To assess late toxicity, quality of life and oncological outcome after consolidative whole abdominal radiotherapy (WART) following cytoreductive surgery and carboplatin/paclitaxel chemotherapy in high risk pat...
Mon Oct 21, 2019 03:00
Background: Increased body mass index (BMI) has been associated with postoperative complications in multiple surgical specialties. In otologic surgery involving the stapes, where appropriate patient positioning and surgical dexterity are necessary for proper prosthesis placement, patients with higher BMI could make surgery more challenging. The purpose of this study is to evaluate the impact of BMI on outcomes after stapes surgery. Methods: Medical records were examined from January 2015...
Mon Oct 21, 2019 03:00
Objective: To examine differences in quality of life in patients with vestibular schwannoma following a single treatment modality: observation, stereotactic radiosurgery (SRS), or microsurgery. Study design: Retrospective review. Setting: Tertiary academic medical center. Patients: Patients diagnosed with sporadic vestibular schwannoma who had completed at least 2 Penn Acoustic Neuroma Quality of Life (PANQOL) surveys. Interventions: Treatment via SRS, microsurgery, or observation. ...
Mon Oct 21, 2019 03:00
Objective: The use of machine learning technology to automate intellectual processes and boost clinical process efficiency in medicine has exploded in the past 5 years. Machine learning excels in automating pattern recognition and in adapting learned representations to new settings. Moreover, machine learning techniques have the advantage of incorporating complexity and are free from many of the limitations of traditional deterministic approaches. Cochlear implants (CI) are a unique fit for machine...
Mon Oct 21, 2019 03:00
Objective: Facial function is a key outcome in surgery of the cerebellopontine angle (CPA). This study describes the natural history of facial weakness after CPA surgery. Study design and setting: Retrospective study of two tertiary centers. Patients and intervention: Patients undergoing surgery for CPA tumors from 2003 to 2017 with preoperatively normal facial function and without subsequent surgical or adjuvant therapy. Main outcome measure: Serial facial nerve examinations using...
Mon Oct 21, 2019 03:00
Objective: The Dizziness Handicap Inventory (DHI) is the most commonly used quality of life measure for vestibular disorders. However, there is wide variability in scores, and little is known about which variables contribute to dizziness-related quality of life. Our goal was to investigate the key demographic and symptom-related factors to that account for DHI variance. Study Design: Cross-sectional survey. Setting: Tertiary referral center. Patients: Adult patients presenting to...
Mon Oct 21, 2019 03:00
Objective: To report the use of multi-frequency intra-cochlear electrocochleography (ECOG) in monitoring and optimizing electrode placement during cochlear implant surgery. An acoustic pure tone complex comprising of 250, 500, 1000, and 2000 Hz was used to elicit ECOG, or more specifically cochlear microphonics (CMs), responses from various locations in the cochlea. The most apical cochlear implant electrode was used as the recording electrode. Study Design: Clinical capsule report. Setting:...
Mon Oct 21, 2019 03:00
House Clinic, the world-renowned center for the treatment of ear disease and neurological disorders, and House Ear Institute, the 501-(c)(3) private nonprofit foundation focused on researching these issues, have officially relaunched as part of the new House Institute, marking a new era for the organization’s nationally-recognized neurosurgeons and neurotologists. Named for the groundbreaking work accomplished by founder Howard P. House, MD. more than 60 years ago, the House Institute will ramp up...
Tue Oct 22, 2019 11:05
Cancers, Vol. 11, Pages 1616: Epigenetic Reprogramming for Targeting IDH-Mutant Malignant Gliomas Cancers doi: 10.3390/cancers11101616 Authors: Jong-Whi Park Şevin Turcan Targeting the epigenome has been considered a compelling treatment modality for several cancers, including gliomas. Nearly 80% of the lower-grade gliomas and secondary glioblastomas harbor recurrent mutations in isocitrate dehydrogenase (IDH). Mutant IDH generates high levels of 2-hydroxyglutarate (2-HG) that inhibit...
Tue Oct 22, 2019 03:00
Cancers, Vol. 11, Pages 1617: MPT0G612, a Novel HDAC6 Inhibitor, Induces Apoptosis and Suppresses IFN-γ-Induced Programmed Death-Ligand 1 in Human Colorectal Carcinoma Cells Cancers doi: 10.3390/cancers11101617 Authors: Chen Lin Liao Liou Chen Colorectal cancer (CRC) is the third most common cancer and the leading cause of cancer-associated death worldwide. Histone deacetylases (HDACs) have been implicated in regulating complex cellular mechanisms to influence tumor...
