Journal of Surgical Education
- Gender Bias Experiences of Female Surgical TraineesPublication date: Available online 7 October 2019Source: Journal of Surgical EducationAuthor(s): K. Lauren Barnes, Lauren McGuire, Gena Dunivan, Andrew L. Sussman, Rohini McKeeObjectiveMedical schools now average approximately 50% female students, yet a disproportionate number of women continue to choose nonsurgical over surgical specialties. Once in training, studies indicate that pervasive gender stereotypes, sexism and harassment negatively af
BioMed Research International
- Synaptic Injury in the Thalamus Accompanies White Matter Injury in Hypoxia/Ischemia-Mediated Brain Injury in Neonatal RatsThe broad spectrum of disabilities caused by white matter injury (WMI) cannot be explained simply by hypomyelination. Synaptic injury in the thalamus may be related to disabilities in WMI survivors. Neuronal injury in the thalamus has been found most commonly in autopsy cases of preterm WMI. We hypothesized that hypoxia/ischemia (HI) in neonatal rats results in synaptic abnormalities in the thalamus that contribute to disabilities in WMI survivor
- Evaluation of RealStar® Alpha Herpesvirus PCR Kit for Detection of HSV-1, HSV-2, and VZV in Clinical SpecimensSeveral commercial PCR kits are available for detection of herpes simplex virus (HSV) and varicella zoster virus (VZV), but the test performance of one CE-marked in vitro diagnostic kit—RealStar® alpha Herpesvirus PCR Kit—has not been well studied. This study evaluated the performance of RealStar® alpha Herpesvirus PCR Kit 1.0 on the LightCycler® 480 Instrument II for detection and differentiation of HSV-1, HSV-2, and VZV in human clinical specim
- Current Trends in the Evaluation of Osteochondral Lesion Treatments: Histology, Histomorphometry, and Biomechanics in Preclinical ModelsOsteochondral lesions (OCs) are typically of traumatic origins but are also caused by degenerative conditions, in primis osteoarthritis (OA). On the other side, OC lesions themselves, getting worse over time, can lead to OA, indicating that chondral and OC defects represent a risk factor for the onset of the pathology. Many animal models have been set up for years for the study of OC regeneration, being successfully employed to test different tre
- Evaluation of the Efficacy of a Recombinant Adenovirus Expressing the Spike Protein of Porcine Epidemic Diarrhea Virus in PigsIn recent years, many studies have shown that recombinant adenovirus live vector-based vaccines are a promising novel vaccine candidate against virus infection. Therefore, in this study, a new type of recombinant adenovirus expressing the spike (S) protein of porcine epidemic diarrhea virus (PEDV), rAd-PEDV-S, was generated, and its characteristics were determined. Then, its efficacy as a vaccine candidate was evaluated in 4-week-old pigs. The re
- Prognostic Nutritional Index and Neutrophil-to-Lymphocyte Ratio Are Respectively Associated with Prognosis of Gastric Cancer with Liver Metatasis Undergoing and without HepatectomyBackground. To clarify the efficacy of hepatectomy for gastric cancer liver metastasis (GCLM) and to investigate the association between prognostic nutrition index (PNI) or neutrophil-to-lymphocyte ratio (NLR) and prognosis of GCLM undergoing or without hepatectomy. Methods. We retrospectively studied 374 patients with GCLM. The ROC curve was used to determine the optimal cut-off of PNI and NLR. Patients were divided into groups based on whether
- Predictors for Unfavorable Early Outcomes in Elective Total Hip Arthroplasty: Does Extreme Body Mass Index Matter?Background. Studies of previous cohorts have demonstrated a controversial association between extreme body mass index (BMI) and complication rates following total hip arthroplasty (THA). The purpose of this study was to compare 30-day perioperative complications in underweight (BMI
