Does Repeated Painful Stimuli Change Cerebral Near-infrared Spectroscopy Response in Healthy Term Large for Gestational Age Newborns? Objective: To evaluate the effect of repeated painful stimuli on short-term pain response in healthy, term, large for gestational age (LGA) newborns by measuring the regional cerebral oxygen saturation (rScO2), behavioral and physiological responses. Methods: We compared term LGA infants who received repeated painful stimuli (study group) to term, appropriate for gestational age (AGA) infants (control group). A pulse oximeter and a near-infrared spectroscopy probes were connected to babies during the study period and babies were recorded by video, from which the crying time, and Neonatal Infant Pain Scale (NIPS), were obtained. The heart rate (HR), peripheral oxygen saturation (SpO2) and rScO2 data were sampled every 1 second and exported to a personal computer via digital output during the study period. The maximum HR, the minimum SpO2, peak, baseline and mean rScO2 measurements following skin puncture were recorded. Data was compared within one group and between the two groups. Results: After the heel prick, crying time (P<0.001) and NIPS scores (P=0.024) increased and SpO2 levels decreased significantly (P=0.012) in the study group versus the control group. Although mean rScO2 increased significantly within one group (P<0.001), it was not significant between the two groups. The percent change in rScO2 was greater in the study group [5.2 (2.5-9.3)] compared to the control group [2.8(1.1-8.2), P=0.037)]. Conclusion: We showed that rScO2 values changed significantly within the first few days of life in babies who received more painful stimuli compared to the control group, similar to behavioral and physiological responses. Abbrevations: AGA, (appropriate for gestational age); LGA, (large for gestational age); NIPS, (neonatal infant pain scale); NIRS, (near-infrared spectroscopy); rScO2, (regional cerebral oxygen saturation); SpO2, (peripheral oxygen saturation). Funding: The authors have no funding to declare. Acknowledgement: We would like to thank Professor Dilsat Save for helping us with the statistical analysis. Conflicts of Interest: The authors have no conflict of interests to declare. Reprints: Hulya Ozdemir, MD, in Neonatology, Department of Pediatrics, Division of Neonatology, Marmara University Faculty of Medicine, Fevzi Cakmak Mah. Sinan Cad. No:41 Ust Kaynarca Pendik, Istanbul,Turkey (e-mail: hulyazeynep@yahoo.com). Received January 3, 2019 Received in revised form August 27, 2019 Accepted September 30, 2019 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Interpersonal Dyadic Influences of Pain Catastrophizing Between Caregivers and Children with Chronic Pain Objectives: Pain catastrophizing is an important predictor of pain-related outcomes. Caregiver and child levels of catastrophizing about child chronic pain are associated cross-sectionally, yet predictive associations testing interpersonal influences within caregiver-child dyads are lacking. The present study tested caregiver and child influences on partner catastrophizing about child pain over 1 month following initiation of interdisciplinary pain treatment and examined whether change in pain catastrophizing was associated with child pain interference. Methods: 113 caregiver-child dyads (Mage=14.41) completed measures at the time of initiating care at a pediatric tertiary outpatient pain management clinic (baseline) and approximately 1 month later. Caregivers and children independently reported on catastrophizing about child pain and child pain interference at baseline and 1 month follow up. Results: Caregiver and child pain catastrophizing decreased over 1 month following initial interdisciplinary pain evaluation, with average scores remaining in the moderate to high range. Change in caregiver, but not child, catastrophizing about child pain was predicted by partner baseline pain catastrophizing. Decreases in catastrophizing about child pain were associated with within person improvement in ratings of child pain interference. Discussion: In the short period following initial pain evaluation, caregivers and children evidenced reductions in pain catastrophizing, which were associated with increased child function. Findings highlight the important role of child cognitive-affective responses to pain in influencing caregiver catastrophizing about child pain. Understanding the individual contributions children and caregivers make to interpersonal pain processes will inform future family-level clinical interventions. Funding: This investigation was supported by funding from the William and Gretchen Kimball Endowment for Pediatric Pain Management. Conflicts: None reported. Reprints: Delana Parker, PhD, Department of Anesthesiology, Perioperative & Pain Medicine, Stanford University, School of Medicine (e-mail: dmparker@ucla.edu). Received March 6, 2019 Received in revised form July 31, 2019 Accepted September 20, 2019 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Parental Proxy PROMIS Pain Interference Scores are only Modestly Concordant with their Child’s Scores: An Effect of Child Catastrophizing Objectives: Pediatric patients with