Abstract Purpose Reducing the time from surgery to adjuvant chemoradiation, by decreasing unnecessary readmissions, is paramount for patients undergoing glioma surgery. The effects of intraoperative risk factors on 30-day readmission rates for such patients is currently unclear. We utilized a predictive model-driven approach to assess the impact of intraoperative factors on 30-day readmission rates for the cranial glioma patient. ...
Tue Oct 22, 2019 03:00
Abstract Purpose Most pediatric spinal tumors are low-grade gliomas (LGGs). Characterization of these tumors has been difficult given their heterogeneity and rare incidence. The objective was to characterize such tumors diagnosed at our institution. Methods Spinal tumors diagnosed in our pediatric patients between 1984 and 2014 were reviewed retrospectively....
Tue Oct 22, 2019 03:00
This manuscript describes two radiotracer administration protocols for FDG-PET (constant infusion and bolus plus infusion) and compares them to bolus administration. Temporal resolutions of 16 s are achievable using these protocols.
Tue Oct 22, 2019 22:00
This manuscript describes a protocol for determining whether exposure to ozone, a criteria air pollutant, impairs alveolar macrophage efferocytosis in vivo. This protocol utilizes commonly used reagents and techniques and can be adapted to multiple models of pulmonary injury to determine effects on alveolar macrophage efferocytosis.
Tue Oct 22, 2019 20:59
The existence of extended post-reproductive lifespan is an evolutionary puzzle, and its taxonomic prevalence is debated. One way of measuring post-reproductive life is with post-reproductive representation, th...
Mon Oct 21, 2019 03:00
The genus Ilex (Aquifoliaceae) has a near-cosmopolitan distribution in mesic habitats from tropical to temperate lowlands and in alpine forests. It has a high rate of hybridization and plastid capture, and compri...
Mon Oct 21, 2019 03:00
Since the introduction of cone-beam computed tomography (CBCT) in dentistry, this technology has enabled distortion-free three-dimensional cephalometric analysis for orthodontic and orthognathic surgery diagno...
Mon Oct 21, 2019 03:00
Abstract Diffuse malignant mesothelioma of the pleura (MPM) is a highly aggressive tumour that typically is associated with short survival. CD70 and CD27 belong to the tumour necrosis factor (TNF) and the TNF receptor (TNFR) superfamily, respectively. Under physiological conditions, the tightly regulated interaction between CD70 and CD27 plays a co‐stimulatory role in promoting T‐cell expansion and differentiation through the NFκB pathway. Aberrantly high CD70 expression has been documented in haematological...
Tue Oct 22, 2019 19:47
While preeclampsia is a common and dangerous complication in pregnancy, characterized by high blood pressure, it is currently only diagnosed by doctors within a clinical setting. We at Medgadget recently reported on a preeclampsia test, developed at Purdue University, that can be used at home, and now researchers have actually had pregnant women try to do it themselves. The so-called supine pressor test was developed decades ago, but eventually it became uncommon because of variations in how...
Tue Oct 22, 2019 21:14
There has been a lot of progress over the past few years in the field of brain-computer interfaces, a technology that may give severely paralyzed people the ability to use robotic arms and legs. As anyone with two arms knows, one is not enough for many tasks. So researchers at Johns Hopkins University have successfully implanted two microelectrode arrays, one on each side of a disabled man’s brain, that have been used to control two independent robotic arms and to also deliver tactile sensations....
Tue Oct 22, 2019 18:49
OmniVision Technologies, a Santa Clara, California firm, just announced that it has won the Guinness World Record for “The Smallest Commercially Available Image Sensor”. The OV6948 sensor was designed for use in catheters and endoscopes, allowing these devices to be as small as possible while also providing high quality imaging from within the body. Measuring only 0.575 mm x 0.575 mm x 0.232 mm, the sensor was identified by Transparency Market Research, an Indian firm, as the smallest commercially...
Tue Oct 22, 2019 17:09
Swapping a single amino acid in a simple bacterial protein changes its structure and function, revealing the effects of complex gene evolution, finds a new study. The study -- conducted using E. coli bacteria -- can help researchers to better understand the evolution of transporter proteins and their role in drug resistance.
Tue Oct 22, 2019 19:11
Human population density and land use is causing changes in animal genetic diversity, according to new research. The research show that environmental changes caused by humans are leading to changes in genetic variation in thousands of species of birds, fish, insects, and mammals. The evidence for human impacts was most clear for insects and fish species.
