- Cathepsin L secretion by host and neoplastic cells potentiates invasion.Related ArticlesCathepsin L secretion by host and neoplastic cells potentiates invasion. Oncotarget. 2019 Sep 17;10(53):5560-5568 Authors: Dykes SS, Fasanya HO, Siemann DW Abstract The presence of macrophages within breast tumors correlates with metastatic potential. These tumor-associated macrophages often take on a pro-tumorigenic (M2-like) phenotype resulting in the secretion of growth factors and
- The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor.Related ArticlesThe effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor. Oncotarget. 2019 Sep 17;10(53):5534-5548 Authors: Aye JM, Stafman LL, Williams AP, Garner EF, Stewart JE, Anderson JC, Mruthyunjayappa S, Waldrop MG, Goolsby CD, Markert HR, Quinn C, Marayati R, Mroczek-Musulman E, Willey CD, Yoon K
- Anti-VEGFR2 therapy delays growth of preclinical pediatric tumor models and enhances anti-tumor activity of chemotherapy.Related ArticlesAnti-VEGFR2 therapy delays growth of preclinical pediatric tumor models and enhances anti-tumor activity of chemotherapy. Oncotarget. 2019 Sep 17;10(53):5523-5533 Authors: Lowery CD, Blosser W, Dowless M, Renschler M, Perez LV, Stephens J, Pytowski B, Wasserstrom H, Stancato LF, Falcon B Abstract Vascular endothelial growth factor receptor 2 (VEGFR2) is an attractive therapeutic targe
- Excision repair cross-complementing group-1 (ERCC1) induction kinetics and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin.Related ArticlesExcision repair cross-complementing group-1 (ERCC1) induction kinetics and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin. Oncotarget. 2019 Sep 17;10(53):5510-5522 Authors: Rao D, Mallick AB, Augustine T, Daroqui C, Jiffry J, Merla A, Chaudhary I, Seetharam R, Sood A, Gajavelli S, Aparo S, Rajdev L, Kaubisch A, Chuy J, Negassa A, Mariadason JM,
- Consuming cholera toxin counteracts age-associated obesity.Related ArticlesConsuming cholera toxin counteracts age-associated obesity. Oncotarget. 2019 Sep 17;10(53):5497-5509 Authors: Varian BJ, Poutahidis T, Haner G, Hardas A, Lau V, Erdman SE Abstract During the past forty years there has been an inexplicable increase in chronic inflammatory disorders, including obesity. One theory, the 'hygiene hypothesis', involves dysregulated immunity arising after to
- Nicotinamide in the prevention of breast cancer recurrences?Related ArticlesNicotinamide in the prevention of breast cancer recurrences? Oncotarget. 2019 Sep 17;10(53):5495-5496 Authors: Dell'Omo G, Ciana P PMID: 31565183 [PubMed]
Oncology Letters
- The microRNA-200 family acts as an oncogene in colorectal cancer by inhibiting the tumor suppressor RASSF2.Related ArticlesThe microRNA-200 family acts as an oncogene in colorectal cancer by inhibiting the tumor suppressor RASSF2. Oncol Lett. 2019 Oct;18(4):3994-4007 Authors: Carter JV, O'Brien SJ, Burton JF, Oxford BG, Stephen V, Hallion J, Bishop C, Galbraith NJ, Eichenberger MR, Sarojini H, Hattab E, Galandiuk S Abstract This study aimed to determine whether manipulation of the microRNA-200 (miR-200) f
- The arylabialis muscle of the túngara frog (Engystomops pustulosus).The arylabialis muscle of the túngara frog (Engystomops pustulosus). Anat Rec (Hoboken). 2019 Sep 30;: Authors: Lagorio AD, Grewal K, Djuhari S, Le K, Mulhim R, Gridi-Papp M Abstract The current functional model of the anuran larynx includes four pairs of laryngeal muscles. Their contractions do not account, however, for the behavioral control of call complexity observed in male túngara frogs (Engyst
- Medications and the larynx.Medications and the larynx. Curr Opin Otolaryngol Head Neck Surg. 2019 Sep 20;: Authors: Harounian J, Postevka E, Jamal N Abstract PURPOSE OF REVIEW: The larynx is a complex organ that houses some of the most intricate structures of the human body. Owing to its delicate nature, the larynx is affected by different medications to varying degrees. Many of these effects manifest in subjective complaints