chronic musculoskeletal conditions such as idiopathic scoliosis awaiting surgical correction can experience pain that interferes with their daily functioning. Reports of this interference are commonly gathered from patients through the Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference Scale and through parent-proxy scores. However, the child and parent/caregiver reports vary. In order to provide appropriate treatment for young patients with pain, the nature of the discrepancies and under which circumstances the reports differ needs to be understood. This report offers new information on the level of concordance among parent and child report of pain interference within this patient population, and which parent and child characteristics may influence concordance rates. Methods: Patients (age=10-17▒y) with a history of musculoskeletal disorders, including idiopathic scoliosis, under consideration for surgical correction of that scoliosis and parent/caregiver dyads (n=103) completed the PROMIS Pain Interference Scale during an orthopedic pre-surgical visit. The current data was taken from a larger study examining post-surgical pain among patients undergoing orthopedic surgical procedures to correct scoliosis. The purpose of the current study was to measure the degree of agreement between parent and child reports of pain interference and discovery of relationships among predictors of pain interference score correspondence among dyads. Results: Correspondence between parent/caregiver and child reports of pain interference was modest (Intra-class correlation=0.530). 46% of dyads had similar pain interference scores, while 24% of parents reported higher pain interference in comparison to their child, the remaining 30% reported lower pain interference in relation to their child’s report. Among patients where discrepancies appeared, using logistic regression models, only child catastrophizing scores were associated with differences in parent and child estimation of child’s pain interference scores. No parental characteristics predicted discrepancies between dyad pain interference reports. Discussion: Parent-proxy and child reports generally correspond, but when discrepant, 24% of parents reported higher pain interference in relationship to the child report of pain interference and 31% noted less intense pain interference than their child’s pain interference. Given these results, care should be taken when interpreting parent reports of child pain interference, especially when a child reports higher degrees of pain interference. Institutional Review Board Approval obtained from the Institutional Review Boards of the University of Michigan Medical School (IRBMED); 2800 Plymouth Road, Building 520, Room 3214, Ann Arbor, MI 48109-2800; Phone: 734-763-4768; Approval ID: HUM00086972. Funding and Disclosures: No external funding supported this work and no conflicts of interest. Reprints: Eric L. Scott, PhD, Department of Pediatrics, D2234 MPB, 1500 East Medical Ctr. Dr., SPC 5718, Ann Arbor, MI 48109-5718 (e-mail: erlscott@med.umich.edu). Received February 4, 2019 Received in revised form September 10, 2019 Accepted September 30, 2019 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Electrocatheter-mediated High-voltage Pulsed Radiofrequency of the Dorsal Root Ganglion in the Treatment of Chronic Lumbosacral Neuropathic Pain: A Randomized Controlled Study Objectives: Despite the interest in scientific community, there is still poor evidence about pulsed radiofrequency efficacy in the treatment of neuropathic pain. In order to determine if high-voltage pulsed radiofrequency plus adhesiolysis (PRF-EA) showed better results than epidural adhesiolysis alone (EA), a randomized, double-blind, comparative-effectiveness study was conducted in patients with chronic lumbosacral radiating pain and neuropathic features. Methods: 41 patients were randomly allocated to two groups. Twenty-one subjects were randomized to receive 2 cycles of 240 seconds high-voltage pulsed radiofrequency followed by the injection of local anaesthetics, hyaluronidase and betamethasone, whereas 20 subjects underwent sham stimulation followed by adhesiolysis. The treatment was delivered at the affected lumbosacral roots and patients, treating physicians and assessors were blinded to intervention. Results: A significant reduction of radiating pain was observed in mean numeric rating scale (NRS) score at follow-up. A change of −3.43 versus −1.75 (P=0.031) after 1 month and −3.34 versus −0.80 (P=0.005) after 6 months was reported in patients undergoing PRF-EA in comparison with EA, respectively. After one month, 57% of patients in the PRF-EA group experienced a pain reduction of 50% or greater versus only 25% of patients allocated to EA (P=0.037). Improvement decreased to 48% in the PRF-EA group whereas only 10% of EA reported significant pain relief after six months (P=0.008). Discussion: High-voltage pulsed radiofrequency of dorsal root ganglion delivered through multifunctional electrode provided significant pain relief and may be considered a valuable treatment in chronic lumbosacral radicular pain with neuropathic features. The authors declare no conflict of interest. Reprints: Simone Vigneri, MD, PhD, Santa Maria Maddalena Hospital, Pain Medicine Unit, Occhiobello (RO), Italy, Department of Experimental Biomedicine and Clinical Neurosciences (BioNeC), University of Palermo, Italy (e-mail: simone.vigneri@gmail.com, simone.vigneri@unipa.it). Received March 6, 2019 Received in revised form August 21, 2019 Accepted September 8, 2019 This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