- Evaluation of Drug Susceptibility of Microorganisms in Odontogenic Inflammations and Dental Surgery Procedures Performed on an Outpatient BasisBacterial infections are the most common cause of purulent soft tissue inflammations in the head and neck area. These bacteria are also responsible for the majority of inflammatory complications after third molar removal. The key to success of antibacterial treatment in both cases is the use of an appropriate antibacterial agent. The aim of the study was to evaluate the susceptibility profile of bacteria isolated from material collected from pati
- Era of Genomic Medicine: A Narrative Review on CRISPR Technology as a Potential Therapeutic Tool for Human DiseasesClustered Regularly Interspaced Short Palindromic Repeats (CRISPR) provides acquired immunity in microorganisms against exogenous DNA that may hinder the survival of the organism. Pioneering work by Doudna and Charpentier in 2012 resulted in the creation of the CRISPR/Cas9 genome editing tool on the basis of this concept. The aim of this was to create a rapid, efficient, and versatile genome-editing tool to facilitate genetic manipulation. The me
- External Control Viral-Like Particle Construction for Detection of Emergent Arboviruses by Real-Time Reverse-Transcription PCRArboviruses have been emerging and reemerging worldwide, predominantly in tropical and subtropical areas. As many arbovirus infections, including dengue (DENV), Zika (ZIKV), and chikungunya (CHIKV), have similar signs and symptoms, clinical diagnosis of arbovirus infections is challenging. Therefore, reliable laboratory tests are necessary to improve the clinical management of patients with suspected arbovirus infections. Real-time reverse-transc
American Goiter Association
- Clinical situation, therapy, and follow up of adult craniopharyngioma - report from the German craniopharyngioma registry.Related ArticlesClinical situation, therapy, and follow up of adult craniopharyngioma - report from the German craniopharyngioma registry. J Clin Endocrinol Metab. 2019 Oct 07;: Authors: Mende KC, Kellner T, Petersenn S, Honegger J, Evangelista-Zamora R, Droste M, Stalla G, Deutschbein T, Wang Y, Moskopp D, Knappe U, Schilbach K, Flitsch J, “pituitary working group” of the German Society of Endocrinology (DGE)
- Glucagon-like peptide 1 receptor agonists, diabetic retinopathy and angiogenesis: The AngioSafe type 2 diabetes study.Related ArticlesGlucagon-like peptide 1 receptor agonists, diabetic retinopathy and angiogenesis: The AngioSafe type 2 diabetes study. J Clin Endocrinol Metab. 2019 Oct 07;: Authors: Gaborit B, Julla JB, Besbes S, Proust M, Vincentelli C, Alos B, Ancel P, Alzaid F, Garcia R, Mailly P, Sabatier F, Righini M, Gascon P, Matonti F, Houssays M, Goumidi L, Vignaud L, Guillonneau X, Erginay A, Dupas B, Jennifer ML, Autié M,
- The Risks of Cardiovascular Disease and Mortality Following Weight Change in Adults with Diabetes: Results from ADVANCE.Related ArticlesThe Risks of Cardiovascular Disease and Mortality Following Weight Change in Adults with Diabetes: Results from ADVANCE. J Clin Endocrinol Metab. 2019 Oct 07;: Authors: Lee AK, Woodward M, Wang D, Ohkuma T, Warren B, Sharrett AR, Williams B, Marre M, Hamet P, Harrap S, McEvoy JW, Chalmers J, Selvin E Abstract CONTEXT: Weight loss is strongly recommended for overweight and obese adults
- Analysis of bone impairment by 3D DXA hip measures in patients with primary hyperparathyroidism: a pilot study.Related ArticlesAnalysis of bone impairment by 3D DXA hip measures in patients with primary hyperparathyroidism: a pilot study. J Clin Endocrinol Metab. 2019 Oct 07;: Authors: Gracia-Marco L, García-Fontana B, Ubago-Guisado E, Vlachopoulos D, García-Martín A, Muñoz-Torres M Abstract CONTEXT: primary hyperparathyroidism (PHPT) has been related to bone loss. Dual-energy X-ray absorptiometry (DXA) canno
