniform IHC Methodology as Potential Patient Stratification Method Cancers doi: 10.3390/cancers11101611 Authors: Tal Flieswasser Valérie Camara-Clayette Alina Danu Jacques Bosq Vincent Ribrag Piotr Zabrocki Luc Van Rompaey Hans de Haard Karen Zwaenepoel Evelien Smits Patrick Pauwels Julie Jacobs The constitutive expression of CD70...
Tue Oct 22, 2019 03:00
Cancers, Vol. 11, Pages 1609: Functionalized Tobacco Mosaic Virus Coat Protein Monomers and Oligomers as Nanocarriers for Anti-Cancer Peptides Cancers doi: 10.3390/cancers11101609 Authors: Coralie Gamper Caroline Spenlé Sonia Boscá Michael van der Heyden Mathieu Erhardt Gertraud Orend Dominique Bagnard Manfred Heinlein Components with self-assembly properties derived from plant viruses provide the opportunity to design biological nanoscaffolds for the ordered display...
Tue Oct 22, 2019 03:00
Cells, Vol. 8, Pages 1298: MicroRNA-29a Suppresses CD36 to Ameliorate High Fat Diet-Induced Steatohepatitis and Liver Fibrosis in Mice Cells doi: 10.3390/cells8101298 Authors: Hung-Yu Lin Feng-Sheng Wang Ya-Ling Yang Ying-Hsien Huang MicroRNA-29 (miR-29) has been shown to play a critical role in reducing inflammation and fibrosis following liver injury. Non-alcoholic fatty liver disease (NAFLD) occurs when fat is deposited (steatosis) in the liver due to causes other than excessive...
Tue Oct 22, 2019 03:00
Cells, Vol. 8, Pages 1301: Invertebrate Retinal Progenitors as Regenerative Models in a Microfluidic System Cells doi: 10.3390/cells8101301 Authors: Pena Zhang Majeska Venkatesh Vazquez Regenerative retinal therapies have introduced progenitor cells to replace dysfunctional or injured neurons and regain visual function. While contemporary cell replacement therapies have delivered retinal progenitor cells (RPCs) within customized biomaterials to promote viability and...
Tue Oct 22, 2019 03:00
Cells, Vol. 8, Pages 1299: Opposite Effects of Moderate and Extreme Cx43 Deficiency in Conditional Cx43-Deficient Mice on Angiotensin II-Induced Cardiac Fibrosis Cells doi: 10.3390/cells8101299 Authors: Valls-Lacalle Negre-Pujol Rodríguez Varona Valera-Cañellas Consegal Martínez-González Rodríguez-Sinovas Abstract: Connexin 43 (Cx43) is essential for cardiac electrical coupling, but its effects on myocardial fibrosis is controversial. Here, we analyzed the...
Tue Oct 22, 2019 03:00
Cells, Vol. 8, Pages 1300: Association of the Rheumatoid Arthritis Severity Variant rs26232 with the Invasive Activity of Synovial Fibroblasts Cells doi: 10.3390/cells8101300 Authors: Dorris Linehan Trenkmann Veale Fearon Wilson rs26232, located in intron one of C5orf30, is associated with the susceptibility to and severity of rheumatoid arthritis (RA). Here, we investigate the relationship between this variant and the biological activities of rheumatoid arthritis...
Tue Oct 22, 2019 03:00
Cells, Vol. 8, Pages 1302: Dental Epithelial Stem Cells as a Source for Mammary Gland Regeneration and Milk Producing Cells In Vivo Cells doi: 10.3390/cells8101302 Authors: Jimenez-Rojo Pagella Harada Mitsiadis The continuous growth of rodent incisors is ensured by clusters of mesenchymal and epithelial stem cells that are located at the posterior part of these teeth. Genetic lineage tracing studies have shown that dental epithelial stem cells (DESCs) are able to generate...