- Laryngeal adductor function following potassium titanyl phosphate laser welding of the recurrent laryngeal nerve.Laryngeal adductor function following potassium titanyl phosphate laser welding of the recurrent laryngeal nerve. Laryngoscope. 2019 Sep 30;: Authors: Bhatt NK, Faddis BT, Paniello RC Abstract OBJECTIVES/HYPOTHESIS: Recurrent laryngeal nerve (RLN) transection injuries may occur during thyroidectomy and other surgical procedures. Laser nerve welding has been shown to cause less technique-related axona
- Synchronized, concurrent optical coherence tomography and videostroboscopy for monitoring vocal fold morphology and kinematics.Related ArticlesSynchronized, concurrent optical coherence tomography and videostroboscopy for monitoring vocal fold morphology and kinematics. Biomed Opt Express. 2019 Sep 01;10(9):4450-4461 Authors: Maguluri G, Mehta D, Kobler J, Park J, Iftimia N Abstract Voice disorders affect a large number of adults in the United States, and their clinical evaluation heavily relies on laryngeal videostroboscopy
- Multiple-CT optimization: An adaptive optimization method to account for anatomical changes in intensity-modulated proton therapy for head and neck cancers.Related ArticlesMultiple-CT optimization: An adaptive optimization method to account for anatomical changes in intensity-modulated proton therapy for head and neck cancers. Radiother Oncol. 2019 Sep 26;: Authors: Yang Z, Zhang X, Wang X, Zhu XR, Gunn B, Frank SJ, Chang Y, Li Q, Yang K, Wu G, Liao L, Li Y, Chen M, Li H Abstract PURPOSE: We aimed to determine whether multiple-CT (MCT) optimization of i
- Transoral videolaryngoscopic surgery for laryngeal and hypopharyngeal cancer - Technical updates and long-term results.Related ArticlesTransoral videolaryngoscopic surgery for laryngeal and hypopharyngeal cancer - Technical updates and long-term results. Auris Nasus Larynx. 2019 Sep 26;: Authors: Tomifuji M, Araki K, Uno K, Kamide D, Tanaka S, Suzuki H, Tanaka Y, Kimura E, Hirokawa S, Taniai S, Shiotani A Abstract OBJECTIVE: Transoral videolaryngoscopic surgery (TOVS) was developed as a non-robotic procedure for en b
- Reinforced Laryngeal Mask in Pediatric Laparoscopic Surgery.Related ArticlesReinforced Laryngeal Mask in Pediatric Laparoscopic Surgery. J Coll Physicians Surg Pak. 2019 Oct;29(10):915-918 Authors: Sun XL, Li J, Wang ZY, Li MY, Duan W, Wu N, Yang O Abstract OBJECTIVE: To determine the frequency of reflux and aspiration in children subjected to reinforced laryngeal mask during laparoscopic surgery in the Trendelenburg position, and evaluate its feasibility.
- Vocal markers of preoperative anxiety: a pilot study.Related ArticlesVocal markers of preoperative anxiety: a pilot study. Br J Anaesth. 2019 Oct;123(4):e486-e488 Authors: Guerrier G, Lellouch L, Liuni M, Vaglio A, Rothschild PR, Baillard C, Aucouturier JJ PMID: 31353020 [PubMed - indexed for MEDLINE]
- Extract of Helicobacter pylori Ameliorates Parameters of Airway Inflammation and Goblet Cell Hyperplasia following Repeated Allergen Exposure.Related ArticlesExtract of Helicobacter pylori Ameliorates Parameters of Airway Inflammation and Goblet Cell Hyperplasia following Repeated Allergen Exposure. Int Arch Allergy Immunol. 2019;180(1):1-9 Authors: van Wijck Y, John-Schuster G, van Schadewijk A, van den Oever RL, Obieglo K, Hiemstra PS, Müller A, Smits HH, Taube C Abstract BACKGROUND: An inverse relation between Helicobacter pylori infect
- Ultrasonographic Evaluation of Upper Airway Structures in Children With Obstructive Sleep Apnea.Related ArticlesUltrasonographic Evaluation of Upper Airway Structures in Children With Obstructive Sleep Apnea. JAMA Otolaryngol Head Neck Surg. 2018 10 01;144(10):897-905 Authors: Lin CY, Chen CN, Kang KT, Hsiao TY, Lee PL, Hsu WC Abstract Importance: Adenotonsillar hypertrophy is an important cause of obstructive sleep apnea (OSA) in children. However, residual OSA and abnormal polysomnographic fi
