Related ArticlesClinical Implications of Carcinoma In Situ in Sinonasal Inverted Papilloma. Otolaryngol Head Neck Surg. 2019 Oct 22;:194599819883298 Authors: Maina IW, Tong CCL, Baranov E, Patel NN, Triantafillou V, Kuan EC, Kohanski MA, Papagiannopoulos P, Yan CH, Workman AD, Lambert JL, Cohen NA, Kennedy DW, Adappa ND, Feldman MD, Palmer JN Abstract OBJECTIVE: Sinonasal inverted papilloma (IP) is a typically benign sinonasal tumor with a tendency to...
Wed Oct 23, 2019 13:00
Although capacity to mount an efficient immune response plays a critical role in individuals’ survival, its dynamics across ontogenetic stages is still largely unexplored. Life stage-dependent variation in the encountered diversity and prevalence of parasites were proposed to contribute to stage-dependent changes in immunity, but differences in life history objectives between developmental stages may also lead to stage-specific changes in efficiency of given immune mechanisms. The reason for this...
Wed Oct 23, 2019 03:00
Intraspecific agonistic interactions are widespread across the animal kingdom, with many individual morphological and physiological characteristics playing important roles in the fate of disputes. Additionally, changes to environmental conditions can influence the outcomes of animal contests. The shore crab (Carcinus maenas) is a globally distributed species, present in numerous coastal and estuarine temperate systems around the world. Although shore crabs are highly tolerant to changes in temperature,...
Wed Oct 23, 2019 03:00
P1B-type ATPases, known as heavy metal ATPases (HMAs), play an important role in the control of cadmium (Cd) accumulation in plants. In this study, a total of 12 ZmHMA genes were identified in the maize genome and particularly classified into six clusters based on their phylogenetic relationship and motif compositions. Furthermore, the expression patterns of different ZmHMA genes varied with developmental stages, and were tissue specific under normal conditions. ZmHMA2 and ZmHMA3 genes exhibited...
Wed Oct 23, 2019 03:00
Osteogenic cells form mineralized matrices in vitro, as well as in vivo. The formation and shape of the mineralized matrices are highly regulated by the cells. In vitro formation of mineralized matrices by osteogenic cells can be a model for in vivo osteogenesis. In this study, using a three-dimensional (3D) collagen gel culture system, we developed a new in vitro model for the formation of mineralized particles, a few µm in size, by the osteogenic cells. Human osteosarcoma (HOS) cells formed spherical...
Wed Oct 23, 2019 03:00
Application of inorganic nitrogen (N) fertilizer and manure can increase nitrous oxide (N2O) emissions. We tested the hypothesis that increased N2O flux from soils amended with manure reflects a change in bacterial community structure and, specifically, an increase in the number of denitrifiers. To test this hypothesis, a field experiment was conducted in a drip-irrigated cotton field in an arid region of northwestern China. Treatments included plots that were not amended (Control), and plots amended...
Wed Oct 23, 2019 03:00
A new genus of Xanthopygina rove beetles is described here as Lendatus gen. nov. The new genus includes three new species: L. bolivianus sp. nov., described from Bolivia, L. philothalpiformis sp. nov. described from Costa Rica and Panama, and L. platys sp. nov. described from Bolivia, Colombia, Ecuador and Peru. Lendatus belongs to the Isanopus group of genera of Xanthopygina and can distinguished from all the genera based on the unique punctation on the pronotum and the long apical setae of the...
Wed Oct 23, 2019 03:00
The genus Cucurbita comprises many popular vegetable and ornamental plants, including pumpkins, squashes, and gourds, that are highly valued in China as well as in many other countries. During a survey conducted in Zhejiang province, Southeast China in 2016, severe symptoms of viral infection were observed on Cucurbita maxima Duch. ex Lam. Diseased plants showed symptoms such as stunting, mosaicking, Shoe string, blistering, yellowing, leaf deformation, and fruit distortion. Approximately, 50% of...
Wed Oct 23, 2019 03:00
Background DegS is a periplasmic serine protease that is considered to be the initiator of the σE stress response pathway, and this protein plays an important role in the regulation of the stress response in E. coli. However, knowledge of the biological function and global regulatory network of DegS in Vibrio cholerae remains limited. In this study, we aimed to characterize the molecular functions and further investigate the regulatory network of degS in V. cholerae. Methods A deletion...