Tue Oct 22, 2019 18:21
Mucosal Immunology, Published online: 22 October 2019; doi:10.1038/s41385-019-0215-8Role of RANK-L as a potential inducer of ILC2-mediated type 2 inflammation in chronic rhinosinusitis with nasal polyps
Tue Oct 22, 2019 03:00
Tue Oct 22, 2019 03:00
Abstract Pancreatic pheochromocytomas are rare and typically diagnosed by local resection. We present the first reported case of metastatic pheochromocytoma to the pancreas diagnosed by endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA) and cytology. A 67‐year‐old female presented with 2 to 3 months of abdominal pain. A CT scan showed a large mass in the head of the pancreas engulfing the superior mesentery artery and vein, along with a large mass in the left adrenal gland. An EUS‐FNA...
Tue Oct 22, 2019 19:20
Abstract Background Although the Pap test has been the standard screening method for cervical precancer/cancer detection, it has been criticized for having a relatively low sensitivity and a low reproducibility between pathologists. There is limited knowledge about inter‐rater agreement and what clinical and demographic factors are associated with disagreements between pathologists reading the same Pap smear. Methods This study aimed to assess inter‐ and intra‐ rater agreement of the Pap...
Tue Oct 22, 2019 19:14
Abstract Bronchoalveolar lavage (BAL) is a useful procedure to evaluate lung infiltrates in order to identify infection, foreign body aspiration, and neoplasms. However, it is indeed unusual to find all three in the same sample. We report such a case in a 68‐year‐old male with a history of metastatic prostate adenocarcinoma and longstanding chronic obstructive pulmonary disease who presented with features of pneumonia. BAL revealed Aspergillus and parainfluenza infections, food particle aspiration...
Tue Oct 22, 2019 19:09
Suppurative Lymphadenitis after Radioactive Iodine Therapy for Graves’ Disease: A Rare Complication?
Background: Radioiodine (RAI) therapy for Graves’ disease is a well-accepted and effective treatment with a good side effect profile. Short-term adverse effects can occasionally include radiation-induced thyroiditis. To my knowledge, cervical lymphadenitis associated with RAI therapy for Graves’ disease has not been reported before. Case Report: A 38-year-old woman initially presented with uncontrolled thyrotoxicosis secondary to Graves’ disease. She subsequently received RAI therapy for her condition....
Tue Oct 22, 2019 16:26
Introduction: Orally and daily levothyroxine (LT4) is the treatment of choice for hypothyroidism. In the majority of cases, the lack of effectiveness by this way may be due to poor adherence; however, gastrointestinal malabsorption may explain more cases of thyroxine refractoriness than previously reputed, due to the number of occult forms of these disorders. Case Presentation: A 55-year-old white man with a diagnosis of low risk of recurrence of follicular variant of papillary thyroid carcinoma...
Tue Oct 22, 2019 13:28
An efficient and modular entry to α‐halogenated amides and esters is reported. This reaction is based on an underrated double electrophilic activation of ynamides sequentially involving highly reactive activated keteniminium and iminium ions. Upon simple reaction with HCl and an electrophilic halogenation reagent in the presence of water or an alcohol, a broad range of ynamides can be transformed, in a highly divergent manner, to α‐halo‐amides and esters with high efficiency and under mild conditions.
Tue Oct 22, 2019 19:31
The gas‐phase reaction of the heteronuclear oxide cluster [VPO4] ·+ with C2H4 is studied under multiple collision conditions at 150 K using cryogenic ion trap vibrational spectroscopy combined with electronic structure calculations. The exclusive formation of acetaldehyde is spectroscopically identified directly and discussed in the context of the underlying reaction mechanism. In line with computational predictions it is the terminal P=O and not the V=O unit which provides the oxygen atom in the...
Tue Oct 22, 2019 19:31
In situ EPR and Mössbauer investigations reveal unprecedented oxygenation of a transient paramagnetic iron(V) nitrido intermediate yielding an iron nitrosyl species. Computational studies suggest that the N−O bond formation involves transfer of a formally closed‐shell singlet O atom to the (FeN)2+ core concurrent with synergetic orbital interactions. Abstract Terminal metal nitrides have been proposed as key intermediates in a series of pivotal chemical transformations. However, exploring the...