- Feasibility of the electrolarynx for enabling communication in the chronically critically ill: The EECCHO study.Related ArticlesFeasibility of the electrolarynx for enabling communication in the chronically critically ill: The EECCHO study. J Crit Care. 2018 10;47:109-113 Authors: Rose L, Istanboulian L, Smith OM, Silencieux S, Cuthbertson BH, Amaral ACK, Fraser I, Grey J, Dale C Abstract PURPOSE: To assess feasibility of producing intelligible and comprehensible speech with an electrolarynx; measure anxiety,
- Assessment of Clinical and Social Characteristics That Distinguish Presbylaryngis From Pathologic Presbyphonia in Elderly Individuals.Related ArticlesAssessment of Clinical and Social Characteristics That Distinguish Presbylaryngis From Pathologic Presbyphonia in Elderly Individuals. JAMA Otolaryngol Head Neck Surg. 2018 07 01;144(7):566-571 Authors: Crawley BK, Dehom S, Thiel C, Yang J, Cragoe A, Mousselli I, Krishna P, Murry T Abstract Importance: An aging population experiences an increase in age-related problems, such as presby
- 3D phase contrast MRI in models of human airways: Validation of computational fluid dynamics simulations of steady inspiratory flow.Related Articles3D phase contrast MRI in models of human airways: Validation of computational fluid dynamics simulations of steady inspiratory flow. J Magn Reson Imaging. 2018 11;48(5):1400-1409 Authors: Collier GJ, Kim M, Chung Y, Wild JM Abstract BACKGROUND: Knowledge of airflow patterns in the large airways is of interest in obstructive airways disease and in the development of inhaled therapies.
- Richieri-Costa-Pereira syndrome: Expanding its phenotypic and genotypic spectrum.Related ArticlesRichieri-Costa-Pereira syndrome: Expanding its phenotypic and genotypic spectrum. Clin Genet. 2018 04;93(4):800-811 Authors: Bertola DR, Hsia G, Alvizi L, Gardham A, Wakeling EL, Yamamoto GL, Honjo RS, Oliveira LAN, Di Francesco RC, Perez BA, Kim CA, Passos-Bueno MR Abstract Richieri-Costa-Pereira syndrome is a rare autosomal recessive acrofacial dysostosis that has been mainly descri
Cells Tissues Organs
- DNA Methylation-Based Regulation of Human Bone Marrow-Derived Mesenchymal Stem/Progenitor Cell Chondrogenic DifferentiationStem cells have essential applications in in vitro tissue engineering or regenerative medicine. However, there is still a need to understand more deeply the mechanisms of stem cell differentiation and to optimize the methods to control stem cell function. In this study, we first investigated the activity of DNA methyltransferases (DNMTs) during chondrogenic differentiation of human bone marrow-derived mesenchymal stem/progenitor cells (hBMSCs) an
Clinical Therapeutics
- Automation With Intelligence in Drug ResearchPublication date: Available online 1 October 2019Source: Clinical TherapeuticsAuthor(s): Hanming Tu, Zhongping Lin, Kevin LeeAbstractThe industry has adopted Clinical Data Interchange Standards Consortium standards for clinical trial data and the Food and Drug Administration electronic common technical document standard for documents for many years but still faces many challenges. The solutions based on these standards enable integration among so
European Review » Radiology
- Critical analysis of major and ancillary features of LI-RADS v2018 in the differentiation of small (≤ 2 cm) hepatocellular carcinoma from dysplastic nodules with gadobenate dimeglumine-enhanced magnetic resonance imagingOBJECTIVE: To evaluate the performance of major features, ancillary features, and categories of Liver Imaging Reporting and Data System (LI-RADS) version 2018 at magnetic resonance (MR) imaging in the differentiation of small hepatocellular carcinoma (HCC) from dysplastic nodules (DNs).PATIENTS AND METHODS: This retrospective study included cirrhotic patients with pathologically proven untreated HCCs and DNs (≤ 2 cm) and liver MR imaging performe
- Professional Oral Care Reduces Carcinogenic Acetaldehyde Levels in Mouth Air of Perioperative Esophageal Cancer Patients: A Prospective Comparative Study.Related ArticlesProfessional Oral Care Reduces Carcinogenic Acetaldehyde Levels in Mouth Air of Perioperative Esophageal Cancer Patients: A Prospective Comparative Study. Tohoku J Exp Med. 2019;249(1):75-83 Authors: Tanda N, Washio J, Kamei T, Akazawa K, Takahashi N, Koseki T Abstract Acetaldehyde is a potential carcinogen for esophageal cancer, and some oral microorganisms produce acetaldehyde from