Wed Oct 23, 2019 03:00
Objective It is controversial whether the mode of delivery is associated with developmental outcome, and little was known about growth and development of cesarean children in poor rural areas in China. We aim to measure the development of both cesarean and vaginal-delivered children by Ages and Stages Questionnaires (ASQ) and explore the association between mode of delivery and developmental outcome in poor rural areas in China. Methods...
Wed Oct 23, 2019 03:00
Understanding of anatomy is based on the study of anatomical variations. Morphometric variations can have important implications for surgical practice. The sizes of some anatomical structures are affected by age; however, cadavers used in anatomical research are usually of advanced age. The main aim of this study is to quantify the mean age of samples in cadaveric studies reporting morphometric values. PubMed was searched for the last three years to locate cadaveric studies reporting size values,...
Tue Oct 22, 2019 22:53
Introduction This study aimed to determine the three‐dimensional (3D) territory and depth of the corrugator supercilii muscle (CSM) using a 3D structured‐light scanner. Materials and Methods Thirty‐two hemifaces from Korean and Thai embalmed cadavers were used in this study, and 35 healthy young Korean subjects also participated. A 3D analysis of the CSM territory and depth was performed using a structured‐light 3D scanner. The most frequently observed locations of the CSM identified in the...
Tue Oct 22, 2019 22:44
Controversies regarding structure and function of the pelvic floor persist because of its poor accessibility and complex anatomical architecture. Most data are based on dissection. This “surgical” approach requires profound prior knowledge, because applying the scalpel precludes a “second look”. The “sectional” approach does not entail these limitations, but requires segmentation of structures and three‐dimensional reconstruction. This approach has produced several “Visible Human Projects”. We dealt...
Tue Oct 22, 2019 19:34
Abstract The food enzyme β‐d‐galactosidase galactohydrolase (EC 3.2.1.23) is produced with Bacillus sp. strain M3‐1 by GenoFocus Inc. The food enzyme β‐galactosidase is intended to be used in the manufacture of galactooligosaccharides (GOS). Since residual amounts of total organic solids are removed by the purification steps applied during the production of GOS, toxicological studies were considered not necessary and no dietary exposure was calculated. Similarity of the amino acid sequence of the...
Tue Oct 22, 2019 12:45
Safety evaluation of the food enzyme triacylglycerol lipase from Trichoderma reesei (strain RF10625)
Abstract The food enzyme triacylglycerol acylhydrolase (EC 3.1.1.3) is produced with a genetically modified Trichoderma reesei strain RF10625 by AB Enzymes. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and recombinant DNA. The food enzyme is intended to be used in baking processes and cereal‐based processes. Based on the maximum use levels, dietary exposure to the food enzyme Total Organic Solids (TOS) was estimated...
Tue Oct 22, 2019 12:43
Abstract Background Although some researchers have positioned microdialysis catheters in the soft tissue surrounding bone, the results did not accurately reflect bone metabolism. The present study's objective was to establish the feasibility of microdialysis with a catheter positioned directly in bone. Methods Thirty‐four patients (19 males, 15 females; median age: 59) were included in a prospective, nonrandomized clinical trial in the Department of Maxillofacial Surgery at Amiens‐Picardie...
Tue Oct 22, 2019 12:09
House Clinic, the world-renowned center for the treatment of ear disease and neurological disorders, and House Ear Institute, the 501-(c)(3) private nonprofit foundation focused on researching these issues, have officially relaunched as part of the new House Institute, marking a new era for the organization’s nationally-recognized neurosurgeons and neurotologists. Named for the groundbreaking work accomplished by founder Howard P. House, MD. more than 60 years ago, the House Institute will ramp up...
Tue Oct 22, 2019 11:05
Abstract Cost and energy reductions in the production process of bismuth chalcogenide (BC) semiconductor materials are essential to make thermoelectric generators comprised of BCs profitable and CO2 neutral over their life cycle. In this study, as an eco-friendly production method, bismuth selenide (Bi2Se3) nanoparticles were synthesized using the following five strains of chalcogen-metabolizing bacteria: Pseudomonas stutzeri NT-I, Pseudomonas sp. RB, Stenotrophomonas maltophilia...