Tue Oct 22, 2019 03:00
Cancers, Vol. 11, Pages 1618: A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer Cancers doi: 10.3390/cancers11101618 Authors: Braicu Buse Busuioc Drula Gulei Raduly Rusu Irimie Atanasov Slaby Ionescu Berindan-Neagoe The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch from extracellular signals to intracellular responses. Alterations of signaling cascades are found in various diseases,...
Tue Oct 22, 2019 03:00
Cancers, Vol. 11, Pages 1614: Recent Advances in Nuclear Imaging of Receptor Expression to Guide Targeted Therapies in Breast Cancer Cancers doi: 10.3390/cancers11101614 Authors: Salvatore Caprio Hill Sarnella Roviello Zannetti Breast cancer remains the most frequent cancer in women with different patterns of disease progression and response to treatments. The identification of specific biomarkers for different breast cancer subtypes has allowed the development of...
Tue Oct 22, 2019 03:00
Cancers, Vol. 11, Pages 1615: Size and Shape Filtering of Malignant Cell Clusters within Breast Tumors Identifies Scattered Individual Epithelial Cells as the Most Valuable Histomorphological Clue in the Prognosis of Distant Metastasis Risk Cancers doi: 10.3390/cancers11101615 Authors: Velicko Vranes Nemanja Rajković Xingyu Li Konstantinos N. Plataniotis Nataša Todorović Raković Jelena Milovanović Ksenija Kanjer Marko Radulovic Nebojša T. Milošević Survival and...
Tue Oct 22, 2019 03:00
Cancers, Vol. 11, Pages 1612: Identification of a Synergistic Multi-Drug Combination Active in Cancer Cells via the Prevention of Spindle Pole Clustering Cancers doi: 10.3390/cancers11101612 Authors: Andrea Weiss Morgan Le Roux-Bourdieu Marloes Zoetemelk George M. Ramzy Magdalena Rausch Daniela Harry Marijana Miljkovic-Licina Katayoun Falamaki Bernard Wehrle-Haller Patrick Meraldi Patrycja Nowak-Sliwinska A major limitation of clinically used cancer drugs...
Tue Oct 22, 2019 03:00
Cancers, Vol. 11, Pages 1613: MicroRNA 452 Regulates Cell Proliferation, Cell Migration, and Angiogenesis in Colorectal Cancer by Suppressing VEGFA Expression Cancers doi: 10.3390/cancers11101613 Authors: Ji Su Mo Won Cheol Park Suck-Chei Choi Ki Jung Yun Soo-Cheon Chae The human microRNA 452 (MIR452) was identified as a colorectal cancer (CRC)-associated micro RNA (miRNA) by miRNA expression profiling of human CRC tissues versus normal colorectal tissues. It was significantly...
Tue Oct 22, 2019 03:00
Cancers, Vol. 11, Pages 1611: Screening a Broad Range of Solid and Haematological Tumour Types for CD70 Expression Using a Uniform IHC Methodology as Potential Patient Stratification Method Cancers doi: 10.3390/cancers11101611 Authors: Tal Flieswasser Valérie Camara-Clayette Alina Danu Jacques Bosq Vincent Ribrag Piotr Zabrocki Luc Van Rompaey Hans de Haard Karen Zwaenepoel Evelien Smits Patrick Pauwels Julie Jacobs The constitutive expression of CD70...
Tue Oct 22, 2019 03:00
Cancers, Vol. 11, Pages 1610: The Epithelial to Mesenchymal Transition Promotes Glutamine Independence by Suppressing GLS2 Expression Cancers doi: 10.3390/cancers11101610 Authors: Esmeralda Ramirez-Peña James Arnold Vinita Shivakumar Robiya Joseph Geraldine Vidhya Vijay Petra den Hollander Neeraja Bhangre Paul Allegakoen Rishika Prasad Zachary Conley José M. Matés Javier Márquez Jeffrey T. Chang Suhas Vasaikar Rama Soundararajan Arun Sreekumar Sendurai...