- High Hematocrit Levels Are Associated with Risk of Cardiovascular Mortality among Middle-Aged Japanese Women: The Ibaraki Prefectural Health Study (IPHS).Related ArticlesHigh Hematocrit Levels Are Associated with Risk of Cardiovascular Mortality among Middle-Aged Japanese Women: The Ibaraki Prefectural Health Study (IPHS). Tohoku J Exp Med. 2019;249(1):65-73 Authors: Takaoka N, Sairenchi T, Irie F, Matsushita M, Nagao M, Umesawa M, Haruyama Y, Watanabe H, Yamagishi K, Iso H, Kobashi G, Ota H Abstract In Japan, heart disease and cerebrovascular disease
- Non-Regular Employment Status Is Associated with Psychological Distress among Young Researchers: A Cross-Sectional Study in Tsukuba, Japan.Related ArticlesNon-Regular Employment Status Is Associated with Psychological Distress among Young Researchers: A Cross-Sectional Study in Tsukuba, Japan. Tohoku J Exp Med. 2019;249(1):57-64 Authors: Takahashi T, Hori D, Ikeda T, Ikeda Y, Shiraki N, Andrea CS, Ohtaki Y, Doki S, Oi Y, Sasahara S, Matsuzaki I Abstract Non-regular employment is increasing and its mental health impact is a globally impo
- THE EFFECT OF STRAIGHT OR LORDOTIC RODS ON CERVICAL SUBAXIAL ALIGNMENT WHILE FUSING C1-C2.THE EFFECT OF STRAIGHT OR LORDOTIC RODS ON CERVICAL SUBAXIAL ALIGNMENT WHILE FUSING C1-C2. World Neurosurg. 2019 Sep 27;: Authors: Iştemen İ, Arslan A, Olguner SK, Gezercan Y, Ökten Aİ, Afşer KA PMID: 31568918 [PubMed - as supplied by publisher]
- Restraint in a neurosurgical setting: A mixed-methods study.Restraint in a neurosurgical setting: A mixed-methods study. World Neurosurg. 2019 Sep 27;: Authors: Holmgren AG, Juth N, Lindblad A, von Vogelsang AC Abstract OBJECTIVES: To investigate the extent to which restraint is used in neurosurgical care, under what circumstances, and how it is documented. METHODS: A cross-sectional study with a mixed-methods approach was used to identify neurosurgi
- Predictors of Surgical Site Infection in Cranioplasty: A Retrospective Analysis of Subcutaneously Preserved Bone Flaps in Abdominal Pockets.Predictors of Surgical Site Infection in Cranioplasty: A Retrospective Analysis of Subcutaneously Preserved Bone Flaps in Abdominal Pockets. World Neurosurg. 2019 Sep 27;: Authors: Alkhaibary A, Alharbi A, Abbas M, Algarni A, Abdullah JM, Almadani WH, Khairy I, Alkhani A, Aloraidi A, Khairy S Abstract OBJECTIVE: Decompressive craniectomy (DC) is a life-saving surgical procedure performed to manage in
- The preoperative risks and 2-year sequelae of postoperative urinary retention: analysis of the Michigan Spine Surgery Improvement Collaborative (MSSIC).The preoperative risks and 2-year sequelae of postoperative urinary retention: analysis of the Michigan Spine Surgery Improvement Collaborative (MSSIC). World Neurosurg. 2019 Sep 27;: Authors: Zakaria HM, Lipphardt M, Bazydlo M, Xiao S, Schultz L, Chedid M, Abdulhak M, Schwalb JM, Nerenz D, Easton R, Chang V, MSSIC Investigators Abstract OBJECTIVE: While postoperative urinary retention (POUR) is comm
- 30-Day Mortality and Survival in Elderly Patients undergoing Neurosurgery.30-Day Mortality and Survival in Elderly Patients undergoing Neurosurgery. World Neurosurg. 2019 Sep 27;: Authors: Bligh ER, Sinha P, Smith D, Al-Tamimi YZ Abstract OBJECTIVES: With an ageing population and advances in neuroanaesthesia and critical care, there is an increasing subgroup of elderly patients undergoing neurosurgery. Of particular relevance is the cohort greater than 80 years of age. The
- Asymptomatic intracranial aneurysms in the elderly: long-term clinical and radiological follow up of 193 consecutive patients.Asymptomatic intracranial aneurysms in the elderly: long-term clinical and radiological follow up of 193 consecutive patients. World Neurosurg. 2019 Sep 27;: Authors: Huang H, O'Neill AH, Chandra RV, Lai LT Abstract BACKGROUND: Evidence is lacking regarding the role of radiological surveillance for asymptomatic intracranial aneurysms (AIAs) in the elderly (≥ 65 years). We sought to establish if long-