Tue Oct 22, 2019 03:00
Cells, Vol. 8, Pages 1297: Inhibition of Non-Small Cell Lung Cancer Cells by Oxy210, an Oxysterol-Derivative that Antagonizes TGFβ and Hedgehog Signaling Cells doi: 10.3390/cells8101297 Authors: Stappenbeck Wang Tang Zhang Parhami Non-Small Cell Lung Cancer (NSCLC) is a common malignancy and leading cause of death by cancer. Metastasis and drug resistance are serious clinical problems encountered in NSCLC therapy. Aberrant activation of the Transforming Growth Factor...
Tue Oct 22, 2019 03:00
Cells, Vol. 8, Pages 1296: Hepatitis C Virus Improves Human Tregs Suppressive Function and Promotes Their Recruitment to the Liver Cells doi: 10.3390/cells8101296 Authors: Laurissa Ouaguia Olivier Moralès Lynda Aoudjehane Czeslaw Wychowski Abhishek Kumar Jean Dubuisson Yvon Calmus Filomena Conti Nadira Delhem Background: The role of regulatory T cells (Tregs) is now well established in the progression of hepatocellular carcinoma (HCC) linked to Hepatitis C virus...
Tue Oct 22, 2019 03:00
Cells, Vol. 8, Pages 1295: Tumor Cells Develop Defined Cellular Phenotypes After 3D-Bioprinting in Different Bioinks Cells doi: 10.3390/cells8101295 Authors: Sonja K. Schmidt Rafael Schmid Andreas Arkudas Annika Kengelbach-Weigand Anja K. Bosserhoff Malignant melanoma is often used as a model tumor for the establishment of novel therapies. It is known that two-dimensional (2D) culture methods are not sufficient to elucidate the various processes during cancer development...
Tue Oct 22, 2019 03:00
Climate, Vol. 7, Pages 124: The Global Trend of the Net Irrigation Water Requirement of Maize from 1960 to 2050 Climate doi: 10.3390/cli7100124 Authors: Abdoulaye Oumarou Abdoulaye Haishen Lu Yonghua Zhu Yousef Alhaj Hamoud Mohamed Sheteiwy Irrigated production around the world has significantly increased over the last decade. However, climate change is a new threat that could seriously aggravate the irrigation water supplies and request. In this study, the data is derived...
Tue Oct 22, 2019 03:00
Cosmetics, Vol. 6, Pages 61: Special Issue “Recent Advances in Hair Science and Hair Care Technologies” Cosmetics doi: 10.3390/cosmetics6040061 Authors: Kenzo Koike Scalp hair is very important for men and women especially in terms of fashion and appearance [...]
Tue Oct 22, 2019 03:00
Diagnostics, Vol. 9, Pages 157: Rapid Gout Detection Method and Kit Diagnostics doi: 10.3390/diagnostics9040157 Authors: Srinivas Pentyala Rebecca Monastero Sai Palati Elizabeth Varghese Amith Anugu Sahana Pentyala Vamiq M. Mustahsan David E. Komatsu James Penna Lawrence C. Hurst Gout is a form of arthritis characterized by buildup of uric acid in synovial fluid, which causes severe swelling and can harm joints, tendons, and other tissues. It affects approximately...
Tue Oct 22, 2019 03:00
Diagnostics, Vol. 9, Pages 156: Glycan Analysis as Biomarkers for Testicular Cancer Diagnostics doi: 10.3390/diagnostics9040156 Authors: Hires Jane Mego Chovanec Kasak Tkac The U.S. Preventive Services Task Force does not recommend routine screening for testicular cancer (TC) in asymptomatic men, essentially because serological testicular cancer (TC) biomarkers are not reliable. The main reason is that two of the most important TC biomarkers, α-fetoprotein...
Tue Oct 22, 2019 03:00
Diagnostics, Vol. 9, Pages 155: Diagnosis of Conversion Disorder Using Diffusion Tensor Tractography and Transcranial Magnetic Stimulation in a Patient with Mild Traumatic Brain Injury Diagnostics doi: 10.3390/diagnostics9040155 Authors: Sung Ho Jang You Sung Seo We report on a patient with mild traumatic brain injury (TBI) who was diagnosed with conversion disorder for severe weakness of an arm, which was demonstrated using diffusion tensor tractography (DTT) and transcranial magnetic...
