Checkmate with checkpoint inhibitors: Hope and hype Jyoti Bajpai, Shubhada V Chiplunkar Indian Journal of Medical and Paediatric Oncology 2019 40(2):159-162

Teenage and young adult cancer: A low-hanging fruit or the final frontier? Colonel Prakash Chitalkar Indian Journal of Medical and Paediatric Oncology 2019 40(2):163-164

Peptide receptor radionuclide therapy in the management of neuroendocrine tumors (Neoplasms)*: Fundamentals and salient clinical practice points for medical oncologists Sandip Basu, Rahul Parghane, Rohit Ranade, Pradeep Thapa, Anant Ramaswamy, Vikas Ostwal, Bhawna Sirohi, Dipanjan Panda, Shailesh V Shrikhande Indian Journal of Medical and Paediatric Oncology 2019 40(2):165-171 This editorial commentary is an expert summary of “Peptide Receptor Radionuclide Therapy (PRRT),” encompassing the essential fundamentals and salient clinical practice points, deliberated and designed in a point-wise manner with theme-based subheadings. Emphasis has been laid on the topics of practical relevance to the referring oncologists with relevant finer points where necessary. A part of the presented overview has been generated from the authors' own practical experience of more than 3500 successful therapies delivered over the last 9 years at a large tertiary care PRRT setting by the joint efforts of Radiation Medicine Centre (RMC), Bhabha Atomic Research Centre (BARC), and Gastrointestinal services of Tata Memorial Hospital (TMH) at the TMH-RMC premises. While the technical indigenization is beyond the scope of this treatise, we must mention here that India had been one of the frontrunners in this treatment modality, and the PRRT services in this country were developed purely as an indigenous effort right from the production of the radionuclide (177-Lutetium) at the reactor and radiolabeling and production of the radiopharmaceutical (177Lu-DOTATATE) by the radiopharmaceutical scientists at the BARC and RMC; such an endeavor allowed this very specialized therapy to be delivered at a very affordable cost in our setting which could be viewed as a major societal contribution of the atomic energy research in this country.

Parasitic infections and cancer: A status report Sora Yasri, Viroj Wiwanitkit Indian Journal of Medical and Paediatric Oncology 2019 40(2):172-174 There are many tropical parasitic infections that are still present public health problem in tropical medicine. Of interest, some diseases are proved for the relationship with carcinogenesis. Many cancers are proved for the etiopathogenesis due to parasitic infections. The well-known tropical parasitic infections that can induce carcinogenesis are opisthorchiasis, clonorchiasis, and schistosomiasis. To prevent parasitic infection related cancer is an important consideration in clinical oncology. The standard practice is the prevention of the infection, but the hope is the development of the new vaccines for cancer prevention. Here, the authors briefly review on the current status on the cancer vaccines against the three important tropical diseases that can result in cancers, opisthorchiasis, clonorchiasis, and schistosomiasis.

Knowledge, attitudes, and beliefs about breast cancer and barriers to breast self-examination among sikkimese women Leima Chanu Shakti Yambem, Hafizur Rahman Indian Journal of Medical and Paediatric Oncology 2019 40(2):175-181 Objectives: The objectives of this study are to assess women's awareness on breast cancer; and their awareness, attitudes, and barriers to practice of breast self-examination (BSE). Methodology: This cross-sectional study was conducted from May 1, 2015 to June 30, 2015, involving 302 women between 18 and 65 years of age attending the Outpatient Department of Central Referral Hospital, Gangtok. Face-to-face semi-structured questionnaire-based interview was conducted among the participant women, after taking their written consent. Results: Three-fourths of the participants were aware of breast cancer. Eighty percent of the women who had heard about breast cancer were not aware of its risk factors. Forty-six percent of the participants were aware of BSE. Most common source of knowledge was from health professionals. Of the 138 women who were aware of BSE, 41.3% ever practiced BSE. Majority had started BSE between 21 and 45 years of age. Thirty-seven percent of the participants practiced BSE once in a year. Working women and students were found to be twice more likely to practice BSE compared to homemakers. Similarly, women belonging to lower socioeconomic status were 70% less likely to practice BSE than women of affluent class. Conclusions: Knowledge of the breast cancer and BSE practices is poor among indexed Sikkimese reproductive women attending tertiary hospital of Sikkim. There is an urgent need for information on the airwaves and in print, and for education at health centers on warning symptoms of breast cancer and various methods of screening for breast cancer including BSE.