- Factors Predictive of Adjacent Segment Disease after Lumbar Spinal Fusion.Factors Predictive of Adjacent Segment Disease after Lumbar Spinal Fusion. World Neurosurg. 2019 Sep 27;: Authors: Maragkos GA, Motiei-Langroudi R, Filippidis AS, Glazer PA, Papavassiliou E Abstract OBJECTIVE: Adjacent segment disease (ASD) is a long-term complication of lumbar spinal fusion. This study aims to evaluate demographic and operative factors which influence development of ASD after fusion
- Big Data Analysis: the leap into a new science methodology.Big Data Analysis: the leap into a new science methodology. World Neurosurg. 2019 Sep 27;: Authors: Cacciola A, Conti A, Tomasello F PMID: 31568910 [PubMed - as supplied by publisher]
- Aulus Cornelius Celsus and the Head Injuries.Aulus Cornelius Celsus and the Head Injuries. World Neurosurg. 2019 Sep 27;: Authors: Talamonti G, D'Aliberti G, Cenzato M Abstract Aulus Cornelius Celsus lived in Rome during the reigns of Augustus and Tiberius. He developed the scientific Latin and his work De Medicina was the first medical textbook to be written in Latin, and subsequently the first medical treatise to be printed. He perhaps was a
- Evaluating the Effects of the Wire Number of Flow Diverter Stents on the Non-stagnated Region Formation in an Aneurysm Sac using Lagrangian Coherent Structure and Hyperbolic Time Analysis.Evaluating the Effects of the Wire Number of Flow Diverter Stents on the Non-stagnated Region Formation in an Aneurysm Sac using Lagrangian Coherent Structure and Hyperbolic Time Analysis. World Neurosurg. 2019 Sep 27;: Authors: Mutlu O, Olcay AB, Bilgin C, Hakyemez B Abstract Giant aneurysms at carotid arteries are typically treated with flow diverter (FD) stents in the clinics. While the goal of an
- Effect of a time delay for concomitant chemoradiation after surgery for newly diagnosed glioblastoma: A single-institution study with subgroup analysis according to the extent of tumor resection.Effect of a time delay for concomitant chemoradiation after surgery for newly diagnosed glioblastoma: A single-institution study with subgroup analysis according to the extent of tumor resection. World Neurosurg. 2019 Sep 27;: Authors: Ahn S, Park JS, Song JH, Jeun SS, Hong YK Abstract OBJECTIVE: Concomitant chemoradiation (CCRT) after surgical resection was established as standard care for patients
- Spinal epidural hematoma associated with epidural metastasis after minor trauma: a case report.Spinal epidural hematoma associated with epidural metastasis after minor trauma: a case report. World Neurosurg. 2019 Sep 27;: Authors: Maejima R, Aoyama M, Hara M, Miyachi S PMID: 31568906 [PubMed - as supplied by publisher]
- Traditional trial-and-error versus neuroanatomical-3D-image software-assisted deep brain stimulation programming in patients with Parkinson's disease.Traditional trial-and-error versus neuroanatomical-3D-image software-assisted deep brain stimulation programming in patients with Parkinson's disease. World Neurosurg. 2019 Sep 27;: Authors: Pavese N, Tai YF, Yousif N, Nandi D, Bain PG Abstract BACKGROUND: Programming Deep Brain Stimulation (DBS) settings in patients with Parkinson's disease (PD) is challenging and time consuming due to the vast numb
- Imaging Characteristics of a Hypervascular Pituitary Spindle Cell Oncocytoma on Magnetic Resonance Imaging and Digital Subtraction Angiography.Imaging Characteristics of a Hypervascular Pituitary Spindle Cell Oncocytoma on Magnetic Resonance Imaging and Digital Subtraction Angiography. World Neurosurg. 2019 Sep 27;: Authors: Li Y, Chen SH, Sheinberg D, Buttrick S, Levine CG, Bhatia RG, Lam BL, Pasol J, Ayala AR, Starke RM Abstract BACKGROUND: Spindle cell oncocytomas (SCO) are rare neuroendocrine tumors of the posterior pituitary that are o
