Re: adjuvant radiation in early oral cancers with isolated perineural invasion

Re: adjuvant radiation in early oral cancers with isolated perineural invasion: We commend Rajappa et al for their recent study on the impact of perineural invasion,1 which has been discussed only scantily in the past. There has been a lack of prospective randomised studies either for or against adjuvant treatment in early oral cancers with singular adverse histopathological features (perineural invasion, lymphovascular invasion, the worst pattern of invasion, and the grade of tumour). Young patients with early oral cancers have a good prognosis, but there is an inclination towards overtreatment (with a limited armamentarium) at the cost of added toxicity.