Procedural pain in lumbar punctures and the impact of preparation in pediatric cancer patients Sudha Sinha, Magdalena Marczak, Jean Jacob, Gayatri Palat, Eva Brun, Thomas Wiebe, Tommy Schyman, Mikael Segerlantz Indian Journal of Medical and Paediatric Oncology 2019 40(2):182-192 Aim: Childhood cancer patients are subjected to recurring painful medical procedures. In low- and middle-income countries (LMIC), where the majority of the world's childhood cancer patients live, pain management is often unsatisfactory due to limited resources. This study aimed to evaluate the possibility of conducting a preprocedural preparation for lumbar punctures (LPs) at a pediatric oncology unit in a LMIC and to assess whether this intervention would decrease procedural pain and fear. Methods: Patients aged 5–18 who underwent LPs between February 25, 2017, and April 12, 2017, were eligible and invited to participate. Included patients were interviewed to assess the procedural pain and fear in conjunction with the LP and the patients' understanding of why an LP was done. Closest caregivers and the medical staff were interviewed to compare the perceptions of pain. The study was conducted in two separate phases; patients included in the period of February 25–March 9 underwent LP according to routines without preparation while patients included in the period of March 10–April 12 received procedural preparation with information. Results from the interviews from the two study groups were compared. Results: Out of 79 patients who met the inclusion criteria, 76 were included and preparation was successfully implemented for 25 of them. The pain decreased significantly (P = 0.022) after preparation. The physicians underestimated the patients' pain (P < 0.0001). The understanding of the reason for the LP increased significantly among patients (P = 0.0081) and their caregivers (P < 0.0001). Conclusions: Preparation by preprocedural information, created to fit the situation at a state-run hospital in a LMIC, is feasible and efficient.

The knowledge, attitude, and practice regarding pap smear, cervical cancer, and human papillomavirus among women attending a mother and child health clinic in Kuantan, Malaysia Tg Faten Nurjihan Tg Abdul Rahman, Nor Azlina A. Rahman, Mohd Affendi Mohd Shafri, Mainul Haque Indian Journal of Medical and Paediatric Oncology 2019 40(2):193-200 Background: Cervical cancer (CC) is a foremost reason of global cancer death in women, and a good portion remains with the developing countries. This study was conducted to assess the knowledge, attitude, and practice regarding Pap smear, CC, and Human Papillomavirus (HPV) among the women attending a Mother and Child Health Clinic in Kuantan, Malaysia. Materials and Methods: A total of 120 respondents involved in this cross-sectional study. The convenience sampling was to select the respondents. The data were collected from in 2013. Results: The mean age 32.19 years. Up to 54.2% of respondents never had Pap smear in the past 5 years, while over 67.5% of respondents never had HPV vaccination. There was a significant correlation between knowledge with attitude (P < 0.001) and attitude with practice (P < 0.001) regarding Pap smear, CC, and HPV. However, knowledge and practice regarding Pap smear, CC, and HPV was not significantly correlated (P = 0.525). There was no significant correlation between mean age and knowledge (P = 0.455) while there was a significant correlation between mean age with attitude (P = 0.011) and practice (P < 0.001) regarding Pap smear, CC, and HPV. It was also shown that there were differences between races in term of knowledge and attitude (P < 0.05). However, there was no significant difference in term of practice regarding Pap smear, CC, and HPV (P > 0.05) between races. Conclusions: Important barriers to Pap smear screening among women are highlighted through this study. The health institution involved needs to come up with better strategies to deal with these barriers to improve the awareness of women regarding Pap smear, CC, and HPV.