- The Effectiveness of Ultrasonography in the Diagnosis of Spontaneous Hourglass-like Constriction of Peripheral Nerve in the Upper Extremity.The Effectiveness of Ultrasonography in the Diagnosis of Spontaneous Hourglass-like Constriction of Peripheral Nerve in the Upper Extremity. World Neurosurg. 2019 Sep 27;: Authors: Deng H, Lu B, Yin C, Xu Y, Ding Y, Mi Y, Xu P Abstract PURPOSE: To investigate the ultrasonographic characteristics in hourglass-like constriction of peripheral nerve in the upper extremity, and to evaluate the value of ul
- Proximal adjacent segment disease manifesting as retro-odontoid pseudotumour following fusion to C2.Proximal adjacent segment disease manifesting as retro-odontoid pseudotumour following fusion to C2. World Neurosurg. 2019 Sep 27;: Authors: Li Y, Levi A PMID: 31568901 [PubMed - as supplied by publisher]
- Quality of Life and Cost Implications of Pseudarthrosis after Anterior Cervical Discectomy and Fusion and its Subsequent Revision Surgery.Quality of Life and Cost Implications of Pseudarthrosis after Anterior Cervical Discectomy and Fusion and its Subsequent Revision Surgery. World Neurosurg. 2019 Sep 27;: Authors: Pennington Z, Mehta VA, Lubelski D, Elliott C, Miller JA, Benzel EC, Mroz TE Abstract BACKGROUND: More than 120,000 anterior cervical discectomy and fusions (ACDF) are performed annually. Pseudoarthrosis is a potential, dela
- Shifting frontiers in basic research on nicotine and tobacco products.Shifting frontiers in basic research on nicotine and tobacco products. Nicotine Tob Res. 2019 Sep 30;: Authors: Bruijnzeel AW PMID: 31566234 [PubMed - as supplied by publisher]
Molecular Carcinogenesis
- The role of polo‐like kinase 3 in the response of BRAF‐mutant cells to targeted anticancer therapiesAbstract The activation of oncogenic mitogen‐activated protein kinase cascade via mutations in BRAF is often observed in human melanomas. Targeted inhibitors of BRAF (BRAFi), alone or as a part of a combination therapy, offer a significant benefit to such patients. Unfortunately, some cases are initially nonresponsive to these drugs, while others become refractory in the course of treatment, underscoring the need to understand and mitigate the u
- Co-delivery of p53 and MDM2 inhibitor RG7388 using a hydroxyl terminal PAMAM dendrimer derivative for synergistic cancer therapy.Co-delivery of p53 and MDM2 inhibitor RG7388 using a hydroxyl terminal PAMAM dendrimer derivative for synergistic cancer therapy. Acta Biomater. 2019 Sep 27;: Authors: Chen K, Xin X, Qiu L, Li W, Guan G, Li G, Qiao M, Zhao X, Hu H, Chen D Abstract P53 inactivation is often achieved through gene mutation and the excessive activity of its major negative regulator, murine double minute 2 protein (MDM2).
- Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health.Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health. Cancer Med. 2019 Sep 30;: Authors: Rather RA, Bhagat M Abstract Cancer is a life-threatening disease afflicting human health worldwide. Recent advances in drug discovery infrastructure and molecular approaches have helped a lot in identifying the novel drug targets for therap
- Chelerythrine induces apoptosis via ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human renal cell carcinoma.Chelerythrine induces apoptosis via ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human renal cell carcinoma. J Cell Mol Med. 2019 Sep 30;: Authors: He H, Zhuo R, Dai J, Wang X, Huang X, Wang H, Xu D Abstract Renal cell carcinoma (RCC) is a heterogeneous histological disease and it is one of the most common kidney cancer. The treatment of RCC has been improved for the past few years
- Diverse roles for CDK-associated activity during spermatogenesis.Diverse roles for CDK-associated activity during spermatogenesis. FEBS Lett. 2019 Sep 30;: Authors: Palmer N, Talib SZA, Kaldis P Abstract The primary function of cyclin-dependent kinases (CDKs) in complex with their activating cyclin partners, is to promote mitotic division in somatic cells. This canonical cell cycle-associated activity is also crucial for fertility as it allows the proliferation an