Tue Oct 22, 2019 03:00
Cancers, Vol. 11, Pages 1609: Functionalized Tobacco Mosaic Virus Coat Protein Monomers and Oligomers as Nanocarriers for Anti-Cancer Peptides Cancers doi: 10.3390/cancers11101609 Authors: Coralie Gamper Caroline Spenlé Sonia Boscá Michael van der Heyden Mathieu Erhardt Gertraud Orend Dominique Bagnard Manfred Heinlein Components with self-assembly properties derived from plant viruses provide the opportunity to design biological nanoscaffolds for the ordered display...
Tue Oct 22, 2019 03:00
We are pleased to announce two Executive Board-approved steps toward a more inclusive membership beginning in 2020: a more equitable and affordable dues structure; and a demographic data update that will help us gauge the impact of Association-wide diversity, equity, accessibility, and inclusion efforts. First, the dues changes, which the Board is convinced help make the dues structure more equitable and create an affordable avenue to AAA membership. You may be aware that AAA changed its dues structure...
Tue Oct 22, 2019 18:14
AbstractEvidence suggests that women outperform men in core aspects of odor perception, and sex hormones may play a significant role in moderating this effect. The gender-affirming treatment (GAT) of transgender persons constitutes a powerful natural experiment to study the psychological and behavioral effects of high dosages of cross-sex hormone applications. Therefore, our aim was to investigate the effects of GAT on odor perception in a sample of 131 participants including female and male controls,...
Tue Oct 22, 2019 03:00
Abstract Halitosis (bad breath) can be a cause of anxiety, depression and psychosocial stress, with pathological changes in the oral microbiota playing an important role in its development. Despite its prevalence, studies on the microbiology of halitosis are rare in Nigeria. This study determines the presence of five putative periodontal pathogens viz: Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, Prevotella intermedia and Treponema...
Tue Oct 22, 2019 03:00
Η νέα τεχνολογία γονιδιωματικής τροποποίησης (gene editing) ονομάζεται πρωτεύουσα τροποποίηση (prime editing) και έχει περιγραφεί ως ένας «γενετικός επεξεργαστής κειμένου» ικανός να ξαναγράψει με ακρίβεια τον γενετικό κώδικα. Στην έρευνα που δημοσιεύθηκε στο Nature χρησιμοποιήθηκε η τεχνική πρωτεύουσας τροποποίησης για να εισαχθούν ή να απαλειφθούν με απόλυτη ακρίβεια τμήματα του DNA σε κυτταρικές σειρές στο εργαστήριο. Επίσης χρησιμοποιήθηκε για τη διόρθωση βλαβών σε μία συγκεκριμένη βάση ή «γράμμα»...
Tue Oct 22, 2019 13:57
Μια μελέτη που παρουσιάστηκε στην Ευρωπαϊκή Εβδομάδα Γαστρεντερολογίας 2019 (UEG Week 2019) έδειξε ότι ορισμένα διατροφικά μοτίβα μπορούν να προστατεύσουν το έντερο, βοηθώντας στην ανάπτυξη των βακτηρίων που έχουν αντιφλεγμονώδεις ιδιότητες. Φυτική και μεσογειακή διατροφή αναδεικνύονται σε παράγοντες διατήρησης της υγείας του εντερικού μικροβιώματος και άρα προστασίας από παθήσεις που συνδέονται με τη μικρή βακτηριακή ποικιλία στο έντερο σύμφωνα με τους ερευνητές από το Ιατρικό Κέντρο του Πανεπιστημίου...
Tue Oct 22, 2019 12:45
Ερευνητές στις ΗΠΑ ανέπτυξαν ένα νέο αλγόριθμο τεχνητής νοημοσύνης, που τα καταφέρνει καλύτερα και από έμπειρους ακτινολόγους στην ανίχνευση μικρών εγκεφαλικών αιμορραγιών. Η εξέλιξη αυτή αναμένεται να συμβάλει μελλοντικά στην καλύτερη διάγνωση και αντιμετώπιση των ασθενών με τραύματα στο κεφάλι, εγκεφαλικά επεισόδια και ανευρύσματα. Το νέο σύστημα μπορεί να απαλλάξει τους ακτινολόγους από μεγάλο φόρτο εργασίας, καθώς η τεχνολογία της τεχνητής νοημοσύνης θα αναλαμβάνει πρώτα να διαχωρίσει τις απεικονιστικές...