Tue Oct 22, 2019 19:31
A radical shielding approach based on supramolecular complexation exploits the protection offered by a [10]cycloparaphenylene ([10]CPP) nanobelt encircling C59N. to stabilize this radical. The EPR signal of C59N.⊂[10]CPP showing characteristic 14N hyperfine splitting was observed even several weeks after its generation. Abstract A major handicap towards the exploitation of radicals is their inherent instability. In the paramagnetic azafullerenyl radical C59N., the unpaired electron is strongly...
Tue Oct 22, 2019 19:31
Hydration of ZnO surfaces: Comprehensive results from IRRAS and theory lead to a fundamental understanding of the surface chemistry of water on ZnO(10 0). The hydration is initiated by the formation of intact water monomers and proceeds by an autocatalytic dissociation of dimers and 2D adlayers, finally leading to the formation of various H‐bonded 3D structures. Abstract The surface chemistry of water on zinc oxides is an important topic in catalysis and photocatalysis. Interaction of D2O...
Tue Oct 22, 2019 19:31
Squaring the hole: Using N,N‐diarylanilinosquaraines as the comonomers gives polysquaraine hole‐transporting materials (HTMs) that have very high hole mobility. As a dopant‐free HTM for α‐CsPbI2Br‐based all‐inorganic perovskite solar cells, the power conversion efficiency (PCE) can reach 15.5 %, among the best for all‐inorganic PVSCs. Abstract Development of high‐performance dopant‐free hole‐transporting materials (HTMs) with comprehensive passivation effects is highly desirable for all‐inorganic...
Tue Oct 22, 2019 19:31
Millennium bug: A simple and highly efficient photosensitizer, called 4TPA‐BQ, operates by aggregation‐induced emission. A broad‐spectrum and potent antibacterial activity was attained after incubating 4TPA‐BQ with pathogens for 15 minutes. Upon lengthening of the incubation time to 12 hours, photodynamic therapy with 4TPA‐BQ targeted cancer cells and presented low toxicity to normal cells. Abstract Pathogen infections and cancer are two major human health problems. Herein, we report the synthesis...
Tue Oct 22, 2019 19:31
Molecular junctions with hemilabile contact moieties show enhanced mechanoresistive behaviour. In their Research Article (DOI: https://doi.org/10.1002/anie.20190640010.1002/anie.201906400), A. Vezzolli, S. Sangtarash, C. J. Lambert, S. J. Higgins, and co‐workers present a system in which the molecule–metal contact is forced to transition from a monodentate to a bidentate configuration as the junction is compressed and stretched, with a resulting modulation in conductance of up to two orders of magnitude....
Tue Oct 22, 2019 19:31
A clear case: The determination of glycan fucosyl positions with MS/MS is complicated due to rearrangements in the gas‐phase, leading to erroneous structural assignments. Unique IMS arrival‐time distributions of MS/MS fragments can be used to discriminate between fucosides originating from parent compounds and rearranged fucosyl residues, preventing misinterpretation of MS/MS spectra. Abstract The fucosylation of glycans leads to diverse structures and is associated with many biological and...
Tue Oct 22, 2019 19:31
Grow, little platelet: The on‐surface reactions of nanoplatelets between the surface Cd sites and activated Se precursors in the solution is found to be strongly facet‐dependent. The process occurs in two stages—rapid adsorption onto the non‐polar side facets and slow surface reaction on the polar {100} basal facets—as well as one destructive (ripening) stage. Abstract Facet‐dependent on‐surface reactions are systematically studied on zinc‐blende CdSe nanoplatelets with atomically‐flat {001}...
Tue Oct 22, 2019 19:31
A porphyrin‐based molecular sensor for selective detection of anions is described by M. O. Senge and co‐workers in their Communication (DOI: https://doi.org/10.1002/anie.20190792910.1002/anie.201907929). The acid‐activated interface between the specially designed binding cavity and corresponding substrates results in distinct spectroscopic alterations with vibrant colorimetric response. The cover picture by Ella Marushchenko illustrates chemically re‐engineered pigments to act like tiny Venus flytraps...
Tue Oct 22, 2019 19:31
Good made better: Controllable anodic oxidation of 2D Ti3C2Tx improves the rate performance of supercapacitor electrodes. The capacitance retention at 2000 mV s−1 increases gradually from 38 % to 66 % by tuning the degree of anodic oxidation. Abstract MXenes are a class of two‐dimensional (2D) transition metal carbides, nitrides and carbonitrides that have shown promise for high‐rate pseudocapacitive energy storage. However, the effects that irreversible oxidation have on the surface chemistry...