Correlation of gleason grading and prognostic immunohistochemistry markers (human epidermal growth factor receptor 2/neu and androgen receptor) in prostatic core needle biopsy: A study in a tertiary care center Utsha Senapati, Moumita Sengupta, Chhanda Datta, Uttara Chatterjee, Dilip Kumar Pal, Diya Das, Piyali Poddar Indian Journal of Medical and Paediatric Oncology 2019 40(2):201-207 Background: Worldwide prostate cancer is the most common cause of cancer and the second leading cause of cancer death among men. Transrectal ultrasound-guided core needle biopsies are the diagnostic modalities which help in proper categorization and grading of prostatic carcinoma, thus facilitating individualized treatment. These biopsies are the primary source for performance of additional diagnostic immunohistochemical testing for basal cell-associated markers to rule out the morphological mimicker and prognostic markers such as androgen receptor (AR) and human epidermal growth factor receptor 2 (HER2)/neu. Materials and Methods: A prospective, observational study was conducted in the department of pathology in collaboration with department of urosurgery of a tertiary care hospital. One hundred and nineteen patients diagnosed with prostatic nodules were included in this study. Values of serum prostate-specific antigen were recorded. Tissue for histopathological study was obtained in the form of core needle biopsy, and Gleason grade was calculated in all malignant cases. Immunohistochemistry for p63 and alpha-methylacyl-CoA racemase was performed as an additional test in premalignant cases. Prognostication of the prostate cancer cases was done using AR and HER2/neu. Results: A total of 119 cases aged between 20 and 90 years were included in this study. Malignant lesions reveal an increase in the percentage of AR staining in comparison to the benign glandular structure. The Gleason score with higher value (8–9) showed increased expression of HER2/neu receptor. Conclusion: Critical histopathological analysis of core needle biopsy along with immunohistochemical evaluation maximizes the diagnostic accuracy in prostate cancer cases and also helps in prognosis assessment.

Docetaxel-induced lung injury: An under-recognized complication of a commonly used chemotherapeutic agent Avaronnan Manuprasad, Prasanth Ganesan, Vandana Mahajan, Trivadi S Ganesan, Venkatraman Radhakrishnan, Manikandan Dhanushkodi, Tenali Gnana Sagar Indian Journal of Medical and Paediatric Oncology 2019 40(2):208-211 Background: Docetaxel-induced pneumonitis is a rare, but potentially serious complication of a commonly used chemotherapeutic agent. Methods: We performed an audit of patients with suspected docetaxel pneumonitis from the tertiary cancer center. Results: Out of 477 patients who received docetaxel over a 1 year period, eight patients (1.7%) developed lung injury. All patients (median age: 43 years [34–65]) had breast cancer (four metastatic on palliative docetaxel, two were on neoadjuvant, and two were on adjuvant therapy) and had received a median of three cycles of docetaxel 75 mg/m2 in a 3 weekly schedule (7 as single agent and 1 in combination with cyclophosphamide). One patient had the preexisting pulmonary disease (localized bronchiectasis), and four had received prior radiation to the chest wall or dorsal spine. The median time from administration of the last dose was 16 days (8–28). Most (n = 6/8, 75%) required hospitalization. Three patients with CTCAE Grade 3 pneumonitis required oxygen support. Radiology showed a pattern of interstitial pneumonitis in most patients. All the patients responded to steroids and follow-up imaging showed resolution of infiltrates. The median duration of hospital stay was 8.5 days (7–18 days). There was no mortality due to this condition. Conclusions: Drug-induced lung injury should be considered in patients presenting with respiratory symptoms after administration of docetaxel. Timely initiation of steroids could reduce complications.

Eosinophil density in common benign and malignant salivary gland tumors with congo red staining Safoura Seifi, Zahra Azizi, Alten Ghanghermeh, Shahriar Eftekharian, Jahanshah Salehinejad, Hemmat Gholinia Indian Journal of Medical and Paediatric Oncology 2019 40(2):212-216 Purpose: Eosinophils are multifunctional leukocytes with unknown mechanisms in salivary gland tumors. Some researchers associate eosinophils with tumor progression and others have proposed them as antitumoral. The present study was conducted to compare the density of eosinophils in common salivary gland tumors and its relationship with the degree of differentiation in malignant salivary gland tumors. Materials and Methods: In this present descriptive-analytical, cross-sectional study, 15 cases of pleomorphic adenoma, 15 cases of adenoid cystic carcinoma (ACC), 30 cases of mucoepidermoid carcinoma (MEC), and 5 cases of normal salivary glands were extracted. Sections were prepared of these cases for Congo red staining. The malignant salivary gland tumors were classified as high-grade and low-grade malignancies. The slides were observed under ×10, and the highest-density areas were selected and counted in ten microscopic fields under ×40. Results: The density of the eosinophils was 4.5 ± 5.6 in the pleomorphic adenoma, 16.2 ± 6.01 in the low-grade MEC, 1.05 ± 1.1 in the high-grade MEC (Grade III), and the ACC, and 0.4 ± 0.89 in the normal salivary gland. Eosinophil density was significantly higher in low-grade malignancies compared to in benign or high-grade malignant neoplasms and normal salivary gland (P < 0.001). Conclusion: This is suggested which the density of eosinophils is associated with the process of tumorigenesis and the degree of malignancy in malignant salivary gland tumors.