Tue Oct 22, 2019 03:00
Foods, Vol. 8, Pages 522: Berberis Plants—Drifting from Farm to Food Applications, Phytotherapy, and Phytopharmacology Foods doi: 10.3390/foods8100522 Authors: Bahare Salehi Zeliha Selamoglu Bilge Sener Mehtap Kilic Arun Kumar Jugran Nunziatina de Tommasi Chiara Sinisgalli Luigi Milella Jovana Rajkovic Maria Flaviana B. Morais-Braga Camila F. Bezerra Janaína E. Rocha Henrique D.M. Coutinho Adedayo Oluwaseun Ademiluyi Zabta Khan Shinwari Sohail Ahmad...
Tue Oct 22, 2019 03:00
Humanities, Vol. 8, Pages 167: Gwendolyn Brooks and the Legacies of Architectural Modernity Humanities doi: 10.3390/h8040167 Authors: Gill This essay reads the work of poet, Gwendolyn Brooks, in terms of its critical engagement with the architectural modernity of her home city, Chicago. Taking her poetry from A Street in Bronzeville (1945) through to the 1968 collection, In the Mecca, as a primary focus, the essay traces the significance of Chicago style architecture on Brooks’...
Tue Oct 22, 2019 03:00
IJERPH, Vol. 16, Pages 4054: Estimating the Responses of Hydrological and Sedimental Processes to Future Climate Change in Watersheds with Different Landscapes in the Yellow River Basin, China International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16204054 Authors: Li Sha Zhao Wang This study concerned the sediment issue of the Yellow River basin. The responses of hydrological and sedimental processes to future climate change in two upland watersheds...
Tue Oct 22, 2019 03:00
IJERPH, Vol. 16, Pages 4052: Anthropogenic Rare Earth Elements: Gadolinium in a Small Catchment in Guizhou Province, Southwest China International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16204052 Authors: Jue Zhang Zhuhong Wang Qixin Wu Yanling An Huipeng Jia Yuanyi Shen Rare earth elements (REEs), known as “industrial vitamins”, are widely used in medical treatment, industry, agriculture, etc. However, with the increasing...
Tue Oct 22, 2019 03:00
IJERPH, Vol. 16, Pages 4053: Potentially Harmful Element Concentrations in the Vegetables Cultivated on Arable Soils, with Human Health-Risk Implications International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16204053 Authors: Gruszecka-Kosowska Potentially harmful elements (PHEs) were investigated in eight groups of vegetables cultivated in southern Poland and the relevant health-risk implications were assessed. The PHE contents belonged to the following...
Tue Oct 22, 2019 03:00
IJERPH, Vol. 16, Pages 4050: A Longitudinal Study of the Associations of Family Structure with Physical Activity across the Week in Boys and Girls International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16204050 Authors: Emma Solomon-Moore Ruth Salway Lydia G. Emm-Collison Simon J. Sebire Janice L. Thompson Russell Jago The aim of this study was to examine how family structure is associated with moderate-to-vigorous-intensity physical activity...
Tue Oct 22, 2019 03:00
IJERPH, Vol. 16, Pages 4051: Relationship between Physical Activity Level and Depression of Elderly People Living Alone International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16204051 Authors: Byeon Background and objectives: Only a few studies analyzed the physical activity level of elderly people living alone in local communities and evaluated the relationship between it and mental health. The purpose of this study was to investigate the relationship...
Tue Oct 22, 2019 03:00
IJERPH, Vol. 16, Pages 4049: Adapting Translational Research Methods to Water, Sanitation, and Hygiene International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16204049 Authors: Karen Setty Ryan Cronk Shannan George Darcy Anderson Għanja O’Flaherty Jamie Bartram Translational research applies scientific techniques to achieve practical outcomes, connecting pure research and pure practice. Many translational research types have arisen since the...