A MAPP Network Case-Control Study of Urologic Chronic Pelvic Pain Compared with Non-Urologic Pain Conditions Objectives: Limited research suggests commonalities between urologic chronic pelvic pain syndromes (UCPPS) and other non-urologic chronic overlapping pain conditions (COPCs) including fibromyalgia, chronic fatigue syndrome, and irritable bowel syndrome. The goal of this case-control study was to examine similarities and differences between UCPPS and these other COPCs. Methods: As part of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network, we examined 1,039 individuals with UCPPS (n=424), non-urologic COPCs (n=200), and healthy controls (n=415). Validated standardized measures were used to assess urological symptoms, non-urological pain symptoms, and psychosocial symptoms and traits. Results: Participants with UCPPS had more urologic symptoms than non-urologic COPCs or healthy controls (P<0.001); non-urological COPC group also had significantly worse urological symptoms than healthy controls (P<0.001). Participants with non-urological COPCs reported more widespread pain than those with UCPPS (P<0.001), yet both groups had similarly increased symptoms of anxiety, depression, negative affect, perceived stress, neuroticism, and lower levels of extraversion than healthy controls (P<0.001). Participants with UCPPS with and without COPCs reported more catastrophizing than those with non-urological COPCs (P<0.001). Discussion: Findings are consistent with the hypothesis of common underlying biopsychosocial mechanisms and can guide the comprehensive assessment and treatment of these conditions regardless of the primary site of pain or diagnosis. Heightened catastrophizing in UCPPS should be examined to inform psychosocial interventions and improve patient care. Acronyms: CFS, chronic fatigue syndrome; CMSI, Complex Multi-Symptom Inventory; COPCs, chronic overlapping pain conditions; CP/CPPS, chronic prostatitis/chronic pelvic pain syndrome; FM, fibromyalgia; HC, healthy control; IBS, irritable bowel syndrome; IC/BPS, interstitial cystitis/bladder pain syndrome; MAPP, Multidisciplinary Approach to Chronic Pelvic Pain; NIDDK, National Institute of Diabetes and Digestive and Kidney Diseases; UCPPS, urological chronic pelvic pain syndrome Conflicts of Interest and Source of Funding: None of the authors have any conflicts of interest to declare. All authors have approved the final article. This research was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Multidisciplinary Approach to Chronic Pelvic Pain (MAPP) Research Network grants DK82370, DK82342, DK82315, DK82344, DK82325, DK82345, DK82333, and DK82316. Reprints: Niloofar Afari, PhD, 9500 Gilman Drive, 0737, La Jolla, CA 92093 (e-mail: nafari@ucsd.edu). Received March 31, 2019 Received in revised form September 8, 2019 Accepted September 11, 2019 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Increasing Parental Access to Pediatric Pain-Related Knowledge: A Systematic Review of Knowledge Translation Research Among Parents Objectives: Parents can play an integral role in managing their child’s pain, yet many parents remain unaware of evidence-based strategies to support their child during painful experiences. Recent advances in Knowledge Translation (KT) research, which include dissemination and implementation studies, have resulted in programs geared towards parents to offset this knowledge gap. The nature of these programs and degree to which parents find them useful remains unclear. Our goal was to systematically review programs aimed as disseminating and implementing evidence-based pain-related knowledge to parents. Methods: Systematic searches of PubMed, Web of Science, CINAHL, and PsycInfo were completed. Articles in which information was disseminated to parents with the goal of assessing dissemination and implementation outcomes were retained. Information was extracted to identify study characteristics, primary outcomes, and quality of evidence. Results: A total of 24,291 abstracts were screened and 12 articles describing programs were retained. Programs were positively rated by parents in terms of the appropriateness of formats selected, presentation of information, and helpfulness of content. The majority of research has been focused in the area of procedural pain among infants. Although several implementation domains are reported by researchers, certain areas have been overlooked to date, including cost and sustainability of programs. The majority of reports presented with methodological limitations and bias. Discussion: Knowledge translation research in pediatric pain is in its infancy. Development of theories and guidelines to increase the utility and quality of evidence are needed. Conflict of Interest and Sources of Funding: No conflicts of