ABSTRACT Peters anomaly (PA) is a congenital corneal opacity associated with corneo‐lenticular attachments. PA can be isolated or part of a syndrome with most cases remaining genetically unsolved. Exome sequencing of a trio with syndromic PA and 145 additional unexplained probands with developmental ocular conditions identified a de novo splicing and three novel missense heterozygous CDH2 variants affecting the extracellular cadherin domains in four individuals with PA. Syndromic anomalies...
Thu Oct 24, 2019 20:18
Thu Oct 24, 2019 11:33
The habits of a needle-toothed tetrapod which lived more than 370 million years ago have filled in a piece of the evolutionary puzzle after an international team of palaeontologists pieced together fossilized skeletons and found unusual characteristics such as a crocodile-like skull with high positioned eyes would have been used to 'keep an eye' on prey before it used its slender needle-like teeth and elastic jaw to snatch its kill and crush it to death.
Thu Oct 24, 2019 17:58
Birds come in an astounding array of shapes and colors. New research helps explain why bird species with similar flight styles or body sizes don't have consistent wing shapes. Bird species tend to reshape the range of motion of their wings -- rather than wing shape or size itself -- as they evolve new ways of flying.
Thu Oct 24, 2019 16:36
Soft Robotics, Ahead of Print.
Thu Oct 24, 2019 10:00
Summary Background Esophageal cancer is a very common malignant tumor in China, especially esophageal squamous cell carcinoma (ESCC), but there is currently no effective treatment for patients after first-line chemotherapy failure. Apatinib has shown promising outcomes in treatment with various solid tumors. Objectives To evaluate the clinical efficacy and safety of apatinib combined with S-1 in the treatment of advanced ESCC patients after first-line chemotherapy failure. Methods...
Thu Oct 24, 2019 03:00
Summary Epithelial ovarian cancer (EOC) accounts for nearly 90% of all ovarian malignancies. The standard therapeutic strategy includes cytoreductive surgery and neo (adjuvant) platinum-based chemotherapy. Relapse of advanced high grade serous ovarian cancer (HGSOC) is related to the development of drug resistance. A defective DNA damage response is a defining hallmark of HGSOC. Poly (ADP-ribose) polymerase (PARP) inhibitors exploit this deficiency through synthetic lethality and...
Thu Oct 24, 2019 03:00
Surgical Infections, Ahead of Print.
Thu Oct 24, 2019 10:00
Abstract The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) assessed the safety of the recycling process Poly Recycling (EU register number RECYC173) using the recoSTAR PET FG technology. The input is hot washed and dried poly(ethylene terephthalate) (PET) flakes originating from collected post‐consumer PET containers, mainly bottles, with no more than 5% PET from non‐food consumer applications. The flakes are heated and crystallised in a continuous first reactor under inert...
Thu Oct 24, 2019 16:36
Abstract The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) assessed the safety of the recycling process Veripack Embalajes (EU register number RECYC168) using the Starlinger Decon technology. The input is hot washed and dried poly(ethylene terephthalate) (PET) flakes originating from collected post‐consumer PET containers, mainly bottles, with no more than 5% PET from non‐food consumer applications. They are preheated before being submitted to solid‐state polycondensation...
Thu Oct 24, 2019 11:32
Abstract The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) assessed the safety of the recycling process V & T Trade (EU register number RECYC165) using the Starlinger Decon technology. The input is hot washed and dried poly(ethylene terephthalate) (PET) flakes originating from collected post‐consumer PET containers, mainly bottles, with no more than 5% PET from non‐food consumer applications. They are preheated before being submitted to solid‐state polycondensation...
Thu Oct 24, 2019 11:31
Abstract The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) assessed the safety of the recycling process Reco‐Kavala (EU register number RECYC164) using the Starlinger Decon technology. The input is hot washed and dried poly(ethylene terephthalate) (PET) flakes originating from collected post‐consumer PET containers, mainly bottles, with no more than 5% PET from non‐food consumer applications. They are preheated before being submitted to solid state polycondensation (SSP)...
Thu Oct 24, 2019 11:30
Abstract The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) assessed the safety of the recycling process Sharpak Bridgewater (EU register number RECYC166). The input is hot washed and dried poly(ethylene terephthalate) (PET) flakes originating from collected post‐consumer PET containers, mainly bottles, with no more than 5% PET from non‐food consumer applications. The flakes are preheated before being submitted to solid‐state polycondensation (SSP) in a continuous reactor...
Thu Oct 24, 2019 11:30
Abstract The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) assessed the safety of the recycling process Pinaform (EU register number RECYC167) using the Starlinger Decon technology. The input is hot washed and dried poly(ethylene terephthalate) (PET) flakes originating from collected post‐consumer PET containers, mainly bottles, with no more than 5% PET from non‐food consumer applications. They are preheated before being submitted to solid‐state polycondensation (SSP) in...
Thu Oct 24, 2019 11:30
Abstract The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) assessed the safety of the recycling process Ferrarelle (EU register number RECYC169) using the Starlinger Decon technology. The input is hot washed and dried poly(ethylene terephthalate) (PET) flakes originating from collected post‐consumer PET containers, mainly bottles, with no more than 5% PET from non‐food consumer applications. They are preheated before being submitted to solid‐state polycondensation (SSP)...