Tue Oct 22, 2019 03:00
IJERPH, Vol. 16, Pages 4047: Utilising Digital Health Technology to Support Patient-Healthcare Provider Communication in Fragility Fracture Recovery: Systematic Review and Meta-Analysis International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16204047 Authors: Lalit Yadav Ayantika Haldar Unyime Jasper Anita Taylor Renuka Visvanathan Mellick Chehade Tiffany Gill The objective of this review is to evaluate the effectiveness of digital health...
Tue Oct 22, 2019 03:00
IJERPH, Vol. 16, Pages 4048: Tobacco Smoke Exposure, Urban and Environmental Factors as Respiratory Disease Predictors in Italian Adolescents International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16204048 Authors: Valeria Bellisario Pavilio Piccioni Massimiliano Bugiani Giulia Squillacioti Stefano Levra Carlo Gulotta Giulio Mengozzi Alberto Perboni Elena Grignani Roberto Bono Risk monitoring in childhood is useful to estimate...
Tue Oct 22, 2019 03:00
IJERPH, Vol. 16, Pages 4046: Study on Status and Willingness towards Hepatitis B Vaccination among Migrant Workers in Chongqing, China: A Cross-Sectional Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16204046 Authors: Hui Xiang Xiaojun Tang Meng Xiao Lin Gan Kun Chu Shan Li Yu Tian Xun Lei Background: Rural-to-urban migrant workers may serve as a bridge population for the cross-regional spread of hepatitis B vaccination...
Tue Oct 22, 2019 03:00
IJERPH, Vol. 16, Pages 4045: Parenting Practices, Life Satisfaction, and the Role of Self-Esteem in Adolescents International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16204045 Authors: María del Carmen Pérez-Fuentes María del Mar Molero Jurado José Jesús Gázquez Linares Nieves Fátima Oropesa Ruiz María del Mar Simón Márquez Mahia Saracostti Introduction: Studies have shown significant associations between parenting practices, life satisfaction,...
Tue Oct 22, 2019 03:00
IJERPH, Vol. 16, Pages 4044: A Study on Small Clinics Waste Management Practice, Rules, Staff Knowledge, and Motivating Factor in a Rapidly Urbanizing Area International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16204044 Authors: Bilal Ahmed Khan Aves Ahmed Khan Haris Ahmed Shazia Shaheen Shaikh Zhaiming Peng Longsheng Cheng Thousands of small clinics in Pakistan are generating dispersed medical waste, unlike large hospitals, small clinic waste...
Tue Oct 22, 2019 03:00
IJERPH, Vol. 16, Pages 4041: Attributable Burden and Expenditure of Cardiovascular Diseases and Associated Risk Factors in Mexico and other Selected Mega-Countries International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16204041 Authors: Kenny Mendoza-Herrera Andrea Pedroza-Tobías César Hernández-Alcaraz Leticia Ávila-Burgos Carlos A. Aguilar-Salinas Simón Barquera Background: This paper describes the health and economic burden of cardiovascular...
Tue Oct 22, 2019 03:00
IJERPH, Vol. 16, Pages 4042: The Association between Autism Spectrum Disorder and Pre- and Postnatal Antibiotic Exposure in Childhood—A Systematic Review with Meta-Analysis International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16204042 Authors: Eunmi Lee Jeonghyun Cho Ka Young Kim Autism spectrum disorder (ASD) is a developmental disorder that begins in early childhood and has been associated with several environmental and genetic factors. We aimed...
Tue Oct 22, 2019 03:00
IJERPH, Vol. 16, Pages 4043: Understanding the Antecedents of Organic Food Consumption in Pakistan: Moderating Role of Food Neophobia International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16204043 Authors: Ahsan Akbar Saqib Ali Muhammad Azeem Ahmad Minhas Akbar Muhammad Danish Environmental and health problems have increased the interest of researchers and practitioners in investigating the factors that affect organic food consumption. However,...
Tue Oct 22, 2019 03:00
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