- In Vitro Antitumor Evaluation of Some Hybrid Molecules Containing Coumarin and Quinolinone Moieties.In Vitro Antitumor Evaluation of Some Hybrid Molecules Containing Coumarin and Quinolinone Moieties. Anticancer Agents Med Chem. 2019 Sep 30;: Authors: Rizzk YW, El-Deen IM, Mohammed FZ, Abdelhamid MS, Khedr AIM Abstract BACKGROUND: Hybrid molecules furnished by merging two or more pharmacophores is an emerging concept in the field of medicinal chemistry and drug discovery. Currently, coumarin hybrid
- Synergistic Effect of Α-Solanine and Cisplatin Induces Apoptosis and Enhances Cell Cycle Arrest in Human Hepatocellular Carcinoma Cells.Synergistic Effect of Α-Solanine and Cisplatin Induces Apoptosis and Enhances Cell Cycle Arrest in Human Hepatocellular Carcinoma Cells. Anticancer Agents Med Chem. 2019 Sep 30;: Authors: El-Daly SM, Gouhar SA, Gamal-Eldeen AM, Abdel Hamid FF, Ashour MN, Hassan NS Abstract AIM: The clinical application of cisplatin is limited by severe side effects associated with high applied doses. The synergistic
- Synthesis, In Vitro Evaluation, Molecular Docking and DFT Studies of Some Phenyl Isothiocyanates as Anticancer Agents.Synthesis, In Vitro Evaluation, Molecular Docking and DFT Studies of Some Phenyl Isothiocyanates as Anticancer Agents. Anticancer Agents Med Chem. 2019 Sep 30;: Authors: Richa K, Karmaker R, Longkumer N, Das V, Bhuyan PJ, Pal M, Sinha UB Abstract BACKGROUND: Isothiocyanates (ITCs) are small molecules having importance in synthetic organic chemistry, but their actual importance lies in their potential
- Targeting EZH1/2 induces cell cycle arrest and inhibits cell proliferation through reactivation of p57CDKN1C and TP53INP1 in mantle cell lymphoma.Related ArticlesTargeting EZH1/2 induces cell cycle arrest and inhibits cell proliferation through reactivation of p57CDKN1C and TP53INP1 in mantle cell lymphoma. Cancer Biol Med. 2019 Aug;16(3):530-541 Authors: Li W, Bi C, Han Y, Tian T, Wang X, Bao H, Xu X, Zhang X, Liu L, Zhang W, Gao H, Wang H, Zhang H, Meng B, Wang X, Fu K Abstract Objective: To explore the effect of dysregulation of epigenetic
- The synergistic antileukemic effects of eltrombopag and decitabine in myeloid leukemia cells.Related ArticlesThe synergistic antileukemic effects of eltrombopag and decitabine in myeloid leukemia cells. Cancer Manag Res. 2019;11:8229-8238 Authors: Shi M, Xu F, Yang X, Bai Y, Niu J, Drokow EK, Chen M, Chen Y, Sun K Abstract Background: Hypomethylating agents (HMAs), such as decitabine (DAC), are currently used as first-line therapy for patients with high-risk myelodysplastic syndromes (MDS) a
- LncRNA XIST depletion prevents cancer progression in invasive pituitary neuroendocrine tumor by inhibiting bFGF via upregulation of microRNA-424-5p.Related ArticlesLncRNA XIST depletion prevents cancer progression in invasive pituitary neuroendocrine tumor by inhibiting bFGF via upregulation of microRNA-424-5p. Onco Targets Ther. 2019;12:7095-7109 Authors: Zhou K, Li S, Du G, Fan Y, Wu P, Sun H, Zhang T Abstract Background: Long noncoding RNAs (lncRNAs) are vital mediators in human cancers including pituitary neuroendocrine tumor (PitNET) and co
- Knockdown of STIM1 expression inhibits non-small-cell lung cancer cell proliferation in vitro and in nude mouse xenografts.Related ArticlesKnockdown of STIM1 expression inhibits non-small-cell lung cancer cell proliferation in vitro and in nude mouse xenografts. Bioengineered. 2019 Dec;10(1):425-436 Authors: Ge C, Zeng B, Li R, Li Z, Fu Q, Wang W, Wang Z, Dong S, Lai Z, Wang Y, Xue Y, Guo J, Di T, Song X Abstract Stromal interaction molecule 1 (STIM1) is a calcium-sensing protein localized in the membrane of the endoplas
- Polo-like kinase 1 inhibitor BI 6727 induces DNA damage and exerts strong antitumor activity in small cell lung cancer.Related ArticlesPolo-like kinase 1 inhibitor BI 6727 induces DNA damage and exerts strong antitumor activity in small cell lung cancer. Cancer Lett. 2018 11 01;436:1-9 Authors: Wang Y, Wu L, Yao Y, Lu G, Xu L, Zhou J Abstract The prognosis of small cell lung cancer (SCLC) is poor despite its good initial response to chemotherapy. Polo-like kinase 1 (PLK1) is a crucial mitotic regulator that is overex