interest are declared. No sources of funding were provided for this project. Reprints: Michelle M. Gagnon, PhD, Department of Psychology, University of Saskatchewan, 9 Campus Drive, Room 164, Saskatoon, SK, Canada (e-mail: michelle.gagnon@usask.ca). Received September 26, 2018 Received in revised form September 5, 2019 Accepted September 11, 2019 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Pre-treatment Exercise-induced Hypoalgesia is Associated with Change in Pain and Function after Standardized Exercise Therapy in Painful Knee Osteoarthritis Objectives: Exercise-induced hypoalgesia (EIH), a measure of descending pain inhibitory control, has been found hyperalgesic in subgroups of painful knee osteoarthritis (KOA) patients. The effect of standardized exercise therapy (ET) on clinical pain intensity in KOA has been demonstrated. However, the prognostic value of EIH in KOA patients completing an ET program has not been investigated. This study investigated the prognostic value of EIH on pain relief following ET in KOA patients. Methods: In 24 painful KOA patients (numeric rating scale [NRS, 0-10] ≥3), EIH was assessed as change in pressure pain threshold (PPT) after 2-minute “lateral raises” (2MLR) before and after ET in this observational study. In addition, temporal summation of pain (TSP), clinical pain scores (NRS, Knee injury and Osteoarthritis Outcome Score [KOOS] and PainDETECT [PDQ]) were assessed before and after ET. The KOOS-4 is defined by the KOOS subscale scores for Pain, Symptoms, Activities of daily living, and Quality-of-life and was used as primary outcome. Results: Following ET, all clinical pain scores improved (P<0.01) but no changes in PPT, TSP or EIH were found (P>0.05). Linear regression models identified pre-treatment EIH (beta=0.59, P<0.005) and PDQ (beta=0.57, P<0.005) as independent factors for relative change in KOOS-4 after ET (adjusted R2=46.8%). Discussion: These preliminary and exploratory results suggest that patients with a high EIH response prior to a standardized ET program may be associated with large improvement in pain after treatment. This measure may potentially help clinicians as a prognostic tool for outcome prediction following ET in KOA patients. Conflicts of Interest and Source of Funding: Kristian Kjær Petersen is supported by The Aalborg University Talent Management Program (j.no. 771126). Center for Neuroplasticity and Pain (CNAP) is supported by the Danish National Research Foundation (DNRF121). None of the authors have conflicts of interest to declare. Reprints: Kristian Kjær Petersen, PhD, MSc, SMI, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Frederik Bajers Vej 7 D3, DK-9220 Aalborg, Denmark (e-mail: KKP@HST.AAU.DK). Received May 22, 2019 Received in revised form September 10, 2019 Accepted September 17, 2019 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Superior Hypogastric Plexus Blocks for Postoperative Pain Management in Abdominal Hysterectomies Objective: To evaluate the efficacy of intraoperative superior hypogastric plexus (SHP) blocks on postoperative pain management in abdominal hysterectomies. Methods: A total of 78 female ASA I-II patients who underwent elective total abdominal hysterectomy for benign reasons were assessed for eligibility. After exclusion of patients who did not fulfil the inclusion criteria, 60 patients were evaluated in 2 groups: patients who had intraoperative SHP block (SHP; n=30), and patients who did not have intraoperative SHP block (No-SHP; n=30). Results: There was no statistically significant difference between the 2 groups in demographic attributes, surgical duration, and length of hospital stay. Opioid requirements in both the post-anaesthesia care unit and gynaecology ward, and non-steroidal anti-inflammatory drug requirements in the ward were statistically significantly higher in the No-SHP group (P<0.05). Rescue analgesic times were found to be significantly longer in the SHP group (627±352.9▒min) (P<0.05). All VAS score assessments were found to be statistically significantly low in the SHP group (P<0.05). No complications related to the SHP blocks were observed. Conclusions: Intraoperative superior hypogastric plexus blocks in abdominal hysterectomies are promising methods for acute postoperative pain management as part of a multimodal analgesia regimen. Although single superior hypogastric plexus blocks provide adequate pain relief and reduce analgesic consumption, these blocks would have better results when used together with somatic nerve blocks, including abdominal wall blocks or wound site infiltrations. Clinical trial registration: NCT03428152. Ahmet Kale and Gulfem Basol: New affiliation: Department of Gynaecology and Obstetrics; University of Health Sciences, Kartal Training and Research Hospital, Istanbul, Turkey. Conflicts of interest: None declared. Funding: None declared. Authors’ contributions and authorship: H.G.A., A.K., G.B., and C.B.: Study design and data analysis; H.G.A., A.K., B.S., and G.B.: Patient recruitment, and data collection; H.G.A., C.B., and T.C. writing up of the first draft of the paper. Conflict of interest: The authors have no conflict of interest. Reprints: Hande Gurbuz Aytuluk, MD, Department