- Regulation of Insulin-Like Growth Factor 2 by Oocyte-Secreted Factors in Primary Human Granulosa Cells.Related ArticlesRegulation of Insulin-Like Growth Factor 2 by Oocyte-Secreted Factors in Primary Human Granulosa Cells. J Clin Endocrinol Metab. 2019 Oct 07;: Authors: Hobeika E, Armouti M, Fierro MA, Winston N, Scoccia H, Zamah AM, Stocco C Abstract CONTEXT: Human granulosa cells (hGCs) produce and respond to insulin-like growth factor 2 (IGF2) but whether the oocyte participates in IGF2 regulation
- Thyroid hormone effects on glucose disposal in patients with insulin receptor mutations.Related ArticlesThyroid hormone effects on glucose disposal in patients with insulin receptor mutations. J Clin Endocrinol Metab. 2019 Oct 07;: Authors: Kushchayeva YS, Startzell M, Cochran E, Auh S, Sekizkardes H, Soldin SJ, Kushchayev SV, Dieckmann W, Skarulis M, Abdul Sater Z, Brychta RJ, Cypess AM, Lin TC, Lightbourne M, Millo C, Brown RJ Abstract CONTEXT: Patients with mutations of the insulin r
- Body mass index, triglycerides and risk of acute pancreatitis: A population-based study of 118,000 individuals.Related ArticlesBody mass index, triglycerides and risk of acute pancreatitis: A population-based study of 118,000 individuals. J Clin Endocrinol Metab. 2019 Oct 07;: Authors: Hansen SEJ, Madsen CM, Varbo A, Nordestgaard BG Abstract OBJECTIVE: The incidence of acute pancreatitis is rising worldwide and currently no curative treatment exist. Clarifying preventable risk factors are important for reduct
- BONE HISTOMORPHOMETRY IN YOUNG PATIENTS WITH TYPE 2 DIABETES IS AFFECTED BY DISEASE CONTROL AND CHRONIC COMPLICATIONS.Related ArticlesBONE HISTOMORPHOMETRY IN YOUNG PATIENTS WITH TYPE 2 DIABETES IS AFFECTED BY DISEASE CONTROL AND CHRONIC COMPLICATIONS. J Clin Endocrinol Metab. 2019 Oct 07;: Authors: Andrade VFC, Chula DC, Sabbag FP, Cavalheiro DDDS, Bávia L, Ambrósio AR, da Costa CRV, Dos Reis LM, Borba VZC, de Aguiar Moreira C Abstract CONTEXT: Type 2 diabetes mellitus (T2DM) is associated with an increased risk of
- Traumatic Neck and Skull Base Injuries.Related ArticlesTraumatic Neck and Skull Base Injuries. Radiographics. 2019 Oct;39(6):1796-1807 Authors: Go JL, Acharya J, Branchcomb JC, Rajamohan AG Abstract Patients with blunt and penetrating traumatic injuries to the skull base and soft tissues of the neck present to the emergency department every day. Fortunately, truly life-threatening injuries to these regions are relatively uncommon. However
Investigative Radiology - Published Ahead-of-Print
- Dedicated Spiral Breast Computed Tomography With a Single Photon-Counting Detector: Initial Results of the First 300 WomenObjectives The aim of this study was to describe our initial clinical experiences using a dedicated spiral breast computed tomography (B-CT) with a single photon-counting detector. Materials and Methods This retrospective study was approved by the institutional review board. Examinations of 300 consecutive women undergoing B-CT were evaluated on reason of assignment for B-CT instead of mammography, detection rate of breast cancer, and qua
- EFFECTIVE DOSE AND RISK ESTIMATES IN ADULT PATIENTS FROM FOUR RADIOLOGICAL PROCEDURES EXTRAPOLATED OVER TWO POPULATIONS AT SOME SELECTED CENTERS IN LAGOS STATE, NIGERIA.Related ArticlesEFFECTIVE DOSE AND RISK ESTIMATES IN ADULT PATIENTS FROM FOUR RADIOLOGICAL PROCEDURES EXTRAPOLATED OVER TWO POPULATIONS AT SOME SELECTED CENTERS IN LAGOS STATE, NIGERIA. Radiat Prot Dosimetry. 2019 Oct 07;: Authors: Balogun FA, Adeyemi FO, Balogun BO, Oketayo OO, Olowookere CJ, Fasan-Odunsi AO Abstract In this study, risk of exposure to adult patients in some common radiological proce