Wed Oct 23, 2019 03:00
Background Although pediatric cancer survivors in the United States are at an increased risk of developing chronic conditions, to the authors' knowledge there is limited information regarding the types and combinations of conditions they experience in the years immediately after the completion of cancer therapy. Methods An observational cohort study of early pediatric cancer survivors (children who were ≥2 years from the end of therapy and aged ≤18 years) was conducted using the Truven Health...
Tue Oct 22, 2019 19:42
Background The objective of this study was to determine whether fertility preservation (FP) with oocyte/embryo cryopreservation is associated with differences in disease‐free survival (DFS). Methods This retrospective study included patients aged 18 to 45 who were diagnosed with invasive breast cancer between 2007 and 2017 and were seen for FP consultation at a university fertility center before cancer treatment. The primary endpoint, DFS, was defined as the time from FP consultation until...
Tue Oct 22, 2019 19:41
Background The extent of breast cancer outcome disparity can be measured by comparing Surveillance, Epidemiology, and End Results (SEER) breast cancer‐specific survival (BCSS) by region and with institutional cohort (IC) rates. Methods Patients who were diagnosed with a first primary, de novo, stage IV breast cancer at ages 25 to 84 years from 1990 to 2011 were studied. The change in 5‐year BCSS over time from 1990 to 2011 was compared using the SEER 9 registries (SEER 9) without the Seattle‐Puget...
Tue Oct 22, 2019 19:40
Background Active surveillance (AS) is an accepted means of managing low‐risk prostate cancer. Because of the rarity of downstream events, data from existing AS cohorts cannot yet address how differences in surveillance intensity affect metastasis and mortality. This study projected the comparative benefits of different AS schedules in men diagnosed with prostate cancer who had Gleason score (GS) ≤6 disease and risk profiles similar to those in North American AS cohorts. Methods Times of GS...
Tue Oct 22, 2019 19:40
Background Significant progress was recently observed in the treatment of metastatic melanoma (MM). With >50% of patients now reaching a second line of treatment and a significant improvement in the survival rate, an assessment of quality of life (QoL) during the whole course of the disease becomes necessary. The objective of this study was to describe the QoL of patients with MM in France, from their diagnosis of advanced disease to their death, in real life. Methods QoL data were collected...
Tue Oct 22, 2019 19:38
Background Metastasectomy of isolated colorectal liver metastases (CRLM) requires significant clinical expertise and may not be readily available or offered. The authors hypothesized that hospitals that treat a greater percentage of patients from higher income catchment areas are more likely to perform metastasectomies regardless of patient or tumor characteristics. Methods Using the National Cancer Data Base, the authors classified facilities into facility income quartiles (FIQs) based on...
Tue Oct 22, 2019 19:37
Abstract Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe cutaneous adverse reactions to drugs. Granulysin (GNLY) plays a key role in keratinocyte apoptosis during SJS/TEN pathophysiology. To determine if GNLY-encoding mutations might be related to the protein’s functional disturbances, contributing to SJS/TEN pathogenesis, we performed direct sequencing of GNLY’s coding region in a group of 19 Colombian SJS/TEN patients. A GNLY genetic screening...
Mon Oct 14, 2019 03:00
Abstract Background The vestibular evoked myogenic potential (VEMP) is a technique used to assess vestibular function. Cervical VEMPs (cVEMPs) are obtained conventionally from the sternocleidomastoid (SCM) muscle; however, the dorsal neck muscle splenius capitis (SPL) has also been shown to be a reliable target alongside the SCM in young subjects. Objective ...
Wed Oct 23, 2019 10:23
Wed Oct 23, 2019 10:23
Wed Oct 23, 2019 10:23
Abstract Purpose To evaluate peripheral blood immunological parameters and the possible correlation with age, gender and adenoid size in children with adenoid hypertrophy with OME. Methods A total of 664 children with adenoid hypertrophy were initially enrolled in our study, of which 83 had concomitant OME. To minimize selection bias, we performed...
Wed Oct 23, 2019 10:23
Abstract Purpose The pathogenesis of persistent allergic rhinitis with chronic and refractory nasal obstruction is still unknown. Inflammation and tissue remodeling are known to play a role, but this has not been studied thoroughly. The purpose of this study is to identify the profile of gene expression of inflammatory and remodeling markers in nasal mucosa of patients with PAR and chronic obstruction. ...