of Anaesthesiology and Reanimation; Derince Training and Research Hospital, 41900, Kocaeli, Turkey (e-mail: handegrbz@gmail.com). Received May 8, 2019 Received in revised form August 22, 2019 Accepted September 8, 2019 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Less Severe Preoperative Synovitis is Associated with Higher Self-reported Pain Intensity 12 Months After Total Knee Arthroplasty – An Exploratory Prospective Observational Study Objectives: Synovitis is one of the possible pain generators in osteoarthritis (OA) and associated with upregulation of pro-inflammatory cytokines, which can lead to worsening of the postoperative pain. This explorative study aimed to investigate the association between perioperative synovitis and self-reported pain 12-months after total knee arthroplasty (TKA) in patients with OA. Methods: Twenty-six knee OA patients were included in this analysis. Perioperative volume of synovitis in predefined locations was assessed by contrast enhanced magnetic resonance imaging (CE-MRI) and dynamic CE-MRI (DCE-MRI). Perioperative synovitis was assessed histologically from biopsies of the synovium. Highest pain intensity within the last 24-hours (visual analog scale, VAS, 0-100) was assessed before and 12-months after TKA. Patients were divided into a low-pain intensity (VAS≤30) and a high-pain intensity (VAS>30) group based on 12-months postoperative VAS. Results: The high-pain intensity group had significantly lower perioperative CE-synovitis (P=0.025), DCE-synovitis (P<0.04) and a trend towards lower histologically assessed synovitis (P=0.077) compared to the low-pain intensity group. Perioperative synovitis scores were inversely correlated with pain intensity 12-months after TKA (P<0.05), indicating that more severe perioperative synovitis is associated with less severe pain intensity at 12-months. Discussion: Higher degrees of perioperative synovitis scores are found to be associated with less postoperative pain 12-months after TKA. Further, correlation analysis revealed that less severe perioperative CE-MRI and DCE-MRI synovitis was associated with higher pain intensity 12-months after TKA, suggesting that CE and DCE-MRI synovitis grades could be used as imaging markers for prediction of chronic postoperative pain after TKA. Original Paper for: Clinical Journal of Pain. Article Type: Clinical/Basic science research report. The authors declare no conflict of interest. Reprints: Kristian Kjær Petersen, PhD, MSc, Center for Neuroplasticity and Pain (CNAP), Center for Sensory Motor Interaction (SMI), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Fredrik Bajers Vej 7 D3, DK-9220 Aalborg, Denmark (e-mail: KKP@HST.AAU.DK). Received March 12, 2019 Received in revised form August 8, 2019 Accepted September 8, 2019 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

The Impact of Emotional Regulation Strategies On Pain Catastrophizing in the Context of Interpersonal Relationships Objectives: The Communal Coping Model suggests that pain catastrophizing may serve to elicit support from others. What is not known is how emotional regulation, namely emotional inhibition, impacts pain catastrophizing within the context of an interpersonal relationship. Individuals who have a greater tendency to emotionally inhibit may have a greater likelihood to use catastrophizing as a means for seeking support, particularly in relationships characterized by satisfaction and emotional validation. Methods: Data were collected from 50 undergraduate couples at the University of Michigan-Dearborn. Participants were videotaped during completion of an acute pain cold pressor task and completed measures involving pain catastrophizing, emotional inhibition, and relationship dynamics (i.e. AEQ, WBSI, DAS). In addition, the videotaped interactions were coded for both invalidation/validation and overt expressions of pain catastrophizing. Results: Emotional inhibition, and both validation and invalidation, were associated with pain catastrophizing. Observed validation and invalidation were not, however, directly associated with relationship satisfaction. Hierarchical linear regression showed a significant interaction between thought suppression and relationship satisfaction to predict pain catastrophizing. Discussion: Results show relationship satisfaction moderates the association between pain catastrophizing and thought suppression in a manner in which couples with high levels of relationship satisfaction who also engage in thought suppression are more likely to use pain catastrophizing as a cognitive strategy to elicit support. This study offers direction into treatment, and suggests that couples based cognitive-behavioral treatments that aim to utilize adaptive cognitive and behavioral coping strategies as well as emotional exploration and validation may be beneficial. The authors declare no conflict of interest. Reprints: Michelle Leonard, PhD, Department of Behavioral Sciences, University of Michigan-Dearborn, 4901 Evergreen Road, Dearborn, MI 48128 (e-mail: mtleon@umich.edu). Received December 5, 2018 Received in revised form July 25, 2019 Accepted August 30, 2019 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.