- A summary of the Clinical Practice Guideline for the Diagnosis and Management of Voice Disorders, 2018 in Japan.Related ArticlesA summary of the Clinical Practice Guideline for the Diagnosis and Management of Voice Disorders, 2018 in Japan. Auris Nasus Larynx. 2019 Oct 03;: Authors: Umeno H, Hyodo M, Haji T, Hara H, Imaizumi M, Ishige M, Kumada M, Makiyama K, Nishizawa N, Saito K, Shiromoto O, Suehiro A, Takahashi G, Tateya I, Tsunoda K, Omori K Abstract OBJECTIVE: To develop a summary of the first version of
- Immunoresolvent Resolvin D1 Maintains the Health of the Ocular Surface.Related ArticlesImmunoresolvent Resolvin D1 Maintains the Health of the Ocular Surface. Adv Exp Med Biol. 2019;1161:13-25 Authors: Dartt DA, Hodges RR, Serhan CN Abstract The present review focuses on the role of one of the D-series resolvins (Rv) RvD1 in the regulation of conjunctival goblet cell secretion and its role in ocular surface health. RvD1 is the most thoroughly studied of the specialized
- [Long-term outcome of patients with pyriform sinus squamous cell carcinoma treated with planned preoperative (chemo-) radiotherapy plus laryngeal function sparing surgery].Related Articles[Long-term outcome of patients with pyriform sinus squamous cell carcinoma treated with planned preoperative (chemo-) radiotherapy plus laryngeal function sparing surgery]. Zhonghua Zhong Liu Za Zhi. 2019 Jul 23;41(7):535-539 Authors: Huang H, Zhang ZM, Zhang Y, Wang XL, Liu SY, Xu ZG Abstract Objective: To analyze the long-term outcome of patients with pyriform sinus squamous cell ca
- AirWay Scope™ for Difficult Ventilation in a Patient With Epiglottic Cyst.Related ArticlesAirWay Scope™ for Difficult Ventilation in a Patient With Epiglottic Cyst. Anesth Prog. 2018;65(3):204-205 Authors: Sugita T, Arisaka H Abstract Epiglottic cysts often cause difficulty in airway management, with potential serious life-threatening complications. 1 This case report describes a patient with an epiglottic cyst in whom mask ventilation became difficult after induction of a
- Tear Lactoferrin and Features of Ocular Allergy in Different Severities of Meibomian Gland Dysfunction.Related ArticlesTear Lactoferrin and Features of Ocular Allergy in Different Severities of Meibomian Gland Dysfunction. Optom Vis Sci. 2018 10;95(10):930-936 Authors: Chao C, Tong L Abstract SIGNIFICANCE: Meibomian gland dysfunction, but not atrophy, was associated with lower tear lactoferrin concentration, greater dry eye, and allergic symptoms, indicating greater inflammation and discomfort in pati
- Hyalinosis cutis et mucosae: A clinical investigation with special regard to mucosal changes.Related ArticlesHyalinosis cutis et mucosae: A clinical investigation with special regard to mucosal changes. J Dtsch Dermatol Ges. 2018 Feb;16(2):211-213 Authors: Epple A, Hoxha E, Schneiderbauer R, Jappel A, Koschny R, Enk A, Haenssle HA PMID: 29337435 [PubMed - indexed for MEDLINE]
- Dynamic Multi-Atlas Selection Based Consensus Segmentation of Head and Neck Structures from CT Images.Related ArticlesDynamic Multi-Atlas Selection Based Consensus Segmentation of Head and Neck Structures from CT Images. Med Phys. 2019 Oct 06;: Authors: Haq R, Berry SL, Deasy JO, Hunt M, Veeraraghavan H Abstract PURPOSE: Manual delineation of head and neck (H&N) organ-at-risk (OAR) structures for radiation therapy planning is time consuming and highly variable. Therefore, we developed a dynamic multi
- Clinical outcome and toxicity after simultaneous integrated boost IMRT in head and neck squamous cell cancer patients.Related ArticlesClinical outcome and toxicity after simultaneous integrated boost IMRT in head and neck squamous cell cancer patients. Oral Oncol. 2019 Oct 03;98:132-140 Authors: Dragan T, Beauvois S, Moreau M, Paesmans M, Vandekerkhove C, Cordier L, Van Gestel D Abstract INTRODUCTION: A simultaneous integrated boost (SIB) intensity modulated radiotherapy (IMRT) in patients with head and neck squamou