Tue Oct 22, 2019 12:13
Βρετανοί και Αμερικανοί επιστήμονες συμπράττουν για να μελετήσουν τα πρώιμα σημάδια του καρκίνου σε μια προσπάθεια να εντοπίσουν και να αντιμετωπίσουν τη νόσο πριν καν εκδηλωθεί. Πρόκειται για το πρώτο φιλόδοξο σχέδιο της νέας διεθνούς σύμπραξης με την ονομασία Διεθνής Συμμαχία για την Πρώιμη Ανίχνευση του Καρκίνου. Οι ερευνητές σκοπεύουν στα πλαίσια ενός εργαστηριακού πειράματος να δώσουν το έναυσμα για τη «γέννηση» του καρκίνου ώστε να μπορέσουν να τον μελετήσουν εν τη γενέσει του. Στη Διεθνή...
Tue Oct 22, 2019 09:03
Εκατοντάδες επιπλέον εμφράγματα, εγκεφαλικά επεισόδια και κρίσεις άσθματος σημειώνονται τις ημέρες που παρατηρείται απότομη αύξηση στα επίπεδα της ατμοσφαιρικής ρύπανσης, σύμφωνα με νέα βρετανική μελέτη που φέρνει στο φως της δημοσιότητας το BBC. Επιστημονική ομάδα του Βασιλικού Κολεγίου του Λονδίνου μελέτησε στοιχεία από το Λονδίνο, το Μπέρμινγκχαμ, το Μπρίστολ, το Ντέρμπι, το Λίβερπουλ, το Μάντσεστερ, το Νότιγχαμ, την Οξφόρδη και το Σαουθάμπτον και διαπίστωσε ότι όταν τα επίπεδα της ατμοσφαιρικής...
Tue Oct 22, 2019 08:47
Η αντίσταση σε ευρείας χρήσης αντιβιοτικά για την θεραπεία επιβλαβών βακτηρίων που προσβάλλουν το στομάχι έχει υπερδιπλασιαστεί τα τελευταία 20 χρόνια, σύμφωνα με στοιχεία που παρουσιάστηκαν στο πλαίσιο του συνεδρίου της Ευρωπαϊκής Ένωσης Γαστρεντερολογίας, στη Βαρκελώνη. Η Ελλάδα, μαζί με τη Νότια Ιταλία και την Κροατία βρίσκονται μεταξύ των πρώτων ευρωπαϊκών κρατών με την υψηλότερη αντίσταση στο αντιβιοτικό κλαριθρομυκίνη, ενώ προβλέπεται ότι η χώρα μας μαζί με την Ιταλία θα είναι μεταξύ των χωρών-μελών...
Tue Oct 22, 2019 08:11
Mon Oct 21, 2019 12:38
Abstract Purpose To investigate long-term oncological outcome and incidence of chronic side effects in patients with breast cancer and intraoperative radiotherapy given as an upfront boost (IORT boost). Methods Retrospective analysis of 400 patients with an IORT boost with low-energy X‑rays (20 Gy), subsequent whole-breast irradiation (46–50 Gy), and annual...
Tue Oct 22, 2019 03:00
Introduction: Treating sources of noise is a novel aspect of voice ergonomics intended to enhance the preconditions for good voice production and easy listening. Objective: To improve experiences of listening and voice ergonomics in classrooms. Methods: Participants were two female elementary school teachers with voice symptoms and their pupils (n = 50). Two interventions were performed: the acoustic intervention and then the workshop intervention where the teachers and pupils were active. Teachers’...
Tue Oct 22, 2019 16:26
Background: Fibreoptic endoscopic evaluation of swallowing (FEES) is an imaging technique used by speech-language pathologists (SLPs) and some other health professionals to assess swallowing. Objectives: The primary aim was to gain an insight into FEES practices in Australia by characterising SLPs who use FEES and identifying areas of consistency and variation in practice. The secondary aim was to explore factors associated with variation in practice. Method: Cross-sectional survey methodology was...
Tue Oct 22, 2019 11:44
Purpose: Several studies have explored relationships between children’s early phonological development and later language performance. This literature has included a more recent focus on the potential for early phonological profiles to predict later language outcomes. Methods: The present study longitudinally examined the nature of phonetic inventories and syllable structure patterns of 48 typically developing children at 7, 11, and 18 months, and related them to expressive language outcomes at 2...
Tue Oct 22, 2019 11:28
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