Thu Oct 24, 2019 11:29
Abstract The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) assessed the safety of the recycling process Marcato (EU register number RECYC162) using the Starlinger Decon technology. The input is hot washed and dried poly(ethylene terephthalate) (PET) flakes originating from collected post‐consumer PET containers, mainly bottles, with no more than 5% PET from non‐food consumer applications. They are preheated before being submitted to solid‐state polycondensation (SSP) in...
Thu Oct 24, 2019 11:25
Abstract The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) assessed the safety of the recycling process PETman (EU register number RECYC163) using the Starlinger Decon technology. The input is hot washed and dried poly(ethylene terephthalate) (PET) flakes originating from collected post‐consumer PET containers, mainly bottles, with no more than 5% PET from non‐food consumer applications. They are preheated before being submitted to solid‐state polycondensation (SSP) in...
Thu Oct 24, 2019 11:24
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01719D, PaperYun Zhou, Ziye Dong, Hermella Andarge, Wei Li, Dimitri PappasCancer is a major health problem in the United States with extremely high mortality. The detection and isolation of cancer cells are becoming increasingly important for cancer diagnosis. We describe...The content of this RSS Feed (c) The Royal Society of Chemistry
Thu Oct 24, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01584A, PaperKristin R. McKenna, Li Li, Andy Baker, Jakub Ujma, Ramanarayanan Krishnamurthy, Charles Liotta, Facundo FernandezOligosaccharides serve many roles in extant life and may have had a significant role in prebiotic chemistry in early Earth. In both these contexts, the structural and isomeric diversity among...The content of this RSS Feed (c) The Royal Society of Chemistry
Thu Oct 24, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01882D, PaperWanda Valeria Fernandez, Rocío Trinidad Tosello, Jose Luis FernándezThis work describes the fabrication, characterization and evaluation of thin gas diffusion electrodes (GDEs) that are capable to electrocatalyze the reaction of dissolved gases operating at high diffusion limiting current...The content of this RSS Feed (c) The Royal Society of Chemistry
Thu Oct 24, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01479A, Paper Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Toan Huynh, Samantha A Byrnes, Tim C Chang, Bernhard Weigl, Kevin P NicholsIn digital assays, devices are typically considered to require precisely controlled volumes since variation in compartment volumes causes biases in concentration estimates. To enable more possibilities in device design, we...The content of this RSS Feed...
Thu Oct 24, 2019 02:00
Publication date: Available online 23 October 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Amy D. Klion, Marc E. RothenbergAbstractInterest in eosinophil biology and eosinophilic diseases is rising as reflected in a doubling of the number of annual articles focused on this topic which were published in the Journal of Allergy and Clinical Immunology over the past decade. Whereas the majority of these publications relate to eosinophilic asthma, a growing proportion focus on breakthroughs...
Thu Oct 24, 2019 18:10
Publication date: Available online 23 October 2019Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Yan Song, Yan Xiong, Jie Yao, Hongkai Wang, Liwen tan, Xin hu, Shaoxiang Zhang, Yi WuAbstractBackgroundTo conduct an anatomical study of the fibular collateral ligament (FCL), popliteus tendon (PT), biceps femoris tendon (BT) and popliteofibular ligament (PFL) of the knee joint posterolateral complex (PLC) at the femoral and fibular tendon-bone junctions based on the Chinese Visible Human...
Thu Oct 24, 2019 17:56
Publication date: Available online 23 October 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Maffia Francesco, Valentino Vellone, Chiara De Quarto, Runci Anastasi Michele, Piero CasconeSummarySynovial chondromatosis (SC) of the temporomandibular joint is a pseudoneoplastic condition characterized by benign cartilaginous metaplasia of synovial tissue mesenchymal residues with intra-articular nodule formation. TMJ involvement is rare. Interposition of loose bodies in the articular space...
Thu Oct 24, 2019 17:50
Publication date: Available online 24 October 2019Source: CortexAuthor(s): Amée F. Wolters, Anja J.H. Moonen, Renaud Lopes, Albert F.G. Leentjens, Annelien A. Duits, Luc Defebvre, Christine Delmaire, Paul A. Hofman, Frank C. van Bussel, Kathy DujardinAbstractCognitive impairment is common in Parkinson’s disease (PD), yet with large heterogeneity in the range and course of deficits. In a cross-sectional study, 124 PD patients underwent extensive clinical and neuropsychological assessment as well as...
Thu Oct 24, 2019 17:24
Publication date: Available online 23 October 2019Source: CortexAuthor(s): Vanessa Siffredi, Amanda G. Wood, Richard Leventer, Maarten Vaessen, Alissandra McIlroy, Vicki Anderson, Patrik Vuilleumier, Megan M. Spencer-SmithAbstractDevelopmental absence (agenesis) of the corpus callosum (AgCC) is a congenital brain malformation resulting from disruption of corpus callosum formation, a structure that is crucial for the transfer and integration of information, including attention processes, across the...