Wed Oct 23, 2019 10:23
Abstract Purpose To evaluate a surgical procedure of canal wall-up mastoidectomy without incision of the canal which enables accelerated healing and enhances hearing outcome. Methods A total of 79 patients were enrolled. A canal-incisionless technique was used in 37 patients undergoing canal wall-up/down mastoidectomy (CWU/DM), explo-mastoidectomy,...
Wed Oct 23, 2019 10:23
Abstract Objectives To compare quality-of-life (QoL) measurements with audiological results after stapes surgery with two different prostheses. Methods This is a retrospective longitudinal study. All patients required stapes surgery for otosclerosis and ossicular chain reconstruction with either a titanium band prothesis (TBP) or receiving a...
Wed Oct 23, 2019 10:23
Abstract Background The endonasal access to the frontal recess and sinus may be complicated by a variety of anatomical variations. Previous classifications of these variants were characterized by proper names or position information without anatomical reference. The IFAC is intended to simplify the classification of anatomical variations of the frontoethmoidal complex. The aim of this study was to analyse a representative number...
Wed Oct 23, 2019 10:23
Abstract Purpose Intense bleeding of the surgical field is a potential factor influencing success of functional endoscopic sinus surgery (FESS). Hypotensive anesthesia with α2 intravenous agonists reduces intraoperative bleeding, but which is the best agent is unknown. The main objective of this trial was to compare the current standard adjuvant drug for hypotensive anesthesia, clonidine, with the recently available alternative dexmedetomidine....
Wed Oct 23, 2019 10:23
Abstract Purpose Functional electrical stimulation (FES) is considered an upcoming treatment modality for a number of laryngeal diseases. However, sound data are scarce when it comes to surface FES to treat voice disorders. Aim of the present study was to identify and differentiate suitable surface FES patterns to activate internal laryngeal muscles. Methods ...
Wed Oct 23, 2019 10:23
Abstract Purpose This study aimed to investigate the prognostic factors for head and neck soft-tissue sarcoma (HNSTS) in adults, with the comparisons between the 7th and 8th edition of AJCC TNM staging system. Methods From a cancer registry of a single, tertiary referral medical center, the medical records of 67 patients treated from February...
Wed Oct 23, 2019 10:23
Abstract Purpose To evaluate the clinical course of children with acute mastoiditis (AM) who required surgical intervention. Material and methods Clinical and biochemical characteristics at the moment of hospital admission were reviewed for patients who required surgery for AM. Children who were successfully managed conservatively during the...
Wed Oct 23, 2019 10:23
Abstract Objective We investigated the correlation between the expression of IL-17A in nasopharyngeal carcinoma tissues and cells and the occurrence and development of NPC was also investigated. Methods Forty-five NPC biopsy specimens from January 2014 to January 2016 were selected. Forty-five NPC tissue specimens and 45 chronic nasopharyngitis...
Wed Oct 23, 2019 10:23
Abstract Purpose To assess preoperative features that could predict the audiological outcome after cochlear implantation in the elderly, in terms of pure tone audiometry, speech audiometry, and speech perception performance. Methods All available records of patients with cochlear implants aged 65 or more at the time of their implantation at...
Wed Oct 23, 2019 10:23
Abstract Purpose The evaluation of Health-Related Quality of Life (HRQoL) in patients with chronic otitis media COM has gained attention over the past years and several questionnaires have been developed to evaluate it in affected patients. The Chronic Otitis Media Questionnaire 12 (COMQ-12) is a widely used disease-specific tool that evaluates the severity of symptoms, the specific impact on work and lifestyle, the effects on the...
Wed Oct 23, 2019 10:23
Abstract Purpose Definitive radiotherapy (RT) is recommended by NCCN guidelines for T4b tumors of sinonasal squamous cell carcinomas (SNSCC). However, no multi-institutional clinical studies have proved its advantage over surgery-based modalities. The aim of this study was to assess the survival of T4bN0M0 SNSCC patients who received surgery plus postoperative radiation (S + PORT) compared with those who received RT. ...
Wed Oct 23, 2019 10:23
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