- Andrographolide Protects against HG-Induced Inflammation, Apoptosis, Migration, and Impairment of Angiogenesis via PI3K/AKT-eNOS Signalling in HUVECsAndrographolide (Andr) is a major component isolated from the plant Andrographis paniculata. Inflammation, apoptosis, and impaired angiogenesis are implicated in the pathogenesis of high glucose (HG)-induced injury of vascular endotheliocytes. Our study is aimed at evaluating the effect of Andr on HG-induced HUVEC injury and the underlying mechanism. HUVECs were exposed to HG levels (33 mM) and treated with Andr (0, 12.5, 25, and 50 μM). Western
- Dynamic Changes of Th1 Cytokines and the Clinical Significance of the IFN-γ/TNF-α Ratio in Acute BrucellosisBackground. T-helper type 1 (Th1) cells and Th1-produced cytokines play essential roles in the immune response to foreign pathogens, such as Brucella spp. The aim of this study was to evaluate the dynamic changes of Th1 cells and Th1-produced cytokines in patients with acute brucellosis and their impact on clinical decision-making. Methods. Fifty-one individuals with acute brucellosis and 17 healthy subjects were enrolled in this study. The bruce
Latest Results for Child's Nervous System
- Systematic review of spinal deformities following multi-level selective dorsal rhizotomyAbstract Purpose Cerebral palsy is a common neurological disorder that involves spasticity of the extremities and can lead to lifelong disability. Selective dorsal rhizotomy (SDR) can improve spasticity and quality of life in these patients, but it may be associated with the development of spinal deformity. Risk factors for spinal deformity after SDR have not yet been systematically ex
- Revascularization surgery in childhood associated with a low incidence of microbleeds in adult moyamoya patients.Related ArticlesRevascularization surgery in childhood associated with a low incidence of microbleeds in adult moyamoya patients. World Neurosurg. 2019 Oct 04;: Authors: Yamao Y, Takahashi JC, Funaki T, Mineharu Y, Kikuchi T, Okada T, Togashi K, Miyamoto S Abstract BACKGROUND: The clinical significance of asymptomatic microbleeds in moyamoya disease remains unclear. The purpose of this study was to c
- Delayed rebleeding from pseudoaneurysm after mechanical thrombectomy using a stent retriever due to small artery avulsion confirmed by open surgery: A case report.Related ArticlesDelayed rebleeding from pseudoaneurysm after mechanical thrombectomy using a stent retriever due to small artery avulsion confirmed by open surgery: A case report. World Neurosurg. 2019 Oct 04;: Authors: Imahori T, Okamura Y, Sakata J, Shose H, Yamanishi S, Kohmura E Abstract BACKGROUND: Pseudoaneurysm after mechanical thrombectomy (MT) is rare but is one of the potential complication
- Diagnosis of a Rare Intraventricular Schwannoma: A Case Report.Related ArticlesDiagnosis of a Rare Intraventricular Schwannoma: A Case Report. World Neurosurg. 2019 Oct 04;: Authors: Chiba R, Akiyama Y, Kimura Y, Yokoyama R, Mikuni N Abstract BACKGROUND: Intraventricular schwannoma is extremely rare, with only 35 cases reported to date in the literature. Consequently, its etiology and pathogenesis are still unclear, and thus require further investigations. Here,
- Texture Analysis of T1-weighted Contrast Enhanced Magnetic Resonance Imaging Potentially Predicts the Outcomes of the Patients with non-WNT/non-SHH Medulloblastoma.Related ArticlesTexture Analysis of T1-weighted Contrast Enhanced Magnetic Resonance Imaging Potentially Predicts the Outcomes of the Patients with non-WNT/non-SHH Medulloblastoma. World Neurosurg. 2019 Oct 04;: Authors: Li J, Chen C, Fu R, Zhang Y, Fan Y, Cen Y, Xu J Abstract BACKGROUND: To investigate whether tumor texture features derived from preoperative T1-weighted magnetic resonance imaging (M