Thu Oct 24, 2019 17:24
Publication date: Available online 23 October 2019Source: Annals of Diagnostic PathologyAuthor(s): Richard A. PraysonAbstractAs of 2016, isocitrate dehydrogenase (IDH)-1 and IDH-2 mutations are part of the definition of an oligodendroglioma and may be seen in a significant subset of grade II-IV fibrillary astrocytomas. Reports of IDH-1 and IDH-2 alterations in pilocytic astrocytomas have been rare. This study reports two cases of pilocytic astrocytomas which harbored IDH-1 polymorphisms (G105G) (c.315C > T)...
Thu Oct 24, 2019 16:50
Publication date: Available online 23 October 2019Source: Medical HypothesesAuthor(s): Yu Huang, Aiguo Liu, Li Liu, Binru Wang, Gengtian LiangAbstractVitamins are indispensable nutrients for metabolism. Adequate vitamin intake plays vital role in physiological processes including embryonic development, cellular and immunity proliferation and differentiation, DNA synthesis and oxidative response. In contrast, insufficient vitamin levels usually lead to a large number of clinical manifestations including...
Thu Oct 24, 2019 16:39
Publication date: Available online 23 October 2019Source: Medical HypothesesAuthor(s): Sherif Nesnawy, Kawther Tolba, Ensherah Roshdy, Mostafa Abdel KaderAbstractAtherosclerosis develops gradually as a subclinical condition and eventually becomes clinically apparent as heart disease or stroke. The degree of decreased arterial compliance affects both pulse pressure (PP) and diastolic blood pressure (DBP). These relations would be clear in the distal periphery. We propose that the ankle PP/ankle DBP...
Thu Oct 24, 2019 16:39
Abstract Agency is the attribution of an action to the self and is a prerequisite for experiencing responsibility over its consequences. Here we investigated agency and responsibility by studying the control of movements of an embodied avatar, via brain computer interface (BCI) technology, in immersive virtual reality. After induction of virtual body ownership by visuomotor correlations, healthy participants performed a motor task with their virtual body. We compared the passive observation of the...
Thu Oct 24, 2019 14:54
Key points •Mechanisms underlying plasticity induction by repetitive transcranial magnetic stimulation protocols such as intermittent theta‐burst stimulation (iTBS) remain poorly understood. •Individual response to iTBS is associated with recruitment of late indirect wave (I‐wave) generating pathways that can be probed by the onset latency of TMS applied to primary motor cortex (M1) at different coil orientations. •We found an association between late I‐wave recruitment (reflected by AP‐LM latency,...
Thu Oct 24, 2019 14:30
Key points •The fine control of food intake is important for the maintenance of a healthy metabolic state. •GVAs are involved in the peripheral regulation of food intake via signalling the degree of distension of the stomach which ultimately leads to feelings of fullness and satiety. •This study provides evidence that endocannabinoids, such as anandamide, are capable of regulating GVA sensitivity in a concentration‐dependent biphasic manner. •This biphasic effect is dependent upon CB1, TRPV1,...
Wed Oct 23, 2019 13:43
Key points •A strong association between disordered breathing patterns, elevated sympathetic activity, and enhanced central chemoreflex drive has been shown in experimental and human heart failure (HF). •We aimed to determine the contribution of catecholaminergic rostral ventrolateral medulla catecholaminergic neurones (RVLM‐C1) on both hemodynamic and respiratory alterations in HF. •Apnoea/hypopnoea incidence (AHI), breathing variability, respiratory‐cardiovascular coupling, cardiac autonomic...
Wed Oct 23, 2019 12:25
No abstract available
Thu Oct 24, 2019 16:26
No abstract available
Thu Oct 24, 2019 16:26
BACKGROUND Incidence trends of nonmelanoma skin cancer show an increase. Few data have been published about the incidence of Bowen disease (BD). Three previous studies, conducted more than 15 years ago in North America, found large variation in incidence rates in Caucasians, and trends over longer periods have never been studied. OBJECTIVE To estimate the incidence of BD in a Caucasian population in Northern Europe (Maastricht, the Netherlands) between 2003 and 2013. METHODS Primary...
Thu Oct 24, 2019 16:26
BACKGROUND The rate of occult invasive disease within biopsy-proven squamous cell carcinoma in situ (SCCIS) is not well defined. OBJECTIVE To examine the rate of occult invasion in SCCIS. METHODS An institutional-wide pathology database was retrospectively searched for “squamous cell carcinoma in situ” over a 6-year period, and the treatment modality and final pathology results were analyzed for evidence of invasion. In addition, consecutive tumor blocks from Mohs micrographic surgery...
Thu Oct 24, 2019 16:26
BACKGROUND Cellular dermatofibromas, a variant of dermatofibroma, are reported to recur at rates of 26% to 50%. OBJECTIVE To determine whether there are distinct clinical or histological differences between cellular dermatofibromas that recur versus those that do not. To determine recurrence rates in a real-world clinical setting. MATERIALS AND METHODS A retrospective analysis of the medical records and skin biopsies of cellular dermatofibroma in the University of Utah Health system...
Thu Oct 24, 2019 16:26
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