Tue Oct 22, 2019 19:31
Solar radiation is a versatile source of energy, convertible to different useful forms of power. A direct path to exploit it is the generation of heat, for applications including passive building heating, but it can also drive secondary energy conversion steps. We present a novel concept for a hybrid material which is both strongly photo‐absorbing and with superior characteristics for the insulation of heat. The combination of that two properties is rather unique, and make of this material an optical...
Tue Oct 22, 2019 16:15
Pretty vacant: Copper vacancies induced in the CuO photocathode facilitates charge separation and transfer, leading to remarkably improved photoelectrochemcial performance. A simple O2 treatment on the CuO photocathode leads to the formation of copper vacancies. Abstract Metal oxides are an important family of semiconductors for effective photoelectrodes in solar‐to‐chemical energy conversion. Defect engineering, such as modification of oxygen vacancy density, has been extensively applied in...
Tue Oct 22, 2019 16:14
What′s my name? In this Viewpoint, a critical discussion about the use of the word “perovskite” and some acronyms (DJ, RP, ACI, d‐HP, hollow perovskites) is proposed, and a description of perovskite networks through an elimination/substitution process from the ABX3 structure is compared to the known dimensional reduction concept. Abstract Hybrid halide perovskites (HP) have emerged in the last decade as a new class of semiconductors with superior performances in photovoltaic and electronic...
Tue Oct 22, 2019 16:12
Growth on the water: A comprehensive kinetic study of the growth mechanism of MAPbBr3 nanocrystals (NCs; MA=CH3NH3+) is made possible through the water–oil interfacial synthesis method. The overall reaction time of MAPbBr3 NCs is thereby prolonged to tens of minutes by reducing the formation rate of PbBr64− octahedra and the diffusion rate of MA. Abstract Fundamental insights into the reaction kinetics of organic–inorganic lead halide perovskite nanocrystals (LHP NCs) are still limited due...
Tue Oct 22, 2019 15:49
Liquid crystalline epoxy thermosets (LCETs) can be reprocessed into various complex 3D soft actuators by reconfiguring, reprogramming, and welding their structures. The slow transesterification reaction of LCETs is, nonetheless, fast enough to allow topology rearrangement and subsequent reprocessing when the transesterification time is prolonged according to the time–temperature equivalence principle. Abstract Widely used traditional thermosets are good candidates for construction of 3D soft...
Tue Oct 22, 2019 15:48
Good COP good COF strategy: The facile construction of highly crystalline and porous covalent‐organic frameworks (COFs) from amorphous covalent organic polymers (COPs) via linkage replacement is possible using a conversion strategy. Four COFs with high crystallinity and porosity are constructed. Abstract Covalent‐organic frameworks (COFs) as porous crystalline materials show promising potential applications. However, developing facile strategies for the construction of COFs directly from amorphous...
Tue Oct 22, 2019 15:46
Open‐cage fullerenes with a 19‐membered orifice were prepared in three steps from C60. Encapsulation of oxygen was achieved at room temperature under moderate pressure (50 atm), and the oxygen could be released slowly under ambient conditions. The activation energy of the oxygen‐releasing process is 18.8 kcal mol−1 and the half‐life at 37 °C was 73 min, which makes this a potential oxygen‐delivery material. Abstract Open‐cage fullerenes with a 19‐membered orifice were prepared in three steps...
Tue Oct 22, 2019 15:45
An eye for an eye: Two artificial predation strategies are spatially and temporally coupled to generate rudimentary tit‐for‐tat behavior in a ternary community of chemically interacting synthetic protocells. Abstract Two different artificial predation strategies are spatially and temporally coupled to generate a simple tit‐for‐tat mechanism in a ternary protocell network capable of antagonistic enzyme‐mediated interactions. The consortium initially consists of protease‐sensitive glucose‐oxidase‐containing...