- Neurosurgical Anatomy of the Internal Carotid Artery: An MRI Study of the Sellar Region.Related ArticlesNeurosurgical Anatomy of the Internal Carotid Artery: An MRI Study of the Sellar Region. World Neurosurg. 2019 Oct 04;: Authors: Newman HJ, Milne N, Lewis SB Abstract BACKGROUND: Trans-sphenoidal surgical approaches involve dissection of the posterior wall of the sphenoid sinus in close proximity to the internal carotid arteries. To reduce the risk of vascular injury, a detailed study
- The need for surgical safety checklists in neurosurgery now and in the future - a systematic review.Related ArticlesThe need for surgical safety checklists in neurosurgery now and in the future - a systematic review. World Neurosurg. 2019 Oct 04;: Authors: Westman M, Takala R, Rahi M, Ikonen TS Abstract Safety checklists have been studied among various surgical patient groups, but evidence of their benefits in neurosurgery remains sparse. Since the implementation of the World Health Organization's
- Usefulness of 3D Printed Models in the Management of Complex Craniovertebral Junction Anomalies: Choice of Treatment Strategy, Design of Screw Trajectory and Protection of Vertebral Artery.Related ArticlesUsefulness of 3D Printed Models in the Management of Complex Craniovertebral Junction Anomalies: Choice of Treatment Strategy, Design of Screw Trajectory and Protection of Vertebral Artery. World Neurosurg. 2019 Oct 04;: Authors: Du YQ, Qiao GY, Yin YH, Li T, Tong HY, Yu XG Abstract BACKGROUND: Choice of treatment strategy, design of screw trajectory and protection of vertebral artery
Progress in Orthodontics - Latest Articles
- Midpalatal suture maturation stage assessment in adolescents and young adults using cone-beam computed tomographyThe aim of this study was to evaluate the midpalatal suture maturation stages in adolescents and young adults using cone-beam computed tomography (CBCT).
- Synthesis, characterization, anti-proliferative properties and DNA binding of benzochromene derivatives: Increased Bax/Bcl-2 ratio and caspase-dependent apoptosis in colorectal cancer cell line.Related ArticlesSynthesis, characterization, anti-proliferative properties and DNA binding of benzochromene derivatives: Increased Bax/Bcl-2 ratio and caspase-dependent apoptosis in colorectal cancer cell line. Bioorg Chem. 2019 Sep 30;93:103329 Authors: Ahagh MH, Dehghan G, Mehdipour M, Teimuri-Mofrad R, Payami E, Sheibani N, Ghaffari M, Asadi M Abstract 3-Amino-1-aryl-1H-benzo[f]chromene-2-carbonit
- Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses.Related ArticlesProximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses. J Clin Invest. 2019 Oct 07;: Authors: Kishi S, Brooks CR, Taguchi K, Ichimura T, Mori Y, Akinfolarin A, Gupta N, Galichon P, Elias BC, Suzuki T, Wang Q, Gewin L, Morizane R, Bonventre JV Abstract Maladaptive proximal tubule (PT) repair has been implicated in kidney fibrosis through induction of cel
- DNA damage response protects against progressive kidney disease.Related ArticlesDNA damage response protects against progressive kidney disease. J Clin Invest. 2019 Oct 07;: Authors: Molitoris BA Abstract The pathophysiology of cellular injury and repair has been extensively studied in acute kidney injury (AKI) for more than 70 years. Although a great deal of knowledge has been generated, a debate over the importance of repairing damaged cells versus replacing th
- Isorhamnetin induces ROS-dependent cycle arrest at G2/M phase and apoptosis in human hepatocarcinoma Hep3B cells.Related ArticlesIsorhamnetin induces ROS-dependent cycle arrest at G2/M phase and apoptosis in human hepatocarcinoma Hep3B cells. Gen Physiol Biophys. 2019 Oct 07;: Authors: Choi YH Abstract Isorhamnetin is a 3'-O-methylated metabolite of quercetin that is found predominantly in a variety of medicinal plants. Although many previous studies have reported that this flavonol has diverse health-promoting