- COPS2 Antagonizes OCT4 to Accelerate the G2/M Transition of Mouse Embryonic Stem Cells.Related ArticlesCOPS2 Antagonizes OCT4 to Accelerate the G2/M Transition of Mouse Embryonic Stem Cells. Stem Cell Reports. 2018 08 14;11(2):317-324 Authors: Li P, Ding N, Zhang W, Chen L Abstract Proper regulation of the cell cycle is essential to safeguard the genomic integrity of embryonic stem cells (ESCs) while maintaining the fast proliferation rate. The pluripotency factor OCT4 has been shown t
- DCZ3112, a novel Hsp90 inhibitor, exerts potent antitumor activity against HER2-positive breast cancer through disruption of Hsp90-Cdc37 interaction.Related ArticlesDCZ3112, a novel Hsp90 inhibitor, exerts potent antitumor activity against HER2-positive breast cancer through disruption of Hsp90-Cdc37 interaction. Cancer Lett. 2018 10 10;434:70-80 Authors: Chen X, Liu P, Wang Q, Li Y, Fu L, Fu H, Zhu J, Chen Z, Zhu W, Xie C, Lou L Abstract Hsp90 regulates the stability of oncoproteins important in tumor development and progression, and represents
- Atypical APC/C-dependent degradation of Mcl-1 provides an apoptotic timer during mitotic arrest.Related ArticlesAtypical APC/C-dependent degradation of Mcl-1 provides an apoptotic timer during mitotic arrest. EMBO J. 2018 09 03;37(17): Authors: Allan LA, Skowyra A, Rogers KI, Zeller D, Clarke PR Abstract The initiation of apoptosis in response to the disruption of mitosis provides surveillance against chromosome instability. Here, we show that proteolytic destruction of the key regulator Mcl-1
- G1/S Transcription Factor Copy Number Is a Growth-Dependent Determinant of Cell Cycle Commitment in Yeast.Related ArticlesG1/S Transcription Factor Copy Number Is a Growth-Dependent Determinant of Cell Cycle Commitment in Yeast. Cell Syst. 2018 05 23;6(5):539-554.e11 Authors: Dorsey S, Tollis S, Cheng J, Black L, Notley S, Tyers M, Royer CA Abstract To understand how commitment to cell division in late G1 phase (Start) is controlled by growth and nutrients in budding yeast, we determined the absolute con
- Interleukin-6 induced overexpression of valosin-containing protein (VCP)/p97 is associated with androgen-independent prostate cancer (AIPC) progression.Related ArticlesInterleukin-6 induced overexpression of valosin-containing protein (VCP)/p97 is associated with androgen-independent prostate cancer (AIPC) progression. J Cell Physiol. 2018 10;233(10):7148-7164 Authors: Duscharla D, Reddy Kami Reddy K, Dasari C, Bhukya S, Ummanni R Abstract Though Androgen deprivation therapy (ADT) is effective initially, numerous patients become resistant to it and
- Alendronate induces osteoclast precursor apoptosis via peroxisomal dysfunction mediated ER stress.Related ArticlesAlendronate induces osteoclast precursor apoptosis via peroxisomal dysfunction mediated ER stress. J Cell Physiol. 2018 09;233(9):7415-7423 Authors: Ding N, Liu C, Yao L, Bai Y, Cheng P, Li Z, Luo K, Mei T, Li J, Xing J, Gao X, Ma Q, Xu J, Luo F, Dou C Abstract Nitrogen-containing bisphosphonates including alendronate (ALN) are the current first line antiresorptive drug in treating os
- MicroRNA-421 suppresses the apoptosis and autophagy of hippocampal neurons in epilepsy mice model by inhibition of the TLR/MYD88 pathway.Related ArticlesMicroRNA-421 suppresses the apoptosis and autophagy of hippocampal neurons in epilepsy mice model by inhibition of the TLR/MYD88 pathway. J Cell Physiol. 2018 09;233(9):7022-7034 Authors: Wen X, Han XR, Wang YJ, Wang S, Shen M, Zhang ZF, Fan SH, Shan Q, Wang L, Li MQ, Hu B, Sun CH, Wu DM, Lu J, Zheng YL Abstract Epilepsy is a group of neurological disorders characterized by epileptic
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- Future Oncology; +41 new citations41 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2019/10/01PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
- Future Oncology; +41 new citations41 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2019/10/01PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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