Tue Oct 22, 2019 15:45
Isolation of a classical diborane(5) complex of tantalum was achieved by the room‐temperature reaction of [Cp*TaCl4] with LiBH4⋅THF followed by addition of S2CPPh3. Reactivity with metal carbonyls was also explored. Abstract The room‐temperature reaction of [Cp*TaCl4] with LiBH4⋅THF followed by addition of S2CPPh3 results in pentahydridodiborate species [(Cp*Ta)2(μ,η2:η2‐B2H5)(μ‐H)(κ2,μ‐S2CH2)2] (1), a classical [B2H5]− ion stabilized by the binuclear tantalum template. Theoretical studies...
Tue Oct 22, 2019 15:45
Both on board: A dinuclear species (RhVO3−) that can mediate co‐conversion of CH4 and CO2 has been identified. The Rh atom is the active site to activate both of the molecules. Abstract Direct conversion of methane with carbon dioxide to value‐added chemicals is attractive but extremely challenging because of the thermodynamic stability and kinetic inertness of both molecules. Herein, the first dinuclear cluster species, RhVO3−, has been designed to mediate the co‐conversion of CH4 and CO2...
Tue Oct 22, 2019 15:43
An irreversible phase transformation was tracked in situ from NiNPS to α‐Ni(OH)2. This result and potential‐dependent reversible conversion between α‐Ni(OH)2 and γ‐NiOOH prior to OER unveil the real active species of γ‐NiOOH in self‐reconstructed Ni‐based catalysts. Abstract The oxygen evolution reaction (OER) has been explored extensively for reliable hydrogen supply to boost the energy conversion efficiency. The superior OER performance of newly developed non‐noble metal electrocatalysts...
Tue Oct 22, 2019 15:43
Concentration matters: CuH‐catalyzed stereoselective reductive coupling of aldehydes with 1,3‐dienes was achieved by employing a suitable chiral ligand system and metered addition of aldehyde substrates. This method enables direct access to a variety of functionalized homoallylic alcohols. DFT and kinetic studies provide mechanistic insights into the effect of the relative concentrations of aldehyde and diene on the chemoselectivity. Abstract Recently, CuH‐catalyzed reductive coupling processes...
Tue Oct 22, 2019 15:41
Forgery‐proof: The novel AIE molecule 1 is designed with high‐contrasted and multi‐state mechanochromic and photochromic properties. Based on these properties, 1 shows great potential for application in advanced multidimensional anti‐counterfeiting, which was demonstrated by fabrication of a model banknote. Abstract Herein the novel tetraphenylethylene (TPE) derivative 1 was designed with an integration of aggregation‐induced emission (AIE), multi‐state mechanochromism and self‐recovery photochromism....
Tue Oct 22, 2019 15:41
Crystal clear: A germanate Rb4Li2TiOGe4O12 mid‐infrared (MIR) nonlinear optical (NLO) crystal, containing well‐aligned compressed TiO5 groups and distorted GeO4 tetrahedra, shows a strong second‐harmonic generation (SHG) response. It exhibits concurrently short ultraviolet and long IR cutoffs, fully covering the atmospheric window spectral range of 3–5 μm. Abstract Practical mid‐infrared (MIR) coherent light beams generated by frequency conversion in nonlinear optical (NLO) crystals are indispensable...
Tue Oct 22, 2019 15:40
I can Si clearly now: The ability of silicon to stabilize vinyl cationic species enables a redox arylation of alkynes whereby the poor reactivity and regioselectivity of alkyl‐substituted alkynes are lifted. This enables the synthesis of a range of α‐silyl‐α′‐arylketones under mild conditions in good to excellent yields. The silicon moiety of the products can either be removed or harnessed for additional C−C bond formation. Abstract The ability of silicon to stabilize vinyl cationic species...
Tue Oct 22, 2019 15:40
Stressed out: Cu2−x Te nanoparticles are presented as a new artificial multienzyme with enzymatic activity reinforced by near‐infrared‐II (NIR‐II) light. Cu2−x Te catalyzes cascade reactions continuously and elevates intratumor oxidative stress, which not only eradicates primary tumors, but also reverses the tumor immunosuppressive (cold) state into a proinflammatory (hot) state to combat tumor metastasis and recurrence. Abstract Current cancer therapy is seriously challenged by tumor metastasis...
Tue Oct 22, 2019 15:38
AI for chemistry: Automated synthesis can now be performed using an artificial intelligence algorithm to propose the synthetic route and a robotic microfluidic platform to execute the synthesis. The Highlight describes this approach towards small‐molecule synthesis and reflects on the significance of this milestone in chemistry.