- Ribociclib (LEE011) suppresses cell proliferation and induces apoptosis of MDA-MB-231 by inhibiting CDK4/6-cyclin D-Rb-E2F pathway.Related ArticlesRibociclib (LEE011) suppresses cell proliferation and induces apoptosis of MDA-MB-231 by inhibiting CDK4/6-cyclin D-Rb-E2F pathway. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):4001-4011 Authors: Li T, Xiong Y, Wang Q, Chen F, Zeng Y, Yu X, Wang Y, Zhou F, Zhou Y Abstract Triple-negative breast cancer (TNBC) stands for a refractory subtype, which predicts poor prognosis and has no e
- Beta-blockers exert potent anti-tumor effects in cutaneous and uveal melanoma.Related ArticlesBeta-blockers exert potent anti-tumor effects in cutaneous and uveal melanoma. Cancer Med. 2019 Oct 07;: Authors: Bustamante P, Miyamoto D, Goyeneche A, de Alba Graue PG, Jin E, Tsering T, Dias AB, Burnier MN, Burnier JV Abstract BACKGROUND: Melanoma is a life-threatening group of cancers mainly affecting the skin (cutaneous melanoma, CM) and the eyes (uveal melanoma, UM). Nearly half
- Activation of the leptin pathway by high expression of the long form of the leptin receptor (Ob-Rb) accelerates chondrocyte senescence in osteoarthritis.Related ArticlesActivation of the leptin pathway by high expression of the long form of the leptin receptor (Ob-Rb) accelerates chondrocyte senescence in osteoarthritis. Bone Joint Res. 2019 Sep;8(9):425-436 Authors: Zhao X, Huang P, Li G, Lv Z, Hu G, Xu Q Abstract Objectives: Activation of the leptin pathway is closely correlated with human knee cartilage degeneration. However, the role of the long
- The chronic effect of amorphous silica nanoparticles and benzo[a]pyrene co-exposure at low dose in human bronchial epithelial BEAS-2B cells.Related ArticlesThe chronic effect of amorphous silica nanoparticles and benzo[a]pyrene co-exposure at low dose in human bronchial epithelial BEAS-2B cells. Toxicol Res (Camb). 2019 Sep 01;8(5):731-740 Authors: Wu J, Zhang J, Nie J, Duan J, Shi Y, Feng L, Yang X, An Y, Sun Z Abstract As the main components of fine particulate matter (PM2.5), silica nanoparticles (SiNPs) and benzo[a]pyrene (B[a]P) hav
- "Verteporfin exhibits anti-proliferative activity in embryonal and alveolar rhabdomyosarcoma cell lines".Related Articles"Verteporfin exhibits anti-proliferative activity in embryonal and alveolar rhabdomyosarcoma cell lines". Chem Biol Interact. 2019 Oct 01;312:108813 Authors: Sanna L, Piredda R, Marchesi I, Bordoni V, Forcales SV, Calvisi DF, Bagella L Abstract Rhabdomyosarcoma (RMS) is a pediatric tumor, which arises from muscle precursor cells. Recently, it has been demonstrated that Hippo Pathway (
- Enhancement of radiotherapeutic efficacy for esophageal cancer by paclitaxel-loaded red blood cell membrane nanoparticles modified by the recombinant protein anti-EGFR-iRGD.Related ArticlesEnhancement of radiotherapeutic efficacy for esophageal cancer by paclitaxel-loaded red blood cell membrane nanoparticles modified by the recombinant protein anti-EGFR-iRGD. J Biomater Appl. 2018 11;33(5):707-724 Authors: Ren W, Sha H, Yan J, Wu P, Yang J, Li R, Zhang H, Yu L, Qian H, Liu B Abstract Paclitaxel is widely used as a radiosensitizer for various tumors, including esophagea
- MicroRNA-7-5p induces cell growth inhibition, cell cycle arrest and apoptosis by targeting PAK2 in non-small cell lung cancer.Related ArticlesMicroRNA-7-5p induces cell growth inhibition, cell cycle arrest and apoptosis by targeting PAK2 in non-small cell lung cancer. FEBS Open Bio. 2019 Oct 06;: Authors: Li Q, Wu X, Guo L, Shi J, Li J Abstract MicroRNAs are known to be critical regulators in tumor progression. miR-7-5p was reported to be involved in several cancers, including glioblastoma, cervical cancer and melanoma but,
- Adjuvant therapy with γ-tocopherol-induce apoptosis in HT-29 colon cancer via cyclin-dependent cell cycle arrest mechanism.Related ArticlesAdjuvant therapy with γ-tocopherol-induce apoptosis in HT-29 colon cancer via cyclin-dependent cell cycle arrest mechanism. J Biochem Mol Toxicol. 2019 Oct 06;:e22399 Authors: Bazzaz R, Bijanpour H, Pirouzpanah SMB, Yaghmaei P, Rashtchizadeh N Abstract Resistance to chemotherapy with 5-fluorouracil (5-FU) in patients with colorectal cancer (CRC) is the major obstacle to reach the maxi
- LncRNA PTCSC3 inhibits the proliferation, invasion and migration of cervical cancer cells via sponging miR-574-5p.Related ArticlesLncRNA PTCSC3 inhibits the proliferation, invasion and migration of cervical cancer cells via sponging miR-574-5p. Clin Exp Pharmacol Physiol. 2019 Oct 06;: Authors: Tong R, Zhang J, Wang C, Li X, Yu T, Wang L Abstract Dysregulation of long non-coding RNA Papillary thyroid carcinoma susceptibility candidate 3 (lncRNA PTCSC3) has been found to correlate with various types of cancers. Q
- Anti-tumor effects and associated molecular mechanisms of myricetin.Related ArticlesAnti-tumor effects and associated molecular mechanisms of myricetin. Biomed Pharmacother. 2019 Oct 03;120:109506 Authors: Jiang M, Zhu M, Wang L, Yu S Abstract Myricetin (3, 5, 7, 3', 4', 5'-hexahydroxyflavone) is a natural flavonol compound found in a large variety of plants, including berries, oranges, grapes, herbs, teas, and wine. In the last decade, a convergence of evidence has
- A potential role of cyclin-dependent kinase inhibitor 1 (p21/WAF1) in the pathogenesis of endometriosis: Directions for future research.Related ArticlesA potential role of cyclin-dependent kinase inhibitor 1 (p21/WAF1) in the pathogenesis of endometriosis: Directions for future research. Med Hypotheses. 2019 Sep 30;133:109414 Authors: Zarkadoulas N, Pergialiotis V, Dimitroulis D, Stefanidis K, Verikokos C, Perrea DN, Kontzoglou K Abstract Endometriosis is a common gynecological disorder that affects approximately 6-10% of the female
- Microwave synthesis of novel halogenated β-enaminonitriles linked 9-bromo-1H-benzo[f]chromene moieties: Induces cell cycle arrest and apoptosis in human cancer cells via dual inhibition of topoisomerase I and II.Related ArticlesMicrowave synthesis of novel halogenated β-enaminonitriles linked 9-bromo-1H-benzo[f]chromene moieties: Induces cell cycle arrest and apoptosis in human cancer cells via dual inhibition of topoisomerase I and II. Bioorg Chem. 2019 Sep 20;93:103289 Authors: Fouda AM, Assiri MA, Mora A, Ali TE, Afifi TH, El-Agrody AM Abstract A novel series of halogenated β-enaminonitriles (4a-m), linke
- Design, synthesis and biological evaluation of some new 1,3,4-thiadiazine-thiourea derivatives as potential antitumor agents against non-small cell lung cancer cells.Related ArticlesDesign, synthesis and biological evaluation of some new 1,3,4-thiadiazine-thiourea derivatives as potential antitumor agents against non-small cell lung cancer cells. Bioorg Chem. 2019 Sep 26;93:103323 Authors: Ragab FAF, Abdel-Aziz SA, Kamel M, Ouf AMA, Allam HA Abstract New 1,3,4-thiadiazine-thiourea derivatives have been synthesized. All the synthesized compounds were examined for
- The antiproliferative effect of spectinabilins from Streptomyces spectabilis on hepatocellular carcinoma cells in vitro and in vivo.Related ArticlesThe antiproliferative effect of spectinabilins from Streptomyces spectabilis on hepatocellular carcinoma cells in vitro and in vivo. Bioorg Chem. 2019 Sep 24;93:103311 Authors: Gao X, Yao H, Mu Y, Guan P, Li G, Lin B, Jiang Y, Han L, Huang X, Jiang C Abstract Spectinabilin (1), spectinabilin derivative (2), and a new analogue, 2-demethyl-spectinabilin (3) were isolated from the fermen
Τετάρτη 9 Οκτωβρίου 2019
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