Tue Oct 22, 2019 15:38
Atroposelective [4+2]: A new organocatalyzed atroposelective arene formation reaction involves a carbene‐catalyzed formal [4+2] cycloaddition of conjugated enals and α‐aryl ketones. This study expands the synthetic potential of N‐heterocyclic carbene (NHC) organocatalysis and provides a competitive pathway for the synthesis of axially chiral ligands, catalysts, and other functional molecules. Abstract Atroposelective arene formation is an efficient method to build axially chiral molecules with...
Tue Oct 22, 2019 15:37
A series of organic phosphors based on paracyclophanes (PCPs) exhibit both strong room‐temperature phosphorescence (RTP) and excellent circularly polarized luminescence. Modulating the PCP core with non‐halogen‐containing electron‐withdrawing units elongates the RTP lifetime to 313.59 and 528.00 ms. The afterglow is visible for several seconds under ambient conditions. Abstract Pure organic materials with intrinsic room‐temperature phosphorescence typically rely on heavy atoms or heteroatoms....
Tue Oct 22, 2019 15:35
A typical N‐doped TiO2 model reveals the anions activation mechanism based on the fundamental delocalized orbital hybridization modulation through O‐vacancy incorporation and demonstrated its necessity and usefulness for pre‐evaluating the role of dopants according to systematically experimental and theoretical studies. Abstract An N‐doped TiO2 model reveals a conceptually different mechanism for activating the N dopant based on delocalized orbital hybridization through O vacancy incorporation....
Tue Oct 22, 2019 15:33
Neat as a new Bpin: Asymmetric catalytic conjugate addition of a borylalkyl copper nucleophile generated in situ from a 1,1‐diborylmethane to α,β‐unsaturated diesters enabled the enantioselective incorporation of a CH2Bpin moiety at the β‐position of the diesters. The resulting β‐chiral alkylboronates were obtained in up to 86 % yield with high enantioselectivity (see scheme). Abstract We report the catalytic enantioselective conjugate addition of a borylalkyl copper nucleophile generated in...
Tue Oct 22, 2019 15:33
Induced volatolomics: A volatile organic compound (VOC) based probe is selectively converted by tumours into a VOC that diffuses into the blood stream and is then released in exhaled breath. The VOC in the exhaled breath can be detected and used as a diagnostic tool for cancer. This approach was used in the detection of several different tumours in mice, and for monitoring tumour growth and tumour response to chemotherapy. Abstract The development of efficient protocols for cancer diagnosis...
Tue Oct 22, 2019 15:30
Mechanoluminescence and room‐temperature phosphorescence were separated in polymorphisms with varied molecular packing. This afforded crucial information to deeply understand the packing–function relationship and the internal mechanism of different emission properties. Abstract Mechanoluminescence (ML) and room‐temperature photophosphorescence (RTP) were achieved in polymorphisms of a triphenylamine derivative with ortho‐substitution. This molecular packing‐dependent emission afforded crucial...
Tue Oct 22, 2019 15:20
Solvent‐induced gelation of Ag nanoclusters with atomic precision has been achieved. The metal–organic gel exhibits aggregation‐induced emission with fluorescence‐to‐phosphorescence switching and reversible changes upon heating‐cooling cycles. Abstract Luminescent metal nanoclusters (NCs) are emerging as a new class of functional materials that have rich physicochemical properties and wide potential applications. In recent years, it has been found that some metal NCs undergo aggregation‐induced...
Tue Oct 22, 2019 15:16
The selectivity control between hydrogen evolution and CO2 reduction at the interface of a semiconductor/electrolyte junction is described by O. S. Joo et al. in their Communication (DOI: https://doi.org/10.1002/anie.20190839810.1002/anie.201908398). Competition between CO2 reduction and hydrogen evolution was observed on (photo)electrodes under electrochemical conditions. However, hydrogen evolution was suppressed under photoelectrochemical conditions, showing a high selectivity for CO2 reduction...
Tue Oct 22, 2019 15:14
Recent developments in fluorescence microscopy call for novel small molecule‐based labels with multiple functionalities to satisfy different experimental requirements. A current limitation in the advancement of live‐cell single‐molecule localization microscopy, is the high excitation power required to induce blinking. This is in marked contrast to the minimal phototoxicity required in live‐cell experiments. At the same time, quality of super‐resolution imaging depends on high label specificity, making...
Tue Oct 22, 2019 13:52
Reversible oxygen conversion is of vital importance for various green energy technologies. Herein we synthesize a series of bimetallic coordination polymers by varying the Ni/Co ratio and using HITP (HITP = 2, 3, 6, 7, 10, 11‐hexaiminotriphenylene) as the ligand, with the aim to interrogate the role of metal centers in modulating the activity of oxygen reduction reaction (ORR). The differences in crystallographic structure, spin character, electric conductivity, and coordination states are elaborately...
Tue Oct 22, 2019 13:14
Making the invisible visible: Shiga toxin B subunits (STxB) bind to liquid‐ordered (l o) domains in model membranes, implying that its receptor Gb3 is localized in these l o domains. The synthetic access to Gb3 glycosphingolipids with labeled head groups allows quantification of their partitioning in coexisting l o/l d (liquid‐disordered) phase giant unilamellar vesicles prior to STxB binding. The data clearly indicate an impact of the fatty acid (un)saturation and α‐hydroxylation on the partitioning...
Mon Oct 21, 2019 21:57
Multifunctional organic emitter: One simple organic molecule exhibits aggregation‐induced emission (AIE), thermally activated delayed fluorescence (TADF), room‐temperature phosphorescence (RTP), and mechanoluminescence (ML) simultaneously. Abstract Aggregation‐induced emission (AIE), thermally activated delayed fluorescence (TADF), room‐temperature phosphorescence (RTP), and mechanoluminescence (ML) have attracted widespread interest. However, a multifunctional organic emitter exhibiting simultaneous...
Mon Oct 21, 2019 21:56
Van der Waals integration of ultrathin Janus‐like 2D heterostructures can also be achieved in a single step through a solution‐based approach. The structural configuration can be simply changed by proper selection of solvents. Such a heteromaterial has tunable properties and can be used as an advanced oxidation catalyst. Abstract A single‐step solution‐based strategy is used to obtain 2D Janus‐like free‐standing ultrathin nanosheets build from two structurally unrelated species, that is, polyoxomolybdate...
Mon Oct 21, 2019 21:54
Despite 450 000 years of human use, carbon combustion still holds secrets. In their Communication (DOI: https://doi.org/10.1002/anie.20190602610.1002/anie.201906026), A. Pénicaud et al. report a new method to study the kinetics of solid/gas reactions under thermogravimetric analysis. This method was applied to carbon combustion and demonstrates why this reaction still challenges scientists, suggesting exciting further studies.
Mon Oct 21, 2019 21:53
Docking and migration: Both activated and unactivated alkenes can be modified by a radical‐mediated monofluoroalkylative alkynylation, generating valuable products in a docking–migration process. Many complex natural products and drug derivatives can be readily functionalized with this approach. Abstract A radical‐mediated monofluoroalkylative alkynylation of alkenes is disclosed for the first time. The reaction demonstrates a remarkably broad substrate scope in which both activated and unactivated...
Mon Oct 21, 2019 21:52
A tandem enzymatic strategy to enhance the scope of C‐alkylation of small molecules via coupling the production of S‐adenosyl methionine (SAM) cofactor analogues with C‐(m)ethyl transfer to coumarin substrates, catalyzed by the methyltransferase (MTase) NovO, is described. This forms C‐(m)ethylated coumarins in superior yield and greater substrate scope relative to that obtained using cofactors lacking nucleobase modifications. Abstract A tandem enzymatic strategy to enhance the scope of C‐alkylation...
Mon Oct 21, 2019 21:48
Acid‐functionalization of carbon support allows enhancing the electrocatalytic activity of Pd to hydrogenate benzaldehyde to benzyl alcohol in proportion to the concentration of Brønsted acid sites. In contrast, the hydrogenation rate is not affected when H 2 is used as reduction equivalent. The different response to catalyst properties is shown to be caused by differences in the hydrogenation mechanism between the electrochemical and the H 2 induced hydrogenation pathways. The enhancement of...
Mon Oct 21, 2019 20:43
It has long been recognized that hydration water greatly impacts the color of inorganic crystals, but it is still unknown whether hydration water can be utilized to systematically manipulate the emission color of organic luminescent groups. Herein, we report that metal ions with different hydration ability allow fine‐tuning the emission color of a fluorescent group displaying aggregation induced emission (AIE). Because the hydration water can be removed facilely by gentle heating or mechanical grinding...
Mon Oct 21